LOCUS       NM_015677               1744 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SH3 and SYLF domain containing 1 (SH3YL1), transcript
            variant 1, mRNA.
ACCESSION   NM_015677
VERSION     NM_015677.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Choi,G.S., Min,H.S., Cha,J.J., Lee,J.E., Ghee,J.Y., Yoo,J.A.,
            Kim,K.T., Kang,Y.S., Han,S.Y., Bae,Y.S., Lee,S.R., Yoo,J.Y.,
            Moon,S.H., Lee,S.J. and Cha,D.R.
  TITLE     SH3YL1 protein as a novel biomarker for diabetic nephropathy in
            type 2 diabetes mellitus
  JOURNAL   Nutr Metab Cardiovasc Dis 31 (2), 498-505 (2021)
   PUBMED   33223406
  REMARK    GeneRIF: SH3YL1 protein as a novel biomarker for diabetic
            nephropathy in type 2 diabetes mellitus.
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Gagne,V., Aubry-Morin,A., Plesa,M., Abaji,R., Petrykey,K.,
            St-Onge,P., Beaulieu,P., Laverdiere,C., Alos,N., Leclerc,J.M.,
            Sallan,S.E., Neuberg,D., Kutok,J.L., Silverman,L.B., Sinnett,D. and
            Krajinovic,M.
  TITLE     Genes identified through genome-wide association studies of
            osteonecrosis in childhood acute lymphoblastic leukemia patients
  JOURNAL   Pharmacogenomics 20 (17), 1189-1197 (2019)
   PUBMED   31686588
  REMARK    GeneRIF: The analyses of variants in theACP1-SH3YL1locus derived
            from whole exome sequencing data showed an association of several
            correlatedSNPs (rs11553746, rs2290911, rs7595075, rs2306060 and
            rs79716074). The rs79716074 defines *B haplotypeof theAPC1gene,
            which is well known for its functional role
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Hasegawa,J., Jebri,I., Yamamoto,H., Tsujita,K., Tokuda,E.,
            Shibata,H., Maki,M. and Itoh,T.
  TITLE     SH3YL1 cooperates with ESCRT-I in the sorting and degradation of
            the EGF receptor
  JOURNAL   J Cell Sci 132 (19) (2019)
   PUBMED   31492760
  REMARK    GeneRIF: This study shows that SH3YL1 cooperates with ESCRT-I in
            the sorting and degradation of the EGF receptor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Kobayashi,M., Harada,K., Negishi,M. and Katoh,H.
  TITLE     Dock4 forms a complex with SH3YL1 and regulates cancer cell
            migration
  JOURNAL   Cell Signal 26 (5), 1082-1088 (2014)
   PUBMED   24508479
  REMARK    GeneRIF: SH3YL1 promotes Dock4-mediated cell migration and promotes
            Dock4-mediated Rac1 activation.
REFERENCE   7  (bases 1 to 1744)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 1744)
  AUTHORS   Hasegawa,J., Tokuda,E., Tenno,T., Tsujita,K., Sawai,H., Hiroaki,H.,
            Takenawa,T. and Itoh,T.
  TITLE     SH3YL1 regulates dorsal ruffle formation by a novel
            phosphoinositide-binding domain
  JOURNAL   J Cell Biol 193 (5), 901-916 (2011)
   PUBMED   21624956
  REMARK    GeneRIF: results provide new insight into the SH3YL1 molecular
            mechanism of dorsal ruffle formation and its regulation by
            phosphoinositide metabolism
REFERENCE   9  (bases 1 to 1744)
  AUTHORS   Shimomura,Y., Aoki,N., Ito,K. and Ito,M.
  TITLE     Gene expression of Sh3d19, a novel adaptor protein with five Src
            homology 3 domains, in anagen mouse hair follicles
  JOURNAL   J Dermatol Sci 31 (1), 43-51 (2003)
   PUBMED   12615363
REFERENCE   10 (bases 1 to 1744)
  AUTHORS   Aoki,N., Ito,K. and Ito,M.
  TITLE     A novel mouse gene, Sh3yl1, is expressed in the anagen hair
            follicle
  JOURNAL   J Invest Dermatol 114 (5), 1050-1056 (2000)
   PUBMED   10771491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY040340.1, DB244375.1, BC008374.1 and CK821806.1.
