LOCUS       NM_001394015           11501 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens SH3 and PX domains 2A (SH3PXD2A), transcript variant
            3, mRNA.
ACCESSION   NM_001394015
VERSION     NM_001394015.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11501)
  AUTHORS   Inoue,H., Kanda,T., Hayashi,G., Munenaga,R., Yoshida,M.,
            Hasegawa,K., Miyagawa,T., Kurumada,Y., Hasegawa,J., Wada,T.,
            Horiuchi,M., Yoshimatsu,Y., Itoh,F., Maemoto,Y., Arasaki,K.,
            Wakana,Y., Watabe,T., Matsushita,H., Harada,H. and Tagaya,M.
  TITLE     A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38353696
  REMARK    GeneRIF: A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis.
REFERENCE   2  (bases 1 to 11501)
  AUTHORS   Ogasawara,N., Yamashita,S., Yamasaki,K., Kawano,T., Kawano,T.,
            Muta,J., Matsumoto,F., Watanabe,T., Ohta,H., Yokogami,K.,
            Fukushima,T., Sato,Y. and Takeshima,H.
  TITLE     Spontaneous malignant transformation of trigeminal schwannoma:
            consideration of responsible gene alterations for tumorigenesis-a
            case report
  JOURNAL   Brain Tumor Pathol 40 (4), 222-229 (2023)
   PUBMED   37515639
  REMARK    GeneRIF: Spontaneous malignant transformation of trigeminal
            schwannoma: consideration of responsible gene alterations for
            tumorigenesis-a case report.
REFERENCE   3  (bases 1 to 11501)
  AUTHORS   Pezinski,M., Maliszewska-Olejniczak,K., Daszczuk,P., Mazurek,P.,
            Niewiadomski,P. and Redowicz,M.J.
  TITLE     Tks5 Regulates Synaptic Podosome Formation and Stabilization of the
            Postsynaptic Machinery at the Neuromuscular Junction
  JOURNAL   Int J Mol Sci 22 (21), 12051 (2021)
   PUBMED   34769479
  REMARK    GeneRIF: Tks5 Regulates Synaptic Podosome Formation and
            Stabilization of the Postsynaptic Machinery at the Neuromuscular
            Junction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11501)
  AUTHORS   Yang,Z., Chen,Z., Wang,C., Huang,P., Luo,M. and Zhou,R.
  TITLE     STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects
            psoriasis pathogenesis via regulating human keratinocyte
            proliferation
  JOURNAL   Cytokine 144, 155535 (2021)
   PUBMED   33994260
  REMARK    GeneRIF: STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop
            affects psoriasis pathogenesis via regulating human keratinocyte
            proliferation.
REFERENCE   5  (bases 1 to 11501)
  AUTHORS   Sugimoto,A., Okuno,T., Tsujio,G., Sera,T., Yamamoto,Y., Maruo,K.,
            Kushiyama,S., Nishimura,S., Kuroda,K., Togano,S., Miki,Y.,
            Yoshii,M., Tamura,T., Toyokawa,T., Tanaka,H., Muguruma,K., Ohira,M.
            and Yashiro,M.
  TITLE     The clinicopathologic significance of Tks5 expression of peritoneal
            mesothelial cells in gastric cancer patients
  JOURNAL   PLoS One 16 (7), e0253702 (2021)
   PUBMED   34255789
  REMARK    GeneRIF: The clinicopathologic significance of Tks5 expression of
            peritoneal mesothelial cells in gastric cancer patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11501)
  AUTHORS   Malinin,N.L., Wright,S., Seubert,P., Schenk,D. and
            Griswold-Prenner,I.
  TITLE     Amyloid-beta neurotoxicity is mediated by FISH adapter protein and
            ADAM12 metalloprotease activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (8), 3058-3063 (2005)
   PUBMED   15710903
REFERENCE   7  (bases 1 to 11501)
  AUTHORS   Seals,D.F., Azucena,E.F. Jr., Pass,I., Tesfay,L., Gordon,R.,
            Woodrow,M., Resau,J.H. and Courtneidge,S.A.
