LOCUS       NM_001394017           11309 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens SH3 and PX domains 2A (SH3PXD2A), transcript variant
            5, mRNA.
ACCESSION   NM_001394017
VERSION     NM_001394017.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11309)
  AUTHORS   Inoue,H., Kanda,T., Hayashi,G., Munenaga,R., Yoshida,M.,
            Hasegawa,K., Miyagawa,T., Kurumada,Y., Hasegawa,J., Wada,T.,
            Horiuchi,M., Yoshimatsu,Y., Itoh,F., Maemoto,Y., Arasaki,K.,
            Wakana,Y., Watabe,T., Matsushita,H., Harada,H. and Tagaya,M.
  TITLE     A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38353696
  REMARK    GeneRIF: A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis.
REFERENCE   2  (bases 1 to 11309)
  AUTHORS   Ogasawara,N., Yamashita,S., Yamasaki,K., Kawano,T., Kawano,T.,
            Muta,J., Matsumoto,F., Watanabe,T., Ohta,H., Yokogami,K.,
            Fukushima,T., Sato,Y. and Takeshima,H.
  TITLE     Spontaneous malignant transformation of trigeminal schwannoma:
            consideration of responsible gene alterations for tumorigenesis-a
            case report
  JOURNAL   Brain Tumor Pathol 40 (4), 222-229 (2023)
   PUBMED   37515639
  REMARK    GeneRIF: Spontaneous malignant transformation of trigeminal
            schwannoma: consideration of responsible gene alterations for
            tumorigenesis-a case report.
REFERENCE   3  (bases 1 to 11309)
  AUTHORS   Pezinski,M., Maliszewska-Olejniczak,K., Daszczuk,P., Mazurek,P.,
            Niewiadomski,P. and Redowicz,M.J.
  TITLE     Tks5 Regulates Synaptic Podosome Formation and Stabilization of the
            Postsynaptic Machinery at the Neuromuscular Junction
  JOURNAL   Int J Mol Sci 22 (21), 12051 (2021)
   PUBMED   34769479
  REMARK    GeneRIF: Tks5 Regulates Synaptic Podosome Formation and
            Stabilization of the Postsynaptic Machinery at the Neuromuscular
            Junction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11309)
  AUTHORS   Yang,Z., Chen,Z., Wang,C., Huang,P., Luo,M. and Zhou,R.
  TITLE     STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects
            psoriasis pathogenesis via regulating human keratinocyte
            proliferation
  JOURNAL   Cytokine 144, 155535 (2021)
   PUBMED   33994260
  REMARK    GeneRIF: STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop
            affects psoriasis pathogenesis via regulating human keratinocyte
            proliferation.
REFERENCE   5  (bases 1 to 11309)
  AUTHORS   Sugimoto,A., Okuno,T., Tsujio,G., Sera,T., Yamamoto,Y., Maruo,K.,
            Kushiyama,S., Nishimura,S., Kuroda,K., Togano,S., Miki,Y.,
            Yoshii,M., Tamura,T., Toyokawa,T., Tanaka,H., Muguruma,K., Ohira,M.
            and Yashiro,M.
  TITLE     The clinicopathologic significance of Tks5 expression of peritoneal
            mesothelial cells in gastric cancer patients
  JOURNAL   PLoS One 16 (7), e0253702 (2021)
   PUBMED   34255789
  REMARK    GeneRIF: The clinicopathologic significance of Tks5 expression of
            peritoneal mesothelial cells in gastric cancer patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11309)
  AUTHORS   Malinin,N.L., Wright,S., Seubert,P., Schenk,D. and
            Griswold-Prenner,I.
  TITLE     Amyloid-beta neurotoxicity is mediated by FISH adapter protein and
            ADAM12 metalloprotease activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (8), 3058-3063 (2005)
   PUBMED   15710903
REFERENCE   7  (bases 1 to 11309)
  AUTHORS   Seals,D.F., Azucena,E.F. Jr., Pass,I., Tesfay,L., Gordon,R.,
            Woodrow,M., Resau,J.H. and Courtneidge,S.A.
