LOCUS       NM_001103161            3898 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SH2 domain containing 5 (SH2D5), transcript variant 1,
            mRNA.
ACCESSION   NM_001103161 XM_375698 XM_939275
VERSION     NM_001103161.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3898)
  AUTHORS   Zhou,H., Li,S. and Lin,Y.
  TITLE     Prognostic significance of SH2D5 expression in lung adenocarcinoma
            and its relation to immune cell infiltration
  JOURNAL   PeerJ 11, e15238 (2023)
   PUBMED   37187527
  REMARK    GeneRIF: Prognostic significance of SH2D5 expression in lung
            adenocarcinoma and its relation to immune cell infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3898)
  AUTHORS   Zheng,Y., Ming,P., Zhu,C., Si,Y., Xu,S., Chen,A., Wang,J. and
            Zhang,B.
  TITLE     Hepatitis B virus X protein-induced SH2 domain-containing 5 (SH2D5)
            expression promotes hepatoma cell growth via an SH2D5-transketolase
            interaction
  JOURNAL   J Biol Chem 294 (13), 4815-4827 (2019)
   PUBMED   30659097
  REMARK    GeneRIF: results suggest that SH2D5 is an HBV-induced protein
            capable of binding to TKT, leading to induction of HCC cell
            proliferation.
REFERENCE   3  (bases 1 to 3898)
  AUTHORS   Gray,E.J., Petsalaki,E., James,D.A., Bagshaw,R.D., Stacey,M.M.,
            Rocks,O., Gingras,A.C. and Pawson,T.
  TITLE     Src homology 2 domain containing protein 5 (SH2D5) binds the
            breakpoint cluster region protein, BCR, and regulates levels of
            Rac1-GTP
  JOURNAL   J Biol Chem 289 (51), 35397-35408 (2014)
   PUBMED   25331951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663074.13, AK124869.1 and DC382086.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001103161.1.
            
            Transcript Variant: This variant (1) includes an alternate exon and
            encodes a predicted protein isoform (1) with a longer N-terminus
            compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.61523.1,
                                           SRR1660807.98835.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444387.7/ ENSP00000406026.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL663074.13        61372-61434         c
            64-477              AK124869.1         1-414
            478-1044            DC382086.1         1-567
            1045-1125           AK124869.1         853-933
            1126-1126           AL663074.13        53196-53196         c
            1127-1245           AK124869.1         935-1053
            1246-1246           AL663074.13        52932-52932         c
            1247-2396           AK124869.1         1055-2204
            2397-2397           AL663074.13        49963-49963         c
            2398-2717           AK124869.1         2206-2525
            2718-2718           AL663074.13        49642-49642         c
            2719-3029           AK124869.1         2527-2837
            3030-3030           AL663074.13        49330-49330         c
            3031-3897           AK124869.1         2839-3705
            3898-3898           AL663074.13        48462-48462         c
FEATURES             Location/Qualifiers
     source          1..3898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..3898
                     /gene="SH2D5"
                     /note="SH2 domain containing 5"
                     /db_xref="GeneID:400745"
                     /db_xref="HGNC:HGNC:28819"
