LOCUS       NM_022071               3276 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SH2 domain containing 4A (SH2D4A), transcript variant
            1, mRNA.
ACCESSION   NM_022071
VERSION     NM_022071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3276)
  AUTHORS   Shi,H., Luo,J., Ye,L., Duan,C., Zhang,M., Ran,H., Li,C., Wu,Q. and
            Shao,Y.
  TITLE     SH2D4A inhibits esophageal squamous cell carcinoma progression
            through FAK/PI3K/AKT signaling pathway
  JOURNAL   Cell Signal 114, 110997 (2024)
   PUBMED   38043670
  REMARK    GeneRIF: SH2D4A inhibits esophageal squamous cell carcinoma
            progression through FAK/PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 3276)
  AUTHORS   Matsumoto,T., Okayama,H., Nakajima,S., Saito,K., Ito,M., Kaneta,A.,
            Kanke,Y., Onozawa,H., Hayase,S., Fujita,S., Sakamoto,W., Saito,M.,
            Seze,Z., Momma,T., Mimura,K. and Kono,K.
  TITLE     SH2D4A downregulation due to loss of chromosome 8p is associated
            with poor prognosis and low T cell infiltration in colorectal
            cancer
  JOURNAL   Br J Cancer 126 (6), 917-926 (2022)
   PUBMED   34893760
  REMARK    GeneRIF: SH2D4A downregulation due to loss of chromosome 8p is
            associated with poor prognosis and low T cell infiltration in
            colorectal cancer.
REFERENCE   3  (bases 1 to 3276)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3276)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3276)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3276)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 3276)
  AUTHORS   Lapinski,P.E., Oliver,J.A., Kamen,L.A., Hughes,E.D., Saunders,T.L.
            and King,P.D.
  TITLE     Genetic analysis of SH2D4A, a novel adapter protein related to T
            cell-specific adapter and adapter protein in lymphocytes of unknown
            function, reveals a redundant function in T cells
  JOURNAL   J Immunol 181 (3), 2019-2027 (2008)
   PUBMED   18641339
  REMARK    GeneRIF: SH2D4A is dispensable for TCR signal transduction in T
            cells
REFERENCE   8  (bases 1 to 3276)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 3276)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 3276)
  AUTHORS   Dai,S., Zhao,Y. and Ding,Q.
  TITLE     [A novel member of SH(2) signaling protein family: cloning and
            characterization of SH(2)A gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19 (6), 458-462 (2002)
   PUBMED   12476414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA952240.1, BC082982.1, AK024799.1 and CA418381.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022071.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.38707.1,
                                           SRR1660809.227735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265807.8/ ENSP00000265807.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               DA952240.1         124-254
            132-1158            BC082982.1         105-1131
            1159-2863           AK024799.1         1160-2864
            2864-3276           CA418381.1         18-430              c
FEATURES             Location/Qualifiers
     source          1..3276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3276
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /note="SH2 domain containing 4A"
                     /db_xref="GeneID:63898"
                     /db_xref="HGNC:HGNC:26102"
                     /db_xref="MIM:614968"
     exon            1..131
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            132..516
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1700
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /note="isoform a is encoded by transcript variant 1; SH2
                     domain-containing protein 4A; protein SH(2)A; protein
                     phosphatase 1 regulatory subunit 38"
                     /codon_start=1
                     /product="SH2 domain-containing protein 4A isoform a"
                     /protein_id="NP_071354.2"
                     /db_xref="CCDS:CCDS6009.1"
                     /db_xref="GeneID:63898"
                     /db_xref="HGNC:HGNC:26102"
                     /db_xref="MIM:614968"
                     /translation="MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREA
                     AMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERA
                     RLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSR
                     PAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEER
                     TKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSP
                     LRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLR
                     AGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCK
                     HFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQLPDYL
                     ELFE"
     exon            517..676
