LOCUS       NM_003022               1764 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SH3 domain binding glutamate rich protein like
            (SH3BGRL), mRNA.
ACCESSION   NM_003022
VERSION     NM_003022.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1764)
  AUTHORS   Liang,X., Huang,Y., Li,D., Yang,X., Jiang,L., Zhou,W., Su,J.,
            Chen,N. and Wang,W.
  TITLE     Distinct functions of CAR-T cells possessing a dectin-1
            intracellular signaling domain
  JOURNAL   Gene Ther 30 (5), 411-420 (2023)
   PUBMED   33953316
  REMARK    GeneRIF: Distinct functions of CAR-T cells possessing a dectin-1
            intracellular signaling domain.
REFERENCE   2  (bases 1 to 1764)
  AUTHORS   Zhang,S., Liu,X., Abdulmomen Ali Mohammed,S., Li,H., Cai,W.,
            Guan,W., Liu,D., Wei,Y., Rong,D., Fang,Y., Haider,F., Lv,H.,
            Jin,Z., Chen,X., Mo,Z., Li,L., Yang,S. and Wang,H.
  TITLE     Adaptor SH3BGRL drives autophagy-mediated chemoresistance through
            promoting PIK3C3 translation and ATG12 stability in breast cancers
  JOURNAL   Autophagy 18 (8), 1822-1840 (2022)
   PUBMED   34870550
  REMARK    GeneRIF: Adaptor SH3BGRL drives autophagy-mediated chemoresistance
            through promoting PIK3C3 translation and ATG12 stability in breast
            cancers.
REFERENCE   3  (bases 1 to 1764)
  AUTHORS   Chen,X., Liu,F., Rong,D., Xu,L., Tong,X. and Wang,H.
  TITLE     Decitabine Enhances Acute Myeloid Leukemia Cell Apoptosis through
            SH3BGRL Upregulation
  JOURNAL   Anticancer Agents Med Chem 22 (12), 2274-2281 (2022)
   PUBMED   34963436
  REMARK    GeneRIF: Decitabine Enhances Acute Myeloid Leukemia Cell Apoptosis
            through SH3BGRL Upregulation.
REFERENCE   4  (bases 1 to 1764)
  AUTHORS   Zhang,S., Guo,X., Liu,X., Zhong,Z., Yang,S. and Wang,H.
  TITLE     Adaptor SH3BGRL promotes breast cancer metastasis through PFN1
            degradation by translational STUB1 upregulation
  JOURNAL   Oncogene 40 (38), 5677-5690 (2021)
   PUBMED   34331014
  REMARK    GeneRIF: Adaptor SH3BGRL promotes breast cancer metastasis through
            PFN1 degradation by translational STUB1 upregulation.
            Erratum:[Oncogene. 2022 Feb;41(8):1227. doi:
            10.1038/s41388-021-02129-1.. PMID: 34930999]
REFERENCE   5  (bases 1 to 1764)
  AUTHORS   Xu,L., Zhang,M., Li,H., Guan,W., Liu,B., Liu,F., Wang,H., Li,J.,
            Yang,S., Tong,X. and Wang,H.
  TITLE     SH3BGRL as a novel prognostic biomarker is down-regulated in acute
            myeloid leukemia
  JOURNAL   Leuk Lymphoma 59 (4), 918-930 (2018)
   PUBMED   28679293
  REMARK    GeneRIF: Study results demonstrated that SH3BGRL is a novel crucial
            player in acute myeloid leukemia progression and could be both a
            potential diagnostic and prognostic marker.
REFERENCE   6  (bases 1 to 1764)
  AUTHORS   Yin,L., Xiang,Y., Zhu,D.Y., Yan,N., Huang,R.H., Zhang,Y. and
            Wang,D.C.
  TITLE     Crystal structure of human SH3BGRL protein: the first structure of
            the human SH3BGR family representing a novel class of thioredoxin
            fold proteins
  JOURNAL   Proteins 61 (1), 213-216 (2005)
   PUBMED   16080146
  REMARK    GeneRIF: h-SH3BGRL should present a novel class of the thioredoxin
            fold proteins
REFERENCE   7  (bases 1 to 1764)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 1764)
  AUTHORS   Egeo,A., Mazzocco,M., Arrigo,P., Vidal-Taboada,J.M., Oliva,R.,
            Pirola,B., Giglio,S., Rasore-Quartino,A. and Scartezzini,P.
  TITLE     Identification and characterization of a new human gene encoding a
            small protein with high homology to the proline-rich region of the
            SH3BGR gene
  JOURNAL   Biochem Biophys Res Commun 247 (2), 302-306 (1998)
   PUBMED   9642120
REFERENCE   9  (bases 1 to 1764)
  AUTHORS   Drutel,G., Arrang,J.M., Diaz,J., Wisnewsky,C., Schwartz,K. and
            Schwartz,J.C.
