LOCUS       NM_004844               3279 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens SH3 domain binding protein 5 (SH3BP5), transcript
            variant 1, mRNA.
ACCESSION   NM_004844
VERSION     NM_004844.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3279)
  AUTHORS   Zhang,B., Qian,R. and Li,X.
  TITLE     METTL3 suppresses invasion of lung cancer via SH3BP5 m6A
            modification
  JOURNAL   Arch Biochem Biophys 752, 109876 (2024)
   PUBMED   38141906
  REMARK    GeneRIF: METTL3 suppresses invasion of lung cancer via SH3BP5 m6A
            modification.
REFERENCE   2  (bases 1 to 3279)
  AUTHORS   Qiao,R., Zhong,R., Liu,C., Di,F., Zhang,Z., Wang,L., Xu,T.,
            Wang,Y., Dai,L., Gu,W., Han,B. and Yang,R.
  TITLE     Novel blood-based hypomethylation of SH3BP5 is associated with very
            early-stage lung adenocarcinoma
  JOURNAL   Genes Genomics 44 (4), 445-453 (2022)
   PUBMED   34783986
  REMARK    GeneRIF: Novel blood-based hypomethylation of SH3BP5 is associated
            with very early-stage lung adenocarcinoma.
REFERENCE   3  (bases 1 to 3279)
  AUTHORS   Chandrakumar,A.A., Coyaud,E., Marshall,C.B., Ikura,M., Raught,B.
            and Rottapel,R.
  TITLE     Tankyrase regulates epithelial lumen formation via suppression of
            Rab11 GEFs
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   34128958
  REMARK    GeneRIF: Tankyrase regulates epithelial lumen formation via
            suppression of Rab11 GEFs.
REFERENCE   4  (bases 1 to 3279)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3279)
  AUTHORS   Hirata,Y., Inoue,A., Suzuki,S., Takahashi,M., Matsui,R., Kono,N.,
            Noguchi,T. and Matsuzawa,A.
  TITLE     trans-Fatty acids facilitate DNA damage-induced apoptosis through
            the mitochondrial JNK-Sab-ROS positive feedback loop
  JOURNAL   Sci Rep 10 (1), 2743 (2020)
   PUBMED   32066809
  REMARK    GeneRIF: trans-Fatty acids facilitate DNA damage-induced apoptosis
            through the mitochondrial JNK-Sab-ROS positive feedback loop.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3279)
  AUTHORS   Court,N.W., Kuo,I., Quigley,O. and Bogoyevitch,M.A.
  TITLE     Phosphorylation of the mitochondrial protein Sab by
            stress-activated protein kinase 3
  JOURNAL   Biochem Biophys Res Commun 319 (1), 130-137 (2004)
   PUBMED   15158451
  REMARK    GeneRIF: mitochondrial protein Sab is phosphorylated by
            stress-activated protein kinase 3
REFERENCE   7  (bases 1 to 3279)
  AUTHORS   Wiltshire,C., Matsushita,M., Tsukada,S., Gillespie,D.A. and
            May,G.H.
  TITLE     A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab
            (SH3BP5), associates with mitochondria
  JOURNAL   Biochem J 367 (Pt 3), 577-585 (2002)
   PUBMED   12167088
REFERENCE   8  (bases 1 to 3279)
  AUTHORS   Yamadori,T., Baba,Y., Matsushita,M., Hashimoto,S., Kurosaki,M.,
            Kurosaki,T., Kishimoto,T. and Tsukada,S.
  TITLE     Bruton's tyrosine kinase activity is negatively regulated by Sab,
            the Btk-SH3 domain-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6341-6346 (1999)
   PUBMED   10339589
REFERENCE   9  (bases 1 to 3279)
  AUTHORS   Baba,Y., Matsushita,M., Matsuda,Y., Inazawa,J., Yamadori,T.,
            Hashimoto,S., Kishimoto,T. and Tsukada,S.
  TITLE     Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding
            protein which preferentially associates with Bruton's tyrosine
            kinase, to human chromosome 1q43 and mouse chromosome 14B by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 221-222 (1999)
   PUBMED   10702676
REFERENCE   10 (bases 1 to 3279)
  AUTHORS   Matsushita,M., Yamadori,T., Kato,S., Takemoto,Y., Inazawa,J.,
            Baba,Y., Hashimoto,S., Sekine,S., Arai,S., Kunikata,T.,
            Kurimoto,M., Kishimoto,T. and Tsukada,S.
