LOCUS       NM_001394023           10766 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens SH3 and PX domains 2A (SH3PXD2A), transcript variant
            11, mRNA.
ACCESSION   NM_001394023
VERSION     NM_001394023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10766)
  AUTHORS   Inoue,H., Kanda,T., Hayashi,G., Munenaga,R., Yoshida,M.,
            Hasegawa,K., Miyagawa,T., Kurumada,Y., Hasegawa,J., Wada,T.,
            Horiuchi,M., Yoshimatsu,Y., Itoh,F., Maemoto,Y., Arasaki,K.,
            Wakana,Y., Watabe,T., Matsushita,H., Harada,H. and Tagaya,M.
  TITLE     A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38353696
  REMARK    GeneRIF: A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis.
REFERENCE   2  (bases 1 to 10766)
  AUTHORS   Ogasawara,N., Yamashita,S., Yamasaki,K., Kawano,T., Kawano,T.,
            Muta,J., Matsumoto,F., Watanabe,T., Ohta,H., Yokogami,K.,
            Fukushima,T., Sato,Y. and Takeshima,H.
  TITLE     Spontaneous malignant transformation of trigeminal schwannoma:
            consideration of responsible gene alterations for tumorigenesis-a
            case report
  JOURNAL   Brain Tumor Pathol 40 (4), 222-229 (2023)
   PUBMED   37515639
  REMARK    GeneRIF: Spontaneous malignant transformation of trigeminal
            schwannoma: consideration of responsible gene alterations for
            tumorigenesis-a case report.
REFERENCE   3  (bases 1 to 10766)
  AUTHORS   Pezinski,M., Maliszewska-Olejniczak,K., Daszczuk,P., Mazurek,P.,
            Niewiadomski,P. and Redowicz,M.J.
  TITLE     Tks5 Regulates Synaptic Podosome Formation and Stabilization of the
            Postsynaptic Machinery at the Neuromuscular Junction
  JOURNAL   Int J Mol Sci 22 (21), 12051 (2021)
   PUBMED   34769479
  REMARK    GeneRIF: Tks5 Regulates Synaptic Podosome Formation and
            Stabilization of the Postsynaptic Machinery at the Neuromuscular
            Junction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10766)
  AUTHORS   Yang,Z., Chen,Z., Wang,C., Huang,P., Luo,M. and Zhou,R.
  TITLE     STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects
            psoriasis pathogenesis via regulating human keratinocyte
            proliferation
  JOURNAL   Cytokine 144, 155535 (2021)
   PUBMED   33994260
  REMARK    GeneRIF: STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop
            affects psoriasis pathogenesis via regulating human keratinocyte
            proliferation.
REFERENCE   5  (bases 1 to 10766)
  AUTHORS   Sugimoto,A., Okuno,T., Tsujio,G., Sera,T., Yamamoto,Y., Maruo,K.,
            Kushiyama,S., Nishimura,S., Kuroda,K., Togano,S., Miki,Y.,
            Yoshii,M., Tamura,T., Toyokawa,T., Tanaka,H., Muguruma,K., Ohira,M.
            and Yashiro,M.
  TITLE     The clinicopathologic significance of Tks5 expression of peritoneal
            mesothelial cells in gastric cancer patients
  JOURNAL   PLoS One 16 (7), e0253702 (2021)
   PUBMED   34255789
  REMARK    GeneRIF: The clinicopathologic significance of Tks5 expression of
            peritoneal mesothelial cells in gastric cancer patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10766)
  AUTHORS   Malinin,N.L., Wright,S., Seubert,P., Schenk,D. and
            Griswold-Prenner,I.
  TITLE     Amyloid-beta neurotoxicity is mediated by FISH adapter protein and
            ADAM12 metalloprotease activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (8), 3058-3063 (2005)
   PUBMED   15710903
REFERENCE   7  (bases 1 to 10766)
  AUTHORS   Seals,D.F., Azucena,E.F. Jr., Pass,I., Tesfay,L., Gordon,R.,
            Woodrow,M., Resau,J.H. and Courtneidge,S.A.
