LOCUS       NM_024577              26468 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SH3 domain and tetratricopeptide repeats 2 (SH3TC2),
            mRNA.
ACCESSION   NM_024577 XM_352958
VERSION     NM_024577.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 26468)
  AUTHORS   Nagappa,M., Sharma,S., Govindaraj,P., Chickabasaviah,Y.T.,
            Siram,R., Shroti,A., Seshagiri,D.V., Debnath,M., Sinha,S.,
            Bindu,P.S. and Taly,A.B.
  TITLE     Characterisation of Patients with SH3TC2 Associated Neuropathy in
            an Indian Cohort
  JOURNAL   Neurol India 71 (5), 940-945 (2023)
   PUBMED   37929431
  REMARK    GeneRIF: Characterisation of Patients with SH3TC2 Associated
            Neuropathy in an Indian Cohort.
REFERENCE   2  (bases 1 to 26468)
  AUTHORS   Shchagina,O., Orlova,M., Murtazina,A., Filatova,A., Skoblov,M. and
            Dadali,E.
  TITLE     Evaluation of Pathogenicity and Causativity of Variants in the MPZ
            and SH3TC2 Genes in a Family Case of Hereditary Peripheral
            Neuropathy
  JOURNAL   Int J Mol Sci 24 (12), 9786 (2023)
   PUBMED   37372933
  REMARK    GeneRIF: Evaluation of Pathogenicity and Causativity of Variants in
            the MPZ and SH3TC2 Genes in a Family Case of Hereditary Peripheral
            Neuropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 26468)
  AUTHORS   Sun,B., He,Z.Q., Li,Y.R., Bai,J.M., Wang,H.R., Wang,H.F., Cui,F.,
            Yang,F. and Huang,X.S.
  TITLE     Screening for SH3TC2 variants in Charcot-Marie-Tooth disease in a
            cohort of Chinese patients
  JOURNAL   Acta Neurol Belg 122 (5), 1169-1175 (2022)
   PUBMED   33587240
  REMARK    GeneRIF: Screening for SH3TC2 variants in Charcot-Marie-Tooth
            disease in a cohort of Chinese patients.
REFERENCE   4  (bases 1 to 26468)
  AUTHORS   Lerat,J., Magdelaine,C., Lunati,A., Dzugan,H., Dejoie,C., Rego,M.,
            Beze Beyrie,P., Bieth,E., Calvas,P., Cintas,P., Delaubrier,A.,
            Demurger,F., Gilbert-Dussardier,B., Goizet,C., Journel,H.,
            Laffargue,F., Magy,L., Taithe,F., Toutain,A., Urtizberea,J.A.,
            Sturtz,F. and Lia,A.S.
  TITLE     Implication of the SH3TC2 gene in Charcot-Marie-Tooth disease
            associated with deafness and/or scoliosis: Illustration with four
            new pathogenic variants
  JOURNAL   J Neurol Sci 406, 116376 (2019)
   PUBMED   31634715
  REMARK    GeneRIF: Implication of the SH3TC2 gene in Charcot-Marie-Tooth
            disease associated with deafness and/or scoliosis: Illustration
            with four new pathogenic variants.
REFERENCE   5  (bases 1 to 26468)
  AUTHORS   Senderek,J., Bergmann,C., Stendel,C., Kirfel,J., Verpoorten,N., De
            Jonghe,P., Timmerman,V., Chrast,R., Verheijen,M.H., Lemke,G.,
            Battaloglu,E., Parman,Y., Erdem,S., Tan,E., Topaloglu,H., Hahn,A.,
            Muller-Felber,W., Rizzuto,N., Fabrizi,G.M., Stuhrmann,M.,
            Rudnik-Schoneborn,S., Zuchner,S., Michael Schroder,J., Buchheim,E.,
            Straub,V., Klepper,J., Huehne,K., Rautenstrauss,B., Buttner,R.,
            Nelis,E. and Zerres,K.
  TITLE     Mutations in a gene encoding a novel SH3/TPR domain protein cause
            autosomal recessive Charcot-Marie-Tooth type 4C neuropathy
  JOURNAL   Am J Hum Genet 73 (5), 1106-1119 (2003)
   PUBMED   14574644
  REMARK    GeneRIF: mutations in an uncharacterized transcript, KIAA1985, in
            12 families with autosomal recessive neuropathy
REFERENCE   6  (bases 1 to 26468)
  AUTHORS   Hiroi,T., Hayashi-Kobayashi,N., Nagumo,S., Ino,M., Okawa,Y.,
            Aoba,A. and Matsui,H.
  TITLE     Identification and characterization of the human serotonin-4
            receptor gene promoter
  JOURNAL   Biochem Biophys Res Commun 289 (2), 337-344 (2001)
   PUBMED   11716477
  REMARK    GeneRIF: This paper presents an analysis of the SH3TC2 promoter
            after identifying a read-through transcript of the SH3TC2 and HTR4
            loci. Available data suggests HTR4 is a separate locus with its own
            promoter, and not the product of a bi-cistronic transcript.
REFERENCE   7  (bases 1 to 26468)
  AUTHORS   LeGuern,E., Guilbot,A., Kessali,M., Ravise,N., Tassin,J.,
            Maisonobe,T., Grid,D. and Brice,A.
  TITLE     Homozygosity mapping of an autosomal recessive form of
            demyelinating Charcot-Marie-Tooth disease to chromosome 5q23-q33
  JOURNAL   Hum Mol Genet 5 (10), 1685-1688 (1996)
   PUBMED   8894708
REFERENCE   8  (bases 1 to 26468)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301641
REFERENCE   9  (bases 1 to 26468)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
REFERENCE   10 (bases 1 to 26468)
  AUTHORS   Azzedine,H. and Salih,M.A.
  TITLE     SH3TC2-Related Hereditary Motor and Sensory Neuropathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY341075.1, AC011364.4,
            AC116312.2 and AF086088.1.
            
            On Aug 31, 2019 this sequence version replaced NM_024577.3.
