LOCUS       NM_031469               4603 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SH3 domain binding glutamate rich protein like 2
            (SH3BGRL2), transcript variant 1, mRNA.
ACCESSION   NM_031469
VERSION     NM_031469.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4603)
  AUTHORS   Nie,Z., Cai,S., Wei,Z., Li,Y., Bian,L., Wang,C. and Wang,C.
  TITLE     SH3BGRL2 functions as a crucial tumor suppressor in glioblastoma
            tumorigenesis
  JOURNAL   Biochem Biophys Res Commun 547, 148-154 (2021)
   PUBMED   33610914
  REMARK    GeneRIF: SH3BGRL2 functions as a crucial tumor suppressor in
            glioblastoma tumorigenesis.
REFERENCE   2  (bases 1 to 4603)
  AUTHORS   Majewska,M., Lipka,A., Paukszto,L., Jastrzebski,J.P.,
            Gowkielewicz,M., Jozwik,M. and Majewski,M.K.
  TITLE     Preliminary RNA-Seq Analysis of Long Non-Coding RNAs Expressed in
            Human Term Placenta
  JOURNAL   Int J Mol Sci 19 (7), 1894 (2018)
   PUBMED   29954144
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4603)
  AUTHORS   Lemaitre,R.N., King,I.B., Kabagambe,E.K., Wu,J.H., McKnight,B.,
            Manichaikul,A., Guan,W., Sun,Q., Chasman,D.I., Foy,M., Wang,L.,
            Zhu,J., Siscovick,D.S., Tsai,M.Y., Arnett,D.K., Psaty,B.M.,
            Djousse,L., Chen,Y.D., Tang,W., Weng,L.C., Wu,H., Jensen,M.K.,
            Chu,A.Y., Jacobs,D.R. Jr., Rich,S.S., Mozaffarian,D., Steffen,L.,
            Rimm,E.B., Hu,F.B., Ridker,P.M., Fornage,M. and Friedlander,Y.
  TITLE     Genetic loci associated with circulating levels of very long-chain
            saturated fatty acids
  JOURNAL   J Lipid Res 56 (1), 176-184 (2015)
   PUBMED   25378659
REFERENCE   4  (bases 1 to 4603)
  AUTHORS   Edwards,D.R., Gilbert,J.R., Hicks,J.E., Myers,J.L., Jiang,L.,
            Cummings,A.C., Guo,S., Gallins,P.J., Konidari,I., Caywood,L.,
            Reinhart-Mercer,L., Fuzzell,D., Knebusch,C., Laux,R., Jackson,C.E.,
            Pericak-Vance,M.A., Haines,J.L. and Scott,W.K.
  TITLE     Linkage and association of successful aging to the 6q25 region in
            large Amish kindreds
  JOURNAL   Age (Dordr) 35 (4), 1467-1477 (2013)
   PUBMED   22773346
REFERENCE   5  (bases 1 to 4603)
  AUTHORS   Kasperaviciute,D., Catarino,C.B., Heinzen,E.L., Depondt,C.,
            Cavalleri,G.L., Caboclo,L.O., Tate,S.K., Jamnadas-Khoda,J.,
            Chinthapalli,K., Clayton,L.M., Shianna,K.V., Radtke,R.A.,
            Mikati,M.A., Gallentine,W.B., Husain,A.M., Alhusaini,S.,
            Leppert,D., Middleton,L.T., Gibson,R.A., Johnson,M.R.,
            Matthews,P.M., Hosford,D., Heuser,K., Amos,L., Ortega,M.,
            Zumsteg,D., Wieser,H.G., Steinhoff,B.J., Kramer,G., Hansen,J.,
            Dorn,T., Kantanen,A.M., Gjerstad,L., Peuralinna,T., Hernandez,D.G.,
            Eriksson,K.J., Kalviainen,R.K., Doherty,C.P., Wood,N.W.,
            Pandolfo,M., Duncan,J.S., Sander,J.W., Delanty,N., Goldstein,D.B.
            and Sisodiya,S.M.
  TITLE     Common genetic variation and susceptibility to partial epilepsies:
            a genome-wide association study
  JOURNAL   Brain 133 (Pt 7), 2136-2147 (2010)
   PUBMED   20522523
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 4603)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 4603)
  AUTHORS   Mazzocco,M., Maffei,M., Egeo,A., Vergano,A., Arrigo,P., Di Lisi,R.,
            Ghiotto,F. and Scartezzini,P.