  TITLE     The adaptor protein Tks5/Fish is required for podosome formation
            and function, and for the protease-driven invasion of cancer cells
  JOURNAL   Cancer Cell 7 (2), 155-165 (2005)
   PUBMED   15710328
  REMARK    GeneRIF: Tks5/Fish appears to be required for podosome formation,
            for degradation of the extracellular matrix, and for invasion of
            some cancer cells
REFERENCE   8  (bases 1 to 11309)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 11309)
  AUTHORS   Abram,C.L., Seals,D.F., Pass,I., Salinsky,D., Maurer,L., Roth,T.M.
            and Courtneidge,S.A.
  TITLE     The adaptor protein fish associates with members of the ADAMs
            family and localizes to podosomes of Src-transformed cells
  JOURNAL   J Biol Chem 278 (19), 16844-16851 (2003)
   PUBMED   12615925
REFERENCE   10 (bases 1 to 11309)
  AUTHORS   Lock,P., Abram,C.L., Gibson,T. and Courtneidge,S.A.
  TITLE     A new method for isolating tyrosine kinase substrates used to
            identify fish, an SH3 and PX domain-containing protein, and Src
            substrate
  JOURNAL   EMBO J 17 (15), 4346-4357 (1998)
   PUBMED   9687503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121929.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3599200.1,
                                           SRR14038191.1618115.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-722               AL121929.17        134719-135440       c
            723-836             AL121929.17        100824-100937       c
            837-920             AL121929.17        96205-96288         c
            921-1038            AL121929.17        90932-91049         c
            1039-1376           AL121929.17        86588-86925         c
            1377-1426           AL121929.17        85316-85365         c
            1427-1546           AL121929.17        79533-79652         c
            1547-11309          AL121929.17        67762-77524         c
FEATURES             Location/Qualifiers
     source          1..11309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..11309
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="SH3 and PX domains 2A"
                     /db_xref="GeneID:9644"
                     /db_xref="HGNC:HGNC:23664"
                     /db_xref="MIM:619455"
     exon            1..722
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..3520
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="isoform 5 is encoded by transcript variant 5; SH3
                     multiple domains 1; SH3 and PX domain-containing protein
                     2A; adapter protein TKS5; tyrosine kinase substrate with
                     five SH3 domains; adaptor protein TKS5; five SH3
                     domain-containing protein"
                     /codon_start=1
                     /product="SH3 and PX domain-containing protein 2A isoform
                     5"
                     /protein_id="NP_001380946.1"
                     /db_xref="GeneID:9644"
                     /db_xref="HGNC:HGNC:23664"
                     /db_xref="MIM:619455"
                     /translation="MDRGRPGRGAMAGRWLTACFLPSPGADATAEPMILEQYVVVSNY
                     KKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTS
                     KTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTV
                     EVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLL
                     NKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAV
                     ARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGI
                     SFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPP
                     APPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGE
                     RRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGD
                     SDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTT
                     CCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVR
                     PKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGS
                     RRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQ
                     ESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIER
                     RVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPK
                     DNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLP
                     AQRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNP
                     NGWWYCQILDGVKPFKGWVPSNYLEKKN"
     exon            723..836
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            837..920
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1038
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1376
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1426
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1546
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..11309
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5017..5022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="hexamer: AATAAA"
     polyA_site      5044
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="major polyA site"
     regulatory      11282..11287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="hexamer: AATAAA"
     polyA_site      11309
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="major polyA site"
ORIGIN      
        1 gagaagctct ctcccgctct ctcctctccc tctcccgccc gagggagcag ggctgccttt
       61 tctctcgggt ttgcaggggt tgggggcaga ggctggagcc tcctgcttgc ctttcctttg
      121 cctctggcct cagccctcat gggccgccca cccgctggct cgccgccctc cccgatgccc
      181 ctgccggccc gagagggagg ccggagagac cccgtcggcc ccaggcctcc ccgcaggctc
      241 cctcatgccg ggctgtgact aactcatcgc agcacaaggc ttctttctga gcttccttgg
      301 cctccgcctc cgctctgcct ctctctttcc tcctcctcct gcccgtcccc tccccggccc
      361 cctggctccc catgtccccc ggaccccgcg gtgcagcggg ccggtctggg gccttgctat
      421 atggcctgtc cttggcgccc tgtgagctgc gagccccggc tgcgggctgc ccctgggagc
      481 ggcgctggcg acagagcagc cacccccgag gaggccgatg gacagggggc gccctggccg
      541 cggggccatg gctggccgct ggctcaccgc gtgctttctg ccctcgccag gtgccgacgc
      601 caccgccgag cccatgatcc tggaacagta cgtggtggtg tccaactata agaagcagga
      661 gaactcggag ctgagcctcc aggccgggga ggtggtggat gtcatcgaga agaacgagag
      721 cggctggtgg ttcgtgagca cttctgagga gcagggctgg gtccctgcca cctacctgga
      781 ggcccagaat ggtactcggg atgactccga catcaacacc tctaagactg gagaagtgtc
      841 caagagacgc aaggcccatc tgcggcgcct ggatcgccgg tggaccctgg gcgggatggt
      901 caacaggcag cacagccgag aggagaagta tgtcaccgtg cagccttaca ccagccaaag
