LOCUS       NM_001122681            9006 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens SH3 domain binding protein 2 (SH3BP2), transcript
            variant 2, mRNA.
ACCESSION   NM_001122681
VERSION     NM_001122681.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9006)
  AUTHORS   Srivastava,T., Garola,R.E., Zhou,J., Boinpelly,V.C.,
            Rezaiekhaligh,M.H., Joshi,T., Jiang,Y., Ebadi,D., Sharma,S.,
            Sethna,C., Staggs,V.S., Sharma,R., Gipson,D.S., Hao,W., Wang,Y.,
            Mariani,L.H., Hodgin,J.B., Rottapel,R., Yoshitaka,T., Ueki,Y. and
            Sharma,M.
  TITLE     Scaffold protein SH3BP2 signalosome is pivotal for immune
            activation in nephrotic syndrome
  JOURNAL   JCI Insight 9 (3), e170055 (2024)
   PUBMED   38127456
  REMARK    GeneRIF: Scaffold protein SH3BP2 signalosome is pivotal for immune
            activation in nephrotic syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9006)
  AUTHORS   Jakob,N., Pinter,G.T., Kotmayer,L., Nagy,P., Bodor,C., Barabas,P.,
            Becser,J., Szabo,G. and Bogdan,S.
  TITLE     [Cherubism in three siblings]
  JOURNAL   Orv Hetil 163 (11), 446-452 (2022)
   PUBMED   35279646
  REMARK    GeneRIF: Cherubism in three siblings.', trans 'A cherubismus
            elofordulasa harom testverben.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9006)
  AUTHORS   Kueper,J., Tsimbal,C., Olsen,B.R., Kaban,L. and Liao,E.C.
  TITLE     SH3BP2-related fibro-osseous disorders of the maxilla and mandible:
            A systematic review
  JOURNAL   Int J Oral Maxillofac Surg 51 (1), 54-61 (2022)
   PUBMED   33941395
  REMARK    GeneRIF: SH3BP2-related fibro-osseous disorders of the maxilla and
            mandible: A systematic review.
            Review article
REFERENCE   4  (bases 1 to 9006)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9006)
  AUTHORS   Serrano-Candelas,E., Ainsua-Enrich,E., Navines-Ferrer,A.,
            Rodrigues,P., Garcia-Valverde,A., Bazzocco,S., Macaya,I.,
            Arribas,J., Serrano,C., Sayos,J., Arango,D. and Martin,M.
  TITLE     Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors
            expression and impairs gastrointestinal stromal tumors growth
  JOURNAL   Mol Oncol 12 (8), 1383-1397 (2018)
   PUBMED   29885053
  REMARK    GeneRIF: The current study shows that SH3BP2 is expressed in
            primary tumors and cell lines from Gastrointestinal stromal tumors
            (GISTs) patients and that SH3BP2 silencing leads to a
            downregulation of oncogenic KIT and PDGFRA expression and an
            increase in apoptosis in imatinib-sensitive and imatinib-resistant
            GIST cells.
REFERENCE   6  (bases 1 to 9006)
  AUTHORS   Deckert,M., Tartare-Deckert,S., Hernandez,J., Rottapel,R. and
            Altman,A.
  TITLE     Adaptor function for the Syk kinases-interacting protein 3BP2 in
            IL-2 gene activation
  JOURNAL   Immunity 9 (5), 595-605 (1998)
   PUBMED   9846481
REFERENCE   7  (bases 1 to 9006)
  AUTHORS   Hadano,S., Ishida,Y. and Ikeda,J.E.
  TITLE     The primary structure and genomic organization of five novel
            transcripts located close to the Huntington's disease gene on human
            chromosome 4p16.3
  JOURNAL   DNA Res 5 (3), 177-186 (1998)
   PUBMED   9734812
REFERENCE   8  (bases 1 to 9006)
  AUTHORS   Bell,S.M., Shaw,M., Jou,Y.S., Myers,R.M. and Knowles,M.A.