            
            Summary: This gene encodes a protein with two N-terminal Src
            homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR)
            motifs, and is a member of a small gene family. The gene product
            has been proposed to be an adapter or docking molecule. Mutations
            in this gene result in autosomal recessive Charcot-Marie-Tooth
            disease type 4C, a childhood-onset neurodegenerative disease
            characterized by demyelination of motor and sensory neurons.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MK193740.1, AY341075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267757, SAMN03568912
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000515425.6/ ENSP00000423660.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3997              AY341075.1         63-4059
            3998-19466          AC011364.4         29354-44822         c
            19467-26159         AC116312.2         1-6693
            26160-26468         AF086088.1         1-309
FEATURES             Location/Qualifiers
     source          1..26468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..26468
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="SH3 domain and tetratricopeptide repeats 2"
                     /db_xref="GeneID:79628"
                     /db_xref="HGNC:HGNC:29427"
                     /db_xref="MIM:608206"
     exon            1..92
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..3907
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="SH3 domain and tetratricopeptide repeats-containing
                     protein 2"
                     /codon_start=1
                     /product="SH3 domain and tetratricopeptide
                     repeat-containing protein 2"
                     /protein_id="NP_078853.2"
                     /db_xref="CCDS:CCDS4293.1"
                     /db_xref="GeneID:79628"
                     /db_xref="HGNC:HGNC:29427"
                     /db_xref="MIM:608206"
                     /translation="MGGCFCIPRERSLTRGPGKETPSKDPTVSSECIASSEYKEKCFL
                     PQNINPDLTLSFCVKSRSRRCVNGPLQEAARRRLWALENEDQEVRMLFKDLSARLVSI
                     QSQRAQFLITFKTMEEIWKFSTYLNLGYVSMCLEHLLFDHKYWLNCILVEDTEIQVSV
                     DDKHLETIYLGLLIQEGHFFCRALCSVTPPAEKEGECLTLCKNELISVKMAEAGSELE
                     GVSLVTGQRGLVLVSALEPLPLPFHQWFLKNYPGSCGLSRKRDWTGSYQIGRGRCKAL
                     TGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPM
                     SRNSAFLSDEERCSLLALGSDKQTECSSFLHTLARTDITSVYRLSGFESIQNPPNDLS
                     ASQPEGFKEVRPGRAWEEHQAVGSRQSSSSEDSSLEEELLSATSDSYRLPEPDDLDDP
                     ELLMDLSTGQEEEAENFAPILAFLDHEGYADHFKSLYDFSFSFLTSSFYSFSEEDEFV
                     AYLEASRKWAKKSHMTWAHARLCFLLGRLSIRKVKLSQARVYFEEAIHILNGAFEDLS
                     LVATLYINLAAIYLKQRLRHKGSALLEKAGALLACLPDRESSAKHELDVVAYVLRQGI
                     VVGSSPLEARACFLAIRLLLSLGRHEEVLPFAERLQLLSGHPPASEAVASVLSFLYDK
                     KYLPHLAVASVQQHGIQSAQGMSLPIWQVHLVLQNTTKLLGFPSPGWGEVSALACPML
                     RQALAACEELADRSTQRALCLILSKVYLEHRSPDGAIHYLSQALVLGQLLGEQESFES
                     SLCLAWAYLLASQAKKALDVLEPLLCSLKETESLTQRGVIYNLLGLALQGEGRVNRAA
                     KSYLRALNRAQEVGDVHNQAVAMANLGHLSLKSWAQHPARNYLLQAVRLYCELQASKE
                     TDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLCHFYSS
                     VSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCIKES
                     LRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKSEEPLLALKLYE
                     EAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQISLEGYEKAL
                     EFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCPPWLQSPK
                     EALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNICQ
                     SPLWHSRPSGCSSERARWLSGGGLAL"
     exon            93..191
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            192..319
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            320..425
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            426..569
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            570..771
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            772..845
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1041
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1175
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1217
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2912
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3093
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3244
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3367
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3518
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3715
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..26468
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7254..7259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="hexamer: AACAAG"
     polyA_site      7272
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="major polyA site"
     polyA_site      7357
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="major polyA site"
     regulatory      8159..8164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="hexamer: AATAAT"
     polyA_site      8177
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="major polyA site"
     regulatory      17856..17861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="hexamer: AATAAA"
     polyA_site      17886
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
     regulatory      17909..17914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="hexamer: ATTAAA"