  TITLE     The adaptor protein Tks5/Fish is required for podosome formation
            and function, and for the protease-driven invasion of cancer cells
  JOURNAL   Cancer Cell 7 (2), 155-165 (2005)
   PUBMED   15710328
  REMARK    GeneRIF: Tks5/Fish appears to be required for podosome formation,
            for degradation of the extracellular matrix, and for invasion of
            some cancer cells
REFERENCE   8  (bases 1 to 10766)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 10766)
  AUTHORS   Abram,C.L., Seals,D.F., Pass,I., Salinsky,D., Maurer,L., Roth,T.M.
            and Courtneidge,S.A.
  TITLE     The adaptor protein fish associates with members of the ADAMs
            family and localizes to podosomes of Src-transformed cells
  JOURNAL   J Biol Chem 278 (19), 16844-16851 (2003)
   PUBMED   12615925
REFERENCE   10 (bases 1 to 10766)
  AUTHORS   Lock,P., Abram,C.L., Gibson,T. and Courtneidge,S.A.
  TITLE     A new method for isolating tyrosine kinase substrates used to
            identify fish, an SH3 and PX domain-containing protein, and Src
            substrate
  JOURNAL   EMBO J 17 (15), 4346-4357 (1998)
   PUBMED   9687503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121929.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.782627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL121929.17        142344-142474       c
            132-263             AL121929.17        134719-134850       c
            264-377             AL121929.17        100824-100937       c
            378-495             AL121929.17        90932-91049         c
            496-833             AL121929.17        86588-86925         c
            834-883             AL121929.17        85316-85365         c
            884-1003            AL121929.17        79533-79652         c
            1004-10766          AL121929.17        67762-77524         c
FEATURES             Location/Qualifiers
     source          1..10766
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..10766
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="SH3 and PX domains 2A"
                     /db_xref="GeneID:9644"
                     /db_xref="HGNC:HGNC:23664"
                     /db_xref="MIM:619455"
     exon            1..131
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            132..263
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2977
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="isoform 10 is encoded by transcript variant 11; SH3
                     multiple domains 1; SH3 and PX domain-containing protein
                     2A; adapter protein TKS5; tyrosine kinase substrate with
                     five SH3 domains; adaptor protein TKS5; five SH3
                     domain-containing protein"
                     /codon_start=1
                     /product="SH3 and PX domain-containing protein 2A isoform
                     10"
                     /protein_id="NP_001380952.1"
                     /db_xref="GeneID:9644"
                     /db_xref="HGNC:HGNC:23664"
                     /db_xref="MIM:619455"
                     /translation="MILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTS
                     EEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEV
                     IRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNK
                     KASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVAR
                     IAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISF
                     RGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAP
                     PSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERR
                     PAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSD
                     SPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCC
                     SSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPK
                     PFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRR
                     SSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQES
                     GWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRV
                     QALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPKDN
                     NLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQ
                     RNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNG
                     WWYCQILDGVKPFKGWVPSNYLEKKN"
     exon            264..377
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            378..495
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            496..833
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            834..883
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1003
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..10766
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4474..4479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="hexamer: AATAAA"
     polyA_site      4501
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="major polyA site"
     regulatory      10739..10744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="hexamer: AATAAA"
     polyA_site      10766
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="major polyA site"
ORIGIN      
        1 actcactgtg gacctcctgc ctgcctaacc gttctctctc tctggttctc ctctcctgct
       61 gccgcttgct ctcggggact cggaagtgtg gctgtccagc tgggctgagt cgcccaagaa
      121 ggacgtgaca ggtgccgacg ccaccgccga gcccatgatc ctggaacagt acgtggtggt
      181 gtccaactat aagaagcagg agaactcgga gctgagcctc caggccgggg aggtggtgga
      241 tgtcatcgag aagaacgaga gcggctggtg gttcgtgagc acttctgagg agcagggctg
      301 ggtccctgcc acctacctgg aggcccagaa tggtactcgg gatgactccg acatcaacac
      361 ctctaagact ggagaagagg agaagtatgt caccgtgcag ccttacacca gccaaagcaa
      421 ggacgagatt ggctttgaga agggcgtcac agtggaggtg atccggaaga atctggaagg
      481 ctggtggtat atcagatacc tgggcaaaga gggctgggcg ccagcatcct acctgaagaa
      541 ggccaaggat gacctgccaa cccggaagaa gaacctggcc ggcccagtgg agatcattgg
      601 gaacatcatg gagatcagca acctgctgaa caagaaggcg tctggggaca aggaaactcc
      661 accagccgaa ggcgagggcc atgaggcccc cattgccaag aaggagatca gcctgcccat
      721 cctctgcaat gcctccaatg gcagtgccgt gggcgttcct gacaggactg tctccaggct
      781 ggcccagggc tctccagctg tggccaggat tgcccctcag cgggcccaga tcagctcccc
