LOCUS       NM_003027               1693 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens SH3 domain containing GRB2 like 3, endophilin A3
            (SH3GL3), transcript variant EEN-B2-L1, mRNA.
ACCESSION   NM_003027
VERSION     NM_003027.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Zou,F., Zhang,Z.H., Zou,S.S., Zhuang,Z.B., Ji,Q., Chang,R.,
            Cao,J.H. and Wang,B.
  TITLE     LncRNA MIR210HG promotes the proliferation, migration, and invasion
            of lung cancer cells by inhibiting the transcription of SH3GL3
  JOURNAL   Kaohsiung J Med Sci 39 (12), 1166-1177 (2023)
   PUBMED   37916731
  REMARK    GeneRIF: LncRNA MIR210HG promotes the proliferation, migration, and
            invasion of lung cancer cells by inhibiting the transcription of
            SH3GL3.
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Nie,Z., Cai,S., Wei,Z., Li,Y., Bian,L., Wang,C., Wang,X. and
            Wang,C.
  TITLE     SH3GL3 acts as a novel tumor suppressor in glioblastoma
            tumorigenesis by inhibiting STAT3 signaling
  JOURNAL   Biochem Biophys Res Commun 544, 73-80 (2021)
   PUBMED   33524871
  REMARK    GeneRIF: SH3GL3 acts as a novel tumor suppressor in glioblastoma
            tumorigenesis by inhibiting STAT3 signaling.
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Lin,Z., Liu,Z., Tan,X. and Li,C.
  TITLE     SH3GL3 functions as a potent tumor suppressor in lung cancer in a
            SH3 domain dependent manner
  JOURNAL   Biochem Biophys Res Commun 534, 787-794 (2021)
   PUBMED   33168185
  REMARK    GeneRIF: SH3GL3 functions as a potent tumor suppressor in lung
            cancer in a SH3 domain dependent manner.
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   So,C.W., Sham,M.H., Chew,S.L., Cheung,N., So,C.K., Chung,S.K.,
            Caldas,C., Wiedemann,L.M. and Chan,L.C.
  TITLE     Expression and protein-binding studies of the EEN gene family, new
            interacting partners for dynamin, synaptojanin and huntingtin
            proteins
  JOURNAL   Biochem J 348 Pt 2 (Pt 2), 447-458 (2000)
   PUBMED   10816441
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Sittler,A., Walter,S., Wedemeyer,N., Hasenbank,R., Scherzinger,E.,
            Eickhoff,H., Bates,G.P., Lehrach,H. and Wanker,E.E.
  TITLE     SH3GL3 associates with the Huntingtin exon 1 protein and promotes
            the formation of polygln-containing protein aggregates
  JOURNAL   Mol Cell 2 (4), 427-436 (1998)
   PUBMED   9809064
REFERENCE   8  (bases 1 to 1693)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     The SH3p4/Sh3p8/SH3p13 protein family: binding partners for
            synaptojanin and dynamin via a Grb2-like Src homology 3 domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8569-8574 (1997)
   PUBMED   9238017
REFERENCE   9  (bases 1 to 1693)
  AUTHORS   Giachino,C., Lantelme,E., Lanzetti,L., Saccone,S., Bella Valle,G.
            and Migone,N.
  TITLE     A novel SH3-containing human gene family preferentially expressed
            in the central nervous system
  JOURNAL   Genomics 41 (3), 427-434 (1997)
   PUBMED   9169142
REFERENCE   10 (bases 1 to 1693)
  AUTHORS   So,C.W., Caldas,C., Liu,M.M., Chen,S.J., Huang,Q.H., Gu,L.J.,
            Sham,M.H., Wiedemann,L.M. and Chan,L.C.
  TITLE     EEN encodes for a member of a new family of proteins containing an
            Src homology 3 domain and is the third gene located on chromosome
            19p13 that fuses to MLL in human leukemia
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2563-2568 (1997)
   PUBMED   9122235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK309086.1, AF036269.1 and BC035598.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003027.4.