     polyA_site      17927
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="major polyA site"
     regulatory      19308..19313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="hexamer: AATAAA"
     polyA_site      19328
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
     regulatory      26448..26453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
                     /note="hexamer: AATAAA"
     polyA_site      26468
                     /gene="SH3TC2"
                     /gene_synonym="CMT4C; MNMN"
ORIGIN      
        1 gtgttcccaa gggcctcggc cagggtagga tggtacacac atgggtggct gcttctgcat
       61 ccccagggag cggagtctga cccggggccc aggtaaagaa actccttcca aggatccaac
      121 tgtatcgagt gagtgtatag cctcatctga atacaaggaa aaatgttttc tgccacagaa
      181 cattaatcca gacctgacac tctccttctg tgtaaagagc cgctccagga ggtgtgtaaa
      241 tggaccccta caggaagctg ctcggaggcg gctctgggca ctggagaatg aggaccagga
      301 ggtgcgcatg ctgtttaagg acctctcagc aaggttggtc agtatccagt ctcagagggc
      361 ccagtttctc atcaccttca agaccatgga ggaaatctgg aagttctcca cctaccttaa
      421 tttaggctac gtatccatgt gtctagaaca tctcctcttt gaccacaagt actggctcaa
      481 ctgcatattg gtggaggata cagagatcca agtgtctgta gatgataaac acctggaaac
      541 aatatacctg ggactcctga tacaggaagg ccacttcttc tgcagagccc tgtgctccgt
      601 gactccacca gccgagaagg aaggggaatg cttgacactt tgcaagaatg agttaatctc
      661 agtgaagatg gcagaagctg gctccgagtt ggaaggcgtg tctttggtga caggtcagcg
      721 gggcctggta ctggtgtcag ccttggagcc tctgcctctc cctttccacc agtggttcct
      781 aaagaattat ccaggaagct gtggcctttc caggaagagg gattggacag gctcctatca
      841 gattggcaga ggacgctgta aggccttgac gggttatgag ccaggagaaa aggatgaact
      901 gaatttctac cagggagaaa gcattgagat catcggcttt gtcatacctg ggcttcagtg
      961 gttcattgga aagtcgacaa gttcaggaca agtgggcttt gtccccacca ggaacataga
     1021 tcctgattct tattccccaa tgagcaggaa ctctgccttt ctcagtgatg aggagagatg
     1081 ctccctgttg gccctgggaa gtgataagca gactgagtgt tccagcttcc tccacactct
     1141 tgctcgcact gacatcacat ctgtctaccg gctcagtggg tttgaatcca tccagaatcc
     1201 tccaaatgat ctgagtgcat cccagcctga aggtttcaag gaggtcaggc ctggcagagc
     1261 ctgggaggag catcaggccg tggggtccag acagtccagc agctctgagg actccagcct
     1321 ggaggaggag ctcctctcgg ccacctcaga cagctatcgc ctgccggagc ctgatgacct
     1381 tgatgacccg gaactgctca tggacctaag cactggtcag gaggaggagg ctgagaactt
     1441 cgcccccata ttggcttttc tggatcatga gggttatgct gaccacttta agagtctcta
     1501 tgacttctcc ttctctttcc tcacttcttc cttttatagc ttctctgagg aggatgagtt
     1561 tgtggcctac ctggaggcat caagaaagtg ggccaagaag agccacatga cctgggccca
     1621 tgcccgtctc tgcttcctcc tgggccggct gagcatcagg aaggtcaaac tctctcaggc
     1681 cagggtgtac ttcgaggagg ccatccacat tctcaatgga gcatttgagg acctatcctt
     1741 ggtggccact ctgtacatca atttggctgc catctacctg aaacagaggc tgagacataa
     1801 aggctccgcc ctgttggaaa aggcaggtgc cctgctggcc tgcctgcctg accgtgagtc
     1861 tagtgccaag catgaactcg acgtggtggc ctacgtgctg cgccagggga ttgtggtggg
     1921 cagcagcccg ctggaggcca gggcctgctt tctggccatc cgcttgctcc tgagcctagg
     1981 ccggcacgag gaggtcctgc cctttgccga gcgcctgcag ctcctctctg gacaccctcc
     2041 tgcctctgag gctgtggcca gtgttttgag ttttctgtat gacaagaaat atcttccaca
     2101 ccttgcagtg gcctctgtcc agcaacatgg tatccagagt gcccaaggga tgtctcttcc
     2161 tatttggcag gtccaccttg tcctccagaa cacaaccaag ctccttggct ttccttcccc
     2221 aggctggggt gaagtttctg ccttggcctg cccaatgctc agacaggccc tggctgcctg
     2281 tgaggaacta gcagaccgga gcacccagag ggccctgtgt ctcatccttt ccaaagtgta
     2341 cctcgagcac aggtctcctg acggtgccat ccactacctg agccaggcct tggtgctagg
     2401 gcagctgctg ggtgagcagg aatcctttga gtcttctctc tgcctggcat gggcctatct
     2461 cttagccagc caggccaaga aggctttgga tgtgcttgag ccactgctat gctccctgaa
     2521 ggagacagag agtctcactc aaaggggagt catctataac ctcctgggac ttgcactcca
     2581 aggtgaaggc cgggtgaaca gggcagccaa gagctatctt cgggccttga acagagccca
     2641 ggaggtggga gatgtgcata accaggcagt ggctatggcc aatcttggcc acctgagcct
     2701 taagtcctgg gctcagcatc cagccagaaa ctatctcctg caggctgtac gactctattg
     2761 tgaacttcag gccagtaagg agacagacat ggaattagta caggtgtttc tctggttggc
     2821 ccaagttctg gtgtctggac accagctgac ccatggcctt ctttgttatg aaatggcatt
     2881 gctgtttggc ttaaggcatc gacatctaaa gagtcagctt caggccacca aatccctctg
     2941 ccatttctac agctctgtgt ccccaaaccc tgaggcatgc atcacctacc atgagcactg
     3001 gctggccctg gctcagcaac tcagggaccg ggagatggaa gggaggctgc tggagtccct
     3061 ggggcagctt tatcggaacc taaataccgc caggtccctc aggaggtcac tcacatgcat
     3121 caaggagagc ctgcgtatct tcattgacct gggggagaca gacaaggctg ctgaggcctg
     3181 gcttggggcg gggcgactcc actacctcat gcaggaagac gagctggtgg agctgtgcct
     3241 gcaggcagcc atccagacag ccctgaagtc agaggagcct ttgctggctc tcaaacttta
     3301 tgaagaagca ggtgatgtgt tcttcaatgg gacccgccac aggcatcatg cagtggagta
     3361 ctaccgagct ggagctgttc ctttagcaag gaggttgaag gcggtgagaa ctgagctccg
     3421 gattttcaat aagctgacag agctgcagat tagcctcgaa ggctatgaga aggctttgga
     3481 atttgccacc ctggccgcca ggctcagcac agtcacagga gatcagaggc aagagctggt
     3541 ggcctttcac cgcctggcta cagtgtacta ctccctgcac atgtatgaga tggctgagga
     3601 ctgctacctg aagaccctgt ccctctgtcc accatggctg cagagtccca aggaggccct
     3661 gtactatgcc aaggtgtatt atcgcctggg cagactcacc ttctgccagc tgaaggatgc
     3721 ccatgatgcc actgagtact tccttctggc cctggcagca gcggtcctgc tgggtgatga
     3781 ggagcttcag gacaccatta ggagcaggct ggacaacatc tgccagagcc ccctgtggca
     3841 cagcaggccc tccgggtgct cctcagagag ggcgcggtgg ctgagtggtg gtggcctggc
     3901 cctctgagga aagctgtcct gtctctggac atttggcatg gccagactct gaccccactg
     3961 ccctaggctc ttaaatactc attgggaggg tccgagtcct tacctggcct agccccctca
     4021 tttcacaaga agaagaatga agtccaggag gagaagggct cattgcaggc cacagaaaga