  TITLE     Identification and characterization of a novel SH3-domain binding
            protein, Sab, which preferentially associates with Bruton's
            tyrosine kinase (BtK)
  JOURNAL   Biochem Biophys Res Commun 245 (2), 337-343 (1998)
   PUBMED   9571151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP308415.1, AB005047.1 and CA429664.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004844.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313167.1, SRR1803611.15222.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383791.8/ ENSP00000373301.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               BP308415.1         43-247
            206-2775            AB005047.1         1-2570
            2776-3279           CA429664.1         12-515              c
FEATURES             Location/Qualifiers
     source          1..3279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..3279
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /note="SH3 domain binding protein 5"
                     /db_xref="GeneID:9467"
                     /db_xref="HGNC:HGNC:10827"
                     /db_xref="MIM:605612"
     exon            1..316
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1546
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /note="isoform a is encoded by transcript variant 1; SH3
                     domain-binding protein that preferentially associates with
                     BTK; SH3-domain binding protein 5 (BTK-associated)"
                     /codon_start=1
                     /product="SH3 domain-binding protein 5 isoform a"
                     /protein_id="NP_004835.2"
                     /db_xref="CCDS:CCDS2625.2"
                     /db_xref="GeneID:9467"
                     /db_xref="HGNC:HGNC:10827"
                     /db_xref="MIM:605612"
                     /translation="MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPR
                     IQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYW
                     EARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLN
                     HATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKY
                     YVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAE
                     GSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEM
                     PDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGAEN
                     KTSDKANNNRGLSSSSGSGGSSKSQSSTSPEGQALENRMKQLSLQCSKGRDGIIADIK
                     MVQIG"
     exon            317..379
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            380..508
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            509..673
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            674..804
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            805..847
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1067
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1328
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..3279
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /note="hexamer: AATAAA"
     polyA_site      2779
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /note="major polyA site"
     regulatory      3256..3261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
                     /note="hexamer: ATTAAA"
     polyA_site      3279
                     /gene="SH3BP5"
                     /gene_synonym="SAB; SH3BP-5"
ORIGIN      
        1 ctctgctccg ccgcggccgg aggtatccgc atcggcgagc tgcgtctccc gggtgtcggc
       61 cccggcggct ccccgaccgt gcccggctgt ggcgaggcgg ctccagccca gcctgtggca
      121 gccgcgaccc ccggggcgct ccggagccca ctgcgcggcg cgcgtgccgg ctgcctgcat
      181 ggacgcggca ctgaagcgga gccgctcgga ggagccagcc gaaatcctgc cgcctgcccg
      241 ggacgaggag gaggaggagg aagaggggat ggagcagggg ctggaggagg aagaagaggt