  TITLE     Identification and characterization of the human homologue of
            SH3BP2, an SH3 binding domain protein within a common region of
            deletion at 4p16.3 involved in bladder cancer
  JOURNAL   Genomics 44 (2), 163-170 (1997)
   PUBMED   9299232
REFERENCE   9  (bases 1 to 9006)
  AUTHORS   Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
  TITLE     Identification of a ten-amino acid proline-rich SH3 binding site
  JOURNAL   Science 259 (5098), 1157-1161 (1993)
   PUBMED   8438166
REFERENCE   10 (bases 1 to 9006)
  AUTHORS   Kannu,P., Baskin,B. and Bowdin,S.
  TITLE     Cherubism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK225497.1, AK312286.1 and
            AL121750.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 13, 2018 this sequence version replaced NM_001122681.1.
            
            Summary: The protein encoded by this gene has an N-terminal
            pleckstrin homology (PH) domain, an SH3-binding proline-rich
            region, and a C-terminal SH2 domain. The protein binds to the SH3
            domains of several proteins including the ABL1 and SYK protein
            tyrosine kinases , and functions as a cytoplasmic adaptor protein
            to positively regulate transcriptional activity in T, natural
            killer (NK), and basophilic cells. Mutations in this gene result in
            cherubism. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) represents use of an
            alternative promoter and 5' UTR and uses a downstream translation
            start site, compared to variant 3. The resulting isoform (a) has a
            shorter N-terminus, compared to isoform b. Variants 1 and 2 encode
            the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1360525.1,
                                           SRR14038196.805219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503393.8/ ENSP00000422168.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AK225497.1         65-540
            477-1744            AK312286.1         477-1744
            1745-9006           AL121750.22        55906-63167         c
FEATURES             Location/Qualifiers
     source          1..9006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..9006
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /note="SH3 domain binding protein 2"
                     /db_xref="GeneID:6452"
                     /db_xref="HGNC:HGNC:10825"
                     /db_xref="MIM:602104"
     exon            1..54
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            55..194
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1744
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /note="isoform a is encoded by transcript variant 2;
                     TNFAIP3 interacting protein 2; Abl-SH3 binding protein 2;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="SH3 domain-binding protein 2 isoform a"
                     /protein_id="NP_001116153.1"
                     /db_xref="CCDS:CCDS33944.1"
                     /db_xref="GeneID:6452"
                     /db_xref="HGNC:HGNC:10825"
                     /db_xref="MIM:602104"
                     /translation="MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLL
                     KWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHIS
                     KKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPV
                     DISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFS
                     DMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRR
                     MSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKL
                     KSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPV
                     PEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEK
                     VPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKV
                     RNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR"
     exon            195..297
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            298..415
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            416..486
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            487..575
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            576..644
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1299
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1408
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1464
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1546
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1606
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..9006
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4932..4937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /note="hexamer: AATAAA"
     polyA_site      4954
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /note="major polyA site"
     regulatory      8979..8984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
                     /note="hexamer: ATTAAA"
     polyA_site      9006
                     /gene="SH3BP2"
                     /gene_synonym="3BP-2; 3BP2; CRBM; CRPM; RES4-23"
ORIGIN      
        1 gagtcaagcc gccgcctcga cccagggccc gcgggccagg agagcgctcg gcggcttcat
       61 ggcggctgaa gagatgcatt ggcctgtccc tatgaaggcc attggtgccc agaacctgct
      121 aaccatgcct gggggcgtgg ccaaggctgg ctacctgcac aagaagggcg gtacccagct
      181 gcagctgctg aaatggcccc tgcgctttgt catcatccac aaacgctgcg tctactactt
      241 caagagtagc acctctgcct ccccgcaggg cgccttctcc ctgagtggct ataaccgggt
      301 gatgcgggcg gctgaggaga ccacgtccaa caacgttttc cccttcaaga tcatccatat
      361 cagcaagaag caccgcacgt ggttcttctc ggcctcctcc gaggaggagc gcaagagctg
      421 gatggccttg ctgcgcaggg agattggcca cttccacgaa aagaaagacc tgcccttgga
      481 caccagcgac tccagctcgg acacagacag cttctacggc gcagttgagc ggcctgtgga
      541 tatcagcctt tccccgtacc ccacggacaa tgaagactat gagcacgacg atgaggatga
      601 ctcctacctg gagcctgact ccccggagcc cggaaggctt gaggatgccc tgatgcaccc
      661 accggcttac ccaccacccc cagtgcccac gcccaggaag ccagccttct ctgacatgcc
      721 ccgggcccac tcctttacct ccaagggccc cggtccccta ctgccacccc cgccccctaa
      781 gcacggcctc ccagatgttg gcctggctgc tgaggactcc aagagggacc cactgtgccc
      841 gaggcgggct gagccttgcc ccagggtacc tgctaccccc cgaaggatga gcgatccccc
      901 tctgagcacc atgcccaccg cacccggcct ccggaaaccc ccttgcttcc gggagagtgc
      961 cagccccagc ccggagccct ggacccctgg ccacggggcc tgctccactt ccagtgctgc
     1021 catcatggcc actgccacct ccagaaactg tgacaaactc aagtccttcc acctgtcccc
     1081 ccgaggacca cccacatctg agcccccacc tgtgccagcc aacaagccca agttcctgaa