  TITLE     The adaptor protein Tks5/Fish is required for podosome formation
            and function, and for the protease-driven invasion of cancer cells
  JOURNAL   Cancer Cell 7 (2), 155-165 (2005)
   PUBMED   15710328
  REMARK    GeneRIF: Tks5/Fish appears to be required for podosome formation,
            for degradation of the extracellular matrix, and for invasion of
            some cancer cells
REFERENCE   8  (bases 1 to 11501)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 11501)
  AUTHORS   Abram,C.L., Seals,D.F., Pass,I., Salinsky,D., Maurer,L., Roth,T.M.
            and Courtneidge,S.A.
  TITLE     The adaptor protein fish associates with members of the ADAMs
            family and localizes to podosomes of Src-transformed cells
  JOURNAL   J Biol Chem 278 (19), 16844-16851 (2003)
   PUBMED   12615925
REFERENCE   10 (bases 1 to 11501)
  AUTHORS   Lock,P., Abram,C.L., Gibson,T. and Courtneidge,S.A.
  TITLE     A new method for isolating tyrosine kinase substrates used to
            identify fish, an SH3 and PX domain-containing protein, and Src
            substrate
  JOURNAL   EMBO J 17 (15), 4346-4357 (1998)
   PUBMED   9687503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133355.13 and AL121929.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000369774.9/ ENSP00000358789.4
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AL133355.13        125769-126150       c
            383-463             AL133355.13        71856-71936         c
            464-539             AL133355.13        37668-37743         c
            540-616             AL133355.13        6306-6382           c
            617-708             AL121929.17        198006-198097       c
            709-737             AL121929.17        166764-166792       c
            738-782             AL121929.17        142344-142388       c
            783-914             AL121929.17        134719-134850       c
            915-1028            AL121929.17        100824-100937       c
            1029-1112           AL121929.17        96205-96288         c
            1113-1230           AL121929.17        90932-91049         c
            1231-1568           AL121929.17        86588-86925         c
            1569-1618           AL121929.17        85316-85365         c
            1619-1738           AL121929.17        79533-79652         c
            1739-11501          AL121929.17        67762-77524         c
FEATURES             Location/Qualifiers
     source          1..11501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..11501
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="SH3 and PX domains 2A"
                     /db_xref="GeneID:9644"
                     /db_xref="HGNC:HGNC:23664"
                     /db_xref="MIM:619455"
     exon            1..382
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..3712
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="isoform 3 is encoded by transcript variant 3; SH3
                     multiple domains 1; SH3 and PX domain-containing protein
                     2A; adapter protein TKS5; tyrosine kinase substrate with
                     five SH3 domains; adaptor protein TKS5; five SH3
                     domain-containing protein"
                     /codon_start=1
                     /product="SH3 and PX domain-containing protein 2A isoform
                     3"
                     /protein_id="NP_001380944.1"
                     /db_xref="CCDS:CCDS91343.1"
                     /db_xref="GeneID:9644"