     4081 tttgatggtg cagcgatgag aattcctggt tccaggcttt gcatctggag cctttaccgg
     4141 ttgactgttg ccttccacac aaacagcctc tgaaaagcac tttctccata cataattctg
     4201 gagaagatga gggatcttgc cctccaggag ccttccttcc tcccccaatg aggaaatcag
     4261 tcactgcact ggtgcaaagg caagcagatt ggaatttgtg ctcttcaccg attttctcag
     4321 ggaaagaccc cttccccttg ccagcagagg aacctgtagt tttttccatt tctttcttca
     4381 gaaccaaagt atgtatcact cctcatgctc acagggattg acaggagaga attcaccagg
     4441 atcttagctc aaaagacaca gcctcagaat ggccagatgg attgcacgaa acctgacttg
     4501 gattcaccat cttcctcctg ccataaggct gtgctcccac ataacctccc agaagctcca
     4561 gggaagcttt ccaagagcaa aggcttggaa attgaatgtt aagaaaatta tgacataaat
     4621 tacatgtaaa tagtgtatat gattaaatat tgtccagtta catttacaca cacattttgt
     4681 ctcatccaca atgggggcag atgagatgga ggacttgatg gatgggagag aataccaata
     4741 catgtctttt tttttttttt ttttttttga gacagtttct cctctgttgc ccaggctgga
     4801 gttcagtggt acagtcaggg cttcctgcga cctcagactc cggggctcaa gtgatcctcc
     4861 agtgtcaacc tcctgagtag ctggaactac aggcatgtgc catacccaac tacaaggcat
     4921 cttattgatt tcagggcagc tgctttacaa agcatctcta ttaataacat cactgcatag
     4981 cacactgagt ggcctaaaac acttataatc tcatggtttc tgaagggcag gaatccaagc
     5041 atgacttagc tgagcccacc agcttagggt ggttcacagg ctgcaatcag ctggggctgc
     5101 agttatctca acttcaacta gagaaggatg ggcttccaag ctcacccaca cagctgttgt
     5161 taggagtcag ttttttgcta gctgttggcc agaggcttcc tgcagccact tgccacgtgg
     5221 gcctctccac agggcagtca caacatggca ccatgcttca ctagagggag caaacaagag
     5281 gagcaagaac cagagtgagc aggagaaaag ggagtgactc tttctataac ctgatcacag
     5341 aagtgacatc tccttagtct tgcctattca attcataata aatgagtcac taggtctagc
     5401 tcccacaaga ggggagtgtt taccaacagc ttgaatacca gatggtgagg aatcattggg
     5461 gatcatttca gaagtgacct accacagtat ctgagttctt tgataatgaa attgggaatt
     5521 ctctaatttc agcaaactga aaatatggtc cactaaccag cagcatcagc atcacctgtg
     5581 agattgtttg aaatgaaaat ctgtggcccc acctatgatc tctgaatcag aatctctgga
     5641 tcccagaacg ctgactcgtc caagctttcc tggtgatttt aatgcaccct aaagtatggg
     5701 aagcaccact gcagggcaag agccctcaga tagtgtgcat aactattacc tggtgaggtt
     5761 gtggaacatg aacttcttgg tttctatctc taataattct gattcagtag atctgggatg
     5821 tatcccagga acatgcattt ttagaaagca actcaagcaa gcctgatgca ggtggttcac
     5881 ccttgctcct tttctgtgaa ccacaaggat accagccata attccctgca tctgatgccc
     5941 atcagcttag cttttattat cagaccatct gcccttaatt tctagcttct tgggctgacc
     6001 agatgattgg ttgtatgaaa gggtgagatg ggagtggtga gttgagccgc cattgcatct
     6061 tctagtcatc aaggttgtct actaattggc acacattttc tcttagagat gtggttggtt
     6121 gtcaaaaggc tgtctactct agagagtatt ctccaggaag gagaagcttc cagttgtcta
     6181 attagtaaag ttatctaatc tactaccatg gagaatagat gtggttttgc ccccaccaca
     6241 agctgtaaaa gccccaagct gggagggacg ttgcggttga ggctattcag tctaatctcc
     6301 cgtgcatagt cctttcaaca acattcctgg gagacagtca ggggcacaca cattccagaa
     6361 cagttacata tcgtgtattt gaagaaggct cacacagccc tggaaaccat gccactggcc
     6421 attccccatc tgactcaggt tacagatccc ctcccttttc ccactgacca ctcactctcc
     6481 tctggccaga tttgtttctg tttctctgaa agagcagttc ccacaactgc atgaggcttt
     6541 tgatattggc cggtgggtga agagtacaga gggatgttac tatacttaat ttgattcttc
     6601 ctctccccag cagccacatc tgtccttggc ttccattgag ctttataatc agttgaaact
     6661 tctgtgtctt ctgacttgaa cttctgtttg gacagatctt tctcaattgc tgcaaatatg
     6721 cacatgcatt tgcatatgca tacacataca cacacatacg tgaagagcgt tgtttctatc
     6781 catgttacat ctccttggaa attttagcta aaatttccca attctgtgca ctttgattta
     6841 cctataaatc tgatgaattt acccataacc aggtcagtta taaaaatgtt tagcatgttt
     6901 ccaaagacaa gggtaagact atttttttaa aataagaaaa acattgtgct atataattgc
     6961 aattactaca ttctatatgt aaaccgcttg ctaaaactct tttaaaaagt gtttaaaatt
     7021 ttcatttttg aaatgtgggc cagctattcc ctttggaaac atgttgatgc tgtctttttt
     7081 tcatgatcca cagagagtaa agtggtgatt ggatttggtc tctacttaaa catttaaaaa
     7141 aataagtgta tcatagccaa acatgatcta gttaccctct ttattctaat tgttccctca
     7201 aatcttatat gggctgtgtg actgctggct ccttacatct aatctaaata aagaacaaga
     7261 agggcattgc aacattgtgg aaaaccctgt aacatgtttt ctcagctttc aggtatacta
     7321 gttccctgtc caacagtatt aacattctga aatccaatat tgcttttgtc cttttcttat
     7381 ttgcttttcc attattttaa gatgccttta tattgtgcat gtgtatatat atgtatgtgt
     7441 gtgtgtgtgt gttcattttc ttcctctttg taaatataat gcacctcatt tggcagaagt
     7501 ttatttgggg aagggaatat gcaggaatgg agggtgttag gatgagggat caggaagcct
     7561 atcactaaag ggaacctgta ttttggtctt gattttgata ttaaattgca gtgcgacctt
     7621 gggcaagtca cttaacctct acacatctca gatatttgtc ctctgataaa agaacctcac
     7681 ctctgggttt ttcagcagtg ctatttttat actgtatgaa taggatgaga aatagtattg
     7741 gagagatgaa ataatatatt tttatagctc aattatatta tcttcttttt acaggtgagt
     7801 aaactgagga acagaagggt aactttctcc cagacacatt ggtagttagt ggcaaagaca
     7861 gtggtacttg aggcgggggt ctcatgactc aaggacttag ttgcacaaat gacaggattt
     7921 ctgctgttca gggcttcctt cacagttgtg tgtgtatatg tacacgtgtg tgtatgtatg
     7981 catgcattta tcacgatatg caccaaagag cctttacaaa acattttcta aattgattta
     8041 cttcttttac tcatattaac ttatttttat aagggatgac tagtctatat agaagaaaaa
     8101 cttgtattgt tttccataaa cagaattatg taaataatgg caaatacaat gaaaataaaa
     8161 taatgcatta acttcaagct aggtcctgtt gctcattgca agcacccagc ctaggcctta
     8221 tctggcattg tttgaaaaca gagagattaa taagtggcag agagtgtaga tgacagacta
     8281 gcaacaacca ctttttcctt gcacactcag agaaatggag taagcaggga agaggactga
     8341 gctccttctg aggagggtca gtgtcattca atgccaggtt tgggcacaca tttcagggaa
     8401 gtggggattc agctgggtga caggaaaggg gcaaatgata tattatgtaa tatgattcag
     8461 tatcagaagc attgtgattg gtgttagtta caggatgtta caggcactgc ggggaaggga