     1141 gatagctgaa gaggaccccc caagggaggc agccatgccc ggactctttg tgccccccgt
     1201 ggctccccgg cctcctgcgc tgaagctgcc agtgcctgag gccatggcgc ggcccgcagt
     1261 cctgcccagg ccagagaagc cgcagctccc gcacctccag cgatcacccc ccgatgggca
     1321 gagtttcagg agcttctcct ttgaaaagcc ccggcaaccc tcacaggctg acactggcgg
     1381 ggacgactcg gacgaggact atgagaaggt gccactgccc aactcggtct tcgtcaacac
     1441 cacggagtcc tgcgaagtgg aaaggttgtt caaggctaca agcccccggg gagagcccca
     1501 ggatggactc tactgcatcc ggaactcctc taccaagtcg gggaaggtcc tggttgtgtg
     1561 ggacgaaacc tctaacaaag tgaggaacta tcgcattttt gagaaggact ctaagttcta
     1621 cctggagggc gaggtcctgt ttgtgagtgt gggcagcatg gtggagcact accacaccca
     1681 cgtgctgccc agccaccaga gcctgctgct gcggcacccc tacggctaca ctgggcctag
     1741 gtgatggcag tccatgtggc tgccaggcca aggcagtcac aggggccctg accccaggcc
     1801 acacagacgg acatgggccc acatgggagg gtgagcagga gcaaggctgt gcttgcctag
     1861 ggcctctgtg atggacatct cgtaggaccc agccagtctc atccagcagg ttgggttcta
     1921 gggctgaacc aggcgccagg ctccagagga cgaagggact ctgttgcccc acactaactt
     1981 gccctgtccc aatcccagaa acccaggacc aagctgtgcc tgggctccaa ggacaggaac
     2041 actggtcccc ccatcacact cacccctaag tgggctggga gccaggcagg gccagggcag
     2101 ctgggtgggg gccggggctg gccctgggac ccccaggaac gctaagacac aggctccagt
     2161 aggggctgtt gcctccaata aagcagcagt gagctttgcc ttggtggctg gggcttgatt
     2221 gggaaggagg ggattaccag cttactgggt gcccatgctg atgtctaagt ggtgaccgca
     2281 gcagtacccg ggaaccccaa cagttggttg tcttgtcttc cagggtgcag gtcactgagt
     2341 gacttcccca gggtgcacag cgagtaacag atcaggaccc aaacttgggc agtctgggct
     2401 gggagcccac accccactca ccagttctgc tgcctcaggt caggccaggg cagtgctgct
     2461 gcagagctag aaggccctgc agctacagct gcttcattcc ctgcattagt gcctggttac
     2521 tgggtacctc ctgagtggct gtccccgttc cagaacttgc atacactgag cgggctacag
     2581 agctagaagg ccctgcagct acagctgctt cattccctgc attagcgagc agttattggg
     2641 tacctcctgc atgcctggtc ccattccaga caggggcctc tggcctggct gagttcacag
     2701 cccagtctgg ggacagctgg gtatgaggtg cttacggcac agtgtccagg gcagctgggt
     2761 gtgcagggac tgggggctcc cggaagattt tttggaggaa gtaacagcta cgatgggatg
     2821 ggaacagtgg accctaagca ggccaagggt gcgtagggac ggtggtaccc agatgcccaa
     2881 gtcttccagg caatacctgg ctcaggccca gccccaatcc atccccttac tttctgccat
     2941 ggagttccag caggtcactc tccctggcac accttccagg ctggattttt aatgaaacag
     3001 actcagggag gtaggggctg gcagggaccc tagaatcctt gtgatttttc ttagcacctt
     3061 atgtcaggga aacctaaact gaggtcagca cttgggccca ctgacagtga ctgactgggg
     3121 gagaaggtcc tgcagccccc ttcccctggg tgtgttctgg ggacctgtgg tttgctggcg
     3181 gaaacaagtg atgaggctgg ttagcggatg tgggaggctg tgaccccagg gggccatagg
     3241 gtgcggtgga actgcaggcc ctgcagatga cggcagccag ctgcttccag gaaccaggtg
     3301 tccaaggcca cctctgcagg ggtttcctct tcagcctgcc tggggtgaga ggtcagtgca
     3361 ccacagccga ggctggagca cagggagctt ctgttgttct gatctatctc tggaaaacca
     3421 gccattcctc ctccctgcag tcagaattct ttgccctgtc tgacctgaac ttgcttaggg
     3481 agtcatgcca ctccccactg tggccatagt ttctcttcct gtaaaatttt attattttag
     3541 ttttttgttt ttgagatgta gtctcaccct gtcgcccagg ctggagtgca atgccgtgat
     3601 ctccgctcac tgccacctcc gcctctctag ttcaagcgat tttcctgcct cagcctcccg
     3661 agtagctggg attccaggcg cccgccacca cgcctggcta attttttgta tttttagtag
     3721 agacgggatt ttatcatgtt ggccaggctg gtctcgaact cctgacctca ggtgatctgc
