LOCUS       NM_001017995            7779 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens SH3 and PX domains 2B (SH3PXD2B), transcript variant
            1, mRNA.
ACCESSION   NM_001017995 XM_496785
VERSION     NM_001017995.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7779)
  AUTHORS   Laszlo,L., Kurilla,A., Tilajka,A., Pancsa,R., Takacs,T., Novak,J.,
            Buday,L. and Vas,V.
  TITLE     Unveiling epithelial plasticity regulation in lung cancer:
            Exploring the cross-talk among Tks4 scaffold protein partners
  JOURNAL   Mol Biol Cell 35 (8), ar111 (2024)
   PUBMED   38985526
  REMARK    GeneRIF: Unveiling epithelial plasticity regulation in lung cancer:
            Exploring the cross-talk among Tks4 scaffold protein partners.
REFERENCE   2  (bases 1 to 7779)
  AUTHORS   Jacksi,M., Schad,E. and Tantos,A.
  TITLE     Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by
            EZH2 Inhibition in Colorectal Carcinoma Cells
  JOURNAL   Biomolecules 14 (4), 445 (2024)
   PUBMED   38672463
  REMARK    GeneRIF: Morphological Changes Induced by TKS4 Deficiency Can Be
            Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7779)
  AUTHORS   Kurilla,A., Laszlo,L., Takacs,T., Tilajka,A., Lukacs,L., Novak,J.,
            Pancsa,R., Buday,L. and Vas,V.
  TITLE     Studying the Association of TKS4 and CD2AP Scaffold Proteins and
            Their Implications in the Partial Epithelial-Mesenchymal Transition
            (EMT) Process
  JOURNAL   Int J Mol Sci 24 (20), 15136 (2023)
   PUBMED   37894817
  REMARK    GeneRIF: Studying the Association of TKS4 and CD2AP Scaffold
            Proteins and Their Implications in the Partial
            Epithelial-Mesenchymal Transition (EMT) Process.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7779)
  AUTHORS   Zhu,Y., Hu,Y., Wang,P., Dai,X., Fu,Y., Xia,Y., Sun,L. and Ruan,S.
  TITLE     Comprehensive bioinformatics and experimental analysis of SH3PXD2B
            reveals its carcinogenic effect in gastric carcinoma
  JOURNAL   Life Sci 326, 121792 (2023)
   PUBMED   37211344
  REMARK    GeneRIF: Comprehensive bioinformatics and experimental analysis of
            SH3PXD2B reveals its carcinogenic effect in gastric carcinoma.
REFERENCE   5  (bases 1 to 7779)
  AUTHORS   Wilson,G.R., Sunley,J., Smith,K.R., Pope,K., Bromhead,C.J.,
            Fitzpatrick,E., Di Rocco,M., van Steensel,M., Coman,D.J.,
            Leventer,R.J., Delatycki,M.B., Amor,D.J., Bahlo,M. and
            Lockhart,P.J.
  TITLE     Mutations in SH3PXD2B cause Borrone dermato-cardio-skeletal
            syndrome
  JOURNAL   Eur J Hum Genet 22 (6), 741-747 (2014)
   PUBMED   24105366
REFERENCE   6  (bases 1 to 7779)
  AUTHORS   Iqbal,Z., Cejudo-Martin,P., de Brouwer,A., van der Zwaag,B.,
            Ruiz-Lozano,P., Scimia,M.C., Lindsey,J.D., Weinreb,R., Albrecht,B.,
            Megarbane,A., Alanay,Y., Ben-Neriah,Z., Amenduni,M., Artuso,R.,
            Veltman,J.A., van Beusekom,E., Oudakker,A., Millan,J.L.,
            Hennekam,R., Hamel,B., Courtneidge,S.A. and van Bokhoven,H.
  TITLE     Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes
            the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter
            Haar Syndrome
  JOURNAL   Am J Hum Genet 86 (2), 254-261 (2010)
   PUBMED   20137777
  REMARK    GeneRIF: These findings establish a role for TKS4 in Frank-Ter Haar
            syndrome and embryonic development.
REFERENCE   7  (bases 1 to 7779)
  AUTHORS   Gianni,D., Diaz,B., Taulet,N., Fowler,B., Courtneidge,S.A. and
            Bokoch,G.M.
  TITLE     Novel p47(phox)-related organizers regulate localized NADPH oxidase
            1 (Nox1) activity
  JOURNAL   Sci Signal 2 (88), ra54 (2009)
   PUBMED   19755710
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7779)
  AUTHORS   Weaver,A.M.
