LOCUS       NM_001410756            4860 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens SH3 domain containing kinase binding protein 1
            (SH3KBP1), transcript variant 11, mRNA.
ACCESSION   NM_001410756 XM_011545498
VERSION     NM_001410756.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4860)
  AUTHORS   Ahmed,S.F., Buetow,L., Gabrielsen,M., Lilla,S., Sibbet,G.J.,
            Sumpton,D., Zanivan,S., Hedley,A., Clark,W. and Huang,D.T.
  TITLE     E3 ligase-inactivation rewires CBL interactome to elicit
            oncogenesis by hijacking RTK-CBL-CIN85 axis
  JOURNAL   Oncogene 40 (12), 2149-2164 (2021)
   PUBMED   33627783
  REMARK    GeneRIF: E3 ligase-inactivation rewires CBL interactome to elicit
            oncogenesis by hijacking RTK-CBL-CIN85 axis.
REFERENCE   3  (bases 1 to 4860)
  AUTHORS   Vittorio,S., Seidel,T., Garon,A., Gitto,R., Langer,T. and De
            Luca,L.
  TITLE     In Silico Identification of Potential Druggable Binding Sites on
            CIN85 SH3 Domain
  JOURNAL   Int J Mol Sci 22 (2), 534 (2021)
   PUBMED   33430321
  REMARK    GeneRIF: In Silico Identification of Potential Druggable Binding
            Sites on CIN85 SH3 Domain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4860)
  AUTHORS   Hua,X.Y., Bie,X.X., Cheng,X. and Zhang,S.G.
  TITLE     High expression of CIN85 promotes proliferation and invasion of
            human esophageal squamous cell carcinoma
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179079
  REMARK    GeneRIF: High expression of CIN85 promotes proliferation and
            invasion of human esophageal squamous cell carcinoma.
REFERENCE   5  (bases 1 to 4860)
  AUTHORS   Soubeyran,P., Kowanetz,K., Szymkiewicz,I., Langdon,W.Y. and
            Dikic,I.
  TITLE     Cbl-CIN85-endophilin complex mediates ligand-induced downregulation
            of EGF receptors
  JOURNAL   Nature 416 (6877), 183-187 (2002)
   PUBMED   11894095
  REMARK    GeneRIF: Cbl-CIN85-endophilin complex mediates ligand-induced
            downregulation of EGF receptors
            Erratum:[Nature 2002 May 2;417(6884):102]
REFERENCE   6  (bases 1 to 4860)
  AUTHORS   Narita,T., Amano,F., Yoshizaki,K., Nishimoto,N., Nishimura,T.,
            Tajima,T., Namiki,H. and Taniyama,T.
  TITLE     Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 133-134 (2001)
   PUBMED   11474197
REFERENCE   7  (bases 1 to 4860)
  AUTHORS   Watanabe,S., Take,H., Takeda,K., Yu,Z.X., Iwata,N. and Kajigaya,S.
  TITLE     Characterization of the CIN85 adaptor protein and identification of
            components involved in CIN85 complexes
  JOURNAL   Biochem Biophys Res Commun 278 (1), 167-174 (2000)
   PUBMED   11071869
REFERENCE   8  (bases 1 to 4860)
  AUTHORS   Gout,I., Middleton,G., Adu,J., Ninkina,N.N., Drobot,L.B.,
            Filonenko,V., Matsuka,G., Davies,A.M., Waterfield,M. and
            Buchman,V.L.
  TITLE     Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein
  JOURNAL   EMBO J 19 (15), 4015-4025 (2000)
   PUBMED   10921882
REFERENCE   9  (bases 1 to 4860)
  AUTHORS   Take,H., Watanabe,S., Takeda,K., Yu,Z.X., Iwata,N. and Kajigaya,S.
  TITLE     Cloning and characterization of a novel adaptor protein, CIN85,
            that interacts with c-Cbl
  JOURNAL   Biochem Biophys Res Commun 268 (2), 321-328 (2000)
   PUBMED   10679202
REFERENCE   10 (bases 1 to 4860)
  AUTHORS   Salvatore,P., Hanash,C.R., Kido,Y., Imai,Y. and Accili,D.