      301 ggatccccgg atccagggag aactggagaa gttaaatcag tccacggatg atatcaacag
      361 acgggagact gaacttgagg atgctcgtca gaagttccgc tctgttctgg ttgaagcaac
      421 ggtgaaactg gatgaactgg tgaagaaaat tggcaaagct gtggaagact ccaagcccta
      481 ctgggaggca cggagggtgg cgaggcaggc tcagctggaa gctcagaaag ccacgcagga
      541 cttccagagg gccacagagg tgctccgtgc cgccaaggag accatctccc tggccgagca
      601 gcggctgctg gaggatgaca agcggcagtt cgactccgcc tggcaggaga tgctgaatca
      661 cgccactcag agggtcatgg aggcggagca gaccaagacc aggagcgagc tggtgcataa
      721 ggagacggca gccaggtaca atgccgccat gggccgcatg cgacagctgg agaagaaact
      781 caagagagcc atcaacaagt ccaagcctta ttttgaactc aaggcaaagt actatgtgca
      841 gctcgagcaa ctgaaaaaga ctgtggatga cctgcaggcc aaactgaccc tggcaaaagg
      901 cgagtacaag atggccctga agaacctgga gatgatctca gatgagatcc acgagcggcg
      961 gcgctccagt gccatggggc ctcggggatg cggtgttggt gctgagggca gcagcacatc
     1021 tgtggaggat ctgccaggga gcaaacctga gcctgatgcc atttctgtgg cctcggaggc
     1081 ctttgaagat gacagctgta gcaactttgt gtctgaagat gactcggaaa cccagtccgt
     1141 gtccagcttt agttcaggac caacaagccc gtctgagatg cctgaccagt tccctgcggt
     1201 tgtgaggcct ggcagcctgg atctgcccag ccctgtgtcc ctgtcagagt ttgggatgat
     1261 gttcccagtg ttgggccctc gaagtgaatg cagcggggcc tcctcccctg aatgtgaagt
     1321 agaacgagga gacagggcag aaggggcaga gaataaaaca agtgacaaag ccaacaacaa
     1381 ccggggcctc agcagtagca gtggcagtgg tggcagcagt aagagccaaa gcagcacctc
     1441 ccctgagggc caggccttgg agaaccggat gaagcagctc tccctacagt gctcaaaggg
     1501 aagagatgga attattgctg acataaaaat ggtgcagatt ggctgattca tcctgggccc
     1561 tggccgatgt gcatatcaac atttatacat ggaactggag aacattgtgc caataatcat
     1621 ttaatatatg ccaaatctta cacgtctact ctaaactgct ctaatgaagt ttcagtgacc
     1681 ttgagggcta aagattgttc ttctgggtaa gagctcttgg gctggttttt cagagcagag
     1741 ttcttgttgt gggtagactg tgactaggtt cacagccttt gtggaacatt ccgtataacg
     1801 gcattgtgga agcaataact agttcctatg aaagaaccag agctgggaag atggctggga
     1861 agccaggcca aagtgggggc aacagcttgc ttctctttct cttctcaccc tcagtttgta
     1921 tgggaaaatg gagatgtcct ctccacttta tcccacgata tctaaatgaa aaagaaagaa
     1981 aacccacaca caaagcaaaa actcaagtat taagagcaca tatttttgac ccagtggagg
     2041 cttaaaaaaa aaaaaatcca agaacacaat tcattttcac cacctctggt gttcagaggg
     2101 ggcttttaaa aaagcgtgta tgctgggata cccattaaaa ccattttcta gaaggctacc
     2161 atgagctgca ctttttgggg tgggaaaggt gaatgccagt ggggatgcgg ggggatgagg
     2221 gtaggaggga cttatagaag gggatttgtg gctgtggggg agaaggttct acagcataag
     2281 ccttatcctg ccagccaagg ggatttattc taagagaagt gcatgtgaag aatggttgcc
     2341 actgttatta gattgacaag atgttaattt ctctgtaggt tgtaacttta aaaataaatg
     2401 aaattattta agggttatgc tgcactagta ttccttagag gaaacagttc tttaaagtta
     2461 ggaaagggag taggcaggca tgtgttggca aaggctgtta atagtagtta agtgttaaga
     2521 ctgcttttct ttaacgtttt catggtaatg catatttaga gcactgtatt tttgtcttgt
     2581 taagaaaatt tagcatttct aaaagaaaaa agcaaccctc tttcaaactg ttaattctgt
     2641 cacagcctgt atattttagt catttgtaaa tctcttcata caatagtgac ttcttttttg
     2701 actgatacag tatcttaatt acaaggttat tttgtacttg tcttaataca ctaagtgtaa
     2761 taaaaacggc ttgagaaaag tttctccttt ctgtgacttc aaataagaac tcccagtatt
     2821 gcctaaatct tctaggcaac cctttttcca taaggaagag catggagtgc tgtggtcacc
     2881 agtaatcatt ttcaattaat taaggtcatg aacagtaata atttaagcct tgtttaccaa
     2941 ggtttgaatt ctacttttgc tgttgctaaa gctgtgggca atgaggagac acagtggcag
     3001 ataaagacga ggtggtgacg ctggaggagt gggcctcggc tgcacactgc agtctcgaag
     3061 cttaagtgtt gctgtcagtc agttctcatc cccagagaat tatttaatta attaactggg
     3121 gggggtacac tggggcatta gacttttaaa agctccccga gggaattcaa atgtgcattc
     3181 agagttgaga atcagatgga ttctttcttt tgtggaaatg ttttataata ttggactctt
     3241 aatccgcatt tcattattaa agcatgctgt ggagaaaaa
//
