LOCUS       NM_001162530            2544 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens SH3 domain containing 21 (SH3D21), transcript variant
            1, mRNA.
ACCESSION   NM_001162530
VERSION     NM_001162530.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2544)
  AUTHORS   Masoudi,M., Seki,M., Yazdanparast,R., Yachie,N. and Aburatani,H.
  TITLE     A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a
            sensitizer for gemcitabine
  JOURNAL   Sci Rep 9 (1), 19188 (2019)
   PUBMED   31844142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2544)
  AUTHORS   Yu,L.R., Zhu,Z., Chan,K.C., Issaq,H.J., Dimitrov,D.S. and
            Veenstra,T.D.
  TITLE     Improved titanium dioxide enrichment of phosphopeptides from HeLa
            cells and high confident phosphopeptide identification by
            cross-validation of MS/MS and MS/MS/MS spectra
  JOURNAL   J Proteome Res 6 (11), 4150-4162 (2007)
   PUBMED   17924679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591845.27.
            
            On Dec 20, 2018 this sequence version replaced NM_001162530.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453908.8/ ENSP00000403476.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AL591845.27        42604-42660
            58-215              AL591845.27        42834-42991
            216-279             AL591845.27        43078-43141
            280-398             AL591845.27        43403-43521
            399-489             AL591845.27        43753-43843
            490-545             AL591845.27        44006-44061
            546-591             AL591845.27        44154-44199
            592-692             AL591845.27        44345-44445
            693-779             AL591845.27        44625-44711
            780-822             AL591845.27        45784-45826
            823-916             AL591845.27        55307-55400
            917-969             AL591845.27        55496-55548
            970-1064            AL591845.27        55678-55772
            1065-2188           AL591845.27        55911-57034
            2189-2252           AL591845.27        57151-57214
            2253-2544           AL591845.27        57292-57583
FEATURES             Location/Qualifiers
     source          1..2544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2544
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /note="SH3 domain containing 21"
                     /db_xref="GeneID:79729"
                     /db_xref="HGNC:HGNC:26236"
     exon            1..57
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2324
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-containing protein C1orf113; SH3 domain-containing
                     protein 21"
                     /codon_start=1
                     /product="SH3 domain-containing protein 21 isoform 1"
                     /protein_id="NP_001156002.1"
                     /db_xref="GeneID:79729"
                     /db_xref="HGNC:HGNC:26236"
                     /translation="MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGR
                     YGLFPERLVQEIPETLRGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADEL
                     KLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQ
                     RPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDK
                     GWWEGECQGRRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKK
                     LATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSV
                     SSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTL
                     GDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERV
                     FSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSS
                     EEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAEL
                     KSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVAS
                     KEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTE
                     NKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQRRRLEVQVMQGT
                     QKSQTPRVIHTQTQTY"
     exon            58..215
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            216..279
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            280..398
