LOCUS       NM_001359228            2236 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SH2B adaptor protein 2 (SH2B2), transcript variant 2,
            mRNA.
ACCESSION   NM_001359228 XM_005276977
VERSION     NM_001359228.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Desbuquois,B., Carre,N. and Burnol,A.F.
  TITLE     Regulation of insulin and type 1 insulin-like growth factor
            signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins
  JOURNAL   FEBS J 280 (3), 794-816 (2013)
   PUBMED   23190452
  REMARK    GeneRIF: Studies indicate that insulin receptor (IR) and IGF Type 1
            Receptor (IGFR) have been identified as important partners of
            Grb10/14 and SH2B1/B2 adaptors.
            Review article
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Gery,S., Cao,Q., Gueller,S., Xing,H., Tefferi,A. and Koeffler,H.P.
  TITLE     Lnk inhibits myeloproliferative disorder-associated JAK2 mutant,
            JAK2V617F
  JOURNAL   J Leukoc Biol 85 (6), 957-965 (2009)
   PUBMED   19293402
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Ng,C., Jackson,R.A., Buschdorf,J.P., Sun,Q., Guy,G.R. and
            Sivaraman,J.
  TITLE     Structural basis for a novel intrapeptidyl H-bond and reverse
            binding of c-Cbl-TKB domain substrates
  JOURNAL   EMBO J 27 (5), 804-816 (2008)
   PUBMED   18273061
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Wakioka,T., Sasaki,A., Mitsui,K., Yokouchi,M., Inoue,A., Komiya,S.
            and Yoshimura,A.
  TITLE     APS, an adaptor protein containing Pleckstrin homology (PH) and Src
            homology-2 (SH2) domains inhibits the JAK-STAT pathway in
            collaboration with c-Cbl
  JOURNAL   Leukemia 13 (5), 760-767 (1999)
   PUBMED   10374881
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Moodie,S.A., Alleman-Sposeto,J. and Gustafson,T.A.
  TITLE     Identification of the APS protein as a novel insulin receptor
            substrate
  JOURNAL   J Biol Chem 274 (16), 11186-11193 (1999)
   PUBMED   10196204
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Yokouchi,M., Wakioka,T., Sakamoto,H., Yasukawa,H., Ohtsuka,S.,
            Sasaki,A., Ohtsubo,M., Valius,M., Inoue,A., Komiya,S. and
            Yoshimura,A.
  TITLE     APS, an adaptor protein containing PH and SH2 domains, is
            associated with the PDGF receptor and c-Cbl and inhibits
            PDGF-induced mitogenesis
  JOURNAL   Oncogene 18 (3), 759-767 (1999)
   PUBMED   9989826
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Glockner,G., Scherer,S., Schattevoy,R., Boright,A., Weber,J.,
            Tsui,L.C. and Rosenthal,A.
  TITLE     Large-scale sequencing of two regions in human chromosome 7q22:
            analysis of 650 kb of genomic sequence around the EPO and CUTL1
            loci reveals 17 genes
  JOURNAL   Genome Res 8 (10), 1060-1073 (1998)
   PUBMED   9799793
REFERENCE   10 (bases 1 to 2236)
  AUTHORS   Yokouchi,M., Suzuki,R., Masuhara,M., Komiya,S., Inoue,A. and
            Yoshimura,A.
  TITLE     Cloning and characterization of APS, an adaptor molecule containing
            PH and SH2 domains that is tyrosine phosphorylated upon B-cell
            receptor stimulation
  JOURNAL   Oncogene 15 (1), 7-15 (1997)
   PUBMED   9233773
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY020205.1, AC091390.1,
            BI261466.1, AB000520.1 and CB053166.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001359228.1.
            
            Summary: The protein encoded by this gene is expressed in B
            lymphocytes and contains pleckstrin homology and src homology 2
            (SH2) domains. In Burkitt's lymphoma cell lines, it is
            tyrosine-phosphorylated in response to B cell receptor stimulation.
