LOCUS       NM_001099289            5948 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SH3 domain containing ring finger 3 (SH3RF3), mRNA.
ACCESSION   NM_001099289 XM_293090 XM_938910
VERSION     NM_001099289.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5948)
  AUTHORS   Fu,S., Ma,C., Tang,X., Ma,X., Jing,G., Zhao,N. and Ran,J.
  TITLE     MiR-192-5p inhibits proliferation, migration, and invasion in
            papillary thyroid carcinoma cells by regulation of SH3RF3
  JOURNAL   Biosci Rep 41 (9) (2021)
   PUBMED   34486645
  REMARK    GeneRIF: MiR-192-5p inhibits proliferation, migration, and invasion
            in papillary thyroid carcinoma cells by regulation of SH3RF3.
REFERENCE   2  (bases 1 to 5948)
  AUTHORS   Zhang,P., Liu,Y., Lian,C., Cao,X., Wang,Y., Li,X., Cong,M.,
            Tian,P., Zhang,X., Wei,G., Liu,T. and Hu,G.
  TITLE     SH3RF3 promotes breast cancer stem-like properties via JNK
            activation and PTX3 upregulation
  JOURNAL   Nat Commun 11 (1), 2487 (2020)
   PUBMED   32427938
  REMARK    GeneRIF: SH3RF3 promotes breast cancer stem-like properties via JNK
            activation and PTX3 upregulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5948)
  AUTHORS   Karkkainen,S., van der Linden,M. and Renkema,G.H.
  TITLE     POSH2 is a RING finger E3 ligase with Rac1 binding activity through
            a partial CRIB domain
  JOURNAL   FEBS Lett 584 (18), 3867-3872 (2010)
   PUBMED   20696164
  REMARK    GeneRIF: POSH2 was found to have a conserved N-terminal extension
            not present in POSH1 and POSH3. POSH2 has GTP-loaded Rac1 binding
            activity and this activity was mapped to a partial
            Cdc42/Rac-interactive binding (CRIB) domain.
REFERENCE   4  (bases 1 to 5948)
  AUTHORS   Karkkainen,S., Hiipakka,M., Wang,J.H., Kleino,I., Vaha-Jaakkola,M.,
            Renkema,G.H., Liss,M., Wagner,R. and Saksela,K.
  TITLE     Identification of preferred protein interactions by phage-display
            of the human Src homology-3 proteome
  JOURNAL   EMBO Rep 7 (2), 186-191 (2006)
   PUBMED   16374509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133109.3, DQ307286.1, DV080665.1, AK074131.1, HY224642.1 and
            AA916456.1.
            
            On May 17, 2019 this sequence version replaced NM_001099289.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000309415.8/ ENSP00000309186.6
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               AC133109.3         55142-55612
            472-1279            DQ307286.1         1-808
            1280-1469           DV080665.1         246-435
            1470-4729           AK074131.1         209-3468
            4730-4812           HY224642.1         27-109              c
            4813-5944           AK074131.1         3552-4683
            5945-5948           AA916456.1         6-9                 c
FEATURES             Location/Qualifiers
     source          1..5948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..5948
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /note="SH3 domain containing ring finger 3"
                     /db_xref="GeneID:344558"
                     /db_xref="HGNC:HGNC:24699"
                     /db_xref="MIM:618933"
     exon            1..909
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2985
