LOCUS       NM_152550               3004 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens SH3 domain containing ring finger 2 (SH3RF2), mRNA.
ACCESSION   NM_152550
VERSION     NM_152550.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3004)
  AUTHORS   Gong,T.T., Liu,F.H., Xiao,Q., Li,Y.Z., Wei,Y.F., Xu,H.L., Cao,F.,
            Sun,M.L., Jiang,F.L., Tao,T., Ma,Q.P., Qin,X., Song,Y., Gao,S.,
            Wu,L., Zhao,Y.H., Huang,D.H. and Wu,Q.J.
  TITLE     SH3RF2 contributes to cisplatin resistance in ovarian cancer cells
            by promoting RBPMS degradation
  JOURNAL   Commun Biol 7 (1), 67 (2024)
   PUBMED   38195842
  REMARK    GeneRIF: SH3RF2 contributes to cisplatin resistance in ovarian
            cancer cells by promoting RBPMS degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3004)
  AUTHORS   Yang,X., Sun,D., Xiang,H., Wang,S., Huang,Y., Li,L., Cheng,X.,
            Liu,H., Hu,F., Cheng,Y., Ma,T., Hu,M., Tian,H., Tian,S., Zhou,Y.,
            Zhang,P., Zhang,X.J., Ji,Y.X., Hu,Y., Li,H. and She,Z.G.
  TITLE     Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD
  JOURNAL   Hepatology 74 (3), 1319-1338 (2021)
   PUBMED   33894019
  REMARK    GeneRIF: Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for
            NAFLD.
REFERENCE   3  (bases 1 to 3004)
  AUTHORS   Chen,H., Zhou,J., Jiao,L., Song,J., Zhong,H., Zhao,Z., Meng,Z.,
            Lu,X., Chen,X., Zhang,W. and Ying,B.
  TITLE     Assessing the role of SH3RF1 and SH3RF2 polymorphisms in
            susceptibility to tuberculosis: A case-control study in the Han
            Chinese population
  JOURNAL   Microb Pathog 152, 104567 (2021)
   PUBMED   33129950
  REMARK    GeneRIF: Assessing the role of SH3RF1 and SH3RF2 polymorphisms in
            susceptibility to tuberculosis: A case-control study in the Han
            Chinese population.
REFERENCE   4  (bases 1 to 3004)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3004)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3004)
  AUTHORS   Wilhelm,M., Kukekov,N.V., Schmit,T.L., Biagas,K.V., Sproul,A.A.,
            Gire,S., Maes,M.E., Xu,Z. and Greene,L.A.
  TITLE     Sh3rf2/POSHER protein promotes cell survival by ring-mediated
            proteasomal degradation of the c-Jun N-terminal kinase scaffold
            POSH (Plenty of SH3s) protein
  JOURNAL   J Biol Chem 287 (3), 2247-2256 (2012)
   PUBMED   22128169
REFERENCE   7  (bases 1 to 3004)
  AUTHORS   Esteves,S.L., Domingues,S.C., da Cruz e Silva,O.A., Fardilha,M. and
            da Cruz e Silva,E.F.
  TITLE     Protein phosphatase 1alpha interacting proteins in the human brain
  JOURNAL   OMICS 16 (1-2), 3-17 (2012)
   PUBMED   22321011
REFERENCE   8  (bases 1 to 3004)
  AUTHORS   Chen,C.Y., Lai,N.S., Yang,J.J., Huang,H.L., Hung,W.C., Li,C.,
            Lin,T.H. and Huang,H.B.
  TITLE     FLJ23654 encodes a heart protein phosphatase 1-binding protein
            (Hepp1)
  JOURNAL   Biochem Biophys Res Commun 391 (1), 698-702 (2010)
   PUBMED   19945436
  REMARK    GeneRIF: the novel protein heart protein phosphatase 1-binding
            protein (Hepp1), encoded by FLJ23654, was identified.Hepp1 can play
            a role in cardiac functions by working in concert with PP1.
REFERENCE   9  (bases 1 to 3004)
  AUTHORS   Voss,M., Lettau,M. and Janssen,O.
  TITLE     Identification of SH3 domain interaction partners of human FasL
            (CD178) by phage display screening
  JOURNAL   BMC Immunol 10, 53 (2009)
   PUBMED   19807924
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3004)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011359.5, AC005351.1, AC005216.1 and AC091887.3.