  TITLE     The identification of a novel human homologue of the SH3 binding
            glutamic acid-rich (SH3BGR) gene establishes a new family of highly
            conserved small proteins related to Thioredoxin Superfamily
  JOURNAL   Gene 291 (1-2), 233-239 (2002)
   PUBMED   12095696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF340151.1, AJ297972.1 and DR422465.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031469.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070059.1, SRR1660805.109650.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369838.6/ ENSP00000358853.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1055              AF340151.1         47-1101
            1056-2742           AJ297972.1         921-2607
            2743-4599           AF340151.1         2789-4645
            4600-4603           DR422465.1         661-664
FEATURES             Location/Qualifiers
     source          1..4603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..4603
                     /gene="SH3BGRL2"
                     /note="SH3 domain binding glutamate rich protein like 2"
                     /db_xref="GeneID:83699"
                     /db_xref="HGNC:HGNC:15567"
                     /db_xref="MIM:615678"
     exon            1..178
                     /gene="SH3BGRL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..457
                     /gene="SH3BGRL2"
                     /note="fovea-associated SH3 domain-binding protein; SH3
                     domain binding glutamic acid-rich protein like 2"
                     /codon_start=1
                     /product="SH3 domain-binding glutamic acid-rich-like
                     protein 2"
                     /protein_id="NP_113657.1"
                     /db_xref="CCDS:CCDS4991.1"
                     /db_xref="GeneID:83699"
                     /db_xref="HGNC:HGNC:15567"
                     /db_xref="MIM:615678"
                     /translation="MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEE
                     QRQWMYKNVPPEKKPTQGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLKPRLA
                     SKAEP"
     exon            179..364
                     /gene="SH3BGRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..445
                     /gene="SH3BGRL2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..4603
                     /gene="SH3BGRL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BGRL2"
                     /note="hexamer: AATAAA"
     polyA_site      3456
                     /gene="SH3BGRL2"
                     /note="major polyA site"
     regulatory      4583..4588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BGRL2"
                     /note="hexamer: AATAAA"
     polyA_site      4603
                     /gene="SH3BGRL2"
                     /note="major polyA site"
ORIGIN      
        1 agatcccagc gatcttcccc gacggcagcg ctttacccag aggctgccgg cggctcgtag
       61 ctgggttcag ctctgcgtcc acgccagccc ggagcccggg gggcaagggg tctgtcccgg
      121 gcgcagcgag aggatggtca tccgcgtgtt catcgcctct tcctcgggct tcgtggcgat
      181 aaagaagaag cagcaagatg tggttagatt tctggaagcc aacaagatag agtttgagga
      241 ggtggatatc acaatgtcag aagaacagag gcaatggatg tacaaaaacg tccccccgga
      301 aaagaaaccc actcagggca accccctgcc acctcagata tttaatggcg accgatactg
      361 tggagattat gacagttttt ttgaatccaa ggaaagcaac acagtctttt catttttagg
      421 cctgaaacca cggttggcat caaaggcaga accttagaga agaagagtgg aagatgacgg
      481 agatgcattt tgaagcaccc ctggtactca gcacacacat gcttacctaa tgcatcactg
      541 tgacaaaagc cacacgcatt atcagtaact ttgcttgcca cggaaaaggt gtttttgaaa
      601 gatgtggcta taatgagaat tgcatgattg ctttaaacca aatcaggtgg tggatttttt
      661 ttttcttatt ctatttgcct gcagttgcct cactcacctg gaaataccgt cacctgttac
      721 aggtgtactt tcttaatgac tgaaagataa gtgggtagca ccgtcagaga gaaaatgttg
      781 gatctgccct aggttatagt agatgccgga attgcgtaaa cccacttctc tttaagctgc
      841 ctggattgca cctttgaaat atgtctgcca agttgttaga atctttgaat cagaaggaaa
      901 aaaagcagcg ctggttgaca aagggtgttg aagatttttg ctgcagaatc agttacaaac
      961 atcacagttc ccatgctttg taataacacc tggtgaaaaa gttagatatt ctagacttgt
     1021 tttagtaatg gaaactctta cctccacata ttatcctaca gatgtttcca gaaatccctg
     1081 ttgtaacatc aagtgatcag aactaagtta ctgggatgac aataattgct atttgaaata
