LOCUS       NM_020870               5120 bp    mRNA    linear   PRI 26-JAN-2024
DEFINITION  Homo sapiens SH3 domain containing ring finger 1 (SH3RF1), mRNA.
ACCESSION   NM_020870
VERSION     NM_020870.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5120)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 5120)
  AUTHORS   Chen,H., Zhou,J., Jiao,L., Song,J., Zhong,H., Zhao,Z., Meng,Z.,
            Lu,X., Chen,X., Zhang,W. and Ying,B.
  TITLE     Assessing the role of SH3RF1 and SH3RF2 polymorphisms in
            susceptibility to tuberculosis: A case-control study in the Han
            Chinese population
  JOURNAL   Microb Pathog 152, 104567 (2021)
   PUBMED   33129950
  REMARK    GeneRIF: Assessing the role of SH3RF1 and SH3RF2 polymorphisms in
            susceptibility to tuberculosis: A case-control study in the Han
            Chinese population.
REFERENCE   3  (bases 1 to 5120)
  AUTHORS   Wang,X., Tian,X., Yang,Y., Lu,X., Li,Y., Ma,Y., Zhang,Y., Zheng,F.,
            Lu,S., Xu,D., Xu,X., Wang,W. and Wang,X.
  TITLE     POSH participates in epileptogenesis by increasing the surface
            expression of the NMDA receptor: a promising therapeutic target for
            epilepsy
  JOURNAL   Expert Opin Ther Targets 21 (12), 1083-1094 (2017)
   PUBMED   29057721
  REMARK    GeneRIF: These results show that POSH plays a critical role in the
            progression of epileptic seizures via N-methyl-D-aspartate receptor
            trafficking
REFERENCE   4  (bases 1 to 5120)
  AUTHORS   de Bock,C.E., Hughes,M.R., Snyder,K., Alley,S., Sadeqzadeh,E.,
            Dun,M.D., McNagny,K.M., Molloy,T.J., Hondermarck,H. and Thorne,R.F.
  TITLE     Protein interaction screening identifies SH3RF1 as a new regulator
            of FAT1 protein levels
  JOURNAL   FEBS Lett 591 (4), 667-678 (2017)
   PUBMED   28129444
  REMARK    GeneRIF: Data show that the two N-terminal SH3 domains of SH3
            domain containing ring finger 1 (SH3RF1) protein interact with FAT1
            protein.
REFERENCE   5  (bases 1 to 5120)
  AUTHORS   Ma,B., Chen,Y., Chen,L., Cheng,H., Mu,C., Li,J., Gao,R., Zhou,C.,
            Cao,L., Liu,J., Zhu,Y., Chen,Q. and Wu,S.
  TITLE     Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3
            ligase
  JOURNAL   Nat Cell Biol 17 (1), 95-103 (2015)
   PUBMED   25438054
REFERENCE   6  (bases 1 to 5120)
  AUTHORS   Lyons,T.R., Thorburn,J., Ryan,P.W., Thorburn,A., Anderson,S.M. and
            Kassenbrock,C.K.
  TITLE     Regulation of the Pro-apoptotic scaffolding protein POSH by Akt
  JOURNAL   J Biol Chem 282 (30), 21987-21997 (2007)
   PUBMED   17535800
REFERENCE   7  (bases 1 to 5120)
  AUTHORS   Alroy,I., Tuvia,S., Greener,T., Gordon,D., Barr,H.M., Taglicht,D.,
            Mandil-Levin,R., Ben-Avraham,D., Konforty,D., Nir,A., Levius,O.,
            Bicoviski,V., Dori,M., Cohen,S., Yaar,L., Erez,O.,
            Propheta-Meiran,O., Koskas,M., Caspi-Bachar,E., Alchanati,I.,
            Sela-Brown,A., Moskowitz,H., Tessmer,U., Schubert,U. and Reiss,Y.
  TITLE     The trans-Golgi network-associated human ubiquitin-protein ligase
            POSH is essential for HIV type 1 production
  JOURNAL   Proc Natl Acad Sci U S A 102 (5), 1478-1483 (2005)
   PUBMED   15659549
  REMARK    GeneRIF: A previously undescribed step in HIV biogenesis that
            suggests a direct function for hPOSH-mediated ubiquitination in
            protein sorting at the trans-Golgi network.
REFERENCE   8  (bases 1 to 5120)
  AUTHORS   Figueroa,C., Tarras,S., Taylor,J. and Vojtek,A.B.