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            677..848
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            849..929
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1041
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1252
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1383
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1607
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..3276
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /note="hexamer: AATAAA"
     polyA_site      2863
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /note="major polyA site"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /note="hexamer: AATAAA"
     polyA_site      3276
                     /gene="SH2D4A"
                     /gene_synonym="PPP1R38; SH2A"
                     /note="major polyA site"
ORIGIN      
        1 gtatttgctc agcccgcctg cgccgcttgg gacgcctctg cctttccctc cctcccttcc
       61 ccgacggctt ctggcggcca agtggatgtg gcgggtgatc gagccaccct gcccaggggc
      121 gcccagcact ggttcagtga acagcatttt ggacaggaca tttggtgcca ggtctgagta
      181 gccagtttgc tgaattattg tcccagtcag ccaggattgt gagctgtttg ggaagtttcg
      241 tggaaacgcc caagtgccag cacaggtgga gggacacctg gaggccagtt tcaggaactt
      301 ttgccacaag tataaaagac ttcagaagtg caaagatgct gaaacagata ctgtcggaga
      361 tgtacataga tcctgatcta ctggcagagc tcagcgaaga acagaaacag atcctgttct
      421 tcaagatgag agaggaacag atccgacgat ggaaagaaag agaagcagct atggaaagaa
      481 aggagtccct gccagtgaaa cccagaccaa agaaagagaa tggcaaatcg gttcattgga
      541 aacttggagc tgataaggaa gtctgggtat gggtgatggg cgaacaccat ctagataaac
      601 cctatgatgt gctctgtaat gaaattattg ctgagagggc ccggctgaaa gcagaacagg
      661 aggcagaaga gcccagaaaa actcactctg aagaattcac caatagcttg aaaacaaaat
      721 cacagtacca tgatctgcag gctccggata accagcagac taaagacatc tggaagaaag
      781 tggcagaaaa ggaggaactg gagcaaggat cgaggccagc accaaccctg gaagaagaga
      841 aaatccgatc actctccagt tcttcaagaa atattcaaca aatgttggca gattcaatca
      901 atcgtatgaa ggcatatgca tttcaccaga agaaagaatc tatgaagaaa aaacaagatg
      961 aagaaataaa tcaaatagaa gaagagagaa cgaagcagat ttgtaagagc tggaaagaag
     1021 actcggaatg gcaggcatct ctgcgaaaat ccaaagcagc tgatgagaag agacgctcct
     1081 tggctaaaca agcacgagaa gactacaaga ggttatccct cggggcccag aaaggaagag
     1141 gcggtgagag gctgcaaagc cccttgcgtg ttccgcagaa accagaaaga cctccccttc
     1201 cacccaagcc tcagttccta aactcagggg catatcctca aaaacctctt agaaatcagg
     1261 gagtggtgag gacactgtcc agctctgccc aagaggacat catccggtgg tttaaagagg
     1321 agcagctacc acttcgagcg ggctaccaga aaacctcaga caccatagcc ccctggttcc
     1381 atggaattct cacactcaag aaagcaaatg aacttcttct gagcacaggc atgcccggca
     1441 gttttctcat ccgagtcagt gaaaggatca aaggctatgc cctgtcctat ctgtcggagg
     1501 acggctgtaa acatttcctc atcgatgcct ctgcagacgc ctacagcttc ctgggcgtgg
     1561 accagctaca gcatgccacc ttggcggatt tggtggaata tcacaaggag gaacccatca
     1621 cttccctggg gaaggagctc cttctctatc cctgtggtca gcaggaccag ctgcctgact
     1681 acctggagct gtttgagtga cagcctccat cagggtcatc ctacagcctc caagcgggct
     1741 ttcccctgga caaatgccac tgcaacattt atgtgtgaag ccaaaatcac cctgcagcag
     1801 agccaatact gatcaactga aagtaaagta tccatggagt cctcattgac acctcttttc
     1861 tgcacaaata ctggaattca atgtcaagag aaaatgacct ctgctcaaaa gggagaagag
     1921 tctcaatttc agcaagtacc tgtcatgaag ggtatgacct taatgatgta cataaaataa
     1981 aacaaatgaa gaaatggaaa acttttagaa attaaggtgt acttgaaaac gaatatctat
     2041 catatgaccc ctgcactccc tctgtatcat ctcaggaggt ttcaggggcc tgttgacatg
     2101 aagtttcgaa gtttcatgtt ggctttggaa tggtagcaaa agcctttcct ggctgagatg
     2161 atgcttaaaa cacacctcac ttattgtaca tgttggaacc aggacatgag agacatagaa
     2221 aaacagaagt catgaatgta aattgaatga gaggcttaac atgcatgaaa atacagatgg
     2281 acctgcagga aagtgagcaa acatcgctga gtttgttttc ttgttcggga gaatggggcc
     2341 ggggctggcc tggcctcccc tggatatact ctatagtgca ccaaaaggat aaagcatctg
     2401 tacatgtatt tttttatttt ttatcagaag tgcttagaca agaacagaat aagcaggctg
     2461 tttggatgct acttgtggtt gaattgtgtt cccccaaaat atatggtgaa gtcttaaccc
     2521 ccatccccgt gaatgggacc ttgtttggaa atagggtctt tgcagatata gtcaagatga
     2581 ggtcacattg gattagggtg ggccccaaat ccaatgactg gcatccttag gagaagagag
     2641 agttttggta atagacacaa atgcagtggg aagaagacca ggggacaaga ggcaagttgg
     2701 agtgatgcag ccggaaggga agggacacca aggatctccg gccaccagca gaagccagca
     2761 gagaggcatg ggacaggttc cccacaagcc ttagaaggaa gcatggccct gacttcagaa
     2821 ttccagactc cagaactgga agaataaatg tctgttgttt taagctgctt agttcatgct
     2881 gagttcatgc tgacttgtta ctatagcccc agaaagctaa tacagtcgtt tatgtaatta
     2941 cataacctga cacacaagat cgacccattc actgctgccc agtccaccat tttcataatg
     3001 aagtagaaat gggaggtaag aaaaacattc cagccagttc tgtttagccc tggcacacat
     3061 atttgtcccg tcaggaatct tatgccctcc tggaaccccc gcccacctca gtccagtccc
     3121 agtcaggcga acggcctctg gacagggact gaggtggctc tgagccactg gagatcattt
     3181 ttcttggagg atggagattg gctagtacct ctggcctaac tgtgtaggtc aatactcttt
     3241 tacattgcct tctaataaaa gcagaatgat acagca
//
