LOCUS       NM_001388272            4207 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens SH2 domain containing 4B (SH2D4B), transcript variant
            3, mRNA.
ACCESSION   NM_001388272
VERSION     NM_001388272.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4207)
  AUTHORS   O'Donnell,P.H., Stark,A.L., Gamazon,E.R., Wheeler,H.E.,
            McIlwee,B.E., Gorsic,L., Im,H.K., Huang,R.S., Cox,N.J. and
            Dolan,M.E.
  TITLE     Identification of novel germline polymorphisms governing
            capecitabine sensitivity
  JOURNAL   Cancer 118 (16), 4063-4073 (2012)
   PUBMED   22864933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021028.12 and AL731544.11.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968540
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000646907.2/ ENSP00000494732.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               AC021028.12        130913-131526
            615-777             AL731544.11        3362-3524
            778-925             AL731544.11        4639-4786
            926-1073            AL731544.11        21838-21985
            1074-1290           AL731544.11        36787-37003
            1291-1418           AL731544.11        42632-42759
            1419-1639           AL731544.11        67493-67713
            1640-4207           AL731544.11        77201-79768
FEATURES             Location/Qualifiers
     source          1..4207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..4207
                     /gene="SH2D4B"
                     /note="SH2 domain containing 4B"
                     /db_xref="GeneID:387694"
                     /db_xref="HGNC:HGNC:31440"
     exon            1..614
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1732
                     /gene="SH2D4B"
                     /note="isoform 3 is encoded by transcript variant 3; SH2
                     domain-containing protein 4B; novel SH2 domain-containing
                     protein"
                     /codon_start=1
                     /product="SH2 domain-containing protein 4B isoform 3"
                     /protein_id="NP_001375201.1"
                     /db_xref="CCDS:CCDS91286.1"
                     /db_xref="GeneID:387694"
                     /db_xref="HGNC:HGNC:31440"
                     /translation="MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERET
                     WEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAE
                     RARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERI
                     HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRS
                     KAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDP
                     GLPQPLALPVSRTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGIISR
                     EDAEALLENMTEGAFLVRVSEKIWGYTLSYRLQKGFKHFLVDASGDFYSFLGVDPNRH
                     ATLTDLVDFHKEEIITVSGGELLQEPCGQRDSPPDYHLLFE"
     exon            615..777
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     exon            778..925
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1073
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1290
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1418
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1639
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..4207
                     /gene="SH2D4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3586..3591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D4B"
                     /note="hexamer: ATTAAA"
     polyA_site      3610
                     /gene="SH2D4B"
                     /note="major polyA site"
ORIGIN      
        1 actaacagat cactcgacac ctaccagccc aggcagggct gggactgggc atttcctggc
       61 tgagctggag gcttgggccc ttcccattgt ctcagaaccc caggtgatgc caagacatgg
      121 gctctcctgg gatgccgtgc ttggtgaccc aggagaagga ctagattgct cctggtggtt
      181 gctccccctt gcagagtccc acctgcccct ttgggtcctg ttgcctggcc tcttttgctg
      241 tcctgggtag aggagatgag ttcgtcgctg gctgcaagct gaggccaact gacaatgctg
      301 cacagagaag gggcaccgag agtggccccg gattgagcag tccgtagtgc agagcagccc
      361 ctcgggcgtt ctgcctggcc ctgcttcccc tgctggctgc ccttctggtg cgtgcatccc
      421 aggtggcatc atgctgcagc agatcctgca cgacatgtac atcgaccccg agctccttgc
      481 cgagctcagc gatgtgcaga agcacatcct cttctacaaa atgcgggagg agcagctgag
      541 gcgctggaag gagcgggaga cttgggaggc cctggcccag gacgagggtc tcaggcctcc
      601 aaagaccaag cgagcagcga gtgacaagca catccaatgg ctcctagggg cagatggcga