                     /db_xref="HGNC:HGNC:23664"
                     /db_xref="MIM:619455"
                     /translation="MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRY
                     SKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCR
                     ALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGAD
                     ATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPAT
                     YLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQP
                     YTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNL
                     AGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAV
                     GVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVE
                     VEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKP
                     NLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFD
                     SEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEG
                     FRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMG
                     KNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDA
                     DANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSE
                     DSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQD
                     SEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPA
                     KGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGV
                     RQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKG
                     RLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEE
                     TAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN"
     exon            383..463
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            464..539
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            540..616
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            617..708
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            709..737
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            738..782
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            783..914
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1028
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1112
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1230
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1568
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1618
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1738
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..11501
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5209..5214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="hexamer: AATAAA"
     polyA_site      5236
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="major polyA site"
     regulatory      11474..11479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="hexamer: AATAAA"
     polyA_site      11501
                     /gene="SH3PXD2A"
                     /gene_synonym="FISH; SH3MD1; TKS5"
                     /note="major polyA site"
ORIGIN      
        1 agttcccgcc ggacccaccg ggcggcggag agagcgagcg ggcgagcgca gcgcggcggc
       61 cgcgcgggag tgaaggggcg cgcggcaggc cggcggggag tcccccgggg cgcacggagc
      121 ccgcgcgccc tccgggaccc tcccccgtcc ctgggccgga cctgtgggcg ccgggagtcc
      181 gggcagcgtt cggcgcgccg ggccggggtg gcgggcggcc ccgggacccc ggcagctgga
      241 gaaggagccg gagcccggcc gggatgagaa ggtgacgccg ccgggggcgc cactcgcttt
      301 gtgggggaag atgctcgcct actgcgtgca ggatgccacc gtggtggacg tggagaagcg
