LOCUS       NM_031286                751 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SH3 domain binding glutamate rich protein like 3
            (SH3BGRL3), mRNA.
ACCESSION   NM_031286
VERSION     NM_031286.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 751)
  AUTHORS   Di Pisa,F., Pesenti,E., Bono,M., Mazzarello,A.N., Bernardi,C.,
            Lisanti,M.P., Renzone,G., Scaloni,A., Ciccone,E., Fais,F.,
            Bruno,S., Scartezzini,P. and Ghiotto,F.
  TITLE     SH3BGRL3 binds to myosin 1c in a calcium dependent manner and
            modulates migration in the MDA-MB-231 cell line
  JOURNAL   BMC Mol Cell Biol 22 (1), 41 (2021)
   PUBMED   34380438
  REMARK    GeneRIF: SH3BGRL3 binds to myosin 1c in a calcium dependent manner
            and modulates migration in the MDA-MB-231 cell line.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 751)
  AUTHORS   Nie,Z., Cheng,D., Pan,C., Wei,Z., Wang,C. and Wang,C.
  TITLE     SH3BGRL3, transcribed by STAT3, facilitates glioblastoma
            tumorigenesis by activating STAT3 signaling
  JOURNAL   Biochem Biophys Res Commun 556, 114-120 (2021)
   PUBMED   33839406
  REMARK    GeneRIF: SH3BGRL3, transcribed by STAT3, facilitates glioblastoma
            tumorigenesis by activating STAT3 signaling.
REFERENCE   3  (bases 1 to 751)
  AUTHORS   Li,H., Zhang,M., Wei,Y., Haider,F., Lin,Y., Guan,W., Liu,Y.,
            Zhang,S., Yuan,R., Yang,X., Yang,S. and Wang,H.
  TITLE     SH3BGRL confers innate drug resistance in breast cancer by
            stabilizing HER2 activation on cell membrane
  JOURNAL   J Exp Clin Cancer Res 39 (1), 81 (2020)
   PUBMED   32381043
  REMARK    GeneRIF: SH3BGRL confers innate drug resistance in breast cancer by
            stabilizing HER2 activation on cell membrane.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 751)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 751)
  AUTHORS   Chiang,C.Y., Pan,C.C., Chang,H.Y., Lai,M.D., Tzai,T.S., Tsai,Y.S.,
            Ling,P., Liu,H.S., Lee,B.F., Cheng,H.L., Ho,C.L., Chen,S.H. and
            Chow,N.H.
  TITLE     SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial
            Carcinoma: A Novel Binding Partner of Epidermal Growth Factor
            Receptor
  JOURNAL   Clin Cancer Res 21 (24), 5601-5611 (2015)
   PUBMED   26286913
  REMARK    GeneRIF: SH3BGRL3 is a novel urinary biomarker for urothelial
            carcinoma. Evaluation of SH3BGRL3 expression status may identify a
            subset of patients with urothelial carcinoma for cotargeting
            candidates in the design of EGFR-based cancer therapies.
REFERENCE   6  (bases 1 to 751)
  AUTHORS   Mazzocco,M., Arrigo,P., Egeo,A., Maffei,M., Vergano,A., Di Lisi,R.,
            Ghiotto,F., Ciccone,E., Cinti,R., Ravazzolo,R. and Scartezzini,P.
  TITLE     A novel human homologue of the SH3BGR gene encodes a small protein
            similar to Glutaredoxin 1 of Escherichia coli
  JOURNAL   Biochem Biophys Res Commun 285 (2), 540-545 (2001)
   PUBMED   11444877
REFERENCE   7  (bases 1 to 751)
  AUTHORS   Henn,A.D., Berleth,E.S., Mihich,E. and Ehrke,M.J.
  TITLE     Changes in cytosolic and membrane TNF inhibitory protein-B1
            (TIP-B1) levels associated with protection from TNF-induced
            cytotoxicity
  JOURNAL   FASEB J 15 (7), 1315-1317 (2001)
   PUBMED   11344125
REFERENCE   8  (bases 1 to 751)
  AUTHORS   Seo,J., Kim,M. and Kim,J.