  TITLE     Cloning of OL1, a putative olfactory receptor and its expression in
            the developing rat heart
  JOURNAL   Recept Channels 3 (1), 33-40 (1995)
   PUBMED   8589991
REFERENCE   10 (bases 1 to 1764)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC103762.1 and CN272007.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003022.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103762.1, SRR3476690.358160.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373212.6/ ENSP00000362308.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-946               BC103762.1         124-1069
            947-1438            CN272007.1         142-633
            1439-1764           BC103762.1         1562-1887
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..1764
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /note="SH3 domain binding glutamate rich protein like"
                     /db_xref="GeneID:6451"
                     /db_xref="HGNC:HGNC:10823"
                     /db_xref="MIM:300190"
     exon            1..144
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..444
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /note="SH3-binding domain glutamic acid-rich protein like;
                     SH3 domain-binding glutamic acid-rich-like protein;
                     epididymis secretory protein Li 115; SH3 domain binding
                     glutamic acid-rich protein like; SH3 domain-binding
                     glutamic acid-rich-like protein 1"
                     /codon_start=1
                     /product="adapter SH3BGRL"
                     /protein_id="NP_003013.1"
                     /db_xref="CCDS:CCDS14449.1"
                     /db_xref="GeneID:6451"
                     /db_xref="HGNC:HGNC:10823"
                     /db_xref="MIM:300190"
                     /translation="MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEE
                     NRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPG
                     SKEAEVQAKQQA"
     exon            145..330
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            331..411
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            412..1764
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /note="hexamer: AATAAA"
     polyA_site      1764
                     /gene="SH3BGRL"
                     /gene_synonym="HEL-S-115; SH3BGR"
                     /note="major polyA site"
ORIGIN      
        1 gccaaccgct gtttcagccc ctagctggat tccagccatt gctgcagctg ctccacagcc
       61 cttttcagga cccaaacaac cgcagccgct gttcccagga tggtgatccg tgtatatatt
      121 gcatcttcct ctggctctac agcgattaag aagaaacaac aagatgtgct tggtttccta
      181 gaagccaaca aaataggatt tgaagaaaaa gatattgcag ccaatgaaga gaatcggaag
      241 tggatgagag aaaatgtacc tgaaaatagt cgaccagcca caggttaccc cctgccacct
      301 cagattttca atgaaagcca gtatcgcggg gactatgatg ccttctttga agccagagaa
      361 aataatgcag tgtatgcctt cttaggcttg acagccccac ctggttcaaa ggaagcagaa
      421 gtgcaagcaa agcagcaagc atgaacctta agcactgtgc tttaagcatc ctgaaaaatg
      481 agtctccatt gcttttataa aatagcagaa ttagctttgc ttcaaaagaa ataggcttaa
      541 tgttgaaata atagattagt tgggttttca catgcaaaca ttcaaaatga atacaaaatt
      601 aaaatttgaa cattatggtg attatggtga ggagaatggg atattaacat aaaattatat
      661 taataagtag atatcgtaga aatagtgttg ttacctgcca agccatcctg tatacaccaa
      721 tgattttaca aagaaaacac ccttccctcc ttctgccatt actatggcaa cttaagtgta
      781 tctgcagctc tacattaaaa aggagaaaga gaaataacct gtctctcatt cctaagttgc
      841 ctcattaatt ttcatgaaca agaatatgta cctttttgat gctatattac tgcgattaaa
      901 aagttcttgc aggtaatgtt tatgatatgt taaacgttgt aatttcctat cgtaattata
      961 acattcccat tcttttgtag atgaaacttc tacatattga accacagatt ttctgagctt
     1021 ctaaatgtag cctttcattg cacatttcag tgatcagaat agatatcctt ttacacgcac
     1081 aaaagcaata gattcattca gtggacaagt tccttgttta actacacagc tatgatggaa
     1141 tgatatatcc aagttccttg cctcagtgaa atatgcatat gtatatcatg aaagtgggat
     1201 gccaagtaag cttaaaatgg cattctctag caaagagatt agacttttaa ataactctta
     1261 taaaacaggt tggcgatcat ttcccaagat tggtttccct tgagtttttg ctaaaacaaa
     1321 tcttagtagt tttgcccgtt taaaacaact cacaatcgta aatgctacta ttcctaagat
     1381 atcttacctt tttatttcag tttagccatg tattgtatga gtgtattagt ctaagcagtg
     1441 agaatctttt ctatgcctct attccagcaa aaagtagaag tatcaaataa aaagggcaac
     1501 ttttaaaata ttaagcctga agacttctaa aaagacaaga aacatggcct aaataaccaa
     1561 catagattta catagtaagt ttcacactac cttattacca aaagcaaaca cctcttactt
     1621 taaactacat tatcatgtat atctattgta tgctggtctt tactttttgc caaaatcaac
     1681 atataatgaa gagatgcctt tgtttcatga gattcaaact tgatgctatg ctttaaaata
     1741 aactcagtac ttttagaaac ataa
//
