LOCUS       NM_053282               2531 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SH2 domain containing 1B (SH2D1B), mRNA.
ACCESSION   NM_053282
VERSION     NM_053282.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2531)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2531)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2531)
  AUTHORS   Taha,M., Nezerwa,E. and Nam,H.J.
  TITLE     The X-ray Crystallographic Structure of Human EAT2 (SH2D1B)
  JOURNAL   Protein Pept Lett 23 (10), 862-866 (2016)
   PUBMED   27586300
  REMARK    GeneRIF: When compared with SAP, the other single SH2 domain
            protein in human, EAT2 shows similar binding energies to
            unphosphorylated ligands. This is inconsistent to the previous data
            showing low affinity of EAT2 toward unphosphorylated peptides
            compared to SAP which shows high affinity
REFERENCE   4  (bases 1 to 2531)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2531)
  AUTHORS   Arking,D.E., Pulit,S.L., Crotti,L., van der Harst,P., Munroe,P.B.,
            Koopmann,T.T., Sotoodehnia,N., Rossin,E.J., Morley,M., Wang,X.,
            Johnson,A.D., Lundby,A., Gudbjartsson,D.F., Noseworthy,P.A.,
            Eijgelsheim,M., Bradford,Y., Tarasov,K.V., Dorr,M.,
            Muller-Nurasyid,M., Lahtinen,A.M., Nolte,I.M., Smith,A.V.,
            Bis,J.C., Isaacs,A., Newhouse,S.J., Evans,D.S., Post,W.S.,
            Waggott,D., Lyytikainen,L.P., Hicks,A.A., Eisele,L., Ellinghaus,D.,
            Hayward,C., Navarro,P., Ulivi,S., Tanaka,T., Tester,D.J.,
            Chatel,S., Gustafsson,S., Kumari,M., Morris,R.W., Naluai,A.T.,
            Padmanabhan,S., Kluttig,A., Strohmer,B., Panayiotou,A.G.,
            Torres,M., Knoflach,M., Hubacek,J.A., Slowikowski,K.,
            Raychaudhuri,S., Kumar,R.D., Harris,T.B., Launer,L.J.,
            Shuldiner,A.R., Alonso,A., Bader,J.S., Ehret,G., Huang,H.,
            Kao,W.H., Strait,J.B., Macfarlane,P.W., Brown,M., Caulfield,M.J.,
            Samani,N.J., Kronenberg,F., Willeit,J., Smith,J.G., Greiser,K.H.,
            Meyer Zu Schwabedissen,H., Werdan,K., Carella,M., Zelante,L.,
            Heckbert,S.R., Psaty,B.M., Rotter,J.I., Kolcic,I., Polasek,O.,
            Wright,A.F., Griffin,M., Daly,M.J., Arnar,D.O., Holm,H.,
            Thorsteinsdottir,U., Denny,J.C., Roden,D.M., Zuvich,R.L.,
            Emilsson,V., Plump,A.S., Larson,M.G., O'Donnell,C.J., Yin,X.,
            Bobbo,M., D'Adamo,A.P., Iorio,A., Sinagra,G., Carracedo,A.,
            Cummings,S.R., Nalls,M.A., Jula,A., Kontula,K.K., Marjamaa,A.,
            Oikarinen,L., Perola,M., Porthan,K., Erbel,R., Hoffmann,P.,
            Jockel,K.H., Kalsch,H., Nothen,M.M., den Hoed,M., Loos,R.J.,
            Thelle,D.S., Gieger,C., Meitinger,T., Perz,S., Peters,A.,
            Prucha,H., Sinner,M.F., Waldenberger,M., de Boer,R.A., Franke,L.,
            van der Vleuten,P.A., Beckmann,B.M., Martens,E., Bardai,A.,
            Hofman,N., Wilde,A.A., Behr,E.R., Dalageorgou,C., Giudicessi,J.R.,
            Medeiros-Domingo,A., Barc,J., Kyndt,F., Probst,V., Ghidoni,A.,
            Insolia,R., Hamilton,R.M., Scherer,S.W., Brandimarto,J.,
            Margulies,K., Moravec,C.E., del Greco,M. F, Fuchsberger,C.,
            O'Connell,J.R., Lee,W.K., Watt,G.C., Campbell,H., Wild,S.H., El
            Mokhtari,N.E., Frey,N., Asselbergs,F.W., Mateo Leach,I., Navis,G.,
            van den Berg,M.P., van Veldhuisen,D.J., Kellis,M., Krijthe,B.P.,
            Franco,O.H., Hofman,A., Kors,J.A., Uitterlinden,A.G.,
            Witteman,J.C., Kedenko,L., Lamina,C., Oostra,B.A., Abecasis,G.R.,
            Lakatta,E.G., Mulas,A., Orru,M., Schlessinger,D., Uda,M.,
            Markus,M.R., Volker,U., Snieder,H., Spector,T.D., Arnlov,J.,
            Lind,L., Sundstrom,J., Syvanen,A.C., Kivimaki,M., Kahonen,M.,
            Mononen,N., Raitakari,O.T., Viikari,J.S., Adamkova,V., Kiechl,S.,
            Brion,M., Nicolaides,A.N., Paulweber,B., Haerting,J.,
            Dominiczak,A.F., Nyberg,F., Whincup,P.H., Hingorani,A.D.,
            Schott,J.J., Bezzina,C.R., Ingelsson,E., Ferrucci,L., Gasparini,P.,
            Wilson,J.F., Rudan,I., Franke,A., Muhleisen,T.W., Pramstaller,P.P.,
            Lehtimaki,T.J., Paterson,A.D., Parsa,A., Liu,Y., van Duijn,C.M.,
            Siscovick,D.S., Gudnason,V., Jamshidi,Y., Salomaa,V., Felix,S.B.,
            Sanna,S., Ritchie,M.D., Stricker,B.H., Stefansson,K., Boyer,L.A.,
            Cappola,T.P., Olsen,J.V., Lage,K., Schwartz,P.J., Kaab,S.,
            Chakravarti,A., Ackerman,M.J., Pfeufer,A., de Bakker,P.I. and
            Newton-Cheh,C.
