LOCUS       NM_030645               3148 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SH3 binding domain protein 5 like (SH3BP5L),
            transcript variant 1, mRNA.
ACCESSION   NM_030645
VERSION     NM_030645.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   Jenkins,M.L., Margaria,J.P., Stariha,J.T.B., Hoffmann,R.M.,
            McPhail,J.A., Hamelin,D.J., Boulanger,M.J., Hirsch,E. and
            Burke,J.E.
  TITLE     Structural determinants of Rab11 activation by the guanine
            nucleotide exchange factor SH3BP5
  JOURNAL   Nat Commun 9 (1), 3772 (2018)
   PUBMED   30217979
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   8  (bases 1 to 3148)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056382.1 and AL136569.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030645.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056382.1, AK125138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157511 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366472.6/ ENSP00000355428.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3142              AK056382.1         41-3182
            3143-3148           AL136569.1         2770-2775
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..3148
                     /gene="SH3BP5L"
                     /note="SH3 binding domain protein 5 like"
                     /db_xref="GeneID:80851"
                     /db_xref="HGNC:HGNC:29360"
                     /db_xref="MIM:620652"
     exon            1..81
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     exon            82..695
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..1694
                     /gene="SH3BP5L"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-binding protein 5-like; SH3BP-5-like"
                     /codon_start=1
                     /product="SH3 domain-binding protein 5-like isoform 1"
                     /protein_id="NP_085148.1"
                     /db_xref="CCDS:CCDS31126.1"
                     /db_xref="GeneID:80851"
                     /db_xref="HGNC:HGNC:29360"
                     /db_xref="MIM:620652"
                     /translation="MAELRQVPGGRETPQGELRPEVVEDEVPRSPVAEEPGGGGSSSS
                     EAKLSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQ
                     GSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMA
                     DKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLCQQAEARVQALQKTLRRA
                     IGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRR
                     GGLPPHPLGPRRSSPVGAEAGPEDMEDGDSGIEGAEGAGLEEGSSLGPGPAPDTDTLS
                     LLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSGGRRGSDGGARGGRHQRSVS
                     L"
     exon            696..758
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     exon            759..887
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1049
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1223
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..3148
                     /gene="SH3BP5L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3123..3128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP5L"
                     /note="hexamer: AATAAA"
     polyA_site      3148
                     /gene="SH3BP5L"
                     /note="major polyA site"
ORIGIN      
        1 gttggatcgg cttgttgcgg ggagggaggg ggggagattg tttgcagcat agaagctccg
       61 cggacgggaa ggtaaactga gctccccaga gacgctcatc ctacagcctc agctcgggcc
      121 cagccttctc tctccagctg ccaccacagc ctggaggcgc ctgcctccac cctcccgaat
      181 ggtgctcctc ctagcaggcc tcggtccagg atccaagccc cctttgcccc ctgccttgga