      841 gaacctacgg acaagacctc caccacgcag agaatccagc ctggggttcc aactgccaaa
      901 gccaccagag cccccttctg ttgaggtgga gtactacacc attgccgaat tccagtcgtg
      961 catttccgat ggcatcagct ttcggggtgg acagaaggca gaggtcattg ataagaactc
     1021 aggtggctgg tggtacgtgc agatcggtga gaaggagggc tgggcccccg catcatacat
     1081 cgataagcgc aagaagccca acctgagccg ccgcacaagc acgctgaccc ggcccaaggt
     1141 gcccccgcca gcacccccca gcaagcccaa ggaggccgag gagggcccta cgggggccag
     1201 tgagagccag gactccccgc ggaagctcaa gtatgaggag cctgagtatg acatccctgc
     1261 attcggcttt gactcagagc ctgagctgag cgaggagccc gtggaggaca gagcctcagg
     1321 ggagaggcgg cctgcccagc cccaccggcc ctcgccggcc tcttctctgc agcgggcccg
     1381 cttcaaggtg ggtgagtctt cagaggatgt ggccctggaa gaggagacca tctatgagaa
     1441 tgagggcttc cggccatatg cagaggacac cctgtcagcc agaggctcct ccggggacag
     1501 cgactcccca ggcagctcct cgctgtccct gaccaggaaa aactccccca aatcaggctc
     1561 ccccaagtca tcatcactcc taaagctcaa ggcagagaag aatgcccagg cagaaatggg
     1621 gaagaaccac tcctcagcct ccttttcctc atccatcacc atcaacacca cttgctgctc
     1681 ctcctcttcc tcctcctcct cttccttgtc caaaaccagt ggcgacctga agccccgctc
     1741 tgcttcggac gcaggcatcc gcggcactcc caaggtcagg gcaaagaagg atgctgatgc
     1801 gaacgctggg ctgacctcct gtccccgggc caagccatcg gtccggccca agccattcct
     1861 aaaccgagca gagtcgcaga gccaagagaa gatggacatc agcactttac ggcgccagct
     1921 gagacccaca ggccagctcc gtggagggct caagggctcc aagagtgagg attcggagct
     1981 gcccccgcag acggcctccg aggctcccag tgaggggtct aggagaagct catccgacct
     2041 catcaccctc ccagccacca ctcccccatg tcccaccaag aaggaatggg aagggccagc
     2101 cacctcgtac atgacatgca gcgcctacca gaaggtccag gactcggaga tcagcttccc
     2161 cgcgggcgtg gaggtgcagg tgctggagaa gcaggagagc gggtggtggt atgtgaggtt
     2221 tggggagctg gagggctggg ccccttccca ctatttggtg ctggatgaga acgagcaacc
     2281 tgacccctct ggcaaagagc tggacacagt gcccgccaag ggcaggcaga acgaaggcaa
     2341 atcagacagc ctggagaaga tcgagaggcg cgtccaagca ctgaacaccg tcaaccagag
     2401 caagaaggcc acgcccccca tcccctccaa acctcccggg ggcttcggca agacctcagg
     2461 cactccagcg gtgaagatga ggaacggagt gcggcaggtg gcggtcaggc cccagtcggt
     2521 gtttgtgtcc ccgccaccca aggacaacaa cctgtcctgc gccctgcgga ggaatgagtc
     2581 actcacggcc actgatggcc tccgaggcgt ccgacggaac tcctccttta gcactgctcg
     2641 ctccgctgcc gccgaggcca agggccgcct ggccgaacgg gctgccagcc agggttcaga
     2701 ctcaccccta ctgcccgccc agcgcaacag catacccgtg tcccctgtgc gccccaagcc
     2761 catcgagaag tctcagttca tccacaataa cctcaaagat gtgtacgtct ctatcgcaga
     2821 ctacgagggg gatgaggaga cagcaggctt ccaggagggg gtgtccatgg aggttctgga
     2881 gaggaaccct aatggctggt ggtactgcca gatcctggat ggtgtgaagc ccttcaaagg
     2941 ctgggtgcct tccaactacc ttgagaaaaa gaactagcag agggcctggg ctcttccagc
     3001 ctcagtgtgc ctctctggcc gcccactgga tgagcggtga gacgaacaaa agggaaagga
     3061 aaaaatgggg gtggggggtg gggggtggac aacattcaac actgcagaat gggtgacctc
     3121 aaagatgccc cctgtccaag ccatcccaca gctggaaggt aggggatggg ggtgcccaca
     3181 ctgagtgagg aagggaatgg accagggagt cccaggcctg ggacccagag ccaagaaagc
     3241 tgagatatcc tgtgcaccat agggacttca ccaatggatt acatgccatc tgggacaggc
