LOCUS       NM_001378122            5207 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SH3 domain containing 19 (SH3D19), transcript variant
            6, mRNA.
ACCESSION   NM_001378122 XM_024453903
VERSION     NM_001378122.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5207)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5207)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5207)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5207)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: occurrence of an unusual TG 3' splice site in intron 6
REFERENCE   6  (bases 1 to 5207)
  AUTHORS   Yam,J.W., Jin,D.Y., So,C.W. and Chan,L.C.
  TITLE     Identification and characterization of EBP, a novel EEN binding
            protein that inhibits Ras signaling and is recruited into the
            nucleus by the MLL-EEN fusion protein
  JOURNAL   Blood 103 (4), 1445-1453 (2004)
   PUBMED   14551139
  REMARK    GeneRIF: identified and characterized EBP, a novel EEN binding
            protein that interacts with the SH3 domain of EEN; normally
            expressed in cytoplasm but recruited to the nucleus by MLL-EEN
            [EBP]
REFERENCE   7  (bases 1 to 5207)
  AUTHORS   Shimomura,Y., Aoki,N., Ito,K. and Ito,M.
  TITLE     Gene expression of Sh3d19, a novel adaptor protein with five Src
            homology 3 domains, in anagen mouse hair follicles
  JOURNAL   J Dermatol Sci 31 (1), 43-51 (2003)
   PUBMED   12615363
REFERENCE   8  (bases 1 to 5207)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5207)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   10 (bases 1 to 5207)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104819.4 and AC095055.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 29, 2020 this sequence version replaced XM_024453903.1.
            
            Summary: This gene encodes a multiple SH3 domain-containing
            protein, which interacts with other proteins, such as EBP and
            members of ADAM family, via the SH3 domains. This protein may be
            involved in suppression of Ras-induced cellular transformation and
            Ras-mediated activation of ELK1 by EBP, and regulation of ADAM
            proteins in the signaling of EGFR-ligand shedding. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.21517.1,
                                           SRR11853562.25412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000604030.7/ ENSP00000488951.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC104819.4         80493-80857         c
            366-405             AC095055.3         162778-162817       c
            406-446             AC095055.3         124154-124194       c
            447-489             AC095055.3         116086-116128       c
            490-628             AC095055.3         113548-113686       c
            629-782             AC095055.3         113265-113418       c
            783-1787            AC095055.3         111401-112405       c
            1788-1895           AC095055.3         102320-102427       c
            1896-2008           AC095055.3         95971-96083         c
            2009-2070           AC095055.3         86231-86292         c
            2071-2335           AC095055.3         84653-84917         c
            2336-2476           AC095055.3         80641-80781         c
            2477-2549           AC095055.3         76506-76578         c
            2550-2680           AC095055.3         74463-74593         c
            2681-2739           AC095055.3         71805-71863         c
            2740-2942           AC095055.3         69765-69967         c
            2943-2995           AC095055.3         69062-69114         c
            2996-3182           AC095055.3         64901-65087         c
            3183-3280           AC095055.3         64349-64446         c
            3281-5207           AC095055.3         57012-58938         c
FEATURES             Location/Qualifiers
     source          1..5207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..5207
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /note="SH3 domain containing 19"
                     /db_xref="GeneID:152503"
                     /db_xref="HGNC:HGNC:30418"
                     /db_xref="MIM:608674"
     exon            1..365
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..3397
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /note="isoform 5 is encoded by transcript variant 6; SH3
                     domain-containing protein 19; SH3 domain protein D19;
                     EEN-binding protein; ADAM-binding protein Eve-1"
                     /codon_start=1
                     /product="SH3 domain-containing protein 19 isoform 5"
                     /protein_id="NP_001365051.1"
                     /db_xref="CCDS:CCDS93652.1"