     8521 ttttacccag acagggttac gggcatcagg aagggctttc tggaggacgt gatatccaaa
     8581 ctgagttctg aaagggacac ttacttaatt ctaactgcag accagcaggt tggtattgac
     8641 agacagtgca tgtgtcaagc aaaggtccag agggtggaca gggggtgatg ttttctgaga
     8701 acaggtcact ctgagtgcag tgaggctgga gcagattcag ggaagcaaag agggtttgga
     8761 ttctacctgg aggttgaggg gaaggtatag aaggattata agcagttgaa agaaacatgg
     8821 tcagatttgt gctttggaaa gatgattcta gaagcagcat gagactagat tagggcagca
     8881 gtggagaagg tagaaaacac attaggactt ggcgattgca acacaacact ccagccttga
     8941 ttcagatatc aacagttttc cccactaatg ttcttctgat cccacattgg atttagttgc
     9001 catatttccc tatgcatctc tggtctatga cggtttctgc ctttccttgt ttttcatgac
     9061 cttgtcagtt ttggtctctt ttcctctttt aattgctccc attgagatgt gtggacaagc
     9121 ggcaaagaag gaagaaattc aagggaatgg gctctgcact cactcaggtg gcagctcagg
     9181 tgggggcaat gtaatgtgtt ttggagttgg gcatacttag gttagaatct gtttcttact
     9241 agctgtgtga ccttctgcaa attaattaac ttccctgagc ccagggctgt cagaattata
     9301 tcagacttac ttatgtcata gacaaggaaa tggctaaaaa ggaaatccat ctttggaggc
     9361 atgtaagcct tgacattgag aagtgcagcc aaacctggag gtgtggccag gcaccctggt
     9421 cctgcattca gggacacttg ggtctgaagc tctttctcct tttcatcact gagtgacctg
     9481 agcaacttac tttacctctt taagcttcaa ttattcctct gctcagactt ttaattgaga
     9541 cgagatgtat ggatggcttg gtatgaatgt caattggtgg tagctgtcac aatgaagcag
     9601 aactgagtag attcttaata agcacatcta ttcctgggtc ccacaccgtt aagcgggagg
     9661 gtgtgtatgt taggggtgct ctttgctact gggcctctca cttggcggtc ttccctcttc
     9721 ggtgggacag catatatttc ctgatatgta ccccctcact ctcccaactc tgtctgatta
     9781 ttccagaact caggggactt gaggatggag gctgctggaa gtgctggctc tgggaatgtg
     9841 cacttcgttc accctcctct aaggggtgtc ttctccccag agaagcagag acaagtgact
     9901 gcttaggggg tggggattct ccccagctgc catggtgcag gatcaagaat aacttgcgtg
     9961 gccaggactg cacagtgggg ctgcttggct tggcttccca gtacagactg cgaggcaggt
    10021 gagagggaag gatgctgtgc tttcaaaacg atttcaaagg tgagaaccca gctgccactt
    10081 ctagtgctgc ctttgactcc ttatccaggg catcacacta gcttgaggga tgaggctctt
    10141 tgagatgaac ttccagacag ggtaggtgag aggatggttg aagtcacatg gctaatgaga
    10201 agacaggcta atccattgct gtccttttct gtgagaaatc caagagttcc agtagggggc
    10261 agtgatgtct tcctaaatag tgtatcattg gtaaagaacg tatttaatat taatagttct
    10321 gaatcagact agggtagtgg ctgtcaaatc cttttttgtt gttatgttgt tgttgttgtg
    10381 gcccacagta agaaatgcat tttatggttt atcctcgtgt gcatatgttt gtgcatatgc
    10441 aacaacatag agaaatgcac tcatacattc tgttttgttc tattcatttt taaaaacatt
    10501 ctattctagt taaaaaatat caaatttatg actcaccaaa tgaatttctc actcattaac
    10561 ctgtagtttg aaaagtgctg acctggaggg tggtctctaa aaaagtgcag gagggctcca
    10621 gcctttgttc ttttctatgt attatttgat ggatatctta cttctttttg agaccagaga
    10681 gtgtgtacat ctcaaaataa aaataacagt tgaggttaat gtgttttatg cattaagtct
    10741 catgcaaaac ctttgtgatg actctcatgt aatcacacaa cattttggtg tagttactat
    10801 tatttttatc tccactgagg tttagagaat tgatgtggct tgtctaagtc cacagttagt
    10861 ggtgatcgag gtgaaatttg aagtcatgtc ctctgatgct ggagctagga aatgaaacca
    10921 ttatattata ttgtgtttct gtcaggtgac acatctctga gagaaatgct atcactaata
    10981 tgatcatgaa tagaagcatt agattaaaac ttgtttcatc agcctgaaat actgggctga
    11041 aatcaacaca atcattctgg tgtaattgaa tcaatcaaaa ttggttactt tagaacagga
    11101 ttggagagaa ctgactttcc aggaggtctt gaaaaagaaa tactggtgtt attgttgacc
    11161 acagtcaggt aacttagcct agaaaaaaag agagactgca tttcccaaat ggaaaataga
    11221 aggaggaaca gaaagctttg acctatagta gtgattggtc aaaacaaatt ataagatcag
    11281 taagttatgt tttgaagaag attccaggtt gggagtgagg tgaatgaggg aaacttgcaa
    11341 gagactccag agccaatcgt agaagactat ggacatctga ggaagggaag cagccaggtg
    11401 gagtttcgtg ggtctcaccc atcatagtac ccgtagctcc aatggtggta gcagaaggaa
    11461 gatcatgaac atgagagaat agcctacttt tgacatcatg gaaaaagcta ttaggaacat
    11521 ccttctcatc caaatatgtg ttgcaaaaca aatagcctgg gaagagccca tgttcatgta
    11581 cagatgcttt gtttcttatg cataaatgtt ggtagtagca ctttttttac tcacttagta
    11641 ttcaggaatg cttaattatc tacttcccta accttccatt ttactgtatt tttatttagg
    11701 gtcacacatt ttactgttat ctatgaaaag gattttgaaa atagatacct cgcttctgtc
    11761 ttttatttta accttccaaa tctagcggac catagttaaa catgatctgt atgactctca
    11821 gctacttgat cttccttgca cgggccaaat atgtgtgaag gtgacttttt tggttattga
    11881 actttcttgc acatagagaa cttctgatgt ttgttcatct ggggatatat ctgacatcta
    11941 cttcatagag acattcatag gaatgcccct gaattctttg aacattgtac cagacagcaa
    12001 gcagtgacaa tggctacatc tgctttcctc ctcaggggag ctgccacggg ctaggctgaa
    12061 ataacagctg cgtggtaatc ctggtgacca aaaagctact tattcataaa acaaaacaaa
    12121 actaactttt gtctgttcta gaacatgtag ctttggggct gtagtgggtg gagggaaagg
    12181 atagcaaaca gaaagattac ttggaggatt ttcatttccg gttgttttac agtcctaaga
    12241 gcttatataa actgatattc tgatcctctt ccaagtcctg tggcattctt ttctttcttt
    12301 ccaagttgta taaagtccat ctgtctgttt ctctctctct ctctctttct ctcttattta
    12361 ggcagggtct cactctgttg cccaggctgg agtgcagtgg ggtggccatg gttcactgct
    12421 acctcgacct tctagactca ggtgcttggg tgatcctccc acttcagcct cccgagtagc
    12481 tgggactaca ggcatgtaca accactccca gctaattttt tttttttttg gtagtttttg
    12541 tagagatggg tttccaccat gttgcccatg ctagtctcaa actcctgggc tcaaatcatc
    12601 cacccacctc agccttccaa agtgctgggg taacaggtgt gagccatggc acccggccag
    12661 ttggtctctt ttttcttttt cctcatgtcc ttagcatctc ccttttgctt gtgctcattt
    12721 gtccctgtac ttttccttca aagcacttat catagtttaa aagtgtactt tatgtgagtt
    12781 tttttatttt aataatccat gtgcaccacc tagattagaa gttccatgaa aacaggaatc
    12841 ttatttgggt cactcagctc tgtatttctg gagcccagcc cagtgtctga tgcatggcag
    12901 gctctcaata aagatttgtt gaatgggtga ataaaaaaat aaaggaatga aatgttggac
    12961 ttgggttttg accttcaggg agaaagtttt aaaactataa tataactact tattgctcat