      361 gaggaacccc tccaagcact acgtatacat aatcaatgtg acctggtctg actccacctc
      421 ccagactatc taccggaggt acagcaagtt ctttgacctg cagatgcagc ttttggataa
      481 gtttcccatt gaaggtggcc agaaggaccc caagcaaagg atcatcccct tcctcccagg
      541 caagatcctc ttccgcagaa gccacatccg ggacgtagct gtgaagagac tgaagcccat
      601 cgatgaatac tgccgggcac ttgtccggct gcccccccac atctcacagt gtgacgaagt
      661 cttccggttc ttcgaggctc gacccgagga tgtcaaccct ccaaaagagg actatggcag
      721 ttccaagagg aaatcagtgt ggctgtccag ctgggctgag tcgcccaaga aggacgtgac
      781 aggtgccgac gccaccgccg agcccatgat cctggaacag tacgtggtgg tgtccaacta
      841 taagaagcag gagaactcgg agctgagcct ccaggccggg gaggtggtgg atgtcatcga
      901 gaagaacgag agcggctggt ggttcgtgag cacttctgag gagcagggct gggtccctgc
      961 cacctacctg gaggcccaga atggtactcg ggatgactcc gacatcaaca cctctaagac
     1021 tggagaagtg tccaagagac gcaaggccca tctgcggcgc ctggatcgcc ggtggaccct
     1081 gggcgggatg gtcaacaggc agcacagccg agaggagaag tatgtcaccg tgcagcctta
     1141 caccagccaa agcaaggacg agattggctt tgagaagggc gtcacagtgg aggtgatccg
     1201 gaagaatctg gaaggctggt ggtatatcag atacctgggc aaagagggct gggcgccagc
     1261 atcctacctg aagaaggcca aggatgacct gccaacccgg aagaagaacc tggccggccc
     1321 agtggagatc attgggaaca tcatggagat cagcaacctg ctgaacaaga aggcgtctgg
     1381 ggacaaggaa actccaccag ccgaaggcga gggccatgag gcccccattg ccaagaagga
     1441 gatcagcctg cccatcctct gcaatgcctc caatggcagt gccgtgggcg ttcctgacag
     1501 gactgtctcc aggctggccc agggctctcc agctgtggcc aggattgccc ctcagcgggc
     1561 ccagatcagc tccccgaacc tacggacaag acctccacca cgcagagaat ccagcctggg
     1621 gttccaactg ccaaagccac cagagccccc ttctgttgag gtggagtact acaccattgc
     1681 cgaattccag tcgtgcattt ccgatggcat cagctttcgg ggtggacaga aggcagaggt
     1741 cattgataag aactcaggtg gctggtggta cgtgcagatc ggtgagaagg agggctgggc
     1801 ccccgcatca tacatcgata agcgcaagaa gcccaacctg agccgccgca caagcacgct
     1861 gacccggccc aaggtgcccc cgccagcacc ccccagcaag cccaaggagg ccgaggaggg
     1921 ccctacgggg gccagtgaga gccaggactc cccgcggaag ctcaagtatg aggagcctga
     1981 gtatgacatc cctgcattcg gctttgactc agagcctgag ctgagcgagg agcccgtgga
     2041 ggacagagcc tcaggggaga ggcggcctgc ccagccccac cggccctcgc cggcctcttc
     2101 tctgcagcgg gcccgcttca aggtgggtga gtcttcagag gatgtggccc tggaagagga
     2161 gaccatctat gagaatgagg gcttccggcc atatgcagag gacaccctgt cagccagagg
     2221 ctcctccggg gacagcgact ccccaggcag ctcctcgctg tccctgacca ggaaaaactc
     2281 ccccaaatca ggctccccca agtcatcatc actcctaaag ctcaaggcag agaagaatgc
     2341 ccaggcagaa atggggaaga accactcctc agcctccttt tcctcatcca tcaccatcaa
     2401 caccacttgc tgctcctcct cttcctcctc ctcctcttcc ttgtccaaaa ccagtggcga
     2461 cctgaagccc cgctctgctt cggacgcagg catccgcggc actcccaagg tcagggcaaa
     2521 gaaggatgct gatgcgaacg ctgggctgac ctcctgtccc cgggccaagc catcggtccg
     2581 gcccaagcca ttcctaaacc gagcagagtc gcagagccaa gagaagatgg acatcagcac
     2641 tttacggcgc cagctgagac ccacaggcca gctccgtgga gggctcaagg gctccaagag
     2701 tgaggattcg gagctgcccc cgcagacggc ctccgaggct cccagtgagg ggtctaggag
     2761 aagctcatcc gacctcatca ccctcccagc caccactccc ccatgtccca ccaagaagga
     2821 atgggaaggg ccagccacct cgtacatgac atgcagcgcc taccagaagg tccaggactc
     2881 ggagatcagc ttccccgcgg gcgtggaggt gcaggtgctg gagaagcagg agagcgggtg
     2941 gtggtatgtg aggtttgggg agctggaggg ctgggcccct tcccactatt tggtgctgga
     3001 tgagaacgag caacctgacc cctctggcaa agagctggac acagtgcccg ccaagggcag
     3061 gcagaacgaa ggcaaatcag acagcctgga gaagatcgag aggcgcgtcc aagcactgaa