                     /db_xref="GeneID:152503"
                     /db_xref="HGNC:HGNC:30418"
                     /db_xref="MIM:608674"
                     /translation="MAEGRRREDEEEELRERRELGGQRRARGRALSGHSAADRNERNK
                     PEHRSSSQGPLSSIRAVIKRSSRTSIQSELHRDRRRPEITIVAAEPLRPASWFPGTPP
                     PGLGFPTSSAAGSWRPNELVPAELPPSYEQVIKEINQVQVNTTNNNNAAATPRHTITS
                     ATQTDFSEEIDNDLPQTLQAPLKPLQPFSAVSSGNLPTNVAPLIVFDISEEPNCPENP
                     SATRCPVPKPRSKSNLRPIPRDSHIKEQSQQKISPAAVGEESSPGRPQSLLDNASTSD
                     SQAVMNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPS
                     VAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLI
                     RSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRL
                     AGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSE
                     MVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIG
                     NTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPP
                     ERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPR
                     PKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRP
                     NDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQI
                     GIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII
                     LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQ
                     VNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV
                     RPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELM
                     GKSGIFPKNYIQFLQIS"
     exon            366..405
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            406..446
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            447..489
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            490..628
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            629..782
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1787
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1895
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2008
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2070
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2335
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2476
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2549
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2680
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2739
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2942
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..2995
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3182
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3280
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..5207
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5181..5186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /note="hexamer: AATAAA"
     polyA_site      5207
                     /gene="SH3D19"
                     /gene_synonym="EBP; Eve-1; EVE1; Kryn; SH3P19"
                     /note="major polyA site"
ORIGIN      
        1 agggattaag aggccgccgg gacgccgcaa ggaggcgggg aatcggctcg gcccgcgccc
       61 tgccgctgcc cggccggctg caggtggagt tcgcggaggt ggccatttcc acagccgccg
      121 ccgacgcctc ctctccggga gccgccttcc ccccggcccg agggcggtgg cgtggggcgc
      181 cgggtgcagg cgttctgggg cgccggggcc gcagctcgct ggccatcccg cggctgcgcc
      241 ccgcgcctcg cccatggctg agggccggcg gcgggaggac gaggaggaag agctacgcga
      301 gcgccgcgaa cttggtggcc agcgccgcgc ccggggccgt gcgctctcgg gccactcggc
      361 cgcagatcgc aacgaacgaa ataaaccaga acatcgttct tcaagccaag gacccttgtc
      421 atccattaga gcggtaatca agagatcttc tcggacttct attcagagtg aacttcatcg
      481 agatagaagg cgcccagaga tcaccattgt ggcagctgag ccactgaggc cagcctcgtg
      541 gtttccagga accccacccc caggactggg atttcctaca tcatctgcag caggctcttg
      601 gaggcctaat gagctggttc ctgctgagct cccaccatct tatgaacaag ttataaaaga
      661 aatcaaccaa gttcaagtta atactacaaa taataataat gctgctgcta ctccaaggca
      721 cactattact tctgcaactc agactgactt ttcagaagaa atagacaacg atctgcctca
      781 aacactacag gcacctctca agcctcttca gcctttctca gcagtctcgt ctggcaatct
      841 tccaacaaat gtggcacctt taatcgtctt tgatatttct gaagaaccga attgtccaga
      901 aaaccccagt gctacaagat gtccagtgcc aaaaccaaga tcaaaaagca acctcagacc
      961 aatacccaga gattctcaca ttaaagagca aagtcaacag aaaatcagcc cagcagccgt
     1021 aggagaggag tcatccccag gccggcccca gtctctgctg gacaacgcta gcacctcaga
     1081 cagtcaggca gtgatgaaca ttatgaacac agaacaaagc caaaatagta ttgtttccag
     1141 aattaaagtg tttgagggtc agacaaacat agaaacctca ggactgccca agaaaccaga
     1201 aattactcca cgttcacttc ctccaaagcc tactgtttcc tcagggaaac cttctgtagc
     1261 tcccaaacca gctgctaaca gagcttctgg agagtgggac tctgggactg agaacagact
     1321 caaggtgacc tccaaggaag gactcacccc ataccctccc ctgcaagaag cgggaagcat