    13021 gagtgattga gaaatcaggt gatagggctg ctcacatata tagcaggtat tcagcaaaag
    13081 tttattgaga ataataagca taatttttgt ttgtttagaa taagttgcta tagctgtggt
    13141 aggtcttttc ttaattttca aacagatagt agtttgacca gggataatca tggtctttta
    13201 ctgaagctgt aatgatggtt gtgctaagta atttacccac agtataggat ttgatcctcc
    13261 aaatgatcct ccaaagaagg tgaccttatc tccccttttc aggtgataga atcaaggttt
    13321 aaagtatttc agatgtttgc agagattcaa aatcactttt gtctgacctg gaaaatcagt
    13381 gctttatata attatgtaat tctgatacac gttttctctt tcagaactta ggatcttcaa
    13441 gataaatatt tctcttttga acatttgaat gtttcccttt gtcttaagga ggagggatga
    13501 tagaaaatct agggagcagg gaccttggct tatataagcc ttattgcacc aaataccaca
    13561 ggaaatccct tcagtgatga atgttctatg gaataaagat ccaggggata ggcagtacct
    13621 ttaaggtatt ttgaggcctg agtggtccag agtattgttt cataatccca agtctctttc
    13681 cttgggaaat cataagttca tggtattgtg ggatgtggat aaaaacctca tccttgccct
    13741 tgagtatctg tcagtctgtt tgggggagat tggatgcata tatgcaaagg actaggaaga
    13801 aaagtctgag tttagctcct ttgggacaga ggatgcagac ggttatccat ctattcatcc
    13861 atctattcat ccatctattc atccatccat ccatccatcc atccatccat ccatccatcc
    13921 ttccatccat ccattcattt atccaaccag ccaattaacc aaccaaccaa ccaaccaacc
    13981 aaccaaccaa ccaaccaacc aaccaaccaa ccaaccatct aaccacccaa ccacccacat
    14041 acccaaccaa tgaaacaacc aactaaccaa tattcaacac ctctcatgtg ctaaactcac
    14101 aatccagtga gcaagataat gacagtccct gtcttcataa gtcctatggg ctccagggca
    14161 agtcagagtc ctctgataaa cttacctatt attcttacca tcacagctta gatttgagca
    14221 cttttacctc aaacactgta ctaaaggtta tactcttatt atatcattga cttctcttaa
    14281 tttctcctac ctgcaagaag taattgcatt gtatagttat tcacataaca catgtgaaga
    14341 aatgagttca aagaggttaa gagattaatc ttacccaaag tcctgtagat agagagtggc
    14401 agcttcagga caccagtcca agccttatct atattgcaag tattgcataa aacctcagct
    14461 gaaattttga taaattttat ggaacttaag ctagatagat cttgttcacc tgaacatcct
    14521 gtctgggatg catggtagta gactgaacag ctccactgct tatgaaatgt gtgacctcag
    14581 gcaagttgtt aagctcttgg tgcttcatgt ttatcattgg caaatggaga tgataatagt
    14641 acttatctca tgggattgtt gtgtggatca aatgtgtgaa tatatgtaaa gtgcctggcc
    14701 catgttatat aagtgttggc tattattgtt attgtgttga cagacatttc agaagagtac
    14761 ttgtttgggc gaagaagtta atgaacactt ctttgttgaa cctgtggggt taaggcatgc
    14821 ttagaggaat gtaatctggg ctagatgctt ggctattcaa gtgagcatgt gacagtgatg
    14881 gtctcagtct gcctcccttg tcagagcatc atctgtaaat gattgcctcc atcacttacc
    14941 aagcacagtc acaggaagtt gtgacctccc tttattggaa ctgtcatttt gaacctatgt
    15001 ttagtctggc agacgttttg acctccgtga tatattgctg agggtgtttt gactccatgc
    15061 ttataactac aacattaaaa acaccaataa tggctgaatt tttatcaaga aagtattttc
    15121 ttaattaatg cttactcaat catttttact ccaagataaa tgttcaatac agagcagtta
    15181 aacaatttct acctttttcc atcttctatt ttatcaaaat cattttatgg agatgaattc
    15241 ttttgcattt ggaattttac aatgatggct tataatttat tgacaataat ttatttaggt
    15301 caaattttag cttctgccac tgaattttcc atcgtagttt tatttctact aagtcaaatt
    15361 ttcctggttt aaatttgatt gatttgaatt ttattgggat aatttgattc ccctgtgaat
    15421 gtttgctcat taacacattc tttgtgtagg ttagctgttg tcagttttat tttgaactga
    15481 ttatttcaat cgaaacggtg agggacaaat gcctaatcac cttaagcgtc tatggaagcc
    15541 aggagtgagg ccaggtaaag gcagcccaga ccagatctaa atgaaacgct gtgggctaag
    15601 ttttcattca cagaagatgg gcagagtggc agatcagagg taactatcaa tgatacaaac
    15661 ttcaaggaaa tgatgagata cagaggacca aagttaaagt caatgatata tgtgaagcat
    15721 gatgattttc caagccatac ccaaacccta tgagctgtgc atgttatacc cagcagttta
    15781 atcctggaag actcttggtg catgttgcag ggatgagtta gctcagtgtg atgtagttaa
    15841 agagcagtgg gattggggtc aggtgatctg gggtctgaac ctagttctgt cactccttgt
    15901 gtatactggg acaagtccat ctcccacctg aggtctcagt tttaccaact gtcaaaagat
    15961 tgccctaaaa gttcatagac cccttcgaaa atctgaaaaa aaaaaaaaaa aaaaaaacca
    16021 atgaaatctc ttcttggaat tatgtataca cacccataca catactttca aaggcctcat
    16081 ggacccttta atgcacgccc aaggatgatg agttaaaaac ctcagtctcg gtaatctgtc
    16141 aggacctgtc cagggttgac atgctagggc ttaggtaggt gttatatatg tatcctccag
    16201 gtgatgcctg agaactgaca tacatactgc ttatggataa aaatggagac atccagaaaa
    16261 gcaggatctg gaaccctttg tatgcattgt tggtttctta gtgttttcat taatattatg
    16321 aatggttaag agcataaacc ttgggattat gctacctggg taaaaatccc cactgtgtgc
    16381 atgaccttgg gcaaggcact taaccattct gggcctccat ttctgcatct gtaatatgga
    16441 agtattaatg atatcaactt catagggctg ttggatgaaa cagctaaatg ttcaattgtt
    16501 acctcttatt acctagtgat tgaattcatg ttctgataat tttatgtcat acaaagtggc
    16561 agctggtggg ctttggagac cctctagctc agctctgttg ttattatatg aaaagtgaac
    16621 cagaaaaggg aaagccttac ccatggtcac ccaacacatg ttagggttgc tctctgacac
    16681 tccccttaga caccaggaaa gttgagccac catgacatca tcagcatacc agcttccagt
    16741 gcaagaggag gctcacctcc atggataaag tcccatgtga tgatctgcca tatttgtaga
    16801 gttctctgac accagctgtt tctgttgtga gtatagagtg attcagggca ggttggacac
    16861 cagtgagtat aatttctaca aaagcagttt gcaagagcct ctcattctac ctggaaatta
    16921 gtcacactga ttctaattac aaggcttttg tgaccccagc tgactggcca cccctcccag
    16981 agcaagcatt tcaaccaccc agctgcaatg tctggagact acttgatgtt actaccacta
    17041 aaagaactgg agctcctggg ggaaaccctt cagatataac cactgtatta tctgacagaa
    17101 agcaaaagct aaggtggaag cccactcaag aaacttccaa agactcctgg gtcctgggaa
    17161 atacaggatg agcccatatg gctaaagtta gctttgttgt tgagggaact gtagatttaa
    17221 ttgctggctg gatggtttgt gttgctactc cccacaaaga aattgaccct cttcttcaga
    17281 gcacagcaag gggtacacat taccctagtg aaagcacctt ctttgccctg ctggtttcag
    17341 ctgcaggaag tacattcttg cagtatattc actctcacat ccaatgtggt atatgggtaa
    17401 aagcttttgt atagagaaga aaaagtcctc tacatatgtt aatttctacc ccatgtgtag
    17461 ttattggtct tttgctgtga atgttcctgg tgttttaaag ggtcatatta aacgttttgg