     3121 caccgtcaac cagagcaaga aggccacgcc ccccatcccc tccaaacctc ccgggggctt
     3181 cggcaagacc tcaggcactc cagcggtgaa gatgaggaac ggagtgcggc aggtggcggt
     3241 caggccccag tcggtgtttg tgtccccgcc acccaaggac aacaacctgt cctgcgccct
     3301 gcggaggaat gagtcactca cggccactga tggcctccga ggcgtccgac ggaactcctc
     3361 ctttagcact gctcgctccg ctgccgccga ggccaagggc cgcctggccg aacgggctgc
     3421 cagccagggt tcagactcac ccctactgcc cgcccagcgc aacagcatac ccgtgtcccc
     3481 tgtgcgcccc aagcccatcg agaagtctca gttcatccac aataacctca aagatgtgta
     3541 cgtctctatc gcagactacg agggggatga ggagacagca ggcttccagg agggggtgtc
     3601 catggaggtt ctggagagga accctaatgg ctggtggtac tgccagatcc tggatggtgt
     3661 gaagcccttc aaaggctggg tgccttccaa ctaccttgag aaaaagaact agcagagggc
     3721 ctgggctctt ccagcctcag tgtgcctctc tggccgccca ctggatgagc ggtgagacga
     3781 acaaaaggga aaggaaaaaa tgggggtggg gggtgggggg tggacaacat tcaacactgc
     3841 agaatgggtg acctcaaaga tgccccctgt ccaagccatc ccacagctgg aaggtagggg
     3901 atgggggtgc ccacactgag tgaggaaggg aatggaccag ggagtcccag gcctgggacc
     3961 cagagccaag aaagctgaga tatcctgtgc accataggga cttcaccaat ggattacatg
     4021 ccatctggga caggccatgt gggagacccc agttgtgcct ttgctacaga tctggaaaag
     4081 acaaggtcat gggggcctcc agtgtcctgc ccctgcttgg cccagttttg attgctggca
     4141 tcttgccacc ccaggtatcc ctggtattgt cctaagctgt atttgtgaat tgtgctggtt
     4201 tcctgggcat tgccacgcct accacaggtg ggtacattag aagccaccac tggctttcag
     4261 gcttgggggt gtcttctgag ctcaagcctg cttctgggcc aggccattgt cactgttagt
     4321 tgaagaaaaa gcagttccca ggtgccagca aagaccatct ttcataactg tcactgtctt
     4381 ggccttgaga agagagcccg ctctccgtgg ggcaccccat ggaggacaca gtaccagagt
     4441 ttacagagag ggtgggcgaa gccaccggtc tcttcctaat ctgcacagac tattttgggt
     4501 atttctgggc gggcagttcc tttgcatgtt tcgggagagg tttgttgatt tggggcttat
     4561 atgtcaggcc tttggtttgc gtcttatttt aggggttgtt tgggggcctg ggtggtcggc
     4621 ctcacatggg aaggggatgg gtagtggatg gggtttctgt tgtatcttgt gggcgggtga
     4681 ttttgctttt gtttttgttt cacattcttc cccctccaca agccaaagtc gtttcatttg
     4741 gtttccactg tgtggactgt gctggagctt ggcgcctgcc agaaaaattt ggggctaggc
     4801 aagccccagg ttgcagacat ggtgaagcag agaaactgtt cttctggttc ctgcacaacc
     4861 tcagaggggc aaaaaccctc cccaggaagg aggagggtgt tcaggagcca gacttttgga
     4921 gagaaggcag ctcccagcct gctgggtgac cgccattctg cgtgtgttcc ccagctgggc
     4981 agggctggaa gccttacgta tgaagcatgg agaagcagcc attgtcccca ctatgggcag
     5041 aggggggacc cggctggccc cttgggtcag actggagcca acaccgccag ccaccccctc
     5101 tggcctgctg gcaatgccac aggtgcccaa gaagatggag gatccctgtg ccaggagcca
     5161 acctggtctt cccgagggtc agtgccccag tgaagacaga agcgagagaa taaagttccc
     5221 tgtaggtcct ctgtcacctt tgggttgtgt ttttcaattg ttgacatttc agaggggacc
     5281 ctccagaagc ccagccggct tcccccaagg actccccctt cgctgggagt ggatttccac
     5341 acgtgccttt gatttcggac agattgggcc tcacagccac cgattcagct gccagggtcc
     5401 ctggactggg ggttggtgtt ttctatagag gaggaaaggc cctccctcac cctgctcccc
     5461 acccaggcag ggcagcatgg gacccagtgt ctcagtgcct tcaaaaccca cccccacccc
     5521 taccctaccc caccacaccc catcccagag gccttgcctg ggcaacccta agcccctgtc
     5581 cctcgccata cactgatgcc tggcagctag agcaaatggc tcgtgttctt tgtcgaaggc
     5641 ctgtggtgag attgttttgt ttccttttgt tttgtgagtt tgtttaaaat tgaaattagt
     5701 tattttcttc tgctggacag tattaaatag agcaggatgt tgagttaatc tgctagattg
     5761 cagtactaat ggtagtggtt tagtgtcttc atgttaatat tatttgtact tatttgaaca
     5821 ataatgataa agaagtggtt cattattttt taattaatgc actttaaata aggtagaatg
     5881 gaaaaaaccc agagagcaaa gtgcattact taaagatgca gtatatactt ttctcatttt
