LOCUS       NM_014521               5150 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SH3 domain binding protein 4 (SH3BP4), transcript
            variant 1, mRNA.
ACCESSION   NM_014521
VERSION     NM_014521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5150)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 5150)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5150)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5150)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   5  (bases 1 to 5150)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 5150)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   7  (bases 1 to 5150)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   8  (bases 1 to 5150)
  AUTHORS   Dunlevy,J.R., Berryhill,B.L., Vergnes,J.P., SundarRaj,N. and
            Hassell,J.R.
  TITLE     Cloning, chromosomal localization, and characterization of cDNA
            from a novel gene, SH3BP4, expressed by human corneal fibroblasts
  JOURNAL   Genomics 62 (3), 519-524 (1999)
   PUBMED   10644451
REFERENCE   9  (bases 1 to 5150)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Binding specificity and in vivo targets of the EH domain, a novel
            protein-protein interaction module
  JOURNAL   Genes Dev 11 (17), 2239-2249 (1997)
   PUBMED   9303539
REFERENCE   10 (bases 1 to 5150)
  AUTHORS   Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
            Pelicci,P.G. and Di Fiore,P.P.
  TITLE     A protein-binding domain, EH, identified in the receptor tyrosine
            kinase substrate Eps15 and conserved in evolution
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9530-9534 (1995)
   PUBMED   7568168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC057396.1 and AF147747.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014521.2.
            
            Summary: This gene encodes a protein with 3 Asn-Pro-Phe (NPF)
            motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting
            signal, and a tyrosine phosphorylation site. This protein is
            involved in cargo-specific control of clathrin-mediated
            endocytosis, specifically controlling the internalization of a
            specific protein receptor. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF147747.1, SRR1660807.231366.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392011.7/ ENSP00000375867.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5065              BC057396.1         45-5109
            5066-5150           AF147747.1         5041-5125
FEATURES             Location/Qualifiers
     source          1..5150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.2"
     gene            1..5150
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="SH3 domain binding protein 4"
                     /db_xref="GeneID:23677"
                     /db_xref="HGNC:HGNC:10826"
                     /db_xref="MIM:605611"
     exon            1..154
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            155..228
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            229..478
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..3252
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="EH-binding protein 10; transferrin
                     receptor-trafficking protein"
                     /codon_start=1
                     /product="SH3 domain-binding protein 4"
                     /protein_id="NP_055336.1"
                     /db_xref="CCDS:CCDS2513.1"
                     /db_xref="GeneID:23677"
                     /db_xref="HGNC:HGNC:10826"
                     /db_xref="MIM:605611"
                     /translation="MAAQRIRAANSNGLPRCKSEGTLIDLSEGFSETSFNDIKVPSPS
                     ALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMG
                     YIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELELLGGWTDDKKVPGRMYSNNP
                     FWNGVQTNPFLNGNVPVMPSLDELNPKSTVDLLLFDAGTSSFTESSSATTNSTGNIFD
                     ELPVTNGLHAEPPVRRDNPFFRSKRSYSLSELSVLQAKSDAPTSSSFFTGLKSPAPEQ
                     FQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPD
                     TSISIHVPEGHVAPGETQQISMKALLDPPLELNSDRSCSISPVLEVKLSNLEVKTSII
