LOCUS       NM_031892               4728 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SH3 domain containing kinase binding protein 1
            (SH3KBP1), transcript variant 1, mRNA.
ACCESSION   NM_031892
VERSION     NM_031892.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Ahmed,S.F., Buetow,L., Gabrielsen,M., Lilla,S., Sibbet,G.J.,
            Sumpton,D., Zanivan,S., Hedley,A., Clark,W. and Huang,D.T.
  TITLE     E3 ligase-inactivation rewires CBL interactome to elicit
            oncogenesis by hijacking RTK-CBL-CIN85 axis
  JOURNAL   Oncogene 40 (12), 2149-2164 (2021)
   PUBMED   33627783
  REMARK    GeneRIF: E3 ligase-inactivation rewires CBL interactome to elicit
            oncogenesis by hijacking RTK-CBL-CIN85 axis.
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Vittorio,S., Seidel,T., Garon,A., Gitto,R., Langer,T. and De
            Luca,L.
  TITLE     In Silico Identification of Potential Druggable Binding Sites on
            CIN85 SH3 Domain
  JOURNAL   Int J Mol Sci 22 (2), 534 (2021)
   PUBMED   33430321
  REMARK    GeneRIF: In Silico Identification of Potential Druggable Binding
            Sites on CIN85 SH3 Domain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Hua,X.Y., Bie,X.X., Cheng,X. and Zhang,S.G.
  TITLE     High expression of CIN85 promotes proliferation and invasion of
            human esophageal squamous cell carcinoma
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179079
  REMARK    GeneRIF: High expression of CIN85 promotes proliferation and
            invasion of human esophageal squamous cell carcinoma.
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Soubeyran,P., Kowanetz,K., Szymkiewicz,I., Langdon,W.Y. and
            Dikic,I.
  TITLE     Cbl-CIN85-endophilin complex mediates ligand-induced downregulation
            of EGF receptors
  JOURNAL   Nature 416 (6877), 183-187 (2002)
   PUBMED   11894095
  REMARK    GeneRIF: Cbl-CIN85-endophilin complex mediates ligand-induced
            downregulation of EGF receptors
            Erratum:[Nature 2002 May 2;417(6884):102]
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Narita,T., Amano,F., Yoshizaki,K., Nishimoto,N., Nishimura,T.,
            Tajima,T., Namiki,H. and Taniyama,T.
  TITLE     Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 133-134 (2001)
   PUBMED   11474197
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Watanabe,S., Take,H., Takeda,K., Yu,Z.X., Iwata,N. and Kajigaya,S.
  TITLE     Characterization of the CIN85 adaptor protein and identification of
            components involved in CIN85 complexes
  JOURNAL   Biochem Biophys Res Commun 278 (1), 167-174 (2000)
   PUBMED   11071869
REFERENCE   8  (bases 1 to 4728)
  AUTHORS   Gout,I., Middleton,G., Adu,J., Ninkina,N.N., Drobot,L.B.,
            Filonenko,V., Matsuka,G., Davies,A.M., Waterfield,M. and
            Buchman,V.L.
  TITLE     Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein
  JOURNAL   EMBO J 19 (15), 4015-4025 (2000)
   PUBMED   10921882
REFERENCE   9  (bases 1 to 4728)
  AUTHORS   Take,H., Watanabe,S., Takeda,K., Yu,Z.X., Iwata,N. and Kajigaya,S.
  TITLE     Cloning and characterization of a novel adaptor protein, CIN85,
            that interacts with c-Cbl
  JOURNAL   Biochem Biophys Res Commun 268 (2), 321-328 (2000)
   PUBMED   10679202
REFERENCE   10 (bases 1 to 4728)
  AUTHORS   Salvatore,P., Hanash,C.R., Kido,Y., Imai,Y. and Accili,D.
  TITLE     Identification of sirm, a novel insulin-regulated SH3 binding
            protein that associates with Grb-2 and FYN
  JOURNAL   J Biol Chem 273 (12), 6989-6997 (1998)
   PUBMED   9507006
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF230904.1 and AL732423.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031892.2.