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /EC_number="2.3.2.27"
                     /note="SH3 multiple domains 4; SH3 domain-containing RING
                     finger protein 3; plenty of SH3s-2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF3"
                     /protein_id="NP_001092759.1"
                     /db_xref="CCDS:CCDS74557.1"
                     /db_xref="GeneID:344558"
                     /db_xref="HGNC:HGNC:24699"
                     /db_xref="MIM:618933"
                     /translation="MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGE
                     DMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVG
                     CGVDELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGST
                     PGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKG
                     DIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDK
                     DCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAA
                     SSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSS
                     QAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAA
                     SVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLR
                     TGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATAT
                     RPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTAT
                     VSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSA
                     ANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPP
                     SVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSL
                     DLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKR
                     EDGWYKGTLQRNGRTGLFPGSFVESF"
     exon            910..1185
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1281
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1635
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1739
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1910
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2164
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2484
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2816
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..5948
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5928..5933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /note="hexamer: AATAAA"
     polyA_site      5948
                     /gene="SH3RF3"
                     /gene_synonym="POSH2; SH3MD4"
                     /note="major polyA site"
ORIGIN      
        1 acagaacccg ttgagcttcg tgcccggcag cacccccggt cccccgcgcg gggcggactt
       61 gcggcgggac aggtgtagcc cgcagccgca ggcgctgcgc tcaggactgg gcgggctcgg
      121 ctggccggtc cccgccacgc aggccggtcc ccgccacgca ggccggtcgg tgagccactt
      181 cgcaccgcca cagccctagc atcgggccac cagccggggt gaagaaagtc acggcggagc
      241 ccggctcccc agtcctgatg ctggctgccg gtggcgggct ccacgccggc cccgggacct
      301 aggcagccgc gcgagaccgc tgcgggcgcc tcccccatgc tgctcggagc gtcctggctg
      361 tgcgcatcca aggcggccgc cgctgctgcg cagagcgagg gcgacgagga caggccaggc
      421 gagcgacggc ggcgtcgggc ggcggccacc gccgcggggg cgggcgagga catggacgag
      481 tcgtcgctgc tggacctgct ggagtgctcc gtgtgtctgg agcgcctgga caccacggcc
      541 aaggtgctgc catgccaaca cactttctgc cgccgctgcc tggagagcat cgtgtgctcg
      601 cgccacgagc tgcgctgccc cgagtgccgc atcctggtgg gctgcggcgt ggacgaactg
