LOCUS       XM_047428026            5471 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SH2B adaptor protein 3 (SH2B3), transcript
            variant X6, mRNA.
ACCESSION   XM_047428026
VERSION     XM_047428026.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..5471
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /note="SH2B adaptor protein 3; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 29 ESTs, 1150 long SRA reads, 4 Proteins, and 97%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 14 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
     CDS             423..2150
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /codon_start=1
                     /product="SH2B adapter protein 3 isoform X4"
                     /protein_id="XP_047283982.1"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
                     /translation="MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQ
                     YWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA
                     SPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTA
                     AAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQ
                     RGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFV
                     LKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGS
                     TDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVR
                     QSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLEC
                     GAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPR
                     GLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLR
                     AIDNQYTPL"
ORIGIN      
        1 gtttaacaca gagagcttcc tggagccaag cctcgagcta actgctttaa tgcattaact
       61 cacttaattc tcactgccag gagagtgggt acacattatt tccatttcat aggcaaggaa
      121 gtggagaggt acggagaagt caagtcattt gcccgggtag gaagaggggg aggcagtgga
      181 atggagacac ttgctgcctg ggaagactcg aggtggcccc tccaagctgg gggcgtgggc
      241 gacttgtttc ctgttggggg agggggagaa gagtacattc ctccctcccc gccctcccac
      301 atgttggggg agaggctggc tgagagcatg tcccactccg gactaggggg aaccccactg
      361 tccgtctcag ctccccatga ggccgtggag aaaatcccgg ccgcaccacc tgggtctccg
      421 ccatgaacgg gcctgccctg cagccctcct cgccctcttc cgcgccctca gcctccccgg
      481 cggcggcccc gcggggctgg agcgagttct gtgagttgca cgccgtagcg gcggcccggg
      541 agctggcccg ccagtactgg ctgttcgccc gggagcatcc gcagcacgcg ccgctgcgcg
      601 ccgagctggt gtcgctgcag ttcaccgacc tcttccagcg ctacttctgc cgcgaggtgc
      661 gcgacggacg ggcgccgggc cgcgactacc gggacacagg ccgtgggccc ccagccaagg
      721 ccgaggcgtc cccggagcca ggccccggcc ccgccgcccc tggcctgccc aaggcccgca
      781 gctctgagga gctggccccg ccgcggccgc ccgggccctg ctccttccag cactttcgcc
      841 gcagcctccg ccacatcttc cgccgccgct cggccgggga gctgccagcg gcccacaccg
      901 ctgccgcccc cgggaccccc ggagaggctg ctgagacccc cgcccggcct ggcctggcca
      961 agaagttcct gccctggagc ctggcccggg agccgccacc cgaggcgctg aaggaggcgg
     1021 tgctgcgcta cagcctggcc gacgaggcct ccatggacag cggggcacgc tggcagcgcg
     1081 ggaggctggc gctgcgccgg gccccgggcc ccgatggccc cgaccgcgtg ctggagctct
     1141 tcgacccacc caagagttca aggcccaagc tacaagcagc ttgctccagc atccaggagg
     1201 tccggtggtg cacacggctt gagatgcctg acaaccttta cacctttgtg ctgaaggtga
     1261 aggaccggac agacatcatc tttgaggtgg gagacgagca gcagctgaat tcatggatgg
     1321 ctgagctctc ggagtgcaca ggccgagggc tggagagcac agaagcagag atgcatattc
     1381 cctcagccct agagcctagc acgtccagct ccccaagggg cagcacagat tcccttaacc
     1441 aaggtgcttc tcctgggggg ctgctggacc cggcctgcca gaagacggac catttcctgt
     1501 cctgctaccc ctggttccac ggccccatct ccagagtgaa agcagctcag ctggttcagc
     1561 tgcagggccc tgatgctcat ggagtgttcc tggtgcggca gagcgagacg cggcgtgggg
     1621 aatacgtgct cactttcaac tttcagggga tagccaagca cctgcgcctg tcgctgacag
     1681 agcggggcca gtgccgtgtg cagcacctcc actttccctc ggtcgtggac atgctccacc
     1741 acttccagcg ctcgcccatc ccactcgagt gcggcgccgc ctgtgatgtc cggctctcca
     1801 gctacgtggt agtcgtctcc caaccaccag gttcctgcaa cacggtcctc ttccctttct
     1861 cccttcctca ctgggattca gagtcccttc ctcactgggg ttcagagttg ggccttcccc
     1921 accttagttc ttctggctgt ccccgggggc tcagcccaga gggtctccca gggcgatcct
     1981 caccccccga gcagatcttc cacctggtgc cttcgcccga agaactggcc aacagcctgc
     2041 agcacctgga gcatgagcct gtgaatcgag cccgggactc ggactacgaa atggactcat