    17521 ggcttctgag ggattggggt tttgaaagtc ccctggaaag tgtcaacaga tgttcaacaa
    17581 gtgatctaat tctgggtttt gggaaatgaa gtttgtgaac ttggctggga cctcagggct
    17641 tggagtcaga tagctttggg accttggaga catgacttaa cctctctggg tctcagtttt
    17701 ctcacctgtc aaatgggtta tcccagaact tgccttatag aattgctgtg aaaattaaaa
    17761 gagataatgt acttagaata cttaactcag ggccttgctt attgcaaata tttaatatat
    17821 aattgctatt atattttgta tcctgtatac tctataataa ataacacagc taatgtttac
    17881 tgagcattta tggtgtataa agcattggat taaattcttt gaatgcatga tttcattttc
    17941 tgtgttcaca acaacctcaa gggtggtatt attaacatgc ccattttata ggtgaggaaa
    18001 caaggtcttg gagaagttca gtaacttgtt tgaggtccaa tagcttgtga gtagcagggg
    18061 cagaatttgc attcaattga tctggtccaa gggcccatgc tgttcgccac caagctgctc
    18121 tgatctcctt ttgctcctga cttggcttca tcagcatggt tgtctttagg ttaacctggt
    18181 cttcccctca aatcctctcc tgtgaaccac ttggcagcac aacattgtgt gggtatgtgt
    18241 gtttgttgac aaaggccagc ttgcttatga tgggaggtgt gaacatttac agcaaactaa
    18301 ggaaactaag gctcagagag gcatatatct gtacttctaa agaggaacag tttgtcatct
    18361 tactatgaat atattttaaa tgaccaatgt cctagtagga gaaaggaact gcaagtgcaa
    18421 gcagagacag gaataaatca gagaaagaac aaaacagagt agcctagcgc acccagagca
    18481 taccatcatg aaacctactt tggggctatc tcagtttccc caggatggtt cacccatgag
    18541 agaaagcagg gaaaactggc ttaagggagc tatattttga gtgagaggag aggttgcttg
    18601 gaaatgactc ctagaaaaga agcagccccc accccatcaa acacacacac atacacacaa
    18661 acatgcacac acttgtgtat ccccacaccc caagaactca ttcttttctg ttatgtatct
    18721 catttttccc cagtgcaggt ggattgattc atagggacat ttcccaaatg tcctggttgc
    18781 tatatagttc ttctctctcc gttcattcca gctgcttctg aataccagat tgttgaagct
    18841 cttgggtccc tgtgactcac tctatcctgg gtcactctcc agatcccctt gaatgagtgg
    18901 ttccagtatt catgttctgg aagaatggca taagatttta tcagactgtt ttattatcag
    18961 tgcaaaccgg acaatacaga attgtaccaa catctgcagc aatatacata ggtggtctga
    19021 aaatgtcaac actttgcaat ccccaaaact cacatgtaag tccttccttc agagtgattt
    19081 tccaaggtac acagttctgc tgaccaaggt atagctcctg ccaaaggatt caacaactac
    19141 aatgtgattt ctggatgtga atgaattcag atattcctca gccatattta tgctggttaa
    19201 ggtagaccta ggttcaaatc ttgtctcaaa gtgcttagta tctgtgtagc attaacaaat
    19261 cactttatct ttctgagcta tggctctttc aactgtaaaa tggggataat aaatacctat
    19321 atagcaaagt tattgtaaaa ttaatgaatt aatatgtcta aagcagttag catggtggct
    19381 ggaatgtaat aggtcgttaa tagattatgg ctatttttaa aacccatgac ttgagcctgt
    19441 aatcttggaa aaaagactca aaaagggaat tcaatgactc caaaaggaac tcaaggaaat
    19501 ataaagaaaa tacgttaaaa aacaatgaca atagcaaatt cttccacaat ccaagacatt
    19561 gttttgtgtg tgttgtgtgt gttatatgag tgtgtggttg gtggttgttt ttttatttcc
    19621 ttcatgtctg ggctcagtag ggcacaacta gaccagataa gggaaacatt ttgagtgaga
    19681 gagaaggttg cttgcaaatg acatctcaaa tccaaagaag aaagcaaagt gataaccctt
    19741 aaacattaaa gttatgggga tcgtgttttt gaaccatgag gtggaacaag tgacataaca
    19801 aaccacccca aaagtttctg atttaaaaca gcttatcatc atctgttggt ctgatggatt
    19861 gactgggctc acccgggcaa ttctcgcttg ggttctctac tgttgttgca gtccaatagt
    19921 ggccagagct ggagtcatca aaggctcctc tgggctgggc atcgaagatg gcttcctcac
    19981 ggggctaaca gttgatgctt gcagttggtt gggagctcag ctggggctgt gatcaactgg
    20041 agccgtgagc catgtcgact ccatgtggct tggccgtctt acagcatggt ggctggttcc
    20101 aagagagtgc attccaagag ctagcattcc aggagattaa acggggagct gcaaagcttc
    20161 ctatgacctg gcctcagaag tcacacagtg tcacatctgc tatattttat tggttataca
    20221 aagccagcct agagctggta taggagggga ttactcaatg gcatgagcac tgggaagcct
    20281 ggttcacttg gggctatctt ggggactaga tagtaaggca gctttacaag accagataac
    20341 attcccatct ggggtaggat ttttgataat gattttcatg tccatgggag aaggagtaaa
    20401 gatgctttgt tacccacttt tcataaaatc tagcttgttc tcttgaatct tccaccactc
    20461 aacttctagc ctgtgtgcat agagttttta ttacccagta aggccaaaag aacccagcct
    20521 tgtccttaag acatgcagga aaaatattag gtaagtcacc ttctctgtct ccaagtgggc
    20581 agatgatatg actctctgtc cttggccaga ggaggtgcaa cagcattctc ggcacttcct
    20641 tgtgggtatc tggagaagtg gccaaagtgg agatggctca cctttaggtg cactcactat
    20701 gtaagcttac tctgggccac agagtggaga ttttcagatg agaagtttca tgatctaaag
    20761 aacacacaca cacacacaca cacacacaca cacacacaca cacacacaga ttttgaatga
    20821 ggcctcgagt gaggacatga cttggtgagc ttcccatgct tgttaagtgg tgggagagtg
    20881 accacagctt tgttcttctc agtcttaatc tgatgatctt cactgaatca ctccaccaca
    20941 ctcgttataa ggtttccctt tgtttctgta gtcattcctg gcacttagtt atttcagtgt
    21001 ttatatatag tgagactctt tgaaaatgct ataggtgaga aacccagcca aatatgtgga
    21061 agtcttatgg aatatgccca agactataga tgtaaagacc atgcaggtct gctgtgggat
    21121 agaaatgtta gctggaagct cagcctgatc tctcatgaat aaggcctggg agagtttcaa
    21181 caccttatct cctcaagttt acttacatac tcaataaata gttgttagat tccttctatg
    21241 tgcctggcac tgccccaggc tgtagcaata gatcaatgaa aaaaacttat aaagttcttg
    21301 tcctcttggc acttgcaatc caatgagaat attcctgaac attcccaatg gtgacagata
    21361 gaaccaatct ttgttcagaa caaagaccat tggcaaaaat gtgctttttc tcctctcccc
    21421 acagaggggt tacagtggtt aaaataattt aaatcaaatt aaatttagaa gcatttgatt
    21481 tacacatttc ttctaaagtg tgagactaat aagatgattt tggaatggat ctaaaataaa
    21541 gaatttcaga ttagagaatt aagcacaatg aactaccatg aaatacatta gctggggaat
    21601 taatatttca ttttccaaaa atcattttag aaacaatagc tccctggcat tgaactggag
    21661 tctttgaaaa ctctgcctct ccttggaatt cttgatatga cctcatatta ttgcattgtt
    21721 aaataatctc agcatttttt gggtgtaact gttttaacaa gttaacactt gatgctgttt
    21781 atacaacgtg tcccttggag gagcaagaca gaacaggact gggagattac agcatgggaa
    21841 tgggatttag gctcgtcaca tttggttgac tgagcaattc ttatgctctg atttggctta
    21901 ttatgatgcc tacaagtcac cctaacaagt ggcttaataa tttgtcaaaa aaggtatctg
    21961 tcatgtactc aaacctgttg tgtatgaata atctaattga agttcacttt taaaatgata