      961 caaggacgag attggctttg agaagggcgt cacagtggag gtgatccgga agaatctgga
     1021 aggctggtgg tatatcagat acctgggcaa agagggctgg gcgccagcat cctacctgaa
     1081 gaaggccaag gatgacctgc caacccggaa gaagaacctg gccggcccag tggagatcat
     1141 tgggaacatc atggagatca gcaacctgct gaacaagaag gcgtctgggg acaaggaaac
     1201 tccaccagcc gaaggcgagg gccatgaggc ccccattgcc aagaaggaga tcagcctgcc
     1261 catcctctgc aatgcctcca atggcagtgc cgtgggcgtt cctgacagga ctgtctccag
     1321 gctggcccag ggctctccag ctgtggccag gattgcccct cagcgggccc agatcagctc
     1381 cccgaaccta cggacaagac ctccaccacg cagagaatcc agcctggggt tccaactgcc
     1441 aaagccacca gagccccctt ctgttgaggt ggagtactac accattgccg aattccagtc
     1501 gtgcatttcc gatggcatca gctttcgggg tggacagaag gcagaggtca ttgataagaa
     1561 ctcaggtggc tggtggtacg tgcagatcgg tgagaaggag ggctgggccc ccgcatcata
     1621 catcgataag cgcaagaagc ccaacctgag ccgccgcaca agcacgctga cccggcccaa
     1681 ggtgcccccg ccagcacccc ccagcaagcc caaggaggcc gaggagggcc ctacgggggc
     1741 cagtgagagc caggactccc cgcggaagct caagtatgag gagcctgagt atgacatccc
     1801 tgcattcggc tttgactcag agcctgagct gagcgaggag cccgtggagg acagagcctc
     1861 aggggagagg cggcctgccc agccccaccg gccctcgccg gcctcttctc tgcagcgggc
     1921 ccgcttcaag gtgggtgagt cttcagagga tgtggccctg gaagaggaga ccatctatga
     1981 gaatgagggc ttccggccat atgcagagga caccctgtca gccagaggct cctccgggga
     2041 cagcgactcc ccaggcagct cctcgctgtc cctgaccagg aaaaactccc ccaaatcagg
     2101 ctcccccaag tcatcatcac tcctaaagct caaggcagag aagaatgccc aggcagaaat
     2161 ggggaagaac cactcctcag cctccttttc ctcatccatc accatcaaca ccacttgctg
     2221 ctcctcctct tcctcctcct cctcttcctt gtccaaaacc agtggcgacc tgaagccccg
     2281 ctctgcttcg gacgcaggca tccgcggcac tcccaaggtc agggcaaaga aggatgctga
     2341 tgcgaacgct gggctgacct cctgtccccg ggccaagcca tcggtccggc ccaagccatt
     2401 cctaaaccga gcagagtcgc agagccaaga gaagatggac atcagcactt tacggcgcca
     2461 gctgagaccc acaggccagc tccgtggagg gctcaagggc tccaagagtg aggattcgga
     2521 gctgcccccg cagacggcct ccgaggctcc cagtgagggg tctaggagaa gctcatccga
     2581 cctcatcacc ctcccagcca ccactccccc atgtcccacc aagaaggaat gggaagggcc
     2641 agccacctcg tacatgacat gcagcgccta ccagaaggtc caggactcgg agatcagctt
     2701 ccccgcgggc gtggaggtgc aggtgctgga gaagcaggag agcgggtggt ggtatgtgag
     2761 gtttggggag ctggagggct gggccccttc ccactatttg gtgctggatg agaacgagca
     2821 acctgacccc tctggcaaag agctggacac agtgcccgcc aagggcaggc agaacgaagg
     2881 caaatcagac agcctggaga agatcgagag gcgcgtccaa gcactgaaca ccgtcaacca
     2941 gagcaagaag gccacgcccc ccatcccctc caaacctccc gggggcttcg gcaagacctc
     3001 aggcactcca gcggtgaaga tgaggaacgg agtgcggcag gtggcggtca ggccccagtc
     3061 ggtgtttgtg tccccgccac ccaaggacaa caacctgtcc tgcgccctgc ggaggaatga
     3121 gtcactcacg gccactgatg gcctccgagg cgtccgacgg aactcctcct ttagcactgc
     3181 tcgctccgct gccgccgagg ccaagggccg cctggccgaa cgggctgcca gccagggttc
     3241 agactcaccc ctactgcccg cccagcgcaa cagcataccc gtgtcccctg tgcgccccaa
     3301 gcccatcgag aagtctcagt tcatccacaa taacctcaaa gatgtgtacg tctctatcgc
     3361 agactacgag ggggatgagg agacagcagg cttccaggag ggggtgtcca tggaggttct
     3421 ggagaggaac cctaatggct ggtggtactg ccagatcctg gatggtgtga agcccttcaa
     3481 aggctgggtg ccttccaact accttgagaa aaagaactag cagagggcct gggctcttcc