  TITLE     Identification of novel genes differentially expressed in
            PMA-induced HL-60 cells using cDNA microarrays
  JOURNAL   Mol Cells 10 (6), 733-739 (2000)
   PUBMED   11211881
REFERENCE   9  (bases 1 to 751)
  AUTHORS   Berleth,E.S., Henn,A.D., Gurtoo,H.L., Wollman,R., Alderfer,J.L.,
            Mihich,E. and Ehrke,M.J.
  TITLE     A novel tumor necrosis factor-alpha inhibitory protein, TIP-B1
  JOURNAL   Int J Immunopharmacol 22 (12), 1137-1142 (2000)
   PUBMED   11137621
REFERENCE   10 (bases 1 to 751)
  AUTHORS   Berleth,E.S., Nadadur,S., Henn,A.D., Eppolito,C., Shiojiri,S.,
            Gurtoo,H.L., Ehrke,M.J. and Mihich,E.
  TITLE     Identification, characterization, and cloning of TIP-B1, a novel
            protein inhibitor of tumor necrosis factor-induced lysis
  JOURNAL   Cancer Res 59 (21), 5497-5506 (1999)
   PUBMED   10554026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030135.2.
            
            On Nov 22, 2018 this sequence version replaced NM_031286.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.138792.1, BC030135.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270792.10/ ENSP00000270792.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               BC030135.2         134-737
            605-751             BC030135.2         739-885
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..751
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /note="SH3 domain binding glutamate rich protein like 3"
                     /db_xref="GeneID:83442"
                     /db_xref="HGNC:HGNC:15568"
                     /db_xref="MIM:615679"
     exon            1..118
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..352
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /note="TNF inhibitory protein; SH3BGRL3-like protein; SH3
                     domain-binding protein 1; epididymis secretory protein Li
                     297; SH3 domain binding glutamic acid-rich protein like 3;
                     epididymis secretory sperm binding protein; TNF inhibitory
                     protein B1"
                     /codon_start=1
                     /product="SH3 domain-binding glutamic acid-rich-like
                     protein 3"
                     /protein_id="NP_112576.1"
                     /db_xref="CCDS:CCDS278.1"
                     /db_xref="GeneID:83442"
                     /db_xref="HGNC:HGNC:15568"
                     /db_xref="MIM:615679"
                     /translation="MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDN
                     ALRDEMRALAGNPKATPPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA"
     exon            119..286
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..751
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /note="hexamer: ATTAAA"
     polyA_site      751
                     /gene="SH3BGRL3"
                     /gene_synonym="HEL-S-297; SH3BP-1; TIP-B1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtctccc ggcagtgcag ctgccgctac cgccgccctc tgcccgccgg cccgtctgtc
       61 tacccccagc atgagcggcc tgcgcgtcta cagcacgtcg gtcaccggct cccgcgaaat
      121 caagtcccag cagagcgagg tgacccgaat cctggatggg aagcgcatcc aataccagct
      181 agtggacatc tcccaggaca acgccctgag ggatgagatg cgagccttgg caggcaaccc
      241 caaggccacc ccaccccaga ttgtcaacgg ggaccagtac tgtggggact atgagctctt
      301 cgtggaggct gtggaacaaa acacgctgca ggagttcctg aagctggctt gagtcaagcc
      361 tgtccagagt tcccctgctg gactccatca ccacactccc cccagccttc acctggccat
      421 gaaggacctt ttgaccaact ccctgtcatt cctaacctaa ccttagagtc cctcccccaa
      481 tgcaggccac ttctcctccc tcctctctaa atgtagtccc ctctcctcca tctaaaggca
      541 acattcctta cccattagtc tcagaaattg tcttaagcaa cagccccaaa tgctggctgc
      601 ccccagccaa gcattggggc cgccatcctg cctggcactg gctgatgggc acctctgttg
      661 gttccatcag ccagagctct gccaaaggcc ccgcagtccc tctcccagga ggaccctaga
      721 ggcaattaaa tgatgtcctg ttccattggc a
//