      661 cccgccaaca tcttgctggt gcgactgctg gacggcatcc gtcagcggcc ccgcgcgggc
      721 accagccccg gcggcagccc gcccgcgcgt cccatcccag gccagagtgc ggcccccacg
      781 ctcgcgggcg gcgggggcgg cgcggcaggc agcaccccgg gttccccggt tttcctctcc
      841 gcggccgcgg gcagcaccgc cggcagtctg cgggagctgg cgaccagcag gaccgcgccg
      901 gcggcaaaga atccctgcct gcttccctat ggcaaggccc tctacagcta cgaggggaag
      961 gaacctggtg acctcaagtt caacaagggg gacatcatcg tcctgcggcg caaggtggat
     1021 gaacagtggt accacggcga gctgcacggc acacagggct tcctcccagc cagctatatc
     1081 cagtgcatcc agcccttgcc acacgccccg ccccagggaa aagcacttta tgatttcgag
     1141 atgaaggaca aagaccaaga caaggactgt ctgaccttca ccaaggacga gattctgacg
     1201 gtgctcagga gagtggatga gaactgggcg gaaggcatgc tgggagacaa gatcgggatc
     1261 ttcccgctcc tgtacgtgga gctcaatgac tccgccaagc agctcattga gatggacaag
     1321 ccatgcccag ccgctgcatc cagctgcaat gcctccctgc cctctgactc cggcgctgtg
     1381 gccagcgtgg ccccaagtcc cactttaagc agctcagggg cggtcagtgc ctttcagcgg
     1441 cgtgtggatg gcaagaagaa caccaagaaa cgccactcct tcaccgcgct cagtgtgacg
     1501 cacagatcct cccaggctgc cagccacagg cattccatgg aaattagtgc tccagtgttg
     1561 atcagctcca gcgatccccg agccgcggcc aggattggag accttgctca tctgtcgtgc
     1621 gctgctccca cccaggatgt ctcctcctcg gcgggatcta cccccacggc tgtcccacgg
     1681 gctgcctcgg tgtctggaga gcagggcacg cctcccaagg tccagctgcc cctcaacgtg
     1741 tacctggcgc tctacgccta caagccccag aagagtgacg agctggagct gcacaaggga
     1801 gagatgtacc gggtcctcga gaagtgtcag gatggctggt tcaagggggc gtctctgagg
     1861 accggggtct ctggggtgtt ccccggaaac tacgtgacac ccgtttccag ggtgcctgca
     1921 ggaggggcag ggccgccccg gaataatgta gtcggagggt ctccactggc caaagggata
     1981 accacaacca tgcacccagg cagtgggagt ctgagcagcc tggccactgc caccaggccc
     2041 gccctgccca tcaccactcc ccaggcccac gcccagcacc ccacagcctc gcccccaaca
     2101 ggcagctgtc tacggcactc agcccagcca acggccagcc aagcccggag caccatttca
     2161 acagctgccc actctgcagc ccaggctcag gaccggccaa ctgccaccgt gtcacccctg
     2221 cgcacccaga actctccatc ccgcctgcct gccaccagcc tcaggcccca ctcggtggtg
     2281 tccccgcagc acagccacca gcccccggtg cagatgtgcc cacggccggc catccccctc
     2341 acatcagcag catcagccat cacacctccc aacgtcagtg ccgcaaacct caacggggag
     2401 gctggagggg ggcccatcgg tgttctgtcc acatccagcc ccaccaacac gggatgcaaa
     2461 ctagacgaga agaaaagtga aaagaaagag aagaagagtg ggctcctgaa gcttctagcc
     2521 ggagcatcca ccaagaagaa gtcacgctcc ccgccatctg tgtctccaac ccacgacccc
     2581 caggtggccg tggacgccct gctccaaggt gcagtgggcc ccgaagtgtc ctcactgtcc
     2641 atccacggca gggcagggtc ctgccccata gagagcgaga tgcagggtgc catggggatg
     2701 gagcctctgc acaggaaggc aggctccttg gatctaaact tcacatctcc ttcccggcaa
     2761 gctccgctgt ccatggctgc catccgcccc gagcccaagc tgttgcccag agagaggtac
     2821 cgcgtggtgg tctcgtaccc accccagagt gaggcggaga tcgagctgaa ggaaggcgac
     2881 atcgtctttg tgcacaagaa gcgtgaggac ggctggtaca aggggaccct gcagcggaac
     2941 ggccgcacag gcctcttccc gggcagcttc gtcgagagct tctgagaact ggtgctccct
     3001 gcacccagct cacagagggg gaggccgcct gggaagctcc acggcacaca gagagggagc
     3061 catggcgccc caagggttcc aggtcatctc caaggcacct ggcgggggat accctggccc
     3121 agggtggggg ccagggactg tggaggtcgt gccttctccc aaaaccccca aacggagagc
     3181 acacctggga tgttcttcaa ggaaatgccc accccctctg tggaaactgc aaagaaagca
     3241 ccttgaggaa gagaggcagg tgccggcgca ggcaggcctg tggctgtggt ttgcagccat