  TITLE     Identification of sirm, a novel insulin-regulated SH3 binding
            protein that associates with Grb-2 and FYN
  JOURNAL   J Biol Chem 273 (12), 6989-6997 (1998)
   PUBMED   9507006
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772197.12, AL732325.6,
            AL732327.6 and AL732423.12.
            
            On Aug 15, 2022 this sequence version replaced XM_011545498.4.
            
            Summary: This gene encodes an adapter protein that contains one or
            more N-terminal Src homology domains, a proline rich region and a
            C-terminal coiled-coil domain. The encoded protein facilitates
            protein-protein interactions and has been implicated in numerous
            cellular processes including apoptosis, cytoskeletal rearrangement,
            cell adhesion and in the regulation of clathrin-dependent
            endocytosis. Alternate splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.8112.1,
                                           SRR1660807.143130.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AL772197.12        17941-18234         c
            295-452             AL732325.6         61523-61680         c
            453-576             AL732327.6         160041-160164       c
            577-680             AL732327.6         120604-120707       c
            681-810             AL732327.6         109335-109464       c
            811-867             AL732327.6         108718-108774       c
            868-942             AL732327.6         101340-101414       c
            943-1148            AL732327.6         97546-97751         c
            1149-1224           AL732327.6         59123-59198         c
            1225-1319           AL732327.6         45587-45681         c
            1320-1427           AL732327.6         21661-21768         c
            1428-1479           AL732327.6         8672-8723           c
            1480-1560           AL732327.6         5790-5870           c
            1561-1720           AL732327.6         2366-2525           c
            1721-1806           AL732423.12        169111-169196       c
            1807-1916           AL732423.12        149982-150091       c
            1917-2045           AL732423.12        145930-146058       c
            2046-2314           AL732423.12        141933-142201       c
            2315-2378           AL732423.12        137725-137788       c
            2379-4860           AL732423.12        133985-136466       c
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..4860
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="SH3 domain containing kinase binding protein 1"
                     /db_xref="GeneID:30011"
                     /db_xref="HGNC:HGNC:13867"
                     /db_xref="MIM:300374"
     exon            1..294
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..2420
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="isoform k is encoded by transcript variant 11; Src
                     family kinase-binding protein 1; src-related kinase
                     binding protein-1; CD2-binding protein 3;
                     migration-inducing gene 18; c-Cbl-interacting protein;
                     cbl-interacting protein of 85 kDa; SH3-domain kinase
                     binding protein 1; human Src family kinase-binding protein
                     1"
                     /codon_start=1
                     /product="SH3 domain-containing kinase-binding protein 1
                     isoform k"
                     /protein_id="NP_001397685.1"
                     /db_xref="CCDS:CCDS94575.1"
                     /db_xref="GeneID:30011"
                     /db_xref="HGNC:HGNC:13867"
                     /db_xref="MIM:300374"
                     /translation="MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGR
                     RGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR
                     CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD
                     ELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYS
                     LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIE