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            399..489
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            490..545
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            546..591
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            592..692
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            693..779
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            780..822
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            823..916
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            917..969
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1064
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..2188
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2252
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2544
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /note="hexamer: AGTAAA"
     polyA_site      2427
                     /gene="SH3D21"
                     /gene_synonym="C1orf113"
                     /note="major polyA site"
ORIGIN      
        1 agtactcggc cgtcagaggg agctgccagg ctctggaggg cgccccggaa accatggaag
       61 tcctcgtcct ggccggatac cgcgcgcaga aggaggacga gctgagtctg gcgcccgggg
      121 acgtggtccg gcaggtgcgc tgggtgcccg cgcggggctg gcttcgcgga gagtttgggg
      181 gccgctatgg cctcttcccc gagcgcctgg tgcaggagat cccagagacc ctgcggggct
      241 ccggagaggc gcggaggccg cgctgtgcgc gccgccgagg tcatcctgcc aaacacccga
      301 ggccccaaag atggtgcaaa gtgaacttca gctacagccc agagcaggcg gacgagctga
      361 agctgcaagc tggggagatc gtggaaatga taaaggagat tgaggacggc tggtggctgg
      421 ggaagaagaa cgggcagctg ggagccttcc catccaactt tgtggaattg ctggacagtg
      481 ggcccccaag ccttggtaac ccagacatgc cttcagtcag ccctggtccc cagcggcctc
      541 ccaagctgag cagcctggcc tatgacagcc ctccagacta cctgcagaca gtctcccacc
      601 ctgaggtcta cagggtcctg tttgactacc agcctgaggc cccagacgag ttggcgctgc
      661 ggagggggga cgtggtaaaa gtactcagca agaccacaga ggataagggc tggtgggaag
      721 gagagtgtca aggacgaaga ggagtttttc cagacaactt tgtactccca ccacccccaa
      781 tcaagaagct ggtcccacgg aaagtggtat ctcgggaatc agctcctatt aaggaaccaa
      841 aaaagttgat gcccaaaaca tccctcccca cagtcaagaa gctagcaaca gccaccactg
      901 ggcccagcaa agccaagaca tctcggacac ccagcaggga cagtcagaag ctcacctccc
      961 gagactcagg ccccaatggt ggcttccaaa gtgggggttc gtatcaccct ggccgaaagc
     1021 gatccaaaac ccagactccc cagcaacgct ctgtgtccag tcaggaggaa gagcacagca
     1081 gcccggtaaa ggccccctct gtgaagagaa cccccatgcc ggacaagact gccaccccag
     1141 agaggccccc agctccagag aacgccccca gctccaagaa gatcccggct cctgacaaag
     1201 tcccctcccc agagaagacc ctcactctag gggacaaggc ctctatccca gggaactcca
     1261 cctcggggaa gatcccagct cctgacaaag tccccacccc agagaagatg gtgactccgg
     1321 aggacaaggc ttctatccca gagaactcca tcatcccaga ggagaccctg actgtggaca
     1381 aaccctccac tccagagagg gtcttttcag tggaagagtc ccctgcccta gaagccccac
     1441 ctatggataa agtccctaat ccaaagatgg cccctctggg ggatgaggcc cccactctag
     1501 aaaaggtctt gaccccagag ctttctgaag aagaggtgtc caccagagat gacattcaat
     1561 tccatcactt ctcttcggag gaagccctgc agaaggtcaa gtactttgta gccaaagagg
     1621 atccatcatc ccaggaggag gcccacacgc cagaggcacc cccaccccag cctccttcct
     1681 cagagaggtg cctgggagag atgaaatgta ccctagttag aggggacagc tccccacgcc
     1741 aggctgagtt gaagtctggg ccagcatcca ggcctgccct tgagaagccc cacccccacg
     1801 aagaggctac aacccttcca gaggaggcac cttccaatga cgagaggacc cctgaagagg
     1861 aggcgccccc caacgagcag aggcctctga gagaggaggt gctccccaaa gagggagtgg
     1921 cttccaaaga ggaggtgacc ctgaaagagg aattgccccc taaagaggaa gtggctccaa
     1981 aagaggaggt gccccccata gaaagagcct ttgcccaaaa aacacgtcct atcaagccgc
     2041 ctccagactc ccaagagacg ctcgcgctcc cctcgctggt cccgcaaaac tacacggaaa
     2101 acaagaatga aggagttgat gtaacgtcgc tgaggggcga ggtggagtct ctaaggaggg
     2161 cgctggagct gatggaggtg cagctggaga ggaagctgac cgacatctgg gaggagctga
     2221 agagcgagaa ggagcagcgc cggcggctgg aggtccaggt gatgcagggg acccagaagt
     2281 cccagacccc gcgcgtcatc cacacgcaga cgcagaccta ctgagggtgg gcctgggaag
     2341 ggaccgcggc ctgacctggc tggggccacc cacgtccttg cacacgactt tgggaaacgc
     2401 gagaaagtaa actctgccta gcacggcgcc acgccggtct ggtcgctggg ggcggggcct
     2461 gcgcgggggc agggcctggg cctccgcatt cctgacggtc cctcccaggc acatctggcc
     2521 aacatgtggc tcccattacc gttc
//