     3301 catgtgggag accccagttg tgcctttgct acagatctgg aaaagacaag gtcatggggg
     3361 cctccagtgt cctgcccctg cttggcccag ttttgattgc tggcatcttg ccaccccagg
     3421 tatccctggt attgtcctaa gctgtatttg tgaattgtgc tggtttcctg ggcattgcca
     3481 cgcctaccac aggtgggtac attagaagcc accactggct ttcaggcttg ggggtgtctt
     3541 ctgagctcaa gcctgcttct gggccaggcc attgtcactg ttagttgaag aaaaagcagt
     3601 tcccaggtgc cagcaaagac catctttcat aactgtcact gtcttggcct tgagaagaga
     3661 gcccgctctc cgtggggcac cccatggagg acacagtacc agagtttaca gagagggtgg
     3721 gcgaagccac cggtctcttc ctaatctgca cagactattt tgggtatttc tgggcgggca
     3781 gttcctttgc atgtttcggg agaggtttgt tgatttgggg cttatatgtc aggcctttgg
     3841 tttgcgtctt attttagggg ttgtttgggg gcctgggtgg tcggcctcac atgggaaggg
     3901 gatgggtagt ggatggggtt tctgttgtat cttgtgggcg ggtgattttg cttttgtttt
     3961 tgtttcacat tcttccccct ccacaagcca aagtcgtttc atttggtttc cactgtgtgg
     4021 actgtgctgg agcttggcgc ctgccagaaa aatttggggc taggcaagcc ccaggttgca
     4081 gacatggtga agcagagaaa ctgttcttct ggttcctgca caacctcaga ggggcaaaaa
     4141 ccctccccag gaaggaggag ggtgttcagg agccagactt ttggagagaa ggcagctccc
     4201 agcctgctgg gtgaccgcca ttctgcgtgt gttccccagc tgggcagggc tggaagcctt
     4261 acgtatgaag catggagaag cagccattgt ccccactatg ggcagagggg ggacccggct
     4321 ggccccttgg gtcagactgg agccaacacc gccagccacc ccctctggcc tgctggcaat
     4381 gccacaggtg cccaagaaga tggaggatcc ctgtgccagg agccaacctg gtcttcccga
     4441 gggtcagtgc cccagtgaag acagaagcga gagaataaag ttccctgtag gtcctctgtc
     4501 acctttgggt tgtgtttttc aattgttgac atttcagagg ggaccctcca gaagcccagc
     4561 cggcttcccc caaggactcc cccttcgctg ggagtggatt tccacacgtg cctttgattt
     4621 cggacagatt gggcctcaca gccaccgatt cagctgccag ggtccctgga ctgggggttg
     4681 gtgttttcta tagaggagga aaggccctcc ctcaccctgc tccccaccca ggcagggcag
     4741 catgggaccc agtgtctcag tgccttcaaa acccaccccc acccctaccc taccccacca
     4801 caccccatcc cagaggcctt gcctgggcaa ccctaagccc ctgtccctcg ccatacactg
     4861 atgcctggca gctagagcaa atggctcgtg ttctttgtcg aaggcctgtg gtgagattgt
     4921 tttgtttcct tttgttttgt gagtttgttt aaaattgaaa ttagttattt tcttctgctg
     4981 gacagtatta aatagagcag gatgttgagt taatctgcta gattgcagta ctaatggtag
     5041 tggtttagtg tcttcatgtt aatattattt gtacttattt gaacaataat gataaagaag
     5101 tggttcatta ttttttaatt aatgcacttt aaataaggta gaatggaaaa aacccagaga
     5161 gcaaagtgca ttacttaaag atgcagtata tacttttctc atttttaaac agcacatatt
     5221 tattaagaga aaaaaagtaa tttatgacta tttaaaataa aatttaaaag tagagtgact
     5281 gtcaggtaaa gaaccttcaa tgtagctatc ttccaggggg agggccctgc agcctcgctc
     5341 ctcagatgtc tgcactgagc cagttcagtc actagtgcgc cagccaggcc aggagggagt
     5401 gcagagcatg tctgccaagc acagagcatc tcagttggac tggaccacag tgctcccgag
     5461 agcctgcctt tcctgccctt ccccaccacc tgcactgccc cccacattct cccagccccc
     5521 cccaaggacc ccctctcctt gacccccagt gctgtaagta atagagtcat taaaatgcag
     5581 gactgaaaga gacctcagag gtctctatcc catcccttcc tgttactgcg gcccaaggac
     5641 aggaaacaac ttttccaaaa tcccacagct agttaatgac agatctcccc actacattaa
     5701 tcccgtgctc ctcctcactg ccattatagt ttattgtgtg gtcatgttta cattgtgaca
     5761 tccagcccca aggatggctg ggagttgctc aggcatccag gaaaagtggg gaatgctgcc