            
            On Nov 23, 2018 this sequence version replaced NM_152550.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074234.1, SRR1803617.280437.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359120.9/ ENSP00000352028.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC011359.5         51407-51523         c
            118-601             AC011359.5         49795-50278         c
            602-871             AC005351.1         43013-43282
            872-967             AC005351.1         47013-47108
            968-1282            AC005216.1         9967-10281
            1283-1374           AC091887.3         31999-32090
            1375-1545           AC091887.3         33302-33472
            1546-1778           AC091887.3         40208-40440
            1779-2137           AC091887.3         44093-44451
            2138-3004           AC091887.3         46653-47519
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..3004
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /note="SH3 domain containing ring finger 2"
                     /db_xref="GeneID:153769"
                     /db_xref="HGNC:HGNC:26299"
                     /db_xref="MIM:613377"
     exon            1..117
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            118..601
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2413
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /EC_number="2.3.2.27"
                     /note="putative E3 ubiquitin-protein ligase SH3RF2; RING
                     finger protein 158; SH3 domain-containing RING finger
                     protein 2; heart protein phosphatase 1-binding protein;
                     protein phosphatase 1 regulatory subunit 39;
                     POSH-eliminating RING protein; phosphatase 1 binding
                     protein; RING-type E3 ubiquitin transferase SH3RF2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF2"
                     /protein_id="NP_689763.4"
                     /db_xref="CCDS:CCDS4280.1"
                     /db_xref="GeneID:153769"
                     /db_xref="HGNC:HGNC:26299"
                     /db_xref="MIM:613377"
                     /translation="MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAH
                     KELRCPECRTPVFSNIEALPANLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKS
                     RTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDE
                     NWYQGEINGISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDD
                     IITVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSS
                     SSRGNTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNP
                     SVITQPMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYS
                     AHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSSFPDSR
                     SPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVNPVRSTAGPGTLGQGS
                     LRKGRSSMRKNGSLQRPLQSGIPTLVVGSLRRSPTMVLRPQQFQFYQPQGIPSSPSAV
                     VVEMGSKPALTGEPALTCISRGSEAWIHSAASSLIMEDKEIPIKSEPLPKPPASAPPS
                     ILVKPENSRNGIEKQVKTVRFQNYSPPPTKHYTSHPTSGKPEQPATLKASQPEAASLG
                     PEMTVLFAHRSGCHSGQQTDLRRKSALGKATTLVSTASGTQTVFPSK"
     exon            602..871
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            872..967
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1282
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1374
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1545
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1778
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2137
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..3004
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /note="hexamer: AATACA"
     polyA_site      2481
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /note="major polyA site"
     polyA_site      2510
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /note="major polyA site"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="SH3RF2"