  TITLE     Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling
            complex
  JOURNAL   J Biol Chem 278 (48), 47922-47927 (2003)
   PUBMED   14504284
  REMARK    GeneRIF: POSH disassociates from the JNK complex after
            phosphorylation of MLK3 by Akt2, which leads to down-regulation of
            the JNK signaling pathway
REFERENCE   9  (bases 1 to 5120)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 5120)
  AUTHORS   Tapon,N., Nagata,K., Lamarche,N. and Hall,A.
  TITLE     A new rac target POSH is an SH3-containing scaffold protein
            involved in the JNK and NF-kappaB signalling pathways
  JOURNAL   EMBO J 17 (5), 1395-1404 (1998)
   PUBMED   9482736
  REMARK    GeneRIF: This publication pertains to studies in mice.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096741.3, AC104783.3 and
            AC021151.8.
            
            On Nov 23, 2018 this sequence version replaced NM_020870.3.
            
            Summary: This gene encodes a protein containing an N-terminus
            RING-finger, four SH3 domains, and a region implicated in binding
            of the Rho GTPase Rac. Via the RING-finger, the encoded protein has
            been shown to function as an ubiquitin-protein ligase involved in
            protein sorting at the trans-Golgi network. The encoded protein may
            also act as a scaffold for the c-Jun N-terminal kinase signaling
            pathway, facilitating the formation of a functional signaling
            module. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.134455.1,
                                           SRR1660807.41015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284637.14/ ENSP00000284637.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC096741.3         140458-140555       c
            99-586              AC096741.3         138419-138906       c
            587-862             AC096741.3         26003-26278         c
            863-958             AC096741.3         25079-25174         c
            959-1261            AC096741.3         5917-6219           c
            1262-1372           AC104783.3         26125-26235         c
            1373-1539           AC104783.3         18179-18345         c
            1540-1710           AC104783.3         16898-17068         c
            1711-1970           AC104783.3         13602-13861         c
            1971-2332           AC104783.3         12348-12709         c
            2333-2691           AC104783.3         2926-3284           c
            2692-5120           AC021151.8         163419-165847       c
FEATURES             Location/Qualifiers
     source          1..5120
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3-q33"
     gene            1..5120
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /note="SH3 domain containing ring finger 1"
                     /db_xref="GeneID:57630"
                     /db_xref="HGNC:HGNC:17650"
                     /db_xref="MIM:618642"
     exon            1..98
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            99..586
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2860
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /EC_number="2.3.2.27"
                     /note="SH3 multiple domains 2; plenty of SH3 domains; ring
                     finger protein 142; RING-type E3 ubiquitin transferase
                     SH3RF1; putative E3 ubiquitin-protein ligase SH3RF1;
                     plenty of SH3s; SH3 multiple domains protein 2; SH3
                     domain-containing RING finger protein 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF1"
                     /protein_id="NP_065921.2"
                     /db_xref="CCDS:CCDS34099.1"
                     /db_xref="GeneID:57630"
                     /db_xref="HGNC:HGNC:17650"
                     /db_xref="MIM:618642"
                     /translation="MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSR
                     NELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSS
                     TVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDI
                     IILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDC
                     LPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDA
                     GECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISS
                     SNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAAL
                     GTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVY
                     VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAV
                     TNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQ
                     TSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLS
                     HHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRI
                     VTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASP
                     TLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRK
                     ASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIV
                     FVHKKREDGWFKGTLQRNGKTGLFPGSFVENI"
     exon            587..862
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..958
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1261
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1372
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1539
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1710
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1970
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2332
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2691
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..5120
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4021..4026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /note="hexamer: AATAAA"
     polyA_site      4050
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /note="major polyA site"
     regulatory      5097..5102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /note="hexamer: ATTAAA"
     polyA_site      5120
                     /gene="SH3RF1"
                     /gene_synonym="POSH; RNF142; SH3MD2"
                     /note="major polyA site"
ORIGIN      
        1 agagacactg cgagcggcga gcgcggtggg gccgcatctg catcagccgc cgcagccgct
       61 gcggggccgc gaacaaagag gaggagccga ggcgcgagag caaagtctga aatggatgtt
      121 acatgagtca ttttaaggga tgcacacaac tatgaacatt tctgaagatt ttttctcagt
      181 aaagtagata aagatggatg aatcagcctt gttggatctt ttggagtgtc cggtgtgtct
      241 agagcgcctt gatgcttctg cgaaggtctt gccttgccag catacgtttt gcaagcgatg
      301 tttgctgggg atcgtaggtt ctcgaaatga actcagatgt cccgagtgca ggactcttgt
      361 tggctcgggt gtcgaggagc ttcccagtaa catcttgctg gtcagacttc tggatggcat
      421 caaacagagg ccttggaaac ctggtcctgg tgggggaagt gggaccaact gcacaaatgc
      481 attaaggtct cagagcagca ctgtggctaa ttgtagctca aaagatctgc agagctccca
      541 gggcggacag cagcctcggg tgcaatcctg gagcccccca gtgaggggta tacctcagtt
      601 accatgtgcc aaagcattat acaactatga aggaaaagag cctggagacc ttaaattcag
      661 caaaggtgac atcatcattt tgcgaagaca agtggatgaa aattggtacc atggggaagt
      721 caatggaatc catggctttt tccccaccaa ctttgtgcag attattaaac cgttacctca
      781 gcccccacct cagtgcaaag cactttatga ctttgaagtg aaagacaagg aagcagacaa
      841 agattgcctt ccatttgcaa aggatgatgt tctgactgtg atccgaagag tggatgaaaa
      901 ctgggctgaa ggaatgctgg cagacaaaat aggaatattt ccaatttcat atgttgagtt
      961 taactcggct gctaagcagc tgatagaatg ggataagcct cctgtgccag gagttgatgc
     1021 tggagaatgt tcctcggcag cagcccagag cagcactgcc ccaaagcact ccgacaccaa
     1081 gaagaacacc aaaaagcggc actccttcac ttccctcact atggccaaca agtcctccca
     1141 ggcatcccag aaccgccact ccatggagat cagcccccct gtcctcatca gctccagcaa
     1201 ccccactgct gctgcacgga tcagcgagct gtctgggctc tcctgcagtg ccccttctca
     1261 ggttcatata agtaccaccg ggttaattgt gaccccgccc ccaagcagcc cagtgacaac
     1321 tggcccctcg tttactttcc catcagatgt tccctaccaa gctgcccttg gaactttgaa
     1381 tcctcctctt ccaccacccc ctctcctggc tgccactgtc cttgcctcca caccaccagg
     1441 cgccaccgcc gctgctgctg ctgctggaat gggaccgagg cccatggcag gatccactga
     1501 ccagattgca catttacggc cgcagactcg ccccagtgtg tatgttgcta tatatccata
     1561 cactcctcgg aaagaggatg aactagagct gagaaaaggg gagatgtttt tagtgtttga
     1621 gcgctgccag gatggctggt tcaaagggac atccatgcat accagcaaga taggggtttt
     1681 ccctggcaat tatgtggcac cagtcacaag ggcggtgaca aatgcttccc aagctaaagt
     1741 ccctatgtct acagctggcc agacaagtcg gggagtgacc atggtcagtc cttccacggc