     5821 atctggtgac agcatgtaga tttgggcagt gaacagggat tgccatgccc cagtcttcgc
     5881 acctcgcccc ctcaccccct aactcacagc acaaaccctg caaacccaaa gagaatatta
     5941 atacttgaag caagaagggt gcatgccagt ccttctccga catggccagg gggtaccagg
     6001 ccttgtgcgc ctggcctcct agccctagcc agggcgagag ggcctttccc ttgagctact
     6061 gagctgcttt gtgatgctga aggatactgc cggcagcagg cagaggaggg agggggccta
     6121 gggctctgac ccatctggag gaaaaccaga tcggactaaa aaaggaaaaa gaaaaacaaa
     6181 atctccgcag tgtccaaacc tagtttccca tgagttgcga ctgaaaatgt gaaacgacac
     6241 tgtattgctg tatactgcaa ctttaaccat aatgagccct tctgaggtca ttattgaggt
     6301 tcatataatg cccgaagatg cagcatttgg tgctttgttt tcctttccgt ttcaagacct
     6361 ttttctttta ttgcaagggg aaaaaaatgt catctccccc cacctcatcc ctctttgtga
     6421 cagcagacct ggctgtgttg cccctctcct cctcactatt ctcaccaggc catgggactt
     6481 tgggggcagt gagagagagc tggaaagggg caaccctgag cagcaggtgt gccccatgcc
     6541 ctgtgggttt cccctatgtc caatgactgt agacgggctg tcttgccagg cctcagcccc
     6601 gtctacccta agcctggccc caaaggtttc tctttcttcc tccttgattt tccatcttga
     6661 cgaaggcatt atatagaatc attttaatca ctttcagatg ttagagcagc gtattttaca
     6721 ggcatttata tccattgctt tcctcagcaa ggcatgttac tacttttatc atctaaggaa
     6781 aaaagacaag ggaattccag tcaggcatta ttttcctatt actagtgttt gcagaatagg
     6841 tgtaggacta tttaagttta gaccttggtt tggtagttct tgtttttaat aaggggaaaa
     6901 agataaaata acccctattt ttcctgttat tgtatttaac taatatatta tttctttaag
     6961 gttactcact tcccctaccc ctccaaatac cttgcattct caatcaaaaa tggaaacaat
     7021 ctgagagaca ggaaaagtgc aatattacca agatggatgc cagggctcat tggggacaat
     7081 ggagggaata ccagtggcgc tcagagagca agaggcaggg agcggggtgc tgaaggaatc
     7141 ctagctgtgg aacaggtggg tgggttggtg gagtttgatc ttgtggcgtt ctcctctccc
     7201 ccttctttgg gaagatgata ggggtccctg ccagatccac ccagaagaaa gggattcagg
     7261 catggggccc ttgacctcta ggccccagtc cctggagcag aggcaggccc tcgggagctg
     7321 ttccttgttt tgatttctgt tgtggtgcag ccagctgctc agagagacct ggcctaaaaa
     7381 tgactcccag cagccctctc tcaccccagt gtcctgatat ttgggctgtg atccttctgg
     7441 tgtatgtttg aatctttcta aaactgggtg ccctcagttc agtttctagg caggaagcct
     7501 agaagtcacc agatcttttt gggggatgtg agaaccttga gccgcgcaca ccctggtgag
     7561 acaccaattc ccacaagcct gcagcagggc ctggggctga gcctgggctg cccattcatc
     7621 tcagcgactt cagcctgaga agtgagccct gcctgggctc cacacccaga gagtccatac
     7681 aaattctgct ccgggaagag tcggggggtc tattcaagtt tctctgcaga caaaacttcc
     7741 cacaacaggt accaatctgg cctccttcct cagcaccggt agagaaagca acagaatggg
     7801 aagtttcctc tgggttggag cctcagagct ctgcccctca aggtgacagg gacgtccctg
     7861 tggcttgttc cctccacctc cagtactgta tgcttgctac ttcaaccccc tatttggtga
     7921 atttctgcac agacacagat ctctgtgcct ggaatgggac tgtgccctgt gcgggtctct
     7981 cccttggcgt atatccatct agatatttag tctttgagaa tctcaaagca gagctctctg
     8041 ggaagagaac tgtccacatt gctaaataat taagattccc tcactttttt gagggccatg
     8101 tgttgtgaga gagagagaga gagagagagt gtgtgtgtgt gtgtgtgtgt gtgtgtgtct
     8161 gtgtatgcaa gtgttggtaa cttcccactt gaactaaata acatggggtt agagaaaaaa
     8221 aaataccagg caagctgtct ccattgaaca agtccttggc aatgggcagg tcccaaggga