            
            Transcript Variant: This variant (EEN-B2-L1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1135998.1,
                                           SRR1803614.267343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427482.7/ ENSP00000391372.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AK309086.1         114-303
            191-1434            AF036269.1         1-1244
            1435-1693           BC035598.1         1265-1523
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..1693
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /note="SH3 domain containing GRB2 like 3, endophilin A3"
                     /db_xref="GeneID:6457"
                     /db_xref="HGNC:HGNC:10832"
                     /db_xref="MIM:603362"
     exon            1..238
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1237
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /note="isoform a is encoded by transcript variant
                     EEN-B2-L1; endophilin-A3; endophilin-3; SH3 domain protein
                     2C; SH3 domain-containing GRB2-like protein 3; SH3-domain
                     GRB2-like 3; SH3 domain containing GRB2 like endophilin
                     A3"
                     /codon_start=1
                     /product="endophilin-A3 isoform a"
                     /protein_id="NP_003018.3"
                     /db_xref="CCDS:CCDS10325.2"
                     /db_xref="GeneID:6457"
                     /db_xref="HGNC:HGNC:10832"
                     /db_xref="MIM:603362"
                     /translation="MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTN
                     KVVAEILSKTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGK
                     ELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKK
                     LEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF
                     IEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVV
                     KTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFF
                     PINYVEVIVPLPQ"
     exon            239..307
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            308..380
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            381..524
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            525..658
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            659..817
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            818..921
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1031
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1693
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /note="hexamer: AATAAA"
     polyA_site      1693
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /note="major polyA site"
ORIGIN      
        1 agtgttgcca tcggcgtgcg cgcgtgtgtg cgagtgtgac agcggctgtg gctgtggccg
       61 tggccgtggg aggcgggccc ggcggagccc agccgcgggg ggaccggccc gggctcccgc
      121 tccccgagcg cgtcgcggcc gcgtggccca gccgagcctt gagaccaccc cgcccctgcc
      181 ggtcgcagtc gcgatgtcgg tggccgggct gaagaagcag ttccacaaag ccagccagct
      241 atttagtgaa aaaataagtg gtgctgaagg aactaaacta gacgatgaat ttcttgacat
      301 ggaaaggaaa atagatgtta ccaataaagt tgttgcagaa attctttcaa aaaccactga
      361 atatcttcag ccaaatccag catacagagc taagctagga atgctgaaca ctgtgtcgaa
      421 gatccgaggg caggtgaaga ccacaggata cccgcagacg gaaggcttgc tgggggactg
      481 tatgctgaaa tacgggaagg agctcgggga agactccacc tttggcaatg cattgataga
      541 agttggtgaa tccatgaagc taatggctga ggtgaaagac tctcttgata ttaatgtaaa
      601 gcaaactttt attgatccac ttcagttact acaagataaa gatttaaaag agatcgggca
      661 tcacctgaaa aagctggaag gccgccgcct ggattacgat tataaaaaga aacgagtagg
      721 taagatacca gacgaagaag tcagacaagc ggtagaaaaa tttgaagagt caaaggagtt
      781 ggctgaaaga agcatgttta actttttaga aaatgatgta gaacaagtca gccagttggc
      841 tgtgttcata gaggcagcat tagactatca cagacagtcc acagagattc tgcaggagct
      901 gcagagcaag ctacagatgc gaatatcagc tgcatccagt gtccccagac gagaatacaa
      961 gccaaggcct gtgaaaagga gttctagtga gctcaatgga gtttccacca cctctgtagt
     1021 gaagacgaca ggttctaaca ttcccatgga ccagccctgc tgtcgtggtc tctatgactt
     1081 tgagccagaa aaccaaggag aattaggatt taaagaaggg gacatcatta cattaaccaa
     1141 tcaaatagat gaaaactggt atgaaggaat gatacacgga gaatcgggat tcttccccat
     1201 taattacgtg gaagtgatcg tgcctttacc tcagtaaatg tgtaacacaa actctggaca
     1261 tactttcgta actgaaatga attcacacca gtgtgctctc agtgcggtgt tctgtgacat
     1321 cctttgctct ctgaccaact taatgacttt tgtatgtgtg ctctctttat aatgtatttt
     1381 atatcacttt aatttgtata aatgattttc ttgtccttgc tacatgaaaa tattttcttt
     1441 tttgcttcct gtcctaaaag tcattggtta aatgtatttg cttcctgtgg ctaaaaataa
     1501 gtctcaccca ttgcagttat gtcaacgaat ggcctatatt cctcagctgc aatgaaatgg
     1561 taacatttga aactaagaaa tgctaaatat tttgtttctc gacattcctg atgacgtctg
     1621 gtcttttctt ttcattgtat tttaagctta cctgtgaata gcccaataaa catgacacac
     1681 tgtgttggca aaa
//