     3781 ccaccttggc ctcccaaagt gctgggatta caggcatgag ccactgtgcc tggccccttc
     3841 ctgtaaaatt tttaaatgga gaattgggtg cgagatgtgg tttccagcct ggtgcctggg
     3901 gtgctgagct agtgagtggt gcagtccagg acacctttgc tttatgtcac ttacacggtc
     3961 acctggagcc ggctcaagtg gctaaagcat cctggggccc agagccaggt gataggtccc
     4021 tctggccaac tggacagttg aggcctgtgg ttacccgaag cccagctggg gccctggtcc
     4081 agcctcgcct cccagactct gcacctgcta gcacagctgt ccacgtctgt gtgagctgct
     4141 ctaggccgag ggcctcagtt tcaagagtgt gttggggtgg gatggggcag gccgtggtcc
     4201 tccagcatga agaaggagcc atgaggagtt cccatgacct cccgagactt gccataagtg
     4261 ttctagtcca catataaggg tagggttggg attaccattt actgaccaca tctgtgaggt
     4321 gccgagctgg gtgcttgaca tcatttgctt ggagaagcag ctgctagtag acccatttta
     4381 caggtgagag aaccaagtct cacagaggcc tgggttcaag tcccacctct gccactaact
     4441 ggcatgtgac cctatctatc cttcactgct ctgagcctag accctggccc ctgcctggct
     4501 ccctgccagg ctccctgcca cccctcacga cctctgatgg tcgttgtggg ggtctcttgc
     4561 ctggctccca gggctagggt tagggctctg gaggtgcttt cactcaacca agggggccac
     4621 agcactgggg agtgaaactg ccccgcctca ccctgcgttg ccctctgggt ctgtgagggt
     4681 gggctggcag gaggcctagg ccttgcccta ggggcagtcc tgcttcctca ttttatagat
     4741 agggaaactg aggctttggg aggactcact gacataccta ccttcaagat gagttcaggt
     4801 gggctcagtt ctggggcttg ggaaaagggc cccagtggct ttgggaagca cccccagccc
     4861 agggtgaaac atgcttcttc tcttcctgtg gttccatccg aaggattgtg gtgagccccg
     4921 tgccttcagt taataaagat ttgtattgtg aaaagatttt ttcttttttt tttgggacac
     4981 agtctcactc tgtcgcccag gctagagtgg attggcgtga tctcggctca atgcaaatct
     5041 ccagggttca atcgattctc ctgcctcacc ctcccatgta gctgggatta cagctgcctg
     5101 ccaaattttt gtatttttag tggaaccggg gtttcaccat gttggccagg ctggtcttga
     5161 actcctgacc tcaactgatc cgcccacctt ggcctcccaa gtgctgggat tacaggcgcg
     5221 agccacggcg cccagccttg aaaagatgtt tttagaacca gaagaaacct cggttcccac
     5281 tgatccttct gggccacgtt gtgcggagct cccctgctgg ttggggctca gcgcagcccc
     5341 agggaggtgc ttcctgcacc tcaggatggg cgagggtggg cattggggga gagggggacc
     5401 tgggacctgc ggcttagttc cctgaggcag gcagggctta ttggggccat ttcatagaaa
     5461 ggcagattga agctcagcag ggaagaggct tttgagggtg atccaggcgc tggagggatg
     5521 gcctaggaca ccagggtcac accaggaaca tgggagggcc gtgcttgtct ctagacgagg
     5581 ggaatggggg aagggccaca acctctgttt ctgtgaccca gcagcatcaa gcccctcgct
     5641 gggcacctcg cacacacccc ctgccttatc tctgcctgca cgccctgttc cctccaccta
     5701 gactgcctgc tgagggggca gtgccaggag gttgcctgtc cttggggaag aggggcagtg
     5761 accctgtgaa gatgcttgac agacaacccc caccacctca gaagtgtgtg tgagtggtga
     5821 acccttttaa gccatcttcc agccattctc actggaggga gatttgatgg gtacagagca
     5881 gacccctacc tgtctaccct ccttcggacc cctaggaagc ttcgcaggcc ttccaggctg
     5941 ccagacagct gccctggcgt tgccgtctgc ttcttccctg gccccactct gaggggctca
     6001 gagctgaggc agaatccctt tttcattcat ttcctgcaga ataaaacaac atacagaaaa
     6061 gtgaataaaa cataaatgca caacctaaca cactgttagg aagtgaacga tctgcaacca
     6121 ccatcaggaa atagttttgc cagcacccaa gtgccctccc ctcacagtgt cacttccggc
     6181 ctctctgccc tggcttatgt gagtcttgtg ttcttgtttt tctaaaaagt cttcagcacc
     6241 caattatgca ggcattgcag tattttcctg tttctgtgct ttatcccctt gaatcataca
     6301 gatgcaaatt ctggcagctg gcttctttgg ctcgttatta tgtctgtgag atttattcat
     6361 gttgctgtgc gtagtatagt ttgtgcatgt tcattgctaa aaacttccat tgtttggctg