     1801 aggagggcct gcccagaagc tccagggaaa tggcgtggct gggagtccca gtgttgtccc
     1861 cgcagctgtg gtatcagcag ctcacatcca gacaagtcct caggctaagg tcttgttgca
     1921 catgacgggg caaatgacag tcaaccaggc ccgcaatgct gtgaggacag ttgcagcgca
     1981 caaccaggaa cgccccacgg cagcagtgac acccatccag gtacagaatg ccgccggcct
     2041 cagccctgca tctgtgggcc tgtcccatca ctcgctggcc tccccacaac ctgcgcctct
     2101 gatgccaggc tcagccacgc acactgctgc catcagtatc agtcgagcca gtgcccctct
     2161 ggcctgtgca gcagctgctc cactgacttc cccaagcatc accagtgctt ctctggaggc
     2221 tgagcccagt ggccggatag tgaccgttct ccctggactc cccacatctc ctgacagtgc
     2281 ttcatcagct tgtgggaaca gttcagcaac caaaccagac aaggatagca aaaaagaaaa
     2341 aaagggtttg ttgaagttgc tttctggcgc ctccactaaa cggaagcccc gcgtgtctcc
     2401 tccagcatcg cccaccctag aagtggagct gggcagtgca gagcttcctc tccagggagc
     2461 ggtggggccc gaactgccac caggaggtgg ccatggcagg gcaggctcct gccctgtgga
     2521 cggggacgga ccggtcacga ctgcagtggc aggagcagcc ctggcccagg atgcttttca
     2581 taggaaggca agttccctgg actccgcagt tcccatcgct ccacctcctc gccaggcctg
     2641 ttcctccctg ggtcctgtct tgaatgagtc tagacctgtc gtttgtgaaa ggcacagggt
     2701 ggtggtttcc tatcctcctc agagtgaggc agaacttgaa cttaaagaag gagatattgt
     2761 gtttgttcat aaaaaacgag aggatggctg gttcaaaggc acattacaac gtaatgggaa
     2821 aactggcctt ttcccaggaa gctttgtgga aaacatatga ggagactgac actgaagaag
     2881 cttaaaatca cttcacacaa caaagtagca caaagcagtt taacagaaag agcacatttg
     2941 tggacttcca gatggtcagg agatgagcaa aggattggta tgtgactctg atgccccagc
     3001 acagttaccc cagcgagcag aatgaagaag atgtttgtgt gggttttgtt agtctggatt
     3061 cggatgtata aggtgtgcct tgtactgtct gatttactac acagagaaac tttttttttt
     3121 ttttaagata tatgactaaa atggacaatt gtttacaagg cttaactaat ttatttgctt
     3181 ttttaaactt gaacttttcg tataatagat acgttctttg gattatgatt ttaagaaatt
     3241 attaatttat gaaatgatag gtaaggagaa gctggattat ctcctgttga gagcaagaga
     3301 ttcgttttga catagagtga atgcattttc ccctctcctc ctccctgcta ccattatatt
     3361 ttggggttat gttttgcttc tttaagatag aaatcccagt tctctaattt ggttttcttc
     3421 tttgggaaac caaacataca aatgaatcag tatcaattag ggcctggggt agagagacag
     3481 aaacttgaga gaagagaagt tagtgattcc ctctctttct agtttggtag gaatcaccct
     3541 gaagacctag tcctcaattt aattgtgtgg gtttttaatt ttcctagaat gaagtgactg
     3601 aaacaatgag aaagaataca gcacaaccct tgaacaaaat gtatttagaa atatatttag
     3661 ttttatagca gaagcagctc aattgtttgg ttggaaagta ggggaaattg aagttgtagt
     3721 cactgtctga gaatggctat gaagcgtcat ttcacatttt accccaactg acctgcatgc
     3781 ccaggacaca agtaaaacat ttgtgagata gtggtggtaa gtgatgcact cgtgttaagt
     3841 caaaggctat aagaaacact gtgaaaagtt catattcatc cattgtgatt ctttccccac
     3901 gtcttgcatg tattactgga ttcccacagt aatatagact gtgcatggtg tgtatatttc
     3961 attgcgattt cctgttaaga tgagtttgta ctcagaattg accaattcag gaggtgtaaa
     4021 aataaacagt gttctcttct ctaccccaaa gccactactg accaaggtct cttcagtgca
     4081 ctcgctccct ctctggctaa ggcatgcatt agccactaca caagtcatta gtgaaagtgg
     4141 tcttttatgt cctcccagca gacagacatc aaggatgagt taaccaggag actactcctg
     4201 tgactgtgga gctctggaag gcttggtggg agtgaatttg cccacacctt acaattgtgg
     4261 caggatccag aagagcctgt ctttttatat ccattccttg atgtcattgg cctctcccac
     4321 cgatttcatt acggtgccac gcagtcatgg atctgggtag tccggaaaac aaaaggaggg
     4381 aagacagcct ggtaatgaat aagatcctta ccacagtttt ctcatgggaa atacataata
     4441 aaccctttca tctttttttt tttcctttaa gaattaaaac tgggaaatag aaacatgaac
     4501 tgaaaagtct tgcaatgaca agaggtttca tggtcttaaa aagatacttt atgtggttga
     4561 agatgaaatc attcctaaat taaccttttt tttaaaaaaa aacaatgtat attatgttcc
     4621 tgtgtgttga atttaaaaaa aaaatacttt acttggatat tcatgtaata tataaaggtt
     4681 tggtgaaatg aactttagtt aggaaaaagc tggcatcagc tttcatctgt gtaagttgac
     4741 accaatgtgt cataatattc tttattttgg gaaattagtg tattttataa aaattttaaa
     4801 aagaaaaaag actactacag gttaagataa tttttttacc tgtcttttct ccatatttta
     4861 agctatgtga ttgaagtacc tctgttcata gtttcctggt ataaagttgg ttaaaatttc
     4921 atctgttaat agatcattag gtaatataat gtatgggttt tctattggtt ttttgcagac
     4981 agtagaggga gattttgtaa caagggcttg ttacacagtg atatggtaat gataaaattg
     5041 cgatttatca ctccttttca tgttaataat ttgaggactg gataaaaggt ttcaagatta
     5101 aaatttgatg ttcaaacctt
//