                     LEMKVSAEIKNDLFSKSTVGLQCLRSDSKEGPYVSVPLNCSCGDTVQAQLHNLEPCMY
                     VAVVAHGPSILYPSTVWDFINKKVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSE
                     VTRQAPNPAPVALQLWGKHQFVLSRPQDLKVCMFSNMTNYEVKASEQAKVVRGFQLKL
                     GKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAILTQFCVQTPQPPPKSAIKPSGQRR
                     FLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGKLLKTVVRQNKNHYLLEYKKGDG
                     IALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVLVVGRARPSLCSGPELSTSVL
                     LEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVNLPLTFFCRAELDSEPERV
                     ASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQR
                     WRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVI
                     QELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQDDFVI"
     exon            479..2838
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3027
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..5150
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4947
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="major polyA site"
     regulatory      5038..5043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="hexamer: AATAAA"
     regulatory      5060..5065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="hexamer: AGTAAA"
     polyA_site      5065
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
     polyA_site      5084
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="major polyA site"
     regulatory      5133..5138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="hexamer: AACAAA"
     polyA_site      5150
                     /gene="SH3BP4"
                     /gene_synonym="BOG25; TTP"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcccg gcactctcgg cggtccgggc ccctcgccac taccgccgcc gccgccgccg
       61 tgagtcccgc ggagccgcgc gcgcccccgg ctgggccgag ccgctggccg acgagcggag
      121 cctcaggagc cggcggggac gccatgcgag ccagcgtctc ccttctctcc tggacagaag
      181 gccgtgtcct gggacttctc tgatggcgag aggctgcggc tgtaccagga agaaacatat
      241 tgccgagtgg atgccgccgc gcagcgtgtt tgcttgaggc agaagcttca gcatctgctg
      301 ggataactgg aggaagaaat atgaagcctt agcggcttta cccgggaagc gagtttcgag
      361 atggcggctc agcggatccg agcggccaac tccaatggcc tccctcgctg caagtcagag
      421 gggaccctga ttgacctgag cgaagggttt tcagagacga gctttaatga catcaaagtg
      481 ccttctccca gtgccttgct cgtagacaac cccacacctt tcggaaatgc aaaggaagtg
      541 attgcgatca aggactattg ccccaccaac ttcaccacac tgaagttctc caagggcgac
      601 catctctacg tcttggacac atctggcggt gagtggtggt acgcacacaa caccaccgaa
      661 atgggctaca tcccctcctc ctatgtgcag cccttgaact accggaactc aacactgagt
      721 gacagcggta tgattgataa tcttccagac agcccagacg aggtagccaa ggagctggag
      781 ctgctcgggg gatggacaga tgacaaaaaa gtaccaggca gaatgtacag taataaccct
      841 ttctggaatg gggtccagac caatccattt ctgaatggga acgtgcccgt catgcccagc
      901 ctggatgagc tgaatcccaa aagtactgtg gatttgctcc tttttgacgc aggtacatcc
      961 tccttcaccg aatccagctc agccaccacg aatagcactg gcaacatctt cgatgagctt
     1021 ccagtcacaa acggactcca cgcagagccg ccggtcaggc gggacaaccc cttcttcaga
     1081 agcaagcgct cctacagtct ctcggaactc tccgtcctcc aagccaagtc cgatgctccc
     1141 acatcgtcga gtttcttcac cggcttgaaa tcacctgccc ccgagcaatt tcagagccgg
     1201 gaggattttc gaactgcctg gctaaaccac aggaagctgg cccggtcttg ccacgacctg
     1261 gacttgcttg gccaaagccc tggttggggc cagacccaag ccgtggagac aaacatcgtg
     1321 tgcaagctgg atagctccgg gggtgctgtc cagcttcctg acaccagcat cagcatccac
     1381 gtgcccgagg gccacgtcgc ccctggggag acccagcaga tctccatgaa agccctgctg
     1441 gaccccccgc tggagctcaa cagtgacagg tcctgcagca tcagccctgt gctggaggtc
     1501 aagctgagca acctggaggt gaaaacctct atcatcttgg agatgaaagt gtcagccgag
     1561 ataaaaaatg acctttttag caaaagcaca gtgggcctcc agtgcctgag gagcgactcg
     1621 aaggaagggc catatgtctc cgtcccgctc aactgcagct gtggggacac ggtccaggca
     1681 cagctgcaca acctggagcc ctgtatgtac gtggctgtcg tggcccatgg cccaagcatc
     1741 ctctaccctt ccaccgtgtg ggacttcatc aataaaaaag tcacagtggg tctctacggc
     1801 cctaaacaca tccacccatc cttcaagacg gtagtgacca tttttgggca tgactgtgcc