            
            Summary: This gene encodes an adapter protein that contains one or
            more N-terminal Src homology domains, a proline rich region and a
            C-terminal coiled-coil domain. The encoded protein facilitates
            protein-protein interactions and has been implicated in numerous
            cellular processes including apoptosis, cytoskeletal rearrangement,
            cell adhesion and in the regulation of clathrin-dependent
            endocytosis. Alternate splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF230904.1, SRR1803614.7499.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397821.8/ ENSP00000380921.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3303              AF230904.1         2-3304
            3304-4728           AL732423.12        133985-135409       c
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..4728
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="SH3 domain containing kinase binding protein 1"
                     /db_xref="GeneID:30011"
                     /db_xref="HGNC:HGNC:13867"
                     /db_xref="MIM:300374"
     exon            1..294
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..2288
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="isoform a is encoded by transcript variant 1; Src
                     family kinase-binding protein 1; src-related kinase
                     binding protein-1; CD2-binding protein 3;
                     migration-inducing gene 18; c-Cbl-interacting protein;
                     cbl-interacting protein of 85 kDa; SH3-domain kinase
                     binding protein 1; human Src family kinase-binding protein
                     1"
                     /codon_start=1
                     /product="SH3 domain-containing kinase-binding protein 1
                     isoform a"
                     /protein_id="NP_114098.1"
                     /db_xref="CCDS:CCDS14193.1"
                     /db_xref="GeneID:30011"
                     /db_xref="HGNC:HGNC:13867"
                     /db_xref="MIM:300374"
                     /translation="MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGR
                     RGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR
                     CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD
                     ELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDI
                     FKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIF
                     PYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEG
                     NRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQK
                     PSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGIL
                     DKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFD
                     SPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPL
                     SSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE
                     TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK"
     exon            295..452
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            453..576
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            577..680
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            681..810
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1016
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1092
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1187
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1295
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1347
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1428
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1588
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1674
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1784
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1913
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2182
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2246
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..4728
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="hexamer: AGTAAA"
     polyA_site      3298
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="major polyA site"
     regulatory      4711..4716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="hexamer: AATGAA"
     polyA_site      4728
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
ORIGIN      
        1 gcaatttcca ctcgcgggga gcaggaaacc cggcgcagcc gggcgcattg ggccgcgatg
       61 caacagcagc agcaggagtc gccccggggc agcagcggca gcagcagcag aggcagcagc
      121 gggcggcgct gagccgccgc cgccgccact gaggaagaag ccggcccagc cgccgccgcg
      181 tccggaccct cgcgcctgga tcccagcgcc ccgatcccgg cgccccaacc cccacgcccg
      241 cctccgccaa ctttcacgct gcctcggcgg cccggcccgg ctcgacgcca atggtggagg
      301 ccatagtgga gtttgactac caggcccagc acgatgatga gctgacgatc agcgtgggtg
      361 aaatcatcac caacatcagg aaggaggatg gaggctggtg ggagggacag atcaacggca
      421 ggagaggttt gttccctgac aactttgtaa gagaaataaa gaaagagatg aagaaagacc
      481 ctctcaccaa caaagctcca gaaaagcccc tgcacgaagt gcccagtgga aactctttgc
      541 tgtcttctga aacgatttta agaaccaata agagaggcga gcgacggagg cgccggtgcc