  TITLE     Regulation of cancer invasion by reactive oxygen species and Tks
            family scaffold proteins
  JOURNAL   Sci Signal 2 (88), pe56 (2009)
   PUBMED   19755707
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7779)
  AUTHORS   Buschman,M.D., Bromann,P.A., Cejudo-Martin,P., Wen,F., Pass,I. and
            Courtneidge,S.A.
  TITLE     The novel adaptor protein Tks4 (SH3PXD2B) is required for
            functional podosome formation
  JOURNAL   Mol Biol Cell 20 (5), 1302-1311 (2009)
   PUBMED   19144821
REFERENCE   10 (bases 1 to 7779)
  AUTHORS   Vogel,C.I., Greene,B., Scherag,A., Muller,T.D., Friedel,S.,
            Grallert,H., Heid,I.M., Illig,T., Wichmann,H.E., Schafer,H.,
            Hebebrand,J. and Hinney,A.
  TITLE     Non-replication of an association of CTNNBL1 polymorphisms and
            obesity in a population of Central European ancestry
  JOURNAL   BMC Med Genet 10, 14 (2009)
   PUBMED   19228371
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011407.6, AK128871.1,
            BC038561.1, AC090064.3, AC008671.6 and CA308160.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001017995.2.
            
            Summary: This gene encodes an adapter protein that is characterized
            by a PX domain and four Src homology 3 domains. The encoded protein
            is required for podosome formation and is involved in cell adhesion
            and migration of numerous cell types. Mutations in this gene are
            the cause of Frank-ter Haar syndrome (FTHS), and also Borrone
            Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of
            this gene results in multiple transcript variants. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ109556.1, AB430862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311601.6/ ENSP00000309714.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC011407.6         99751-99752         c
            3-574               AK128871.1         1-572
            575-1361            BC038561.1         408-1194
            1362-2266           AC090064.3         10343-11247         c
            2267-7738           AC008671.6         93864-99335         c
            7739-7779           CA308160.1         17-57               c
FEATURES             Location/Qualifiers
     source          1..7779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..7779
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /note="SH3 and PX domains 2B"
                     /db_xref="GeneID:285590"
                     /db_xref="HGNC:HGNC:29242"
                     /db_xref="MIM:613293"
     exon            1..248
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2909
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /note="isoform a is encoded by transcript variant 1;
                     adapter protein HOFI; adaptor protein HOFI; tyrosine
                     kinase substrate with four SH3 domains; factor for
                     adipocyte differentiation 49"
                     /codon_start=1
                     /product="SH3 and PX domain-containing protein 2B isoform
                     a"
                     /protein_id="NP_001017995.1"
                     /db_xref="CCDS:CCDS34291.1"
                     /db_xref="GeneID:285590"
                     /db_xref="HGNC:HGNC:29242"
                     /db_xref="MIM:613293"
                     /translation="MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRR
                     YSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYC
                     KALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVV
                     ANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSL
                     QPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLK
                     KNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGD
                     AKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG
                     LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLG
                     EAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGY
                     EEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPA
                     KHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPE
                     EKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLD
                     GEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVS
                     KSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRAL
                     LVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYV
                     AVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP"
     exon            249..329
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            330..405
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..482
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            483..574
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            575..600
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            601..735
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..840
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..958
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1185
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1235
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1361
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..7779
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7739..7744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /note="hexamer: AATAAA"
     polyA_site      7779
                     /gene="SH3PXD2B"
                     /gene_synonym="FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4"
                     /note="major polyA site"
ORIGIN      
        1 ggagtgcgcg ccgagcgaag ggcggcggcg gtggcggcgg cggctcgtgc tcggccccgg
       61 ctgcgattgc gctcagctcc aggttccctg cccgcggcgg cgcgccccca gcgctccctg
      121 caccccgcgc cacccgcacc cgcgctcggc ccgctgcggg cggaggagcg gccatgccgc
      181 cgcggcgcag catcgtggag gtgaaggtgc tagacgtgca gaagcggcgg gtgcccaaca
      241 agcattatgt ctacatcatc cgggtcacgt ggtccagcgg ctccaccgag gccatttacc
      301 ggcgctacag caagtttttt gacctccaga tgcagatgtt ggacaaattt cccatggaag
      361 gaggacagaa ggaccccaag cagcggatca tcccctttct gccaggtaag attctcttca
      421 gacgaagcca catccgggac gtggctgtca aacgcctgat accaattgat gaatactgta
      481 aggccctcat ccagctgccc ccctacatct ctcagtgtga tgaggtgctg cagttctttg
      541 agacaagacc tgaggacctg aatcccccca aagaggagca cattgggaaa aagaaatctg
      601 ggggtgacca aacctcagtg gaccccatgg tcctggagca gtatgtggtg gtagccaact
      661 accagaagca ggagagttcg gagatcagcc tcagcgtggg gcaggtggtg gacatcatcg
      721 agaagaatga gtcaggttgg tggttcgtca gcactgccga ggagcaaggc tgggtccctg
      781 caacgtgcct cgaaggccag gatggggtgc aggatgagtt ttctctgcag cctgaagaag
      841 aggagaagta cacagtcatc tacccgtaca cagctcggga ccaggatgaa atgaacctgg
      901 agagaggggc tgtggtggag gtcatccaga aaaacctgga aggctggtgg aagatcaggt
      961 accagggcaa agaaggctgg gcccccgcct cctacctaaa gaagaacagt ggggagccct
     1021 tgcccccgaa gccaggccct ggctcaccct cccacccggg tgcccttgac ttggatggtg
     1081 tttcccggca gcagaacgcg gtgggcaggg agaaggagct gctcagcagc cagagggacg
     1141 ggcggtttga aggccgcccg gtgcccgacg gtgacgccaa gcagagatca ccaaagatga
     1201 ggcagagacc ccctcctcgc cgggacatga ccattcctcg aggcctcaac ctgccgaagc
     1261 cgcccatccc gccccaagtg gaggaagagt attacaccat cgccgaattc cagacaacca
     1321 tcccagacgg catcagcttc caggcaggcc tgaaggtcga ggtgatcgag aaaaacttga
     1381 gtggctggtg gtacattcag attgaagata aggaagggtg ggccccggcc accttcattg
     1441 acaagtacaa gaagacgagc aacgcgtcga gacccaactt tctggctccc ctgccccacg
     1501 aggtgaccca gctccggctg ggggaagcag cagcgctgga gaacaacacg ggcagcgaag
     1561 ccacgggccc ctcccggccc ctgcctgacg caccgcatgg tgtcatggac tcggggttgc