                     VENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKE
                     GDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVI
                     KQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPP
                     KTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLE
                     GFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISL
                     AHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGT
                     AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLL
                     SELDEEKKIRLRLQMEVNDIKKALQSK"
     exon            295..452
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            453..576
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            577..680
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            681..810
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            811..867
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            868..942
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1148
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1224
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1319
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1427
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1479
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1560
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1720
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1806
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1916
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2045
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2314
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2378
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..4860
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="hexamer: AGTAAA"
     polyA_site      3430
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="major polyA site"
     regulatory      4843..4848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
                     /note="hexamer: AATGAA"
     polyA_site      4860
                     /gene="SH3KBP1"
                     /gene_synonym="AGMX2; CD2BP3; CIN85; GIG10; HSB-1; HSB1;
                     IMD61; MIG18"
ORIGIN      
        1 gcaatttcca ctcgcgggga gcaggaaacc cggcgcagcc gggcgcattg ggccgcgatg
       61 caacagcagc agcaggagtc gccccggggc agcagcggca gcagcagcag aggcagcagc
      121 gggcggcgct gagccgccgc cgccgccact gaggaagaag ccggcccagc cgccgccgcg
      181 tccggaccct cgcgcctgga tcccagcgcc ccgatcccgg cgccccaacc cccacgcccg
      241 cctccgccaa ctttcacgct gcctcggcgg cccggcccgg ctcgacgcca atggtggagg
      301 ccatagtgga gtttgactac caggcccagc acgatgatga gctgacgatc agcgtgggtg
      361 aaatcatcac caacatcagg aaggaggatg gaggctggtg ggagggacag atcaacggca
      421 ggagaggttt gttccctgac aactttgtaa gagaaataaa gaaagagatg aagaaagacc
      481 ctctcaccaa caaagctcca gaaaagcccc tgcacgaagt gcccagtgga aactctttgc
      541 tgtcttctga aacgatttta agaaccaata agagaggcga gcgacggagg cgccggtgcc
      601 aggtggcatt cagctacctg ccccagaatg acgatgaact tgagctgaaa gttggcgaca
      661 tcatagaggt ggtaggagag gtagaggaag gatggtggga aggtgttctc aacgggaaga
      721 ctggaatgtt tccttccaac ttcatcaagg agctgtcagg ggagtcggat gagcttggca
      781 tttcccagga tgagcagcta tccaagtcaa ggcctgaagg tctccctcca gcttctctgc
      841 tgccctttcc agctcacgga gcaaaaggaa agactacctt tgaagggaca attctgtacc
      901 gagctgcacc gggaaagacg gagggccaca gacgctatta cagtttaagg gaaaccacag
      961 gctccgagag tgatgggggt gactcaagca gcaccaagtc tgaaggtgcc aacgggacag
     1021 tggcaactgc agcaatccag cccaagaaag ttaagggagt gggctttgga gacattttca
     1081 aagacaagcc aatcaaacta agaccaaggt caattgaagt agaaaatgac tttctgccgg
     1141 tagaaaagac tattgggaag aagttacctg caactacagc aactccagac tcatcaaaaa
     1201 cagaaatgga cagcaggaca aagagcaagg attactgcaa agtaatattt ccatatgagg
     1261 cacagaatga tgatgaattg acaatcaaag aaggagatat agtcactctc atcaataagg
     1321 actgcatcga cgtaggctgg tgggaaggag agctgaacgg cagacgaggc gtgttccccg
     1381 ataacttcgt gaagttactt ccaccggact ttgaaaagga agggaataga cccaagaagc
     1441 caccgcctcc atccgctcct gtcatcaaac aaggggcagg caccactgag agaaaacatg
     1501 aaattaaaaa gatacctcct gaaagaccag aaatgcttcc aaacagaaca gaagaaaaag