     3541 agcctcagtg tgcctctctg gccgcccact ggatgagcgg tgagacgaac aaaagggaaa
     3601 ggaaaaaatg ggggtggggg gtggggggtg gacaacattc aacactgcag aatgggtgac
     3661 ctcaaagatg ccccctgtcc aagccatccc acagctggaa ggtaggggat gggggtgccc
     3721 acactgagtg aggaagggaa tggaccaggg agtcccaggc ctgggaccca gagccaagaa
     3781 agctgagata tcctgtgcac catagggact tcaccaatgg attacatgcc atctgggaca
     3841 ggccatgtgg gagaccccag ttgtgccttt gctacagatc tggaaaagac aaggtcatgg
     3901 gggcctccag tgtcctgccc ctgcttggcc cagttttgat tgctggcatc ttgccacccc
     3961 aggtatccct ggtattgtcc taagctgtat ttgtgaattg tgctggtttc ctgggcattg
     4021 ccacgcctac cacaggtggg tacattagaa gccaccactg gctttcaggc ttgggggtgt
     4081 cttctgagct caagcctgct tctgggccag gccattgtca ctgttagttg aagaaaaagc
     4141 agttcccagg tgccagcaaa gaccatcttt cataactgtc actgtcttgg ccttgagaag
     4201 agagcccgct ctccgtgggg caccccatgg aggacacagt accagagttt acagagaggg
     4261 tgggcgaagc caccggtctc ttcctaatct gcacagacta ttttgggtat ttctgggcgg
     4321 gcagttcctt tgcatgtttc gggagaggtt tgttgatttg gggcttatat gtcaggcctt
     4381 tggtttgcgt cttattttag gggttgtttg ggggcctggg tggtcggcct cacatgggaa
     4441 ggggatgggt agtggatggg gtttctgttg tatcttgtgg gcgggtgatt ttgcttttgt
     4501 ttttgtttca cattcttccc cctccacaag ccaaagtcgt ttcatttggt ttccactgtg
     4561 tggactgtgc tggagcttgg cgcctgccag aaaaatttgg ggctaggcaa gccccaggtt
     4621 gcagacatgg tgaagcagag aaactgttct tctggttcct gcacaacctc agaggggcaa
     4681 aaaccctccc caggaaggag gagggtgttc aggagccaga cttttggaga gaaggcagct
     4741 cccagcctgc tgggtgaccg ccattctgcg tgtgttcccc agctgggcag ggctggaagc
     4801 cttacgtatg aagcatggag aagcagccat tgtccccact atgggcagag gggggacccg
     4861 gctggcccct tgggtcagac tggagccaac accgccagcc accccctctg gcctgctggc
     4921 aatgccacag gtgcccaaga agatggagga tccctgtgcc aggagccaac ctggtcttcc
     4981 cgagggtcag tgccccagtg aagacagaag cgagagaata aagttccctg taggtcctct
     5041 gtcacctttg ggttgtgttt ttcaattgtt gacatttcag aggggaccct ccagaagccc
     5101 agccggcttc ccccaaggac tcccccttcg ctgggagtgg atttccacac gtgcctttga
     5161 tttcggacag attgggcctc acagccaccg attcagctgc cagggtccct ggactggggg
     5221 ttggtgtttt ctatagagga ggaaaggccc tccctcaccc tgctccccac ccaggcaggg
     5281 cagcatggga cccagtgtct cagtgccttc aaaacccacc cccaccccta ccctacccca
     5341 ccacacccca tcccagaggc cttgcctggg caaccctaag cccctgtccc tcgccataca
     5401 ctgatgcctg gcagctagag caaatggctc gtgttctttg tcgaaggcct gtggtgagat
     5461 tgttttgttt ccttttgttt tgtgagtttg tttaaaattg aaattagtta ttttcttctg
     5521 ctggacagta ttaaatagag caggatgttg agttaatctg ctagattgca gtactaatgg
     5581 tagtggttta gtgtcttcat gttaatatta tttgtactta tttgaacaat aatgataaag
     5641 aagtggttca ttatttttta attaatgcac tttaaataag gtagaatgga aaaaacccag
     5701 agagcaaagt gcattactta aagatgcagt atatactttt ctcattttta aacagcacat
     5761 atttattaag agaaaaaaag taatttatga ctatttaaaa taaaatttaa aagtagagtg
     5821 actgtcaggt aaagaacctt caatgtagct atcttccagg gggagggccc tgcagcctcg
     5881 ctcctcagat gtctgcactg agccagttca gtcactagtg cgccagccag gccaggaggg
     5941 agtgcagagc atgtctgcca agcacagagc atctcagttg gactggacca cagtgctccc
     6001 gagagcctgc ctttcctgcc cttccccacc acctgcactg ccccccacat tctcccagcc
     6061 ccccccaagg accccctctc cttgaccccc agtgctgtaa gtaatagagt cattaaaatg