     1621 catggtctaa agactggaag ggcagtaagg atgtcctgag gaaggcatct tcagacatgt
     1681 ctgcgtcagc aggctacgag gagatctcag accccgacat ggaggagaag cccagcctcc
     1741 ctccgcggaa agaatccatc atcaagtcgg agggggagct gctggagcgg gagcgggagc
     1801 ggcagaggac ggagcagctc cggggcccca ctcccaagcc tccgggcgtg attttgccga
     1861 tgatgccagc caaacacatc cctccagccc gggacagcag gaggccagag cccaaacctg
     1921 acaaaagcag actgttccag ctgaaaaatg acatggggct ggagtgtggc cacaaggtct
     1981 tggccaagga agtgaagaag cccaacctcc ggcccatctc caaatccaaa actgacctgc
     2041 cagaggagaa gccagatgcc actccccaga atcccttctt gaagtccaga cctcaggtta
     2101 ggccaaaacc agctccttcc cccaaaacgg agccacctca gggcgaagac caagtcgaca
     2161 tctgcaacct caggagtaag ctcaggcctg ccaagtccca agacaagtcc ttgttggatg
     2221 gggagggccc ccaggcagta gggggccaag acgtggcctt cagccgaagc ttcctcccag
     2281 gagaggggcc tggccgcgcc caggacagga cgggcaaaca ggatggtctc agcccaaaag
     2341 agatttcctg cagagcccct ccgaggccag ccaagaccac agatcctgtg tctaagagcg
     2401 tgcctgttcc tctccaagag gctccccagc agagacctgt ggtcccaccc cgcagaccac
     2461 ctcccccaaa gaaaacctct tcgtcatcca ggccgctccc agaggtcaga ggtccacagt
     2521 gtgaaggcca cgaaagcagg gcagctccca ccccaggccg tgctctcctc gtccctccaa
     2581 aagccaaacc ttttctctcc aactctttgg ggggccagga tgacacgcga ggcaaaggca
     2641 gcctggggcc atgggggacc ggcaagattg gagaaaacag ggagaaagca gctgcagcct
     2701 ctgtccccaa tgccgacggc ctgaaggact ctttgtatgt ggccgtggcc gactttgaag
     2761 gagacaaaga caccagcagc ttccaggaag ggacagtgtt tgaagtccgg gagaagaaca
     2821 gcagtggctg gtggttctgc caggtcctga gcggagcccc ttcctgggaa gggtggattc
     2881 cttccaacta tctcagaaag aagccgtagc cgactccctt tctgcctaga gggcccgctg
     2941 gtccttgctg gctttaccca cgtatttaat acgcctctta atttatcatt ctccacgcag
     3001 cttccaaggc agacagactc tggggtactg tgacttcttg cctcccatgg gtggagagtg
     3061 agtttcggac acctcgggcg cccctgggcc tgatccctcc tatcacagca tcactggagg
     3121 ctcagaaccc acagcctttg ctttctgtcc atgtcagcat ccctgcctta agagaactcc
     3181 tcctggccaa tggcattgcc acccagcagt gggaccaaga ctctccaaga cctccaggac
     3241 tggatcccat tgcctggaga aactccagca agggtctctc atggcttgga catggcacag
     3301 taaggggcag ccaacccagt ccatgatgac ttttgctcca acttcttcat gtttctaaaa
     3361 gcccagtggc tttattcact cctcctaaat tgcctgctac cagaaggaac ttcatcctga
     3421 agaaatgcat tccattacca gttccaggga aagtgtcccc ttccccaaag cctcaggccc
     3481 gtgggcctct gaggttccac tggatgcggc tcccccagga gtgggcctgg agatccgctc
     3541 agccgccctg cctcccacct tctatcttgg gaccgtggtc agccctgaag ggtggttcca
     3601 gccccgcgta tgctgcgctt tgctgctgca ggctccggtc cctccagggc ttttcaatga
     3661 gagttcccac cccaacttgg agcatttcat ttttgcctac ctaaagcaag aatctcaaag
     3721 tttgtttgaa taagaggccc attcacaagt cgtgcccttg tgagcacccc tttgctgagt
     3781 gcctcgtggg tgccaaacac tgtacttggc gctttgcatt catgctttga ccctcacaac
     3841 ctccctttat agatgaggaa attcacgctc catgtgccca aggacacacc agccaggagg
     3901 aagagggaag aggatttgag tccaggcctg cctgacttca gtgcctgtgc cctcccctct
     3961 gtaaaagaca aaccaggcag ggaagagata gaagctggct aagtggtggc caagtggctt
     4021 cattgtgagg ggggtgaggg ggcattcgtg gctgctccca cacccaccat ccctccagcc
     4081 cacagcagcc tataccaaag gctgccctgg actcaacagc tgcatctcca tgacaggaga
     4141 atgccagggt cctggtggtt gacacagagc cctgttccct cttctaagct gttgccccct
     4201 ggggaataga gcttatggag caacgggagc tgaggtggcc tcgagggcca gcctggaggg
     4261 ctctgagcat agcatgcagc ggtcccatag ggaggcaggt aaccaagggc caggcagagc
     4321 tgcttcctgt gcctctccgg catttgtaat gtttttttct tttttcacgc actgccaaat
     4381 ctgttttctc ccttgaagaa acccagggca gatgtggtca tctgtcaaac tgaggtctgg
     4441 agaggcatga ctaaatcact gcagaagcaa aatcaggacc cagcatttct agctcccagc
     4501 ccagagtaag agagcagagc agaacccctt cccattctac ccgaccgagg cagccctgcc
     4561 ctgccctgcc ccgcccctcc ccaccctgcc ctgccccaga gatctccagt tcacagtgtt
     4621 catcaggcga gatacttttg gacccacaaa gccagttttt tggggggatg ctcagtgtct