     6421 tatcgtagtt cacagattca tttcactgtc agtcaagctt gtccaatgca tgcagcccag
     6481 gatgcctttg aatgtggccc aacacaaatt tgtaaacttt cttaaaacat tataaagatt
     6541 tttgtttgcg attttttttt ttagctcatc agctatagtt agtggtagtg tattttatgc
     6601 gtgacccgag acagttcttc cggtatggtc catggaagcc aaaagattgg acatgcctgc
     6661 tgtagatgga cagttggttt gtttctagtt tggggtaact acacacaatg ctgctagcaa
     6721 cagttttgtc catgtctctg atgcacgtgt gttttttgca aatggtgcac aaatttttct
     6781 agggtttgta ctcaggagtc tgactcctgg gttctagggt atgaagatct ttctaaatat
     6841 tgttctagtt tacgtgccca ccagcagtaa aacagaattc ccttgccttc ccatccttgg
     6901 cagacatttc acttttgcca gtctggtggg gtgtatagtt atggccttaa tttgcattta
     6961 gctaattacc aaggagattg agcatatttt tatgttttta ttaaccattt tgattttgtc
     7021 tcctgtgaag tgtctatcat cttttgccca ttttttaact tgttgtcttt ttctttttct
     7081 tttctttttt tttttttctg agacagggtc tcactctgtt gccctggctg gagtgcagtg
     7141 gtgcaatctc agctcactgc agccttgagt caggctcagg tgattctctc acctcagcct
     7201 cccaagtagc tgggaccaca ggcccacacc accaagccca gctaattttt tgtattttta
     7261 agtagagacg ggtttcatca tgttatgcag gctgctctca aactcttgag ctcaagcgat
     7321 ctgctggcct cagcctccca aagttgggat tataggcgtg agctaccaga ttttttctta
     7381 ttaatctaat aattctttgt atagtcttga tattatccat aatgtgtatt gcaaatatct
     7441 tctctaactc tggcttgact gtttatggtg tccttttttt ttgggggggg ttttttgaga
     7501 caaggtcttg ctctgtcacc caggctggag tgttatggca caatcttggc ttattgcagc
     7561 ctcaattcct aggcttaaac agtcctccca cctcagcctc ctgagtagcc ggaactacag
     7621 tcacgcactt ccatgtccag ataatttttt tttttttttt agagatagga tcttactatg
     7681 ccccagctgg tctcaaactc ctagactcaa tgagcctccc atcttgacct cccaaagtgc
     7741 tgggagtaca ggcatgagcc actgtgcatg ccagttctta tttttaatgc agttgaattg
     7801 atcagtgttt tcattttggt tagtgctttt tgtggcttaa gaaattcttt ccaggctggg
     7861 tacagtggct cacacctgta atgccagcac tttgggggca gaggcaggag gattacttga
     7921 gctcaggagt ttgagaccaa cctggacaac atggcgaaac accatctcta caaaaaatac
     7981 aaaaattagc tggacatggt ggtgcgtgcc tgtagtccca gctactcagg tggctggggt
     8041 gagaggattg cttgagccca gaaggtcaag gctgcagtga gctgtgattg tgccactgca
     8101 cttcagcctg tgagacagag tgagacccta tctcaaaaaa aaccaaaaaa aaaaaaaaaa
     8161 aaaagaaaac cactgaaatt atttccactc caaggtcatg aagatagtct cttagattat
     8221 attctgaaat ccttataaat gtaaatttca tatttaggcc tttaattcac ctagatttgg
     8281 ttttttgcat atggtgtgag gtaaggattc actttcattt ttttctctcc atagggttac
     8341 acacctgtcc tatcattgtt tgtaatctaa ctttctgcgc ccatctgcaa tgccacctct
     8401 gtcatatgtc cacatatgac atatgtagat ctgttgttgg attctttcct ctgttccatt
     8461 agtctgtctg ttcttgtgcc aatatcaagc tgtcttcatt attatcaatt atgtattgag
     8521 atctgataaa gtaagtcttt tccaccttat ttttcttctt tgagagtgtc ttgactattc
     8581 tggctctttg tattttcatg taaggttttt ctcccatata agttttaaaa tcagcttgtc
     8641 aattccaaca acaatgatgc acttgatagt ttgggaattt attatagcta tcaatcagtt
     8701 ttgggaaaat tgacgtcttt acaatattga gttttctgat tcatgaacat ggtttacctc
     8761 tctttccatt tgggtcttct ttaaggttta ccaataggat tttatatttt tgtccattgt
     8821 ggtcttgctt atcttaagtt tgatttgtaa atattttatg tttcttttag tctattgtaa
     8881 attgtgtatt tttaatttca tttttttttt tgttaatagc atataaaaca caccttgtct
     8941 tttaactgga gcattttgtc cattgtgtat ttaatgtaat taaatctacc atcttatttt
     9001 atgcta
//