     5941 taaacagcac atatttatta agagaaaaaa agtaatttat gactatttaa aataaaattt
     6001 aaaagtagag tgactgtcag gtaaagaacc ttcaatgtag ctatcttcca gggggagggc
     6061 cctgcagcct cgctcctcag atgtctgcac tgagccagtt cagtcactag tgcgccagcc
     6121 aggccaggag ggagtgcaga gcatgtctgc caagcacaga gcatctcagt tggactggac
     6181 cacagtgctc ccgagagcct gcctttcctg cccttcccca ccacctgcac tgccccccac
     6241 attctcccag ccccccccaa ggaccccctc tccttgaccc ccagtgctgt aagtaataga
     6301 gtcattaaaa tgcaggactg aaagagacct cagaggtctc tatcccatcc cttcctgtta
     6361 ctgcggccca aggacaggaa acaacttttc caaaatccca cagctagtta atgacagatc
     6421 tccccactac attaatcccg tgctcctcct cactgccatt atagtttatt gtgtggtcat
     6481 gtttacattg tgacatccag ccccaaggat ggctgggagt tgctcaggca tccaggaaaa
     6541 gtggggaatg ctgccatctg gtgacagcat gtagatttgg gcagtgaaca gggattgcca
     6601 tgccccagtc ttcgcacctc gccccctcac cccctaactc acagcacaaa ccctgcaaac
     6661 ccaaagagaa tattaatact tgaagcaaga agggtgcatg ccagtccttc tccgacatgg
     6721 ccagggggta ccaggccttg tgcgcctggc ctcctagccc tagccagggc gagagggcct
     6781 ttcccttgag ctactgagct gctttgtgat gctgaaggat actgccggca gcaggcagag
     6841 gagggagggg gcctagggct ctgacccatc tggaggaaaa ccagatcgga ctaaaaaagg
     6901 aaaaagaaaa acaaaatctc cgcagtgtcc aaacctagtt tcccatgagt tgcgactgaa
     6961 aatgtgaaac gacactgtat tgctgtatac tgcaacttta accataatga gcccttctga
     7021 ggtcattatt gaggttcata taatgcccga agatgcagca tttggtgctt tgttttcctt
     7081 tccgtttcaa gacctttttc ttttattgca aggggaaaaa aatgtcatct ccccccacct
     7141 catccctctt tgtgacagca gacctggctg tgttgcccct ctcctcctca ctattctcac
     7201 caggccatgg gactttgggg gcagtgagag agagctggaa aggggcaacc ctgagcagca
     7261 ggtgtgcccc atgccctgtg ggtttcccct atgtccaatg actgtagacg ggctgtcttg
     7321 ccaggcctca gccccgtcta ccctaagcct ggccccaaag gtttctcttt cttcctcctt
     7381 gattttccat cttgacgaag gcattatata gaatcatttt aatcactttc agatgttaga
     7441 gcagcgtatt ttacaggcat ttatatccat tgctttcctc agcaaggcat gttactactt
     7501 ttatcatcta aggaaaaaag acaagggaat tccagtcagg cattattttc ctattactag
     7561 tgtttgcaga ataggtgtag gactatttaa gtttagacct tggtttggta gttcttgttt
     7621 ttaataaggg gaaaaagata aaataacccc tatttttcct gttattgtat ttaactaata
     7681 tattatttct ttaaggttac tcacttcccc tacccctcca aataccttgc attctcaatc
     7741 aaaaatggaa acaatctgag agacaggaaa agtgcaatat taccaagatg gatgccaggg
     7801 ctcattgggg acaatggagg gaataccagt ggcgctcaga gagcaagagg cagggagcgg
     7861 ggtgctgaag gaatcctagc tgtggaacag gtgggtgggt tggtggagtt tgatcttgtg
     7921 gcgttctcct ctcccccttc tttgggaaga tgataggggt ccctgccaga tccacccaga
     7981 agaaagggat tcaggcatgg ggcccttgac ctctaggccc cagtccctgg agcagaggca
     8041 ggccctcggg agctgttcct tgttttgatt tctgttgtgg tgcagccagc tgctcagaga
     8101 gacctggcct aaaaatgact cccagcagcc ctctctcacc ccagtgtcct gatatttggg
     8161 ctgtgatcct tctggtgtat gtttgaatct ttctaaaact gggtgccctc agttcagttt
     8221 ctaggcagga agcctagaag tcaccagatc tttttggggg atgtgagaac cttgagccgc
     8281 gcacaccctg gtgagacacc aattcccaca agcctgcagc agggcctggg gctgagcctg
     8341 ggctgcccat tcatctcagc gacttcagcc tgagaagtga gccctgcctg ggctccacac
     8401 ccagagagtc catacaaatt ctgctccggg aagagtcggg gggtctattc aagtttctct
     8461 gcagacaaaa cttcccacaa caggtaccaa tctggcctcc ttcctcagca ccggtagaga
     8521 aagcaacaga atgggaagtt tcctctgggt tggagcctca gagctctgcc cctcaaggtg
     8581 acagggacgt ccctgtggct tgttccctcc acctccagta ctgtatgctt gctacttcaa
     8641 ccccctattt ggtgaatttc tgcacagaca cagatctctg tgcctggaat gggactgtgc