     4681 acctgcagtg ccaaagtttt gcttgaacag ccctcttctg ccgcgcctcc cagctccacc
     4741 ccctatcacg tgggtgctgg ctgcttctgc gtgaggagct tcctctgatc acctgtagca
     4801 tctttagtgc cttcgtccag tcggcctgca aatcccattt cccagagagg cttgggcagg
     4861 gcccacttgc cacttggccc tgtgcccaga gcgttggggg cagatggcag ccaggggaag
     4921 aagggaggtg gggaagggcc gccaccgctt gagggtcccc tcccttgaga ggaggcccca
     4981 tggcagtttt cctgagttct tgatccactt tggtttaaac aacttttgtg aagctatgtg
     5041 agatttgact gcatttcaaa agacaaaaca catgtttttt tctgatttgc tctttgcctt
     5101 tcagcgacgc tttcagatac tttgtgagtg tctactctgt gctaggtgct gagtagactg
     5161 ggatgtgtgt ggctccatcc ctggctggaa gagctttgag tcctgtctgc tgacttcact
     5221 gaaggagttt ctctcttgct tcattccttc ctcccggggg tcagctgggt aggagcagac
     5281 ttgccctgcc ttcctctagg cagaaagttt tcctgcaaat gaaagaatct gccattctct
     5341 tttgctatga tgatgatgat tattctgaca tgacccgcgg gtactgaagc cacagtcctc
     5401 tctgttcact gttctctcct tgagtcatat ctatggcctg aggacgtctg tatccagctc
     5461 cttttcctac aatggtagac acttccccag gcagtgggtg ggtcagggtg gccagtcact
     5521 ctcctagctg tccttgcctg gggacttaga tttaccccat ccaggactgt ggtcgctatt
     5581 ctgtgagcga ttgatggcgc atatgcagaa ctcccctgga gtcatggctc tagaaagtgt
     5641 ccaggcccat cgtgacaatg gtgccaagca ccgggctggt gaccagtgcc taaacacaca
     5701 cgctccttta atccttacgg caagcctgtg aggcggatag gaccagccct gatctatagt
     5761 gagaaaatta aggttcagag ggagaaggtc caaatagtgg ccaagctggg actgagatct
     5821 cgagtttggg tttgtttggt tttgttgttg ttgttctttc cctcgtgtcc atgacttttc
     5881 tctgccatta gcagggaagt gtgcggaggg cttccaggga atcaagtgac cctccctctg
     5941 aatttcggtg cctcttcccc ccgccccttg ctcacacatt tcagtaggtc acaggccaaa
     6001 tggcagccca aaaggtgggc agagattttt ttttcttccc ctcacccctg cttattaaca
     6061 caattgtgac aactacttta ccttacatcc cagggcaaac ggacagcttg cggtacctcc
     6121 aaaaatttgg aaaaccctga gtctaagacc acctcttgat aaaagaggcc tttgctcaca
     6181 tgttctgctc ggaatctttc tttgccattg gtgggtgtat gtcgtcccag ctgagactgc
     6241 gggagagctg agctccagct taaaccgctt ttaatggccc ttccctactg ggggatcgct
     6301 ggagcccatg ccaggttacg gtagtcattt taaacctctg ccacaaggcc acgccataga
     6361 atcaatttcc aagtcaatgt tcttggccct aaaatgtttg cgcccactga ggatttcatt
     6421 accaggtgga agatggggga acatatgcca cgttaaagag caagtgctga gtgtgccagg
     6481 acttgagaag gaccttaggc tgaggagtgg acagtctggt atttatttcg cctctcccaa
     6541 gtacccagca cagagtggga aaaagaagaa actgctcctg ccttccagta gctggcaact
     6601 tgacatcaag aacaaaaaca ttcgtagctg gacccccgtc ctttcatcgt gcccaagtct
     6661 tacatgttgg cttaagctgc ccccttggag gccgtacctt tctctttgga ctgtgacagt
     6721 ggacacctaa cagcctgagc catgtgtggc tgtcttatcc cccaagggtt gtccaggccc
     6781 gttctgcagg gctgttgtgt agactgcaga catccatacc tcaccacaga ccaaagatga
     6841 cctcgtgtca gactgtgggc tgatgagagg tagagcagca tgcatcgagg cctgagggtg
     6901 cagggcgccc tctcttggcc tggaggaatt gctcctaact agagtaagtt tccacgaggg
     6961 tcccaggcag agctgcagag ctggaaccgg aggctccaca gtccttgcct gctcatggac
     7021 ctccttcaga gcacctttct acagactgga ctgcccagct ccgtggggtg gcatctggtt
     7081 tctggtgcta ttctgccaag ttatcgagct cctcctcatg tttcaacatt ccatcttccc
     7141 gtttctatcc tcgactccaa agtaagcctt cttagctcca atcagggatg aggggctcaa
     7201 cctcttctgt cctcaaagag gccaaacgca gtgccacagt cggtagcctt cacttttaga
     7261 tgtcctattc atgtaaaaaa gaaggtgccc ccaccaggct tacatcagca ataagcaatt
     7321 ctaatgcaac gatggtgtcc acattttacc ccagtgtgtg cccatgtatg cctttgtgcc
     7381 cgtgtaatta ttgttagcgc ccctttcact tagaggggtg atgataaact gtggccacct
     7441 tgattacaac ccacatttcc tgctttgggg agcttccaag taacaggcca tttcttacct
     7501 ccctccagga acagtgggca ctgcccacca cctcgtgtct gctcatagga tgacgctgga
     7561 gatccccaca cttactctac cctcttggca aattggcatt ccggtggtgg tttttgtttc
     7621 ctttaacaca ttaaataaat gagtatatag gatgtgaggg gaggggtgag aacaactagc
     7681 tgtagcatgt gtaggctata tactttacca tttgacttct ttcctttttt tttttttaaa
     7741 taaaaaaagt gcttgactgg tttcaagctt catcatgaa
//