    22021 attcaacaag catttattaa gaacttactg cattctaagc aatgtagttg atggaggttg
    22081 ctaccctggc agatcttaac tcacaaaggg tcagagaaac agcagaaaaa tgagtgctat
    22141 gataaaagta agacaaggag atgtaatagg gagtgagtgg ggttaccttg gctttccagg
    22201 gcttccgttt tctcactaag tctatcattt agagctggga cctaatggaa gatctctaag
    22261 gttcttttag ttctaacatt tagtaatcac atgatttgtg ctattaggtt tttagaacag
    22321 tcactagcaa tgtctgtttt ttaattagca caatatttaa ttgctttctg atttcagata
    22381 catttttttt ctcttgttct tacaaaaacc ctgcagagat gaagaagctg tggtttaagg
    22441 cagttatgta acatacccaa gttcacacgg gcagtaaaat aggctattaa gcagggcctt
    22501 agtgagtgaa aattgattat aattggatca aaacagcctt acttaaagaa gttgaactaa
    22561 tgagttctaa tttcctttta aacaccaaga ttctgcattt atgtgttttt caaaaatcac
    22621 cctagagatg atactctgta agtctcatgt cagaaaaatg atcgagtggt atctataggt
    22681 tactttgctc ccagcacaga catgaagtct tttgagccct aatggagata tgatagtggg
    22741 ccaaatctat ataaaaatga cattccacac attgaaaaat aaaagtggct attgctgctg
    22801 ggaatgcaaa atgaaacagc tgttttggaa aatgctttga tagtttctta taaattaaac
    22861 atacacttac aaagtgatcc agaattgcta ctcctaggta tttatatcaa agaaatgaaa
    22921 acttatgtat acaaaagcct atacacaaat gtttagagtg gatttattca tagttgccag
    22981 aaattggaac aacccaatgt cttcaaactg ggaaatggat aaacaaacta tggtgtattc
    23041 atacagtgga atactactca gtaataaaaa gaaatgagca cccaatacat gcaacaactt
    23101 ggagttacat caaatgcatt atgctaatta gaggaagtca gacttaaaat gctacatact
    23161 gtatataatc catatggcat tttaaaaact acaggatcag caaacagatc tgtgctgtga
    23221 gttggaggaa gaattgatga aaaaagacac aagaaaattg tttgaagtga tggagctgtt
    23281 ctatatcttg attgtagtag tgatggcatt gaatgcattt gccaaaactc atagaactct
    23341 gtaactaaaa aataatgaat tttattatat ataaattata ccttcataac agggtaccct
    23401 caaatgagta gtaatatatt tttgcgtgtg ttttgatttt aagtgctttg agtgaatagt
    23461 tttttttttt tccagaaaag tagctcattc ttattcagtg tttgttttct gaggatgtca
    23521 agtggagtca gaaccaataa aagttctatc aagaagagtc tcagttaacc agattagctt
    23581 gcccaggttg gtggaaccat gaaaaccaga ttaaaaataa tgggagtaat cttccattgc
    23641 ttccatccct aggattcact tcctgtcctg ttttatacac tttgtaaatg gtacctctat
    23701 aacccattat gctttttggc atcattgctc actttgacta tttgcagatt acaaattatt
    23761 tgaggtcaaa gaagtgagtg gagtacataa ccttcaaggt gaagcaggaa gcagatgcct
    23821 ccttctgagt ataagttctc ttaggtcaga tactgggaac aaatttgttt acagcaccaa
    23881 gcacagctct ttgagggttg gaatacccac taaacatcta agcaaatgtg gacatttacc
    23941 cttcagggat acatgctgac aaattccttc ctatatgcca acctgaaaga ccaaccttgg
    24001 agatatatga agcattgcct agtccagagt gaggcagaag actgagtcag gggtttcgac
    24061 ttagtcaagg aatgctcaat tttcaccttt tccctcttcc tgcatacctt cctcatgagt
    24121 catgagccca gacaaggccc cagggttttt cccaatatag ttcttcagga agtcactata
    24181 agtcaagtgg agttggtatt tatatggcat ttgttccttt taaaatgtat ttttaattga
    24241 taaataataa ttgtatatat ttataatgta taatgaataa actgaaaaat tcaatagaaa
    24301 gcttcaacag taggttcaat taagcagaag aaagaataag tgaactcaaa gacaggacac
    24361 ttgaaattat ccagtcgaag gaacaaaaag aaaaaagaat aaaagaagtc tatgggatct
    24421 atgggaaacc atcaagagaa ctaatattta cataatgcaa tttcagaaag agaagagaga
    24481 gataaaggga cacaaagcct atctaaagaa ataatagctg aaaacgtccc aaatctggga
    24541 agtgatatca atattcatgt acaagaagtt gtatgcaggt tcttttcact ttgagaaaca
    24601 gaaggtgaaa ctcaaactgg cttaagtaat tttaaaaaaa tgtattggtt caagtgactt
    24661 aaaaaccaca ctggttccag gagcaggttg atagtacctc aaagatgtca ccatctcttg
    24721 gatgtgcttt ccctgttcat tcctaagctt catgcagttt cagggtggtg accagaagtt
    24781 tacatcttat cttccctctc ccctgtgttt gactggaaca gaaaaaagag tgtcttattc
    24841 cctagcactt tggacaaaag ctctggacat gatggccatt tgtgacaggg aagtagaata
    24901 ccattatttg accagtctgg gacatctgaa ttcagggcta gagaacacag acaggggcta
    24961 atggggtgcg gggtaggggg aaggaaaccc caaaatagga agctagattg ctgttactgg
    25021 aaggggaatg tgcacttcag caagatgaaa tcagtatgca attcagctcc cacatatgca
    25081 gaactgtaaa aaagggagct gcatttggtt tcttgggacc tccacctgga taaactgagt
    25141 tcgggggttc agcatgcatc taacaagatg ctcctattcc cagcaaattt tttcttggtg
    25201 ctccttgcta tctccttttg agctattttc atccactcag aacctggtct gttccctcca
    25261 ttaccatatc ttaggccaca ggtgtattca tgacacccag gtgcccctct tcagagagat
    25321 ggagagagtg ggagcttttc aaaaggaatt tgtactaaaa atggtaagtg gcaatttgaa
    25381 aaacaaacaa acgaatgaag caaagtaaca aaaaatactg tactcaaaat gcttttaaca
    25441 ggacatgttt tatacagcat gtgctttaag ccaaattaag taaagcctag ccacagatta
    25501 gatcccagaa ggtgagacta gcaggaggta tttaaaacac ctgctagttc tccctcttta
    25561 tcccatagat gggacactga ggcccaggaa agggaacacc ttgacatcag catcaatgtc
    25621 aatgccaatg tcaatgtcag agctgggcct gagaccaaca tcttctactt gcagacatga
    25681 tgcctctgct gcgtcagtct cctaaagtta tctttcacaa ggtccactgg tgttaaaaca
    25741 gctcattttt tattttaaaa gtatttttaa gtaatctata tgaacaaata atgaattctc
    25801 atgattccca aatgaaaaat taaacaagga atagcatgcc cccatttccc taccataggc
    25861 cacatttaaa aaattagttt cttgtgtatt cttccaggga tattttgtgt gtataaaaac
    25921 aattcagtga catactctcc cgccatttta aatattatag catactatac actctgcttt
    25981 gtaccttgct tatttcaaaa tgtaaatctt ggaaaatctt tcatatgact ctacaaacag
    26041 tatcctcatt catttttaca gctgtaaagt atctccttgc atgatgggaa taacagttta
    26101 tttagctggt tctctagtgg tgtcaatttg gttatttttg atactgtgct actgtaaaca
    26161 atgctgcaat caataacttt atacacatgt catttcatgt gattgtgatt atatatgtag
    26221 gaaaaattcc acaaaagtga aatagcagaa tactaagggc atatgcattt gttgttttga
    26281 tagacgctga atggcccttc atgatgctct tgtcaatgta ttctcctaca atgcggagag
    26341 tgcctttttc ctcaggccct ccccaacaca gccagttact aatgttgtct ttgagtgttt
    26401 aatagttgtg aggtggtatc tcaatgtttt aaaatttaaa ctacagaaat aaaaaaaaaa
    26461 tactggaa
//