  CONSRTM   CARe Consortium; COGENT Consortium; DCCT/EDIC; eMERGE Consortium;
            HRGEN Consortium
  TITLE     Genetic association study of QT interval highlights role for
            calcium signaling pathways in myocardial repolarization
  JOURNAL   Nat Genet 46 (8), 826-836 (2014)
   PUBMED   24952745
REFERENCE   6  (bases 1 to 2531)
  AUTHORS   Veillette,A. and Latour,S.
  TITLE     The SLAM family of immune-cell receptors
  JOURNAL   Curr Opin Immunol 15 (3), 277-285 (2003)
   PUBMED   12787752
  REMARK    Review article
REFERENCE   7  (bases 1 to 2531)
  AUTHORS   Tangye,S.G., van de Weerdt,B.C., Avery,D.T. and Hodgkin,P.D.
  TITLE     CD84 is up-regulated on a major population of human memory B cells
            and recruits the SH2 domain containing proteins SAP and EAT-2
  JOURNAL   Eur J Immunol 32 (6), 1640-1649 (2002)
   PUBMED   12115647
REFERENCE   8  (bases 1 to 2531)
  AUTHORS   Morra,M., Lu,J., Poy,F., Martin,M., Sayos,J., Calpe,S., Gullo,C.,
            Howie,D., Rietdijk,S., Thompson,A., Coyle,A.J., Denny,C.,
            Yaffe,M.B., Engel,P., Eck,M.J. and Terhorst,C.
  TITLE     Structural basis for the interaction of the free SH2 domain EAT-2
            with SLAM receptors in hematopoietic cells
  JOURNAL   EMBO J 20 (21), 5840-5852 (2001)
   PUBMED   11689425
REFERENCE   9  (bases 1 to 2531)
  AUTHORS   Morra,M., Howie,D., Grande,M.S., Sayos,J., Wang,N., Wu,C., Engel,P.
            and Terhorst,C.
  TITLE     X-linked lymphoproliferative disease: a progressive
            immunodeficiency
  JOURNAL   Annu Rev Immunol 19, 657-682 (2001)
   PUBMED   11244050
  REMARK    Review article
REFERENCE   10 (bases 1 to 2531)
  AUTHORS   Thompson,A.D., Braun,B.S., Arvand,A., Stewart,S.D., May,W.A.,
            Chen,E., Korenberg,J. and Denny,C.
  TITLE     EAT-2 is a novel SH2 domain containing protein that is up regulated
            by Ewing's sarcoma EWS/FLI1 fusion gene
  JOURNAL   Oncogene 13 (12), 2649-2658 (1996)
   PUBMED   9000139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512785.7.
            
            On Nov 23, 2018 this sequence version replaced NM_053282.4.