     exon            1..523
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            524..652
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..1837
                     /gene="SH2D5"
                     /note="isoform 1 is encoded by transcript variant 1; SH2
                     domain-containing protein 5"
                     /codon_start=1
                     /product="SH2 domain-containing protein 5 isoform 1"
                     /protein_id="NP_001096631.1"
                     /db_xref="CCDS:CCDS44080.1"
                     /db_xref="GeneID:400745"
                     /db_xref="HGNC:HGNC:28819"
                     /translation="MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQES
                     VWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADC
                     QFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPC
                     PGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEG
                     RARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPR
                     GPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSV
                     RTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLDMGRLNPTY
                     EEQDCGPPGRPPRTLRPLSHAKSEAELQGLG"
     exon            653..733
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            734..808
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            809..955
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1195
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1364
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1473
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1633
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..3898
                     /gene="SH2D5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3880..3885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D5"
                     /note="hexamer: AATAAA"
     polyA_site      3898
                     /gene="SH2D5"
                     /note="major polyA site"
ORIGIN      
        1 agttcccggc tgagaacgtc ccggcaggaa gaaagtgagg aggaggatgc gcaacgaccc
       61 tccactcaca agggccgggc ccgaaccacc ctgagcgcct cctccgagcc aggctcgatc
      121 cttcacactg ggaacggaga cactccggtc cagtgtcact tgtcctcgag taagaggaga
      181 gggatgacag gcgagcaacg gagtcacaag ggctctgcag agaatgaagc gtgagtggtg
      241 gtcgtggaag gcttcccgga ggaggcggtg cggtagccgc ggctcggatg acgcggagga
      301 gccagccaga gaggggaggg gcagaggccc tccaggagga gggacccgtg agtgaggcgc
      361 gggggattca gcgcccccag cccgggagga ggtgccttct gagctccggg cgagcccctc
      421 ccgcccttcc aggcggagcg ccgggcgtgg gcagtgccag ggcccctcgc ggccgctgat
      481 tgggtggtgc ggccgagcgg agcggctccg cgggcgccga ttgcctcccc tcccgtggag
      541 ctggaagcca ggcaccctgg gggccatgca gaaggcgggg gctgggggcc gcagggcctc
      601 tgactgcggg ctggcccctc accggcccag gtgcatcacc aagtttgccc agtacgtggg
      661 ctccttccct gtggatgacc tggacaccca ggagagcgtg tggctggtgc agcagcagct
      721 gtgggcgctg aaggactgtc cccgacgccg ggccgtcatc ctgaaattca gccttcaggg
      781 tctcaagatc tacagcgggg agggtgaggt gctgctgatg gctcatgccc tgaggcgcat
      841 actctactcc acctggtgcc ctgccgactg ccagtttgcc ttcatggctc gaaacccacg
      901 gagcccagcc agcaagctct tctgccacct ctttgtgggc agccagccag gagaggtcca
      961 gatcctgcac ctgctgctgt gccgctcttt ccagctggct tacctcttgc agcaccctga
     1021 ggagcgggca cagccagagc cctgcccagg gcccacaggg gaggtgcccc tgaagccact
     1081 gtccagctct gggggcctgg tgcgggagcc cttcggccgt gatcagctct ctcagaacgt