     1381 cccagtaacc aaacctgaat tgccaaagaa accaaaccct ggccttatac gaagtgttaa
     1441 tcctgagatt ccgggaagag ggcccctggc tgagagctct gatagtggga agaaagtgcc
     1501 aactcctgcc ccgcggcctt tgctgctgaa gaaatctgtt tcctcagaaa accccaccta
     1561 cccttcagct ccactgaaac ctgtcactgt tcctccccga ctcgcagggg catcacaagc
     1621 caaagcatac aagtcactgg gagaagggcc cccagccaac cccccagttc cagttctgca
     1681 gagcaagccc ttggtggaca tcgatctcat cagctttgat gatgatgttt tgcccacccc
     1741 atcggggaac ctggctgaag aatctgttgg ttcagagatg gttctagatc cctttcagct
     1801 ccctgcaaaa acagaaccaa taaaagaacg agcagttcaa ccagcaccca ccaggaagcc
     1861 cactgtaatt cgaattccag ccaaaccagg aaaatgttta catgaggatc cacaaagtcc
     1921 acctcctctc cctgctgaaa aacctattgg aaacactttc agtacagtat ctggaaagct
     1981 cagtaatgtt gagagaacta gaaacttgga atccaaccac ccaggtcaaa caggaggttt
     2041 tgtgcgagta cccccaaggt tgccaccgag acctgtgaat ggaaaaacca ttccaactca
     2101 acagcctcca accaaggtgc cccctgagag accacctccc ccaaagcttt ctgcaaccag
     2161 aagatctaat aagaaactgc cttttaatcg atcctcttct gacatggatc ttcagaaaaa
     2221 acaaagtaac ttggcaactg gactctcaaa agccaagagt caagttttta aaaatcaaga
     2281 tccggtgcta ccccctcgtc ccaaaccagg acaccctctc tacagtaaat acatgcgtgg
     2341 ggatgtactt gtgatgctga agcagacgga aaataattac ttggagtgcc aaaagggaga
     2401 agacactggc agagttcacc tgtctcaaat gaagattatc actccacttg atgaacatct
     2461 tagaagcaga ccaaacgatc caagccacgc tcagaagcct gttgacagtg gtgctcctca
     2521 tgctgtcgtt cttcatgatt tcccagcaga gcaagttgat gatttgaacc tcacttctgg
     2581 agaaattgtt tatcttctgg agaagataga tacagattgg tacagaggga actgtagaaa
     2641 ccagattggc atatttcctg ccaactatgt caaagtgatt attgatatcc cagaaggagg
     2701 aaatgggaaa agagaatgtg tttcatctca ttgtgttaaa ggctcaagat gtgttgctcg
     2761 gtttgaatat attggagagc agaaggatga gttgagtttc tcagagggag aaattattat
     2821 tcttaaagag tatgtgaatg aggaatgggc cagaggagaa gttcgaggca gaactgggat
     2881 tttccccctg aactttgtgg agcctgttga ggattatccc acctctggtg caaatgtttt
     2941 aagcacaaag gtaccactga aaaccaaaaa agaagattct ggctcaaact ctcaggttaa
     3001 cagtcttccg gcagaatggt gtgaagctct tcacagtttt acagcagaga ccagtgatga
     3061 cttatcattc aagaggggag accggatcca gattctggaa cgtctggatt ctgactggtg
     3121 caggggcaga ctgcaggaca gggaggggat cttcccagca gtgtttgtga ggccctgccc
     3181 agctgaggca aaaagtatgt tggccatagt accgaagggg aggaaggcca aagccttata
     3241 tgatttccga ggggagaatg aagatgaact ttccttcaag gctggagata taataacaga
     3301 gctggaatct gtagatgatg actggatgag tggagaactt atgggaaaat ctggaatatt
     3361 tcccaaaaac tacatacagt ttctacagat cagctagagg agaagcttgt ctgtgttcct
     3421 tggcacaaga actcacttga actatcacct tgactatcag atatgttttt gcactatttt
     3481 ttttaactga aaaagaaata tctaagctgt acatggtaca ctagaatttt ctgaaagcag
     3541 aaaacgttca gattttgtag ttaattttca ttacaataga aacatgcaca tggaaaccca
     3601 tgagctagga ttctaccgag gaaaacatct agtgggatta gcaaggtgaa gggaaagcat
     3661 ctggtggcat ggcagcatgg ggaggctcac acacagaagt tgcacgtgga catctgtttt
     3721 aatcagcaca agtgaattaa ccatgcttct tcattttttt actttagtta aaaaagagga
     3781 catttaatat tctacatgct gtaactatca ggacatggtt agcaatctca atttcatttt
     3841 tgatattcaa attaattctt acagcttgag catatcagcc ttattaccag agcaaatcct
     3901 tccttcagat gggatagttt actgactagt tggagcattt gtaagcacat ggtgaaatca
     3961 gcccctgccc accaaaataa tctttatgtt accaagtgat tcccatttgt ctaaggattt
     4021 gaagggggtc taaattggat gtatcttact tagtctaaag aaccaaaacc atccctgaaa
     4081 tgccttgcta atacaactaa tccttccata tatgtgccat acttattttt ttcctcagtg
     4141 tatactttat gttaacaggg ttattacaaa gcacattttc tgaatctgca atcattcctt
     4201 tgacaattac tggacccaaa ggaaaattca ttttctttgc attattccag taatatataa
     4261 aaactgtgtc ttgttatagt agtacattat gaatcacata taaaatctta caatacagaa
     4321 caactgttaa gatggaaaac agtgccaaac ctccacagct catttctttg taatataatc
     4381 agaatgaaaa ataatttaag aggacagaag actggtactt ttttgtttta ttttttctct
     4441 agcttatccc tgcacaatta ttagagtgaa tgaaaaacca ctttcctgct ttccattgtt
     4501 ataaattcta agcttaagat aaaagtggtt ctttacatga ctgaatcaat tacaatttat
     4561 gggctagagc caaataggtt gaagacaatc atccaaacag atcaatggaa tagaatttca
     4621 ttggaaatgt aaaacacttt cccaacaatg gtcatgactt tcttctgttt ttgagaagag
     4681 tttcatatgc tggaccacat tttagctttt attgtttttt ttttcccatt gtccaaaaag
     4741 ttaagcaaca agtggccaca cttttacgtg actacaacct ggagttctgc aaagaaggta
     4801 atatttactt ggtctttgac taaagttatc tccccattct atggttacat tttattttgg
     4861 actatgggga cttctaatac gttttggtaa agaagagagt ataaagaaaa ttcttgtcaa
     4921 atttcactca aaagtaattt catgagaaat caatgattta aagcattatc caaattaaat
     4981 tatcatttgc agcaaactgt acaacagcag gaaggatatg gaatggaaca tgaggtatat
     5041 atctttgcct ttataatttt aacatcttat attgaagatt ctgaaaacct atctttatta
     5101 gaggaaaatc tcaatcttca gttttggcct tctgtcagca gaatgataag tgcaatagtt
     5161 gtaaatctac ttgacactgt aataaactga actgaacttt caaagtc
//