     8281 ctcacagctt ctggcagcaa gtgtgtcatt cacacacatc attctggctg gagagtgcaa
     8341 tgtgtcattt ttttttcttt ttgtaattat tttattaagt atttagttgg aaatttcaca
     8401 ctggcattaa caggtctagc ataagtggcc taggcagtca tcccaggctc caaaatgaag
     8461 atgtgcaaaa gagatgccac tgggaataga aacactgagt tggttcagtt aggtcatccc
     8521 ctgcagacgt gtcatcgagc aggctgactc ccacccctca gccatgccat gggtatgaga
     8581 agccccttat aatgaaagct gccagccctt tcgtccttgt ttcagagggt gggtcaggtg
     8641 gttggggtga gaacttgctc acggtgcacc caacaagacc tgcaggtgca tataagttta
     8701 gtcccaactg cagggccaga ccaaacactt cctgggaagt gtgtggaggg ctgtgctaga
     8761 ccttcctgag tttctggcta aatcatcagc cctgtttggt gcagtctcat gtctctgtgg
     8821 ttcccaagct gcatgatcag agccagtgag aagacaggat cagtgaccca cagctttggg
     8881 gaaaaacagc cccactgtta acttccctcc tgcaaacctg ggtccccagg ccataaggtg
     8941 ggcacactgg tgcttacaga ctgggtggag agccctacct tccaaggtct tgatcccagc
     9001 ctgcctataa ggttgggatt agcatgcaat cccccttccc caatcctgtc tttttaaaat
     9061 ctcaagtttg cacttaacct tgacaacagc accctctcct actccagtcc tagaactcag
     9121 tggccttaga gaatggggtc ccctgcactg aaggtccccg ccttgctccc agttccatcc
     9181 tggccaatag gctgcgcctc aagaggtgaa agagaaaaaa gggagggagg gaggaagaat
     9241 tatttagaac aaaaggatgg ctcgagcacg ttagaggcaa gtgagaggca cgttggtgag
     9301 aagagcatgt gcatgtttgg ggtagctggg gcctactgtc ccttcattag ggaaggaggc
     9361 ttccagaagc ggatgtcttc tagaaagaaa aattgtgtga aggctgaaaa ggggcttgga
     9421 gttttgtctt tgttgattag aaagaaggaa gaagtcagct ctgagtgttt caggaagaag
     9481 agagcaggta gaaagggaat ttagtgattt aacacccaag ggtccagcca tagcaggttg
     9541 gaaaatcctc caaatttggc cacagaaact ggctaggaaa aaactgccac tcattgggcc
     9601 acacgctggg tccccatcag ttctcaatga atggtcattg atttacttag cagagagaag
     9661 tcaccagcca caaaccaatc tttgagtttg caggccctga ttccagaata tatgcatcca
     9721 gctcccgggt tctcagctgg ttttgcccac ttccctttga ctgtccaatc caaagccagt
     9781 ctctcaagtt gtatggctca aagagcagtg accacaatgg gtcatacagt agggacccac
     9841 ctccacaaat tagaaccaga gttcagactc cattgggcac atctgggagg aaggcaacct
     9901 cctttgtcgt cttgttggta ccagtcattc tcaagtatct ctgacacctg tggtggttca
     9961 gtttgctgag cctgccacct ggtatgaatt agactgggtg tgatgaacat tcatccatgg
    10021 atatacccta ccattttgcg ttgccttata accaaggcac actccccata agagtttact
    10081 gcagagaaag aacagcaaaa cagccaccct ccttgaattt acaactcatt atctgcaaca
    10141 ggttttcttt aaatccaaga cacaggatgg gaaatgggtt tccccaccag gtactcagag
    10201 gtctgcagga agtgactccc gggcaaggca gacttcagta atccctgaag cgtgagcatg
    10261 tggactgcat ggctgggtgg ggactggtgg atgtctctgg agctccagaa ccttggagaa
    10321 ttcctcatgg aattcccctc ccagctctta gtgggctctg tggggtcagg aggagccctt
    10381 cctccaggtt ttccttcttt cctcctcagc agagaaactg gagaaaggac attaaactca
    10441 gtgcagtcga tttgagtgct gaaatatttc cagaatcaat ggtggtgcta aactatctcc
    10501 atgtttctag catttttaat agtggagttg gtttgttttt aatctcatca caaaaatgca
    10561 gtgcccttgg ggaagggacc agccccttgg cctgccactt tccaggtgtc ctttatcact
    10621 ttgacgggac tctttggtct gcagaaaatg ctctgtcttg gcatgcttct agactgtaag
    10681 atttgggttt tgttttgtat tttatgttta catgcatctt atatttccct gaaaactaaa
    10741 taaagttttg ggccttttta accgaa
//