      661 ggtctgggtc tggatcatgg gagaaggccc tggtgacaag ccctacgaag agatctctga
      721 ggagctgatt gcagagaggg cgcggctgca ggcacagagg gaagctgagg agctctggag
      781 acagaaggag gcagagatca ccaagaagtt ccgggatgct ctggccaatg agaaagcccg
      841 gatcttggcg gagaagtgga aagtggagat ggaagaccgc aaggctgcca aagtcctgga
      901 ggaacgcatc cacgaggaat tcaagaggaa agaggaagag gagaggaagc gaggagaaga
      961 gcagattcgc ctccaggaag agcagagggc gaaggagctc tactggaccc tgaagcaggc
     1021 tcagctgcat tgccaagcca gtgagaaaga ggagcgagag tgggaagaac agttgcgccg
     1081 gtccaaggcg gctgatgagg agaggagccg ccgagcccag cgcgcccggg acgagtaccg
     1141 acaccactcg ctccgtgcta tccagaaggg cacggtcgct ggcctcagct ccatgttccg
     1201 ggagcttggc cagagccatg agcaggaggc aagactctac caccacctcc ccgacccggg
     1261 tctgccgcag ccccttgccc tgccggtcag caggacctgg gagcgcccgc tgcgcccagt
     1321 ctccagagat gtcatcgtcc gctggtttaa ggaggagcag ctgcctcgcc gagctggctt
     1381 cgagaggaac accaagttca tcgccccctg gttccatgga attattagcc gagaagatgc
     1441 agaagctctc ctggagaaca tgactgaggg agcattcctg gtccgggtca gtgagaaaat
     1501 ctggggttac accctctcct accgcctgca gaaagggttc aaacactttc ttgtggatgc
     1561 ttctggggat ttttacagct tcctgggagt ggaccccaat cgccatgcaa cgctcacgga
     1621 tctcgttgat ttccataagg aggaaattat cactgtttca ggaggagagt tacttcagga
     1681 accctgcgga cagagggaca gcccaccaga ctaccatctg ttgtttgaat aatttttttc
     1741 cttatcaatt ggattcattt tggtatcctg tttttgaact cagcttaaga acttctcatc
     1801 tcaaatccta tggccttctg gaagatccac cactatccaa aggaaaaagt agattaatat
     1861 gcctcaaggg atatgacatc tatggcatag ggctactggt ctcatcccag cgatcgggac
     1921 agaaattgct aatagctcat gcaactcttt catgaagagc ttagctatga ccttagaaga
     1981 caaagcctgt ttgtcatggc tgccgtaaac cgagctctta cagtgcgtgg accatgtttt
     2041 aataatccaa aataattcca gtgccgaacc ctgaatttaa catatggtag acattcagta
     2101 aatgtttgtt gaatgaatgc atgtcttcta aaagttttcc aacacaaatt agcagtggtt
     2161 tcttgtaaat tatttcctac tcgccactct ataaaatcat ggcaataata gaagattatg
     2221 aaggatttct atggaggaca taaatgctgc atctttcata atctccatta tcaccctcat
     2281 tgatattatc attggaatta tctaaggtga gccccagttt ccagggcagc tgattgacac
     2341 cgtcctgcct tccttattta acctcttctt ttgccactcg cctctatctt tgaatcatat
     2401 tttggccttg gttttgcaat ggttttatgt catcctacag atgtcttcaa gacctggggt
     2461 gagttatcaa tgcaagaatg gttcttagaa atctgatgag gcctctgctc tctgggatgt
     2521 ggccctctct atgcaggtta ctccaatgat tagctctgtc ctcattgtcc ttttaattcc
     2581 cttgtcaact taatctcagt atgttgctta tattaacaag aagactcacg caataactcc
     2641 tcgataactc tcagtgatgg tatctgttgg tgcatacttg tgttccacag ttatggccat
     2701 atacacagag gtagtatatg atgaagagaa gattacagtc tttacagtca agaagacttg
     2761 ggttcatatc ctaaccctgg aacttactag cattataatg cttgcagcat tgtgtttggt
     2821 gagaggaaaa gaatgaatgg attctaggaa tgttagggaa cgatttactt tacccgatgg
     2881 ctgtatcaaa catctatgcc ccacttcttc tcttgcctca cctattcctt agattcttgg
     2941 tcacttctct accacaagcc accagcacta taaccagttt tgcgtgggtt ctgctcttcc
     3001 tccctatgtt gatcagtgtc atgtgagcat aagccaatgg tagcttgcca catgccccat
     3061 ctcccattgc tgcagaggca taagacagaa gagatgggaa gtgaatgccc gatgtggtga
     3121 atctgggatg aatgggagtc ataggctggt agatcgcttt ttcctccttc ttcctcctgg
     3181 aggaactatt ctgagagtca tctgtttgta tggtcttgta gaagacagtc ctgtaagatc
     3241 gagcaaccag tcatgatgaa accaagtggt ggccggatca gtatgacacc ctgctgcccc
     3301 cgtttttaat tcttctctgc cttgccctgc tctctcctgt tgctctggga ttgcacttct
     3361 gaatgaagta gcagctcata agcttttgcc acaggctctg tcttttgggg aatccaggat
     3421 aagaacccat tatacagaag tgttcaataa tatcaatttt gcaactcact cagctccatg
     3481 gcttcccccg gtctacctgt ctcactacat gcataaagtg aaatgatgga aggaatctgc
     3541 tttctgaact ctaatgtgcc ttcattgatt atcattaaaa ttatcattaa aattgcctta
     3601 tttctatgga ctcagaggaa tgatgtttta gttttggctc tctgatttac caactatgtg
     3661 actttgtcca agtcatttaa cttcagtaaa cctcggtatg actgaaaagg gagttttctg
     3721 tatggccgtc actaggtttt tttgtgggtt agttaaatga taaacatgaa agctctgtcc
     3781 aaatgaaaaa ggtatttcta acaacaacca caataacaat aacaacttag tgcttagccc
     3841 atgatgtatc aggggatatg atgtgatgat tttcaaggtg ttggaggcaa cttctgttcc
     3901 aagaactccc agcagctttg aaagcagact gagatgagtt gagaccctga atccctgggc
     3961 tgttgttcct gtcaccccta attaatatgt gagagacaac agctgggttt tccatcccta
     4021 acacatttat ttcattttat ttggggcctg caatttctgc atgtctcata tattttaggt
     4081 tttacctttt tacctggctt taaaataaat cccttgtaag ttgtcctgca aatgaaatta
     4141 ctgtctggaa aactgcaatt tcatcttgag agttttatta tgctaataaa tgtcaggatt
     4201 ctcatat
//