     6121 caggactgaa agagacctca gaggtctcta tcccatccct tcctgttact gcggcccaag
     6181 gacaggaaac aacttttcca aaatcccaca gctagttaat gacagatctc cccactacat
     6241 taatcccgtg ctcctcctca ctgccattat agtttattgt gtggtcatgt ttacattgtg
     6301 acatccagcc ccaaggatgg ctgggagttg ctcaggcatc caggaaaagt ggggaatgct
     6361 gccatctggt gacagcatgt agatttgggc agtgaacagg gattgccatg ccccagtctt
     6421 cgcacctcgc cccctcaccc cctaactcac agcacaaacc ctgcaaaccc aaagagaata
     6481 ttaatacttg aagcaagaag ggtgcatgcc agtccttctc cgacatggcc agggggtacc
     6541 aggccttgtg cgcctggcct cctagcccta gccagggcga gagggccttt cccttgagct
     6601 actgagctgc tttgtgatgc tgaaggatac tgccggcagc aggcagagga gggagggggc
     6661 ctagggctct gacccatctg gaggaaaacc agatcggact aaaaaaggaa aaagaaaaac
     6721 aaaatctccg cagtgtccaa acctagtttc ccatgagttg cgactgaaaa tgtgaaacga
     6781 cactgtattg ctgtatactg caactttaac cataatgagc ccttctgagg tcattattga
     6841 ggttcatata atgcccgaag atgcagcatt tggtgctttg ttttcctttc cgtttcaaga
     6901 cctttttctt ttattgcaag gggaaaaaaa tgtcatctcc ccccacctca tccctctttg
     6961 tgacagcaga cctggctgtg ttgcccctct cctcctcact attctcacca ggccatggga
     7021 ctttgggggc agtgagagag agctggaaag gggcaaccct gagcagcagg tgtgccccat
     7081 gccctgtggg tttcccctat gtccaatgac tgtagacggg ctgtcttgcc aggcctcagc
     7141 cccgtctacc ctaagcctgg ccccaaaggt ttctctttct tcctccttga ttttccatct
     7201 tgacgaaggc attatataga atcattttaa tcactttcag atgttagagc agcgtatttt
     7261 acaggcattt atatccattg ctttcctcag caaggcatgt tactactttt atcatctaag
     7321 gaaaaaagac aagggaattc cagtcaggca ttattttcct attactagtg tttgcagaat
     7381 aggtgtagga ctatttaagt ttagaccttg gtttggtagt tcttgttttt aataagggga
     7441 aaaagataaa ataaccccta tttttcctgt tattgtattt aactaatata ttatttcttt
     7501 aaggttactc acttccccta cccctccaaa taccttgcat tctcaatcaa aaatggaaac
     7561 aatctgagag acaggaaaag tgcaatatta ccaagatgga tgccagggct cattggggac
     7621 aatggaggga ataccagtgg cgctcagaga gcaagaggca gggagcgggg tgctgaagga
     7681 atcctagctg tggaacaggt gggtgggttg gtggagtttg atcttgtggc gttctcctct
     7741 cccccttctt tgggaagatg ataggggtcc ctgccagatc cacccagaag aaagggattc
     7801 aggcatgggg cccttgacct ctaggcccca gtccctggag cagaggcagg ccctcgggag
     7861 ctgttccttg ttttgatttc tgttgtggtg cagccagctg ctcagagaga cctggcctaa
     7921 aaatgactcc cagcagccct ctctcacccc agtgtcctga tatttgggct gtgatccttc
     7981 tggtgtatgt ttgaatcttt ctaaaactgg gtgccctcag ttcagtttct aggcaggaag
     8041 cctagaagtc accagatctt tttgggggat gtgagaacct tgagccgcgc acaccctggt
     8101 gagacaccaa ttcccacaag cctgcagcag ggcctggggc tgagcctggg ctgcccattc
     8161 atctcagcga cttcagcctg agaagtgagc cctgcctggg ctccacaccc agagagtcca
     8221 tacaaattct gctccgggaa gagtcggggg gtctattcaa gtttctctgc agacaaaact
     8281 tcccacaaca ggtaccaatc tggcctcctt cctcagcacc ggtagagaaa gcaacagaat
     8341 gggaagtttc ctctgggttg gagcctcaga gctctgcccc tcaaggtgac agggacgtcc
     8401 ctgtggcttg ttccctccac ctccagtact gtatgcttgc tacttcaacc ccctatttgg
     8461 tgaatttctg cacagacaca gatctctgtg cctggaatgg gactgtgccc tgtgcgggtc
     8521 tctcccttgg cgtatatcca tctagatatt tagtctttga gaatctcaaa gcagagctct
     8581 ctgggaagag aactgtccac attgctaaat aattaagatt ccctcacttt tttgagggcc
     8641 atgtgttgtg agagagagag agagagagag agtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     8701 tctgtgtatg caagtgttgg taacttccca cttgaactaa ataacatggg gttagagaaa