            
            On May 17, 2019 this sequence version replaced NM_015677.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008374.1, SRR7346977.606547.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356150.10/ ENSP00000348471.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY040340.1         67-79
            14-26               DB244375.1         50-62
            27-1741             BC008374.1         1-1715
            1742-1744           CK821806.1         26-28               c
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..1744
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /note="SH3 and SYLF domain containing 1"
                     /db_xref="GeneID:26751"
                     /db_xref="HGNC:HGNC:29546"
                     /db_xref="MIM:617314"
     exon            1..49
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1077
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-containing YSC84-like protein 1; SH3 domain
                     containing, Ysc84-like 1"
                     /codon_start=1
                     /product="SH3 domain-containing YSC84-like protein 1
                     isoform 1"
                     /protein_id="NP_056492.2"
                     /db_xref="CCDS:CCDS42646.2"
                     /db_xref="GeneID:26751"
                     /db_xref="HGNC:HGNC:29546"
                     /db_xref="MIM:617314"
                     /translation="MNNPIPSNLKSEAKKAAKILREFTEITSRNGPDKIIPAHVIAKA
                     KGLAILSVIKAGFLVTARGGSGIVVARLPDGKWSAPSAIGIAGLGGGFEIGIEVSDLV
                     IILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAVFTYCKSRGLFA
                     GVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEG
                     QRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPGLSSYH
                     ERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIF
                     PANYVTMN"
     exon            50..160
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            161..274
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            275..339
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            340..452
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            453..581
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            582..750
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            751..829
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            830..886
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1744
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /note="hexamer: TATAAA"
     polyA_site      1256
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /note="major polyA site"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /note="hexamer: AATAAA"
     polyA_site      1744
                     /gene="SH3YL1"
                     /gene_synonym="RAY"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcctgg gcagcctcgg gacggggcgc cgcggccggg cgggcagcat gaataaccct
       61 ataccttcca atttgaaatc agaagcaaaa aaggctgcca aaatattaag agaattcaca
      121 gaaataactt ccagaaatgg acctgataag atcattcctg ctcacgtaat tgcgaaggct
      181 aaaggccttg caattctgtc tgtgatcaaa gccgggttcc tggtgactgc cagaggaggc
      241 agcgggattg tagtggcgcg ccttccagat ggaaaatggt ctgcaccctc agccattggg
      301 atagctggcc ttggtggagg atttgaaata ggaattgagg tatcagactt ggtgataatt
      361 ctgaattatg accgtgctgt agaagctttt gcaaaaggcg gaaatctgac cctcggaggg
      421 aacttgactg tggcggttgg gcccttggga aggaacttgg aaggaaacgt ggccctgaga
      481 agctccgctg ccgtcttcac gtactgcaag tcaaggggac tctttgcagg cgtgtcttta
      541 gaagggagct gtttgattga aaggaaagaa actaatagaa aattttattg tcaagatatc
      601 cgagcttatg acattttatt tggagataca ccgcggcctg ctcaagccga agatctttat
      661 gaaattcttg attcctttac tgaaaagtat gaaaatgaag gacaacgaat caatgcaaga
      721 aaagcagcaa gggagcagag gaagtcttct gctaaagaat tacctccaaa gccattgtca
      781 agaccacagc agtcatctgc accagtccag ctgaactctg gctctcaaag taacagaaat
      841 gaatataagc tctatcctgg actttccagc tatcatgaga gagttggcaa tttgaatcaa
      901 cccatagaag tgacagcgct gtattcattt gaaggacagc agcctgggga tttgaatttt
      961 caagctggag acagaatcac agttatatca aaaacagatt cacattttga ttggtgggaa
     1021 ggaaaacttc gaggtcaaac tggcattttt ccagccaact acgtaaccat gaattaaagc
     1081 gtatactatt ttcttctttg agaattacaa aaaaattatt tctacactga caggatttac
     1141 tagttaagca atgtttaata taaattttaa aaaacttctg ttctacaaaa tttccattcc
     1201 gtatgtaaaa gattttgttt ttctatataa aaagagctga ctgacatatc tttaaatact
     1261 ttgtactaac tttatcacac ttactgtgtc atagaatatc atacagttta tacgctcata
     1321 gttctcttgt gaacacttca aacatcgcta agcatttgat ctggccatgt atatggtagc
     1381 tgtgttttaa tttgagaatc ttgagggtag agccacaaat ttcaattctt acatttccat
     1441 ttgcaaagtg actagagaaa aagaaatcag cttaaatgag gtattaagta atgtttagag
     1501 tcgtaggtat taactagaat ataaatcctt agaaattgtc tttatacctt caaaaattat
     1561 actatgcatt tatcatagaa atgtgattac aaagaagtct gactaccatg tctttaaaca
     1621 tatggcatct ctcaactttt cttccttatg gggctacatt tgttcatttc cagcagtagc
     1681 ataaacttac ggtgacatgg tagacttgtc tctaaataaa atttttaaat gtttactaag
     1741 ttaa
//