     3301 ggcagcgttc tcatttacca cctaagcagg gttggaggtt gcaggaggtc tgcaggcgag
     3361 gtgggtggca tgggggccag gagcgctgga gatcatcttt ctgggctgcc ctgggcttcc
     3421 cgcggggccc aggttgctct gtcaccattc tatatacctc agtcacctgc cgcccggctg
     3481 ctcagcaggg gtgtttgtga ggccctgggg gtgccccgga aggggcaccc caccgcccct
     3541 gttgggaacc agagcagaat ctgtgggctt gtcgcctgcc agtagtataa gcaacacttt
     3601 ctgttcacca ccattgtccc ttgcattact tctttcttac agcatatttt taacataaag
     3661 ctgttagact ttatatattt ctaataggtc agacattgcc tatttttcat acatctggtg
     3721 ctgccttttt gtaaaactaa taatgacttg gttgagcttg aaagaaaaga tgtctgaggc
     3781 gacatcaaag gggcagaatt tttatatttc ccatatggct ttgggagagc gccgagaagc
     3841 cgccatcccg cacctcagcg ctggccagta ctctgggggc tggcggggtg gatccattga
     3901 gggggtcgga gggagcttgg aagcagccgg tttctttaaa ctcttaccaa aaccccgcgc
     3961 tctgtctaga cggtgatgat tattattcaa gacctggaaa catttcgagg aagggccact
     4021 ataattgtcc ttttgtgtgg cggtagaagg agcacgcagg tcaaccccag ccgggaaggc
     4081 aaaatcttcc ctttattgcc tcagagagaa ctgcaattag cattctcaga agatgatttc
     4141 ttggtatcaa aatgtgcagt ttctacaaca gtttagatca ccaccaccat ttttcttctt
     4201 ttttaaaaat aaataactgc tcccatttca ggcagtgcaa accttcatct gctggagacc
     4261 agaggtacaa ggagatcagg gggttgcagc accgctgcag gcttgcaaga tcggggagtt
     4321 gggagggcga gagaggagga ggtgcagctt tgatgctggg acctccctga gtggggctga
     4381 tgaatgtata ttcattagca ccatggctca cttcccagga agactgatca ggagcccttc
     4441 agggacaatt ttgttctcaa gattcacacc ttaggaacac atttttatca cctcaaaatt
     4501 ttgatccatc acccctctct ccacctatat ttttacaaat accattcaga cttaaattaa
     4561 gctgaagaaa ctagcctttg gtaacatagg gtgtcattgg ttttcaggga tgtaaccaat
     4621 tccagaaata cattcttttg cctggcatga agactttgaa acacgggccg cttattttca
     4681 gagttcctgt tttgggacgt gacttggcta cttgttactt ccaggtggtc accacacggc
     4741 gggggtcatg cctttccctc ccccaagatg ataatagatt taatagactc aaagaagttg
     4801 ttcagaatca aagaagaaaa agtctggctt aaacatagta acttctgtgt gccaggttaa
     4861 tgacaaccaa aagctctcta tttaccatta ttgccaaact tcatcagttg cccatcctgc
     4921 accaaaatcc tgtgcgtgtt taaattcacg ttgtcaccaa agaggtgcac agatcaacaa
     4981 cctggatgac gcaggtgttc tccagggaaa ccagaccaag tcaagtctcc aggtaacttt
     5041 tttgaagtct tttttttaag gcgcgcaggt accaagcaac agaatagagt aacctgaacg
     5101 ttcttactct cccaggcatg gcccacgtgg tgcttcaggt agaaatgtgc ttcaccctcc
     5161 tggtgggggg cgaggacaca gcccactgca tgcagcatgg tagagagctg gggcgaatat
     5221 ctccatgtct ttggaggatg tcagctggcc gctttcaggg cagagtcggg tgggcgttgg
     5281 tgccacctta ggaaggagag cgatgcgtgg gtctggccag agctctggag ccaatgccgg
     5341 gctgcctgag agcagaggaa atgcatggcc catgtgcatt tctgagtatt ttaaactcgt
     5401 tcaggccctg cagccttcat gatgatgtag ctcgcagaga agagcaggag cagaattagc
     5461 cctttcttca ggccatcttg cctcaaaggg tacacatgtt tggcggttaa gatgaaacta
     5521 acccttatgt ttcatcctgg ccccatgatg tacacatctt agccatgtag tggccttggg
     5581 gggccacaga gatttccttt gaggagcatg gtagagtcca cagccatggc tgaagtcagt
     5641 ggacaccgag gggacaggac tgcaggccac caggggcctc tgcccagagg gaggcagaga
     5701 ggatggcggc cacgggtgct ctcctggcat cctcatgggg tgatgccagg ccgggcactt
     5761 caaaacaggc tcagccgact gggagatcct ttgtactttg cacagttcac acacacaaac
     5821 acacacaccc tatcccaagt gtttttgtta gacacaaatg tcagcgtgtg attttggaag
     5881 acttgtcagt gatgacaaac catgatgcct gtgtttctga gtctttaaat aaaaatgaac
     5941 atggagaa
//