     8761 aaaaaatacc aggcaagctg tctccattga acaagtcctt ggcaatgggc aggtcccaag
     8821 ggactcacag cttctggcag caagtgtgtc attcacacac atcattctgg ctggagagtg
     8881 caatgtgtca tttttttttc tttttgtaat tattttatta agtatttagt tggaaatttc
     8941 acactggcat taacaggtct agcataagtg gcctaggcag tcatcccagg ctccaaaatg
     9001 aagatgtgca aaagagatgc cactgggaat agaaacactg agttggttca gttaggtcat
     9061 cccctgcaga cgtgtcatcg agcaggctga ctcccacccc tcagccatgc catgggtatg
     9121 agaagcccct tataatgaaa gctgccagcc ctttcgtcct tgtttcagag ggtgggtcag
     9181 gtggttgggg tgagaacttg ctcacggtgc acccaacaag acctgcaggt gcatataagt
     9241 ttagtcccaa ctgcagggcc agaccaaaca cttcctggga agtgtgtgga gggctgtgct
     9301 agaccttcct gagtttctgg ctaaatcatc agccctgttt ggtgcagtct catgtctctg
     9361 tggttcccaa gctgcatgat cagagccagt gagaagacag gatcagtgac ccacagcttt
     9421 ggggaaaaac agccccactg ttaacttccc tcctgcaaac ctgggtcccc aggccataag
     9481 gtgggcacac tggtgcttac agactgggtg gagagcccta ccttccaagg tcttgatccc
     9541 agcctgccta taaggttggg attagcatgc aatccccctt ccccaatcct gtctttttaa
     9601 aatctcaagt ttgcacttaa ccttgacaac agcaccctct cctactccag tcctagaact
     9661 cagtggcctt agagaatggg gtcccctgca ctgaaggtcc ccgccttgct cccagttcca
     9721 tcctggccaa taggctgcgc ctcaagaggt gaaagagaaa aaagggaggg agggaggaag
     9781 aattatttag aacaaaagga tggctcgagc acgttagagg caagtgagag gcacgttggt
     9841 gagaagagca tgtgcatgtt tggggtagct ggggcctact gtcccttcat tagggaagga
     9901 ggcttccaga agcggatgtc ttctagaaag aaaaattgtg tgaaggctga aaaggggctt
     9961 ggagttttgt ctttgttgat tagaaagaag gaagaagtca gctctgagtg tttcaggaag
    10021 aagagagcag gtagaaaggg aatttagtga tttaacaccc aagggtccag ccatagcagg
    10081 ttggaaaatc ctccaaattt ggccacagaa actggctagg aaaaaactgc cactcattgg
    10141 gccacacgct gggtccccat cagttctcaa tgaatggtca ttgatttact tagcagagag
    10201 aagtcaccag ccacaaacca atctttgagt ttgcaggccc tgattccaga atatatgcat
    10261 ccagctcccg ggttctcagc tggttttgcc cacttccctt tgactgtcca atccaaagcc
    10321 agtctctcaa gttgtatggc tcaaagagca gtgaccacaa tgggtcatac agtagggacc
    10381 cacctccaca aattagaacc agagttcaga ctccattggg cacatctggg aggaaggcaa
    10441 cctcctttgt cgtcttgttg gtaccagtca ttctcaagta tctctgacac ctgtggtggt
    10501 tcagtttgct gagcctgcca cctggtatga attagactgg gtgtgatgaa cattcatcca
    10561 tggatatacc ctaccatttt gcgttgcctt ataaccaagg cacactcccc ataagagttt
    10621 actgcagaga aagaacagca aaacagccac cctccttgaa tttacaactc attatctgca
    10681 acaggttttc tttaaatcca agacacagga tgggaaatgg gtttccccac caggtactca
    10741 gaggtctgca ggaagtgact cccgggcaag gcagacttca gtaatccctg aagcgtgagc
    10801 atgtggactg catggctggg tggggactgg tggatgtctc tggagctcca gaaccttgga
    10861 gaattcctca tggaattccc ctcccagctc ttagtgggct ctgtggggtc aggaggagcc
    10921 cttcctccag gttttccttc tttcctcctc agcagagaaa ctggagaaag gacattaaac
    10981 tcagtgcagt cgatttgagt gctgaaatat ttccagaatc aatggtggtg ctaaactatc
    11041 tccatgtttc tagcattttt aatagtggag ttggtttgtt tttaatctca tcacaaaaat
    11101 gcagtgccct tggggaaggg accagcccct tggcctgcca ctttccaggt gtcctttatc
    11161 actttgacgg gactctttgg tctgcagaaa atgctctgtc ttggcatgct tctagactgt
    11221 aagatttggg ttttgttttg tattttatgt ttacatgcat cttatatttc cctgaaaact
    11281 aaataaagtt ttgggccttt ttaaccgaa
//