            Because it binds Shc independent of stimulation and Grb2 after
            stimulation, it appears to play a role in signal transduction from
            the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.237435.1,
                                           SRR1163657.85083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444095.3/ ENSP00000401883.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY020205.1         7-19
            14-14               AC091390.1         102325-102325       c
            15-467              HY020205.1         20-472
            468-882             BI261466.1         259-673
            883-2025            AB000520.1         754-1896
            2026-2236           CB053166.1         110-320
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2236
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /note="SH2B adaptor protein 2"
                     /db_xref="GeneID:10603"
                     /db_xref="HGNC:HGNC:17381"
                     /db_xref="MIM:605300"
     exon            1..227
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            228..985
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2155
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /note="isoform 2 is encoded by transcript variant 2; SH2
                     and PH domain-containing adapter protein APS; adapter
                     protein with pleckstrin homology and Src homology 2
                     domains"
                     /codon_start=1
                     /product="SH2B adapter protein 2 isoform 2"
                     /protein_id="NP_001346157.1"
                     /db_xref="CCDS:CCDS78264.2"
                     /db_xref="GeneID:10603"
                     /db_xref="HGNC:HGNC:17381"
                     /db_xref="MIM:605300"
                     /translation="MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCR
                     FLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELA
                     DTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEP
                     DAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQW
                     QKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVL
                     KVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCE
                     LLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDS
                     NNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETR
                     PGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSAD
                     ITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGA
                     SSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARA
                     VENQYSFY"
     exon            986..1087
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1179
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1271
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1442
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1651
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1823
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2236
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /note="hexamer: ATTAAA"
     polyA_site      2236
                     /gene="SH2B2"
                     /gene_synonym="APS"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgcgct ggggctgggc ttggagcgcg cggagctcgg ctgccagaga gccgcgcggg
       61 ggacgcgccg ggaccgcgag gagcgcagga gccttcgagg cggtgaacga gggagggagc
      121 ccagtccgcc gcgggccatg agccaccggg cccggggagc ccggccgcgg tccgggcagc
      181 gctcagccgg cgccccagcc cgctcggccg cagctgcgcg cctgtagccg caggtggctg
      241 cgatgggacg gaagccatga atggtgccgg ccctggcccc gccgcagccg ccccggtccc
      301 agtcccggtc ccggtcccgg actggcggca gttctgcgag ctgcatgcgc aggcggccgc
      361 cgtggacttt gcgcacaagt tctgccgttt cctgcgggac aacccagctt acgacacgcc
      421 cgacgccggc gcctccttct cccgccactt cgccgccaac ttcctggacg tcttcggcga
      481 ggaggtgcgc cgcgtgctgg tggctgggcc gacgactcgg ggcgcggccg tgagcgcaga
      541 ggccatggag ccggagctcg cggacacctc tgcactcaag gcggcgccct acggccactc
      601 gcggagctcg gaggacgtgt ccacgcacgc ggccaccaag gcccgcgttc gcaagggctt
      661 ctcgctgcgc aacatgagcc tgtgcgtggt ggacggcgtg cgcgacatgt ggcaccggcg
      721 cgcctcgccc gagcccgacg cggcagctgc cccgcgcacc gccgagcccc gcgacaagtg
      781 gacgcggcgc ctgaggctgt cgcggacgct ggctgccaag gtggagctgg tggacattca
      841 acgcgagggg gcgctgcgct tcatggtggc cgacgacgcg gccgcgggct ccgggggctc
      901 ggctcagtgg cagaagtgcc gcctgctcct gcgcagggct gtggccgagg aacgcttccg
      961 cctggagttc ttcgtgccgc ccaaagcctc caggcccaag gtcagcatcc cactgtcagc
     1021 catcattgag gtccgcacca ccatgcccct ggaaatgcca gagaaggata acacattcgt
     1081 cctcaaggta gagaatggag ccgaatacat cttggagacc atcgactctc tgcagaagca
     1141 ctcgtgggta gctgacatcc agggctgcgt ggaccccggt gacagtgagg aagacaccga
     1201 gctctcctgt acccgaggag gctgtctggc cagccgcgtg gcctcctgca gctgtgagct
     1261 cctgactgat gcagtcgacc tgccccgccc cccagagacg acagccgtgg gtgcagtggt
     1321 gacagccccc cacagccgag gtcgagatgc cgtcagagaa tccctgatcc acgtcccgct
     1381 agagaccttt ctgcagaccc tggaatcccc gggcggcagc ggcagtgaca gcaataacac
     1441 aggggaacag ggtgcagaga cggatcccga ggctgaaccc gagctggagc tatccgacta
     1501 cccatggttc cacgggacac tgtcccgggt caaggctgct caactggttc tggcaggggg
     1561 gccccggaac cacggcctct tcgtgatccg ccaaagtgag actcggcctg gggagtacgt
     1621 gctgaccttc aacttccagg gcaaggccaa gcacctgcgc ctgtccctga acggccacgg
     1681 ccagtgtcac gtacagcatc tgtggttcca gtctgtgctt gacatgctcc gccacttcca
     1741 cacacacccc atcccactgg agtcaggggg ctcggccgac atcacccttc gcagctatgt
     1801 gcgggcccag gaccccccac cagagccggg ccccacgccc cctgccgcgc ccgcgtcccc
     1861 ggcctgctgg agcgactcgc ccggccagca ctacttctcc agcctcgccg cggccgcctg
     1921 cccgcctgcc tcgccctccg acgccgccgg cgcctcctcg tcttccgcct cgtcgtcctc
     1981 tgccgcgtcg gggcccgccc ccccgcgccc cgtcgagggc cagctcagcg cgcggagccg
     2041 cagcaacagc gccgagcgcc tgctggaggc cgtggccgcc accgccgccg aggagccccc
     2101 ggaggccgcg cccggccgcg cgcgcgccgt ggagaaccag tactccttct actagcccgc
     2161 ggcgccgccc gggtgggaca cgccaagctc ttcagtgaag acacgatgtt attaaaagcc
     2221 tgttttaggg actgca
//