     1141 tatgcttctt tatttcttgc aaggggcaag tttcacccaa atgcctgaga ctgcttgaaa
     1201 gatatatttt aagtggtgca ctaattagtg aatatatagg aaaattatct gacgagtatc
     1261 tgaaggcatt ttcagctcta gcaatttatt tataatatat aagttcatat attttttaat
     1321 ccagctcccc taacagacag ctgctgcttc tattttgtga agggactata ttttttgaga
     1381 aaggaaaatc tcagttagat atattttgtg aacccttgat tagacatatt aaaatatacc
     1441 aatgttgtag taaaatttaa tttttccttt tgttactttt catttgcctc taattttgct
     1501 tgctcatatt tctggccaat gtacagcctc atatttttca gagtaataca gatacttgtt
     1561 ctcattccgt atatgagcac aagtaaggtt tcagagcaac acacatgaga aagagagtaa
     1621 cccggaattg tacttgtcaa gcaaaatcta tactcctatt ggagtggatg ctgatgaaca
     1681 tcgaacatat ctacttcatt agagcagagg ctatttttct gcattcttgt ccctataaca
     1741 gggatgctta attttttttt taacttagag ttttaaattg ccaaacatgg gaacagcctt
     1801 gaataggata aattttcaga gggctgccta aaatatttta tttctagcat cctgattctg
     1861 gacttttcat tataattctg agcaggaaat ttataagaaa ttgaaagagc agaagaatta
     1921 cagccctgtc acatgtgccc agcactccgc cccatgcctt gctaaatgta gactaaagaa
     1981 cttgttgaat gctaaggctg aaatcccaac ctgagatttg tagtccagga ttacaaccag
     2041 aaggaaagta tgacagattt ctacttaact agaatggaca catgatccac aattttctct
     2101 tcaagggaag ctgttgtcaa attatggata ttactggtta gttgtcatta agtaagatcc
     2161 aggtcaaatt ccatttgaca aatcccaggg actatccagg aatttttttt taactggata
     2221 ttgtgtttga gtatgtgagt cttctgataa aactcagaat ttctttttaa gcagttgtaa
     2281 aaattgtcat gttgtaattc attactcagc taacatttag tctactcttg ctagtgagtg
     2341 ccaagaacca acttggtaag gttgaggctt tgcaagttaa ctgctggggt tataggatca
     2401 ataccatact tgctagacaa agctacccag atttgtctta tattataatt tttgagttaa
     2461 ccgtagtata cctattatga ttatagtaaa cagactagtg ggtagtaatg ctaaattacc
     2521 atcacagtta tgtgccatct ccccacccca tttttttttt tttttttttg atcagcaaag
     2581 aaatacagga gaccagtctc gagtggtgct gtacttgtta tgagtgaggc agcagcacag
     2641 tgtgtggcat ttacatggta cccaggctcc acagagtacc aagatgttgc cctctgggac
     2701 cacacttagc tcagagaata tggggtcctt acttgtattc ttttatcagc tgattttgaa
     2761 acatataata atgattttct tgttcccttc tttaactagc tgcctttaga ttttgataat
     2821 cacagtctta aaatactagg aaagaagtgg atgggaattg taggcataga tttcatatca
     2881 agggcatttc aagacagaat ttttatttcc tgtagtaggc ttgctggagc aaaggaaatg
     2941 tgctgctaaa aatcaactta tgccatttta aaattagata aaatatggag tgccatcctg
     3001 ctaggtgagt acagaccaga agaaaattta gttgggaaaa tacttgtttt tccaaattcc
     3061 ggtgttttat tacaatcaaa gaagaggaaa gcaaggtatt ttttcacctc agattctaat
     3121 atattctaga tttgtttctg ttttatagat ttaattcaat acctccacat agatgttttt
     3181 atattacatg aatttaataa taaactaaac ttttttttgt ctcccgttat tgaaaagtac
     3241 caaagcttct ttctgttgtg tttgatttta ctataggggt tttgcttttt ctagagatac
     3301 ttttcattta acagcttttg ttaagtgtca ggctgcactt tgctccatat aattattgtt
     3361 ttcagatttc aacttgtatg tgtttgtctc ttaaagcatt ggtgaaatca catattttat
     3421 attcagcata aaggagaata aattccagaa aacacatatt ctgaaaatgg agtgtttgtt
     3481 ccctgccatt tttcacacct ctcttaattt tagttctgtt tagttgagag gctgtgattt
     3541 tactcttgcc tgtgaacctc atgcatgaaa gcagcacatt aaattgtaaa aatacaaaca
     3601 gatcgtgtga tcattcaagg agccagacat gaggtcctgc acgagggtgt tgggaggaca
     3661 ccacagattc atctcagaca gtgatcagga ctgaggatgg agttaaatca ctcagcccct
     3721 gggtggggtg gggtggttca aatggatgac tgatctcctg agtacactga agccacaggc
     3781 tggtggccat gttctctgaa ttgggtgcag aagacaaggg cagagtggct gcggccccta
     3841 ttacctttgt agcagccaca tcagaaagca gaagaaaaca gtatttctga aggcattgtt
     3901 tgaggttgat ctcagcactg aacgatttca agccctacgc accagaacag aaggagggtg
     3961 gaggaagtga tcagagggaa cgagctgtag gtttgcagaa atgtgtgaaa ccaaaatgat
     4021 cactgcctac ttgtgattca aatcttcaga gttttcctag ttcttctaga aatacatgtc
     4081 aggtttgttt gttcatcctt tctgtcagca tggatcaagc ccctaaaatg tggtaagtgt
     4141 tgtcagagca gggcaatatc tctactctca agtatgaggg gaatagaaac aaagcagcag
     4201 ttttagccag ggttcaatga tagagtggag gtaaattaag agcctccagg ctgtgattca
     4261 ccatttgaga cattatacat aatttgtttt tgttataagc catttgaatt tttaaaaaat
     4321 ttcatacatg caatggaata tagatatgta tatacacata taatatatat gctaaagtat
     4381 aaagagtaat aataatgaca ataaacaaac ccctgtgtgc ctaccaccca ccttattgcc
     4441 tttcctttga ggtaccgtgt gcggtttcct gaacctatct ctatccctgt ctgatagagg
     4501 gaacccctgt actgaacttt gtgttgacca tagccttctt gtctttcatc actttatctc
     4561 catgtatgta tccttaaaga ataataaatg gaattaaact gaa
//