            
            Summary: By binding phosphotyrosines through its free SRC (MIM
            190090) homology-2 (SH2) domain, EAT2 regulates signal transduction
            through receptors expressed on the surface of antigen-presenting
            cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF484964.1, AK097162.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367929.3/ ENSP00000356906.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AL512785.7         99118-99371         c
            255-318             AL512785.7         89974-90037         c
            319-483             AL512785.7         86158-86322         c
            484-2531            AL512785.7         82503-84550         c
FEATURES             Location/Qualifiers
     source          1..2531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2531
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="SH2 domain containing 1B"
                     /db_xref="GeneID:117157"
                     /db_xref="HGNC:HGNC:30416"
                     /db_xref="MIM:608510"
     exon            1..254
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..519
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="SH2 domain-containing molecule EAT2; EAT-2;
                     EWS/FLI1-activated transcript 2"
                     /codon_start=1
                     /product="SH2 domain-containing protein 1B"
                     /protein_id="NP_444512.2"
                     /db_xref="CCDS:CCDS30928.1"
                     /db_xref="GeneID:117157"
                     /db_xref="HGNC:HGNC:30416"
                     /db_xref="MIM:608510"
                     /translation="MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCV
                     SFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIK
                     RTSPSLRWRGLKLELETFVNSNSDYVDVLP"
     exon            255..318
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..483
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..2531
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="major polyA site"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="hexamer: AATAAT"
     polyA_site      2218
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="major polyA site"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="hexamer: AATAAA"
     polyA_site      2531
                     /gene="SH2D1B"
                     /gene_synonym="EAT2"
                     /note="major polyA site"
ORIGIN      
        1 agaggaagag gtagctccac aggaggtaca gctgcttaca catctctcct cagagctgtc
       61 ccttgacttg ggggtgaatt tcaggccaac agggcttcct gggatacaag agcgttctcc
      121 atggatctgc cttactacca tggacgtctg accaagcaag actgtgagac cttgctgctc
      181 aaggaagggg tggatggcaa ctttctttta agagacagcg agtcgatacc aggagtcctg
      241 tgcctctgtg tctcgtttaa aaatattgtc tacacatacc gaatcttcag agagaaacac
      301 gggtattaca ggatacagac tgcagaaggt tctccaaaac aggtctttcc aagcctaaag
      361 gaactgatct ccaaatttga aaaaccaaat caggggatgg tggttcacct tttaaagcca
      421 ataaagagaa ccagccccag cttgagatgg agaggattga aattagagtt ggaaacattt
      481 gtgaacagta acagcgatta tgtggatgtc ttgccttgaa gataaggctg ccggacaaag
      541 caagttgaag agatgagtaa cagttctcac tgatgaccca cttctgcagg cataggtcca
      601 gagcaccaaa ctctagtgga caattcagac tctcctggtt gtgtaactga agatgttctg
      661 cccaccagca ccagaggtca ctctccacat ccccgcctcc cagacatata ccaggagcaa
      721 tttcaaaacc ctctccagtt tcactcttct ttcttggaat gggacagcct gaacattttc
      781 cctttgactt gttaaaggta ccaccctaca tcatggttga caccctcctt tggaccatgc
      841 agtcagaggg gcagctttat acagaggagg ggcacacttg tctgtgagtt tgaagccctg
      901 agttccagtc ctgtggctgt gtgactttga acacgtttct gcccatctcc aggtcttagt
      961 ttctttgtct ctgtggttgg gtgggatgat aaacattgcc ccagtctctc tgttgagcct
     1021 gcttgtgtca ggtgaaggtg agggatcggg agtgatggag atgcatacag atcagcacct
     1081 tctctgtacc tgctggaccc ccatgtgcac ccttctccct ccagcctggg ctactctcct
     1141 cctggttctt tctaatctta aacttcctgg tgagcattgc cccagccaca ctttctccct
     1201 ggttttgctt aattccactt atgcatcagt catttcaaca gcatgaatgt ggttctgtac
     1261 agtgatgtat gtggagattt ctaaaatatt ctatgtgtga tttctgttcc caactaggtt
     1321 ctaagtgcca tcaaagcacg gttgggtctc ccttgtatct tccacagtgt gtagaaattt
     1381 gtgctgccca gagctgtgcc tagttcatag aaactgactg gaagcacatt gctgagggag
     1441 gtttgttgaa ttggttttta aggtttactg aaattgattt gctgaatttt tctgctagtt
     1501 caaaatgtga attaggacct ggtcagtttg aaatatacca aattctatgc cctttctctt
     1561 acctatcatc aaattgtagt aatgtatttc accccactgg acttatcttc agagttttaa
     1621 aagagaggag ctctcgactt agaggtaata tgaacagatg aacagacact gtggctggag
     1681 ccccaaagtg tggagcattg tgagatttgg ggtcacagca atttatggct actattccct
     1741 gggtctggta ggtaggacaa atgtcctctt ttacttttca aaactggctt aggtattcat
     1801 ggaccttgat tcttctatat acattttata ataaatacgt gaaattgctt aaaacctctt
     1861 tttggaattt ttaatgaact tgcaacaaat ttgtaaatag gagagaactg acgttcttgt
     1921 gatgttttcc catgcataaa catgccacat ccatgttctt gggtcatctt ttttgccctt
     1981 tcatggagtc ataaattttc ccaactgaag tcttgtatat tctgttagat taattcctat
     2041 ttctagttgc tgtaaatgat atcttatgtt ttattacatt tctaatagga tatggtgttg
     2101 gtgaaatgtt aaccctctca ttagatctac tagtttacct gttgattcta ttgtgttttc
     2161 tatgtaaatg attttgtcag ctataaataa taacatttta ttttctcttt ccttgcaata
     2221 cctatgctca tttatttttt atgtttaccc attggttagg gcctcctgta tacattaaac
     2281 agttcatagt catgatagtg agtattctta cactgttccc agtattacag ggaatgctta
     2341 gaaattttct ttatttaaac attatgtttg ttgtagcctt gttaaaggct attttataat
     2401 ttttactaga aatattttga catttattgt gatttttttc tatctctaat ctattgagat
     2461 agtcacattc cttttgtctt cactccatta taaaggtaag ttaccttaat aaaattgttg
     2521 atatcatttc a
//