      241 gctgttgctc cgggtttgtc acagtggact ccctgtggcg ggaagggaag aacttttgca
      301 cagacaaggc ttcagctcta ggaaccccac tgacaacttg aatctcaacc tctaacctag
      361 tgtgaggttc ttcctgtgcc caccttttct gccttttgag aagagaaact cttctcctgg
      421 ccatctagag cccaggaagc cccaagctgg ggccctggtc ccagcatgtc agtcctctct
      481 tgtgcatagg gctctgccct ccccctgtca gcatggctga gctcagacag gttccaggag
      541 ggcgggagac cccacagggg gagctgcggc ctgaagttgt agaggatgaa gtccctagga
      601 gcccagtcgc agaagagcct ggaggaggtg gaagcagcag cagtgaggcc aaattgtccc
      661 caagagagga ggaagaactg gatcctagaa tacaggagga gttggagcac ctgaaccagg
      721 ccagcgagga gatcaaccag gtggaactac agctggatga ggccaggacc acctatcgga
      781 ggatcctaca ggagtcggcg aggaaactga atacacaggg ttcccacttg gggagctgca
      841 tcgagaaagc ccggccctac tatgaggctc ggcggctggc taaggaggct cagcaggaga
      901 cacagaaggc agcgctgcgg tacgagcggg ccgtaagcat gcacaacgct gctcgagaaa
      961 tggtgtttgt ggctgagcag ggcgtcatgg ctgacaagaa ccgactggac cccacgtggc
     1021 aggagatgct gaaccatgct acctgcaagg tgaatgaggc ggaggaagag cggcttcgag
     1081 gtgagcggga gcaccagcga gtgactcggc tgtgccaaca ggctgaggct cgggtccaag
     1141 ccctgcagaa gaccctccgg agggccatcg gcaagagccg cccctacttt gagctcaagg
     1201 cccagttcag ccagatcctg gaggagcaca aggccaaggt gacagaactg gagcagcagg
     1261 tagctcaggc caagacgcgc tactccgtgg cccttcgtaa cctggagcag atcagcgagc
     1321 agattcacgc acggcgccgc gggggtctgc ctccccaccc cctgggccct cggcgctcct
     1381 cccccgtggg ggccgaggca ggacccgagg acatggagga cggagacagc gggattgagg
     1441 gggccgaggg tgcggggctg gaggagggca gcagcctggg gcccggcccc gcccccgaca
     1501 ccgataccct gagtctgctg agcctgcgca cggtggcttc agacctgcag aagtgcgact
     1561 ccgtggagca cttgcgaggc ctctcggacc acgtcagtct ggacggccaa gagctgggaa
     1621 cgcggagtgg agggcgccgg ggcagcgacg gcggagcccg tgggggtcgg caccagcgca
     1681 gcgtcagcct gtagccgagg ggccagggtt cctggcttga atctgccacc acgggccggt
     1741 tggggcccac agtcttctca cgccctctcc tctggggcct cgtcttcccg aaggtcccct
     1801 tctccagtgc ttccctggga gaggccagct gtgttcgagt cctctgtgcc tgccctggcg
     1861 ttctcacagc ctcccccttc ccctcagcag gcggctctct ttgccttacc cattcagaag
     1921 gctcgccctc ggcgctctgt ctgcctctgc ctgccagctc atcacgatct gcagggcatt
     1981 gaccctttgc tttccctttc tgctccctct ctttccatct gtttggcttt ttccctcagg
     2041 gaacttggtc tagaaggcac tgggaagctc atcagagaaa atgggtgctg ggcctgagta
     2101 ctcccgtcgg aggggatgga cagtcacccc tcccgttggt ttccagcccc gccccccttc
     2161 ccaaggcaac tctggagggt accctaggta tgctgctgag ccctgccccc cgtcctgctc
     2221 cagcctgccc gtgtgtaacc tgtaagatgt actgtgtgcc tccggaagac accacctttc
     2281 ccttcagcat tccctttcat gacctgaggc actctgcgat gtgtgcccca aagcagaact
     2341 tacagggcct gcaggaagct ggtgtcaggg agagaaaccc aaccccactg tcaacatagg
     2401 gagcatcacc aactccagac tggctcctgt gggtatggtg tttccgctgg gctgggtcct
     2461 caacattgcc aaggtgctag tgggtcccta agagggccca tgttgggggt gaagtcatga
     2521 ggtcctgaag gcttaggccc ctgtcattcc caccctcact cttgctgcac agttgtgttt
     2581 actttttctg ggtagaggat gctgaactga ctcagcaccc tcctgcagga cggggttagg
     2641 gaatttggtg ctcaattgct ctcccttgct cttccccaaa ctgaaaatac ctactgcagg
     2701 atccctcggg gcacactgaa gcttggctgc caaccctctt acttcctttg ttacagggag
     2761 gggttggctt ggggtgaaaa gttctgccct ccgcagggag cagctccagc tgcctggcag
     2821 tgctcccagt ttgtagggaa gccacaccag atctgggtgc cttgggagaa ccagtccttc
     2881 cttttgaccc accccaggaa gatggagtgc tcttttctag gcccatgttc tgccagcaac
     2941 cgggatgcgt gggcaactgg actctgcacg ggggtctaca ggttgaggga ggttggtcac
     3001 aatgagaacc tcggggtttg aggtggccat gggcagacag ccgaaaggga gggagggtgt
     3061 gggtgtgcgt gtgtgcatgt gctggtgtgt aagggggaaa gggtctttcc tggttttatt
     3121 taaataaagt agtttatgta acagttaa
//