     1141 ccatgccctg gtctcctttc ggcggctgcc agcagagggg ctggtgggca gtgggaagga
     1201 gctgccagag tcggaaggcc gtgcccgcca tgcccgcctg gggaatccct actgctcgcc
     1261 cacgctggtg cgcaagaagg ccattcgcag caaggtgatc cgctcggggg cctaccgcgg
     1321 ctgcacctat gagacccagc tgcagctgtc ggctcgggag gcctttcctg ccgcatggga
     1381 ggcatggccc cggggtcctg gtggccactc gtgcctggtg gagagcgagg gcagcctgac
     1441 ggagaacatc tgggccttcg ctggcatctc caggccctgt gccctggccc tgttgcggag
     1501 agacgtgctg ggggccttcc tgctgtggcc tgagctgggt gctagcggcc agtggtgtct
     1561 gtccgtgcgc acgcagtgcg gcgtggtgcc ccaccaggtc ttccggaacc acctgggccg
     1621 ctactgcttg gagcacctgc cggcagagtt ccccagcctg gaggctctgg tggagaacca
     1681 cgcggttact gaacgtagcc tcttctgtcc cctcgacatg ggccgcctga accccaccta
     1741 cgaggagcag gactgtgggc ccccaggcag gccgccccgg actctccggc ccctcagcca
     1801 tgccaagtcc gaggcagagc tgcagggcct gggctaagag gtagggcccc ggtcccacag
     1861 gccccgcctc accccggctc ctgggcccca gcagcatctc tgcccgtcct gcacccctct
     1921 ggttgccagt tccatccagt caccctgccc ttggagcagt cttccatcgc gtcactgtcc
     1981 gtgggagggg agccctgagg gtgggtatcg ccaatggctt cttggagaac atgtggcctg
     2041 ctgagattcc aggagggcag gtggagttgc aggcttcgga taaccctttg ggtggcttcg
     2101 gatgacctgc tgtgtggctt cggatgcttt gggacttctg ggcttctgct ttactcctgg
     2161 ggcaggagct tgttcacggc aaagctgcag ccctctccta aggaggctag gccttggggc
     2221 gctgactggg agtctccaga aagagggttt tggggaggca ggagtgagct tttactctgg
     2281 gcaaagacct ggagtgagcc accctgtcta tgagagcaga gatgactcca tggagcttgt
     2341 gggcaggagg ctggggatga gccccatcta ggctgacaga gcagggctgt ttctcatatg
     2401 tatctgagag tgaaggaggg gtgggaaggt gcagagaggg caggagggac agagggctgt
     2461 acctaacgct cacgcacggt ggactcctgt gtgcagaaag ggatgcgcac cagcagacag
     2521 ggccaagaat ctccatgctg tctccactca aaacctcagg gctgtgactc ccgctttctc
     2581 agaagggatg cgcaggctca ccccttcccc ctaggaatca ccagggcacc cccaccccca
     2641 gctcatctcc tttagccatt tgacagggag gggccagcag tgagctgcag gcttagaggg
     2701 gtgaccaggg cccttcctaa ctcgaccgca tgtggtttgg tggctgcctt gggagggagg
     2761 ctgtccgatg ctgacattcc ccttagcatg gccctgaccg tggctgtcag gggccacctt
     2821 gcctcaccag gccagcccca ctgggaatgg ggtcagtcac agcagaaccg tcgaaaggtg
     2881 gacctgatgt gggccctgcc gggggcgctt ggcctcagcg ggccatggga gacccaggga
     2941 aacgactcta gtgtgaggca gtggtcctgc cagtgactga caaaccctct ttgtaagcaa
     3001 acttgacaaa taatgaatct actgaactct gttatagaac aagttcattt tgcatgaact
     3061 tctcttattg aagcagaagc cacgtcatga gcctgggggc tgccctctcc ccgtctggga
     3121 gtgggacaga actgttcagt gccttgaaag tcacagattt ctgactcctg gaaggaactg
     3181 ggcagtccca ccagagcaga aagaaaggag gcaaacttgg ggagtgagaa gccagcctcc
     3241 cagaggccca ggcctcgtgt tccccacctc caaccctccc gtgaggagag gggcttggcc
     3301 tgggaccttg taacttcctt gcaagttaag tgagctatcc tgtcacaaaa gatagaagga
     3361 actgcccttt gggacttctt ttcactggaa acccagcact ggttttatgt tgagtgagtg
     3421 ggaagctggg actctgtttt acagccatct gtactggagc ctggacaaac cactggtctc
     3481 tatgggaggc cccagcctca catttccctg gcaaggagag agaggtttag ccatgtcctg
     3541 ggtctaggat tacagcccag agatgggcac ttaagaagac ctggtcattg gtccagactt
     3601 gggccaaggc tctcctctgt gagggatggg ttttactggt gaattacctg tgtggagaag
     3661 ctatcagggc catgtttagc acactgaagg gaccagtctc caccaagcac tttaacatcc
     3721 ctccagccag catagattga tctcgtgtta cagagagggc aaggtttttg gcccctgttt
     3781 gcagactcca tgtcttaatc agagaccaca gttttctctt tgttccaatc tgcgccacct
     3841 cggtagcccc actttccttg ctgtgtggac ttgaaacaaa ataaaatgtg ttgcttca
//