      601 aggtggcatt cagctacctg ccccagaatg acgatgaact tgagctgaaa gttggcgaca
      661 tcatagaggt ggtaggagag gtagaggaag gatggtggga aggtgttctc aacgggaaga
      721 ctggaatgtt tccttccaac ttcatcaagg agctgtcagg ggagtcggat gagcttggca
      781 tttcccagga tgagcagcta tccaagtcaa gtttaaggga aaccacaggc tccgagagtg
      841 atgggggtga ctcaagcagc accaagtctg aaggtgccaa cgggacagtg gcaactgcag
      901 caatccagcc caagaaagtt aagggagtgg gctttggaga cattttcaaa gacaagccaa
      961 tcaaactaag accaaggtca attgaagtag aaaatgactt tctgccggta gaaaagacta
     1021 ttgggaagaa gttacctgca actacagcaa ctccagactc atcaaaaaca gaaatggaca
     1081 gcaggacaaa gagcaaggat tactgcaaag taatatttcc atatgaggca cagaatgatg
     1141 atgaattgac aatcaaagaa ggagatatag tcactctcat caataaggac tgcatcgacg
     1201 taggctggtg ggaaggagag ctgaacggca gacgaggcgt gttccccgat aacttcgtga
     1261 agttacttcc accggacttt gaaaaggaag ggaatagacc caagaagcca ccgcctccat
     1321 ccgctcctgt catcaaacaa ggggcaggca ccactgagag aaaacatgaa attaaaaaga
     1381 tacctcctga aagaccagaa atgcttccaa acagaacaga agaaaaagaa agaccagaga
     1441 gagagccaaa actggattta cagaagccct ccgttcctgc cataccgcca aaaaagcctc
     1501 ggccacctaa gaccaattct ctcagcagac ctggcgcact gcccccgaga aggccggaga
     1561 gaccggtggg tccgctgaca cacaccaggg gtgacagtcc aaagattgac ttggccggca
     1621 gttcgctatc tggcatcctg gacaaagatc tctcggaccg cagcaatgac attgacttag
     1681 aaggttttga ctccgtggta tcatctactg agaaactcag tcatccgacc acaagcagac
     1741 caaaagctac agggaggcgg cctccgtccc agtccctcac atcttcatcc ctttcaagcc
     1801 ctgatatctt cgactcccca agtcccgaag aggataagga ggaacacatt tcacttgcgc
     1861 acagaggagt ggacgcgtca aagaaaactt ccaagactgt taccatatcc caagtgtctg
     1921 acaacaaagc atccctgccg cccaagccgg ggaccatggc agcaggtggc ggtgggccag
     1981 cccctctgtc ctcagcggcg ccctcccccc tgtcatcctc tttgggaaca gctggacaca
     2041 gagccaactc cccgtctctg ttcggcacgg aaggaaaacc aaagatggag cctgcggcca
     2101 gcagccaggc ggccgtggag gagctaagga cacaggtccg cgagctgagg agcatcatcg
     2161 agaccatgaa ggaccagcag aaacgagaga ttaaacagtt attgtctgag ttggatgaag
     2221 agaagaaaat ccggcttcgg ttgcagatgg aagtgaacga cataaagaaa gctctacaat
     2281 caaaatgaat acttgatcaa tgaaatgtca cattattcat cctgagtccg agactcaaat
     2341 tttctgcccc agccaaaata atcttgtgcc aaaagattaa aggtttgcct caaaatgtcc
     2401 ctgtttgaaa gattagcaca aaagtcttga tagcacaaca caaattccat ccaagaggag
     2461 aatcttcccc agggtttagt cctggggctg gcactcgttg tgacttacac agagcaaaat
     2521 tgtgctaaag gcttttctac tctgagatct caatgcgaaa tgaaaactca ggcagtttag
     2581 tccatagtgg tactattttg atgatatttt ccattaataa aatgtaattt cagattattc
     2641 gtttacaagc tttataattt tatgattttt taatcgtgtt ttgtcacaga cttccctagt
     2701 gtttgtacta cacgtagtca gaagcgagtg tccttttctt ttgcttcagg ctaagagctg
     2761 cctcgctctt tgtcccccca ttaggattct attacatatg caattgtagg ttcaacctgt
     2821 ccctttccct gccagcaaac cccaccaccc taagagaaat tttagcttat atatgacggt
     2881 atatttacaa aaagagaaag agaaaatctg gtatttgcaa tgatctgtgc cttcttttta
     2941 ccaccctctt gattggagct tttgtgatgc agctaccatg attcaaaaaa attaaaaatt
     3001 aaaaaaaaaa aatctgccac ttatccaagt ccactagagg ccactgtctt caaagcttct
     3061 ctcaccctag ccaaaggtcc taagaggaga cagctgtgaa gttgggcgtg ctctgtggta
     3121 ccagctgtga cttttctatt tctcctagtt ttaggttgtt catgaaacta gaaatgtcat
     3181 cctgcttgat ttttcatcag ccaagttaaa cccctgcttt ctgtcctttg caccttttgc
     3241 gtgaacagaa tatgcattat taaagcaaaa ataaataaaa gtaaaatgca aatgaaaaca
     3301 agggagggaa agttgtatta tttcctgcac tgggttaccc gtgtgtgtta tcgtttaaac
     3361 tgtattcaca taatgtcatt tgccttgctc acttgtaacc ccttcctcag gtccaagaga
     3421 atgggaggag ggtcatgttg aagtgtagcc actggaactt tcttgcattt atggagttgc
     3481 tttttctttc ccaaggaaac tgatgtttgc ctgtccgctt tatctttgta gtacatgaac
     3541 agttcagcct tagactatgt aactgttttc tcatccttag ctgaaaatga ggggcctact
     3601 gtattgcgag actgttcagg ggtaggggtg gagggggtgg tcccttaatg gcccctgaag
     3661 atgttggatg tgtttctcaa aagctgcttt gtctctttcc tgagtttaat agtgaaacta
     3721 ctaaacatta atagatttgc acagccacaa agaatgagag ttgataatac cgaagaagtg
     3781 atgcaaaaac aaaaaatcac attactgatc attgatagta ttacaaataa atgtctcttc
     3841 ctttctcttc ctcccttcct ccccctgcct tcctcttaac ctatgtgctc atccttgcta
     3901 cttgaggctg ttatttccct ccgagtattt aaggagccca aacaccttgg tcttcctggg
     3961 tgggggcata attaagggaa gggagtgtat aaggaaggaa acctcatacc ctccattccc
     4021 atccctggat atattgcctt ttcagcagcc tcgggttcag tgtgcttggg gtcaggagtg
     4081 ccaggttccc aagagcagcg taaaacatcc ctgtacccct tgacagttat aagcatttct
     4141 gcgttaaact tgaagattcc agagattccc cacgacctaa tgatctaaga atgcagattg
     4201 gattctttga tgttcaaatt tctcatttac ttatgaaaat ccctaattat atagttttat
     4261 ataatgtgta tacagagtag gattgttgat gaaattgagc ggttggaaca ccctcatgga
     4321 acactggcaa catggaatgt agagagctga tgtcttcccc ctcatagagg ccattggctt
     4381 cctttgtata aggagaggga gaagtgattc tggaaggaga agttggtatg tctagcttca
     4441 ttgcggcccc tcgggctacc cagcaagagg attctgcatc aaggaactgg acgagccgct
     4501 acccaaactg ccaccatctt tactctttac aaaatggacc catcgagaat gttgaaaagc
     4561 ttggaagtat cacttttgaa aaaaaaaaaa attattttgc attcagcatg gactcgacca
     4621 ggcatctatg gagattattt ttttgcttca ttttataaag ttgtatttag aaaagtctta
     4681 agtattgtgc tttgtaaaga agatgattaa aatgaaattt tgtgagaa
//