                     /gene_synonym="HEPP1; POSHER; PPP1R39; RNF158"
                     /note="major polyA site"
ORIGIN      
        1 caaagcggtt ggcagcagcg gcgcttggag gaaaggaagc cggttggagg gcgcagcgca
       61 cccctgctgc gcggaggagg gggctgagct gaactcagca gaagttacat gcacaaggca
      121 aaaattctga cgttctcaag agaccagctc tgcccccgtg gctcaactga ccctaccatg
      181 tggacgctgc tcctccaggt gggaactgga gttttgaaat aaaatggatg atttgacgtt
      241 acttgatctt ctggagtgcc ctgtgtgctt tgagaagctc gatgtcacag ccaaagtcct
      301 cccttgccag cacaccttct gcaaaccatg tctacagagg gttttcaagg cccacaaaga
      361 gctgcggtgc cccgaatgca ggacgcctgt gttttccaac attgaggcgc tgccggccaa
      421 cctgctgctc gtgcgccttc tggatggagt gcgctcaggg cagagctccg ggagaggggg
      481 ctccttccgc aggcctggca cgatgacctt gcaggatggc aggaaaagca ggaccaaccc
      541 cagacgtctg caggccagtc ctttccggct agtgcctaat gtcagaatcc acatggatgg
      601 ggtgcctcga gcaaaggcct tatgcaacta cagagggcag aatcccggtg acctaaggtt
      661 taataaggga gatatcatcc ttctccggag acagcttgat gagaattggt accaggggga
      721 aatcaatggc atcagcggga acttcccagc cagctccgtg gaagtcatca agcagctgcc
      781 ccagccgccc ccgctctgca gggccctcta caacttcgac ctacgaggca aggacaagag
      841 tgagaaccag gattgcctga ccttcctcaa ggacgatatc atcactgtga tcagccgagt
      901 ggatgagaac tgggcagaag gcaagttagg agataaagta ggcatcttcc ctatcttgtt
      961 tgtagagcca aacctcaccg caagacacct tttagagaag aacaaaggtc gccagtcatc
     1021 ccgcacaaaa aacctgtccc tggtgtcctc gtcctccaga ggcaacacgt ctaccctccg
     1081 taggggccca gggtccagga ggaaggtgcc tgggcagttt tccatcacaa cagccttgaa
     1141 cactctcaac cggatggtcc attctccttc agggcgccat atggtagaga tcagcacccc
     1201 agtgctcatc agctccagca acccctctgt gatcacccag cccatggaga aagcagacgt
     1261 tccttccagc tgtgtgggac aggtcagcac ttatcacccc gcacctgtct ctccaggaca
     1321 ttccacagcc gtggtcagtc tgcctggctc ccagcaacac ctctcagcga acatgtttgt
     1381 agccctgcac tcctactcag cccatggacc cgatgagctg gacctgcaaa agggagaagg
     1441 cgtcagggtc ctggggaagt gccaggacgg ctggctcagg ggcgtctcct tggtcaccgg
     1501 gcgagtcggc atcttcccaa acaattacgt catccccatt ttcagaaaga cctctagttt
     1561 tccagactcc cggagccctg gtctctacac cacatggacg ttatccacct cctctgtgtc
     1621 ctcccaaggc agcatttcag aaggtgatcc acggcaaagc cgtcccttca aatccgtctt
     1681 tgtgcccact gccatagtca accccgtgag aagcacagcc ggccctggga ctttaggaca
     1741 agggtctctt cggaaagggc ggagcagcat gagaaagaat ggatccctgc agagacccct
     1801 ccagtccggg atccccactc tcgtggtagg ctccctcaga cgcagcccca ccatggtcct
     1861 tcggcctcag cagttccaat tctaccagcc acaggggatc ccctcctccc cctcagccgt
     1921 ggtggtggag atggggtcca agcctgccct cacgggggag cccgccctca cgtgcatcag
     1981 caggggcagt gaggcctgga tccactccgc ggccagctcc ctcattatgg aagacaaaga
     2041 aatccccatc aagagtgagc ctctgccaaa accgcccgca tctgccccac catccatcct
     2101 ggtgaaacca gaaaactcaa gaaatggcat cgaaaagcaa gtcaaaaccg tgagatttca
     2161 gaattacagc cctcctccca ccaaacatta cacctcccat cccacctccg gaaagcctga
     2221 acagccagcc accctcaagg cgtcccagcc tgaagcagcg tccttgggcc cagagatgac
     2281 cgtcctattt gcccaccgaa gtggctgcca ctccggacag cagacagacc tccggagaaa
     2341 gtcagctctt ggcaaggcca caaccctggt gtccactgcc tcaggcacgc agaccgtgtt
     2401 tcccagcaaa tgaacctacg ggtggctttt cctagacccc aaagaggtga attgcattta
     2461 aatacagtct gcctccactg agggcatcct gccattcttt ggggacttga gcatgggtcc
     2521 ttgttcttcc tatttcacct ccaggaaagc aaaagtggga gcagaaattc ctgccctggg
     2581 tgggaggata gatggcgtgg ccttccaaac atacaaacat aatgatttga tgccacaaag
     2641 ctcgcttact cagaccaagg agtgaaaaat tgtcgtgccc actttatgcc ccagcatgga
     2701 gtatgtggcc tcttgtcatc cccgtgttac tgtgtagaat ttctatggtg tcctaaaggg
     2761 ggctgcagca ggggtgtgac aacggtggga ttgttggcgt tgcttctttg accttacaat
     2821 atcctcaaca agcattagaa caacttctgc catcttctgg ggcctgtaca ctggccacta
     2881 gtagctgcca tatctttttc cctctgtaaa gtcataatcc tggctgcaaa gggaggattt
     2941 ctgcgcgggg tgtgaggtgg atactttgaa cattctgaga acccaataaa actagaagga
     3001 gcca
//