     2101 cctcccggag ccacctgcgg gccatagaca atcagtacac acctctctga ccagtgagga
     2161 attccaggcc tcaacagctg cccttgagga gcacaggcag aagtgtgaac ttgtgaatgt
     2221 aattgatctt tccttccttc cagagaaaga tttaagggac actgttaact gctcgtgcca
     2281 gtttggaagt gacccttcta ttaggcctgt tgaagggccc tcctgtaggt ttcatctatc
     2341 cacctggctt tctccttatt gtttacagat gtagttcttg ttagaggatg ccgctagctc
     2401 ctgcccgggg tccctatgcc cagtccccgt tactcttaga gaaaggagtt ggggtgaggg
     2461 ccagagctgg cagtggaaac ttgttctctt tttcactgac actgtcacag cggatgacag
     2521 actttctacg gggaggaggg ggggatcatc aggaagccca gaacactaac aagcggttct
     2581 cccatctacc gtcagtccac atggcaggtc tgctgtgtcc acaccacaga tgaccacatc
     2641 taatcctgct tctactctca gctttaggac aaaagctctg tcagaggcac aagctgaagg
     2701 tcaaaaatga tttaaaacat tttacctcag actaatttct ttaaaggatt caggttcaaa
     2761 acttaaccac tgcttatttc agtgcactgt ttcaactaac acccatgcta tttttgtagt
     2821 cagaaacagc tatgcaaacc ctacctaatt tacagtctga gccagcatgc tggcttgtct
     2881 actgcatcct cgggacagtc acctgccact gagtggccac tgtccttcct aaatgtcaag
     2941 aagtgaagta tgtcaccctt tcagggaaat tcaggcaatt actgaaatag gagggtggca
     3001 agaacagttc tatcctggtg ccttacgaat aaaaaactgg attctggttt acagcagctt
     3061 tacagtgata gttaaattaa ctggggctag gggaagagca agcaaaaagg gaagaaggac
     3121 tcctaggccc tttctagtaa atccttcagc aacaaggctg gcttggtgcc ctccaagcat
     3181 ctaatggctt attaaattat cccacaagtg ggttttaggc tccttttttg agccaaaatg
     3241 gaagctggga atctggtgcc ataactaatg agaaactcct ttaatagccc acaatcagtg
     3301 ttctgttcta gctggctact gcttcactgg attgagaatc tatctatctc cttgcacaca
     3361 tgggcacaca caatctccac catccaggga ggtcctgaag tcaaatctct atctatacaa
     3421 gtgatacaat tcataggggg ctggctcctc ccagaacctg tctggaggct cagaaacggg
     3481 ggcagtgaca gtggagtcag ctgctcttgg gtgccagcag agccattcag tacaaccccc
     3541 aggctcacag cagtggcttc taggaaactg ggagtttaga tcagctttac agatacatcg
     3601 atcagaggct aaaatgaaac ctcagcctaa aactcatagg actgactgcc tgggaggagg
     3661 gttaggtctg cttcttccac ttatacttag tctctgtgct ccaagaggtc aaatttttgc
     3721 ttctagaatt tccttggggt ctttcagagg gtgggggaac aaacccctat gcacttttct
     3781 tttttttttt tttgagatgg agtttctctt gtcaaccggg ctggagtgca gtggtgcaat
     3841 cttggctcac tgcaacctcc accttcctgg ttcaagcgat tctgcctcga cctctcaagt
     3901 agctgggatt acaagcacca gccaccatgc ctggctaatt ttgtattttt agtagagaca
     3961 gggtttcacc atgttggcca ggctggtctc gaatgtctga cctcaggtga tccacccgcc
     4021 ttggcctccc aaagtgctgg gattacaggc gcgagccacc gcgcccagcc tacaccactt
     4081 ttagtaccaa cactcttggg tgatttcatg gaccctaaag cagacctgac actgatccag
     4141 atttgcagtc catttttaag gacacctgtc tttatttcct caaagtcaag cagctttctc
     4201 tggaaaatga atgctaatta gtgtgaacca aaagagtaag taagagtctg aagttttttt
     4261 aaaggagaaa gcttattatg gaaagtcact ggtcctcccc tccgcacagg aaaggtaccc
     4321 agtagataat gaaccaaatt aagttccctc cctccagcca gaagttaaac atctgggata
     4381 tgacgtcttc atgccagggg cactcatttc ttagcagcct ctctacatac atctctcagg
     4441 tggtgccaag aggcacacca ggtagagcaa acttagcagc tctgactaac aggctgcaaa
     4501 gtgcaagttc agattctgtg gcagagattt ggaaggcacc cacctccaga ctgcttcccg
     4561 tccaagttac caggacagct caaaaacatg ctgacagaaa actcccatgg ctctaggaag
     4621 aagtgacact aagccaacac ctttctttat gtgggagcag aatcagctga tgaaggggtg
     4681 ggcagcagtg tggggcaggc accccactgg ctgcagctag cccaccatag gcacagcaca
     4741 tcccaccact ctccttccag tcctgaccag gccccagccg gcaacttcta ccgagagcca
     4801 tggctcaaca ccaaactgga cagtagacat catgatccct ccagttagct ctaattacag
     4861 accccaccag tacagcttga cagctcccgg caccatccct tccttcatct gacttattga
     4921 acttttacaa actaacagtc accagcacca aagaattaag tcaactaacc tgccttgaat
     4981 tttagaccag caatccatat ggctttatct ggtataaatc ttctgccttt gatcatttct
     5041 ggaccgtagg aaaaaggaat agcaatcatt aaaatcttgg gccagagaac actattttta
     5101 cataacagtt tcttaaccta aagtcaaggc cttggactct tccctgaggg ttgcctgaga
     5161 ttccttcatg ctttctattc aggactaagt cccttactgc aaatgtgtta gctctaacat
     5221 ctcccacaag ctagaggaac ttgcgagtat attaacaagg acacatctga catcctgtgt
     5281 ttggttagaa tatacagcac attgtgataa cataaagtgg attcatcttg tatcattata
     5341 ggcagaaggt atttggcaaa tttttatgta ttgttttatg tactgtacaa gtaacttatt
     5401 cttgaataat gcaaattttg ctataatgta caaattgcta tatgtgaatt aaaaagtttt
     5461 cagaatcttg a
//