     8701 cctgtgcggg tctctccctt ggcgtatatc catctagata tttagtcttt gagaatctca
     8761 aagcagagct ctctgggaag agaactgtcc acattgctaa ataattaaga ttccctcact
     8821 tttttgaggg ccatgtgttg tgagagagag agagagagag agagtgtgtg tgtgtgtgtg
     8881 tgtgtgtgtg tgtctgtgta tgcaagtgtt ggtaacttcc cacttgaact aaataacatg
     8941 gggttagaga aaaaaaaata ccaggcaagc tgtctccatt gaacaagtcc ttggcaatgg
     9001 gcaggtccca agggactcac agcttctggc agcaagtgtg tcattcacac acatcattct
     9061 ggctggagag tgcaatgtgt catttttttt tctttttgta attattttat taagtattta
     9121 gttggaaatt tcacactggc attaacaggt ctagcataag tggcctaggc agtcatccca
     9181 ggctccaaaa tgaagatgtg caaaagagat gccactggga atagaaacac tgagttggtt
     9241 cagttaggtc atcccctgca gacgtgtcat cgagcaggct gactcccacc cctcagccat
     9301 gccatgggta tgagaagccc cttataatga aagctgccag ccctttcgtc cttgtttcag
     9361 agggtgggtc aggtggttgg ggtgagaact tgctcacggt gcacccaaca agacctgcag
     9421 gtgcatataa gtttagtccc aactgcaggg ccagaccaaa cacttcctgg gaagtgtgtg
     9481 gagggctgtg ctagaccttc ctgagtttct ggctaaatca tcagccctgt ttggtgcagt
     9541 ctcatgtctc tgtggttccc aagctgcatg atcagagcca gtgagaagac aggatcagtg
     9601 acccacagct ttggggaaaa acagccccac tgttaacttc cctcctgcaa acctgggtcc
     9661 ccaggccata aggtgggcac actggtgctt acagactggg tggagagccc taccttccaa
     9721 ggtcttgatc ccagcctgcc tataaggttg ggattagcat gcaatccccc ttccccaatc
     9781 ctgtcttttt aaaatctcaa gtttgcactt aaccttgaca acagcaccct ctcctactcc
     9841 agtcctagaa ctcagtggcc ttagagaatg gggtcccctg cactgaaggt ccccgccttg
     9901 ctcccagttc catcctggcc aataggctgc gcctcaagag gtgaaagaga aaaaagggag
     9961 ggagggagga agaattattt agaacaaaag gatggctcga gcacgttaga ggcaagtgag
    10021 aggcacgttg gtgagaagag catgtgcatg tttggggtag ctggggccta ctgtcccttc
    10081 attagggaag gaggcttcca gaagcggatg tcttctagaa agaaaaattg tgtgaaggct
    10141 gaaaaggggc ttggagtttt gtctttgttg attagaaaga aggaagaagt cagctctgag
    10201 tgtttcagga agaagagagc aggtagaaag ggaatttagt gatttaacac ccaagggtcc
    10261 agccatagca ggttggaaaa tcctccaaat ttggccacag aaactggcta ggaaaaaact
    10321 gccactcatt gggccacacg ctgggtcccc atcagttctc aatgaatggt cattgattta
    10381 cttagcagag agaagtcacc agccacaaac caatctttga gtttgcaggc cctgattcca
    10441 gaatatatgc atccagctcc cgggttctca gctggttttg cccacttccc tttgactgtc
    10501 caatccaaag ccagtctctc aagttgtatg gctcaaagag cagtgaccac aatgggtcat
    10561 acagtaggga cccacctcca caaattagaa ccagagttca gactccattg ggcacatctg
    10621 ggaggaaggc aacctccttt gtcgtcttgt tggtaccagt cattctcaag tatctctgac
    10681 acctgtggtg gttcagtttg ctgagcctgc cacctggtat gaattagact gggtgtgatg
    10741 aacattcatc catggatata ccctaccatt ttgcgttgcc ttataaccaa ggcacactcc
    10801 ccataagagt ttactgcaga gaaagaacag caaaacagcc accctccttg aatttacaac
    10861 tcattatctg caacaggttt tctttaaatc caagacacag gatgggaaat gggtttcccc
    10921 accaggtact cagaggtctg caggaagtga ctcccgggca aggcagactt cagtaatccc
    10981 tgaagcgtga gcatgtggac tgcatggctg ggtggggact ggtggatgtc tctggagctc
    11041 cagaaccttg gagaattcct catggaattc ccctcccagc tcttagtggg ctctgtgggg
    11101 tcaggaggag cccttcctcc aggttttcct tctttcctcc tcagcagaga aactggagaa
    11161 aggacattaa actcagtgca gtcgatttga gtgctgaaat atttccagaa tcaatggtgg
    11221 tgctaaacta tctccatgtt tctagcattt ttaatagtgg agttggtttg tttttaatct
    11281 catcacaaaa atgcagtgcc cttggggaag ggaccagccc cttggcctgc cactttccag
    11341 gtgtccttta tcactttgac gggactcttt ggtctgcaga aaatgctctg tcttggcatg
    11401 cttctagact gtaagatttg ggttttgttt tgtattttat gtttacatgc atcttatatt
    11461 tccctgaaaa ctaaataaag ttttgggcct ttttaaccga a
//