     1561 aaagaccaga gagagagcca aaactggatt tacagaagcc ctccgttcct gccataccgc
     1621 caaaaaagcc tcggccacct aagaccaatt ctctcagcag acctggcgca ctgcccccga
     1681 gaaggccgga gagaccggtg ggtccgctga cacacaccag gggtgacagt ccaaagattg
     1741 acttggccgg cagttcgcta tctggcatcc tggacaaaga tctctcggac cgcagcaatg
     1801 acattgactt agaaggtttt gactccgtgg tatcatctac tgagaaactc agtcatccga
     1861 ccacaagcag accaaaagct acagggaggc ggcctccgtc ccagtccctc acatcttcat
     1921 ccctttcaag ccctgatatc ttcgactccc caagtcccga agaggataag gaggaacaca
     1981 tttcacttgc gcacagagga gtggacgcgt caaagaaaac ttccaagact gttaccatat
     2041 cccaagtgtc tgacaacaaa gcatccctgc cgcccaagcc ggggaccatg gcagcaggtg
     2101 gcggtgggcc agcccctctg tcctcagcgg cgccctcccc cctgtcatcc tctttgggaa
     2161 cagctggaca cagagccaac tccccgtctc tgttcggcac ggaaggaaaa ccaaagatgg
     2221 agcctgcggc cagcagccag gcggccgtgg aggagctaag gacacaggtc cgcgagctga
     2281 ggagcatcat cgagaccatg aaggaccagc agaaacgaga gattaaacag ttattgtctg
     2341 agttggatga agagaagaaa atccggcttc ggttgcagat ggaagtgaac gacataaaga
     2401 aagctctaca atcaaaatga atacttgatc aatgaaatgt cacattattc atcctgagtc
     2461 cgagactcaa attttctgcc ccagccaaaa taatcttgtg ccaaaagatt aaaggtttgc
     2521 ctcaaaatgt ccctgtttga aagattagca caaaagtctt gatagcacaa cacaaattcc
     2581 atccaagagg agaatcttcc ccagggttta gtcctggggc tggcactcgt tgtgacttac
     2641 acagagcaaa attgtgctaa aggcttttct actctgagat ctcaatgcga aatgaaaact
     2701 caggcagttt agtccatagt ggtactattt tgatgatatt ttccattaat aaaatgtaat
     2761 ttcagattat tcgtttacaa gctttataat tttatgattt tttaatcgtg ttttgtcaca
     2821 gacttcccta gtgtttgtac tacacgtagt cagaagcgag tgtccttttc ttttgcttca
     2881 ggctaagagc tgcctcgctc tttgtccccc cattaggatt ctattacata tgcaattgta
     2941 ggttcaacct gtccctttcc ctgccagcaa accccaccac cctaagagaa attttagctt
     3001 atatatgacg gtatatttac aaaaagagaa agagaaaatc tggtatttgc aatgatctgt
     3061 gccttctttt taccaccctc ttgattggag cttttgtgat gcagctacca tgattcaaaa
     3121 aaattaaaaa ttaaaaaaaa aaaatctgcc acttatccaa gtccactaga ggccactgtc
     3181 ttcaaagctt ctctcaccct agccaaaggt cctaagagga gacagctgtg aagttgggcg
     3241 tgctctgtgg taccagctgt gacttttcta tttctcctag ttttaggttg ttcatgaaac
     3301 tagaaatgtc atcctgcttg atttttcatc agccaagtta aacccctgct ttctgtcctt
     3361 tgcacctttt gcgtgaacag aatatgcatt attaaagcaa aaataaataa aagtaaaatg
     3421 caaatgaaaa caagggaggg aaagttgtat tatttcctgc actgggttac ccgtgtgtgt
     3481 tatcgtttaa actgtattca cataatgtca tttgccttgc tcacttgtaa ccccttcctc
     3541 aggtccaaga gaatgggagg agggtcatgt tgaagtgtag ccactggaac tttcttgcat
     3601 ttatggagtt gctttttctt tcccaaggaa actgatgttt gcctgtccgc tttatctttg
     3661 tagtacatga acagttcagc cttagactat gtaactgttt tctcatcctt agctgaaaat
     3721 gaggggccta ctgtattgcg agactgttca ggggtagggg tggagggggt ggtcccttaa
     3781 tggcccctga agatgttgga tgtgtttctc aaaagctgct ttgtctcttt cctgagttta
     3841 atagtgaaac tactaaacat taatagattt gcacagccac aaagaatgag agttgataat
     3901 accgaagaag tgatgcaaaa acaaaaaatc acattactga tcattgatag tattacaaat
     3961 aaatgtctct tcctttctct tcctcccttc ctccccctgc cttcctctta acctatgtgc
     4021 tcatccttgc tacttgaggc tgttatttcc ctccgagtat ttaaggagcc caaacacctt
     4081 ggtcttcctg ggtgggggca taattaaggg aagggagtgt ataaggaagg aaacctcata
     4141 ccctccattc ccatccctgg atatattgcc ttttcagcag cctcgggttc agtgtgcttg
     4201 gggtcaggag tgccaggttc ccaagagcag cgtaaaacat ccctgtaccc cttgacagtt
     4261 ataagcattt ctgcgttaaa cttgaagatt ccagagattc cccacgacct aatgatctaa
     4321 gaatgcagat tggattcttt gatgttcaaa tttctcattt acttatgaaa atccctaatt
     4381 atatagtttt atataatgtg tatacagagt aggattgttg atgaaattga gcggttggaa
     4441 caccctcatg gaacactggc aacatggaat gtagagagct gatgtcttcc ccctcataga
     4501 ggccattggc ttcctttgta taaggagagg gagaagtgat tctggaagga gaagttggta
     4561 tgtctagctt cattgcggcc cctcgggcta cccagcaaga ggattctgca tcaaggaact
     4621 ggacgagccg ctacccaaac tgccaccatc tttactcttt acaaaatgga cccatcgaga
     4681 atgttgaaaa gcttggaagt atcacttttg aaaaaaaaaa aaattatttt gcattcagca
     4741 tggactcgac caggcatcta tggagattat ttttttgctt cattttataa agttgtattt
     4801 agaaaagtct taagtattgt gctttgtaaa gaagatgatt aaaatgaaat tttgtgagaa
//