     1861 ccaaagacgc tcctggtcag cgaggtcaca cgccaggcac ccaaccctgc cccggtggcc
     1921 ctgcagctgt gggggaagca ccagttcgtt ttgtccaggc cccaggatct caaggtctgt
     1981 atgttttcca atatgacgaa ttacgaggtc aaagccagcg agcaggccaa agtggtgcga
     2041 ggattccagc tgaagctggg caaggtgagc cgcctgatct tccccatcac ctcccagaac
     2101 cccaacgagc tctctgactt cacgctgcgg gttcaggtga aggacgacca ggaggccatc
     2161 ctcacccagt tttgtgtcca gactcctcag ccacccccta aaagtgccat caagccttcc
     2221 gggcaaagga ggtttctcaa gaagaacgaa gtcgggaaaa tcatcctgtc cccgtttgcc
     2281 accactacaa agtacccgac tttccaggac cgcccggtgt ccagcctcaa gtttggtaag
     2341 ttgctcaaga ctgtggtgcg gcagaacaag aaccactacc tgctggagta caagaagggc
     2401 gacgggatcg ccctgctcag cgaggagcgg gtcaggctcc ggggccagct gtggaccaag
     2461 gagtggtaca tcggctacta ccagggcagg gtgggcctcg tgcacaccaa gaacgtgctg
     2521 gtggtcggca gggcccggcc cagcctgtgc tcgggccccg agctgagcac ctcggtgctg
     2581 ctggagcaga tcctgcggcc ctgcaaattc ctcacgtaca tctatgcctc cgtgaggacc
     2641 ctgctcatgg agaacatcag cagctggcgc tccttcgctg acgccctggg ctacgtgaac
     2701 ctgccgctca cctttttctg ccgggcagag ctggatagtg agcccgagcg ggtggcgtcc
     2761 gtcctagaaa agctgaagga ggactgtaac aacactgaga acaaagaacg gaagtccttc
     2821 cagaaggagc ttgtgatggc cctactgaag atggactgcc agggcctggt ggtcagactc
     2881 atccaggact ttgtgctcct gaccacggct gtagaggtgg cccagcgctg gcgggagctg
     2941 gctgagaagc tggccaaggt ctccaagcag cagatggacg cctacgagtc tccccaccgg
     3001 gacaggaacg gggttgtgga cagcgaggcc atgtggaagc ctgcgtatga cttcttactc
     3061 acctggagcc atcagatcgg ggacagctac cgggatgtca tccaggagct gcacctgggc
     3121 ctggacaaga tgaaaaaccc catcaccaag cgctggaagc acctcactgg gactctgatc
     3181 ttggtgaact ccctggacgt tctgagagca gccgccttca gccctgcgga ccaggacgac
     3241 ttcgtgattt gaatgggtcc cctcccctcc tgctgctctg gagtgcaagc cctcttctgc
     3301 cctgcgtgcc ctgctgtcac cgcggagctg aagagggagg aaggggcggc tgctcagaca
     3361 gatttagggc ccgccagcta ggctacaccc atcatgcgcc gccctcctcc atcgagggag
     3421 aggcctgaag ggactgccta ctgcagctcg ttgccaatca catagctttc tatttgttaa
     3481 gtataaattt aaatttaaaa tcactttttt aacgaatggg gggaagggat ctatgagaaa
     3541 ggtggtatct aattttttta tggaccataa aggtttaaaa gaaaataggg gcacaggctg
     3601 ttgaggtttt tatgttgtta tagacctttt taaattatgt tagagatgta tataggtatt
     3661 taaaggtcac tgggagcgtt tctgattccc ggccacactt tgcatttcaa cactcagccc
     3721 ggaaagatgc tcgttcggtt gttggacctc tttcactccc tgcgtgtaag aaggtgaatc
     3781 acgtgggaaa aagtggcttt tcagtaaacg ggtacagctc attctttctg agaaggcccc
     3841 aggtcctgct ccctcctcgg atttgattgt cttccgtgct ttgcctcact cgtagtaaat
     3901 gaccatccat agaatatgtg aatctttggt gagcttcagt gggcagagtg aagtcccgca
     3961 ttagcattta ggtgccctga gctgtttctg ccaatagatt agaaagcagc catgagttga
     4021 cagtctttag ggcccctgcc agtgtgcaat tagtcattga caagaacaat gccatttgag
     4081 agtgaggtgg tccctgctgc tacgaggcca ttgtactgtt ttttccttga ggtcaaagca
     4141 gtgcttccca tagagtttgc tgcctcttct gtggacagga agaaaacttc atgaccgaat
     4201 cagagccttg gtggccactg actctcgtgc ttattgcaga tgctgtggtt ggcctcacaa
     4261 gcaacgcctt atgctgatgt gcagaggtgc cagctgccat ttgccaaact ctgcatttca
     4321 tttcatctaa ggcttaaccc ctcttccttc ctggtgtacc tgtgtctcct cggaaggaag
     4381 tcatagttta gatgaaacca ttttttgtac aatgtaaaga tcatctgagc aagatgagca
     4441 ttttgtaaaa atgaaaatgt gactcacata aaatcaggaa cttgacacag tgttgcatta
     4501 ataactttag ggtgcagaca tgctgtgtga atctcacaat gcgtcgtaga tgtcgcgtgt
     4561 tggaagggag caggaggaag gactgatact ggcaaatcag tagagtgagg tgatccttag
     4621 caacgtgcca ggacacttcc tgtgtgcctg cagttgtcag ggaccatttg ggatcccgaa
     4681 tctcattctc taaaactgct ttcttgaaac atgttacttc cttagtataa tcaatgtata
     4741 ctcccttact ggcctgaaac gttgtatagc tacttattca gatactgaag accaacggac
     4801 tgaaaaaaag aacaaacatt agctatttta tgctgcaaga accaggacac acaattcgcc
     4861 aatcatccca ccatataacc ttcgattgtg cttctcaact ccaccccata atttctccca
     4921 gagaccatct atcacctttt ccccaaagaa gaaacaaaac cagttgcacc ttaaaccatg
     4981 gatatttttt cctcaggggc tttaaatagt ttcctatgca acgtgtcttg tagcacaaat
     5041 aaaattctac aaaagttgca gtaaatttta tttggatatt ttaacctgtt aagtgtgtgt
     5101 gtgttttctg tacccaacca gactttaaat aaaacaaaca tgaaacctaa
//
