LOCUS       NM_019072               5448 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens small glutamine rich tetratricopeptide repeat
            co-chaperone beta (SGTB), mRNA.
ACCESSION   NM_019072
VERSION     NM_019072.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5448)
  AUTHORS   Cho,H., Liu,Y., Chung,S., Chandrasekar,S., Weiss,S. and Shan,S.O.
  TITLE     Dynamic stability of Sgt2 enables selective and privileged client
            handover in a chaperone triad
  JOURNAL   Nat Commun 15 (1), 134 (2024)
   PUBMED   38167697
  REMARK    GeneRIF: Dynamic stability of Sgt2 enables selective and privileged
            client handover in a chaperone triad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5448)
  AUTHORS   Shi,L., Kan,J., Zhuo,L., Wang,S., Chen,S., Zhang,B. and Ke,B.
  TITLE     Bioinformatics identification of miR-514b-5p promotes NSCLC
            progression and induces PI3K/AKT and p38 pathways by targeting
            small glutamine-rich tetratricopeptide repeat-containing protein
            beta
  JOURNAL   FEBS J 290 (4), 1134-1150 (2023)
   PUBMED   36180981
  REMARK    GeneRIF: Bioinformatics identification of miR-514b-5p promotes
            NSCLC progression and induces PI3K/AKT and p38 pathways by
            targeting small glutamine-rich tetratricopeptide repeat-containing
            protein beta.
REFERENCE   3  (bases 1 to 5448)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5448)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5448)
  AUTHORS   Tian,Q., Sun,H.F., Wang,W.J., Li,Q., Ding,J. and Di,W.
  TITLE     miRNA-365b promotes hepatocellular carcinoma cell migration and
            invasion by downregulating SGTB
  JOURNAL   Future Oncol 15 (17), 2019-2028 (2019)
   PUBMED   30943053
  REMARK    GeneRIF: miR-365b promoted hepatocellular carcinoma (HCC) cell
            motility and spreading. Furthermore, SGTB was found to be a
            downstream target of miR-365b, and knockdown of the SGTB gene could
            mimic the effect of miR-365b in hastening HCC cell migration and
            invasion. These results imply that miR-365b plays a tumor-promoting
            role in HCC by suppressing SGTB expression.
REFERENCE   6  (bases 1 to 5448)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 5448)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   8  (bases 1 to 5448)
  AUTHORS   Cao,M., Xu,W., Yu,J., Zheng,H., Tan,X., Li,L., Rui,Y., Xu,G.,
            Cui,G., Xu,J., Cao,J., Tao,T., Ke,K. and Wu,Q.
  TITLE     Up-regulation of SGTB is associated with neuronal apoptosis after
            neuroinflammation induced by lipopolysaccharide
  JOURNAL   J Mol Histol 44 (5), 507-518 (2013)
   PUBMED   23820636
REFERENCE   9  (bases 1 to 5448)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 5448)
  AUTHORS   Heavner,G.A., Audhya,T. and Goldstein,G.
  TITLE     Peptide analogs of thymopentin distinguish distinct thymopoietin
            receptor specificities on two human T cell lines
  JOURNAL   Regul Pept 27 (2), 257-262 (1990)
   PUBMED   2158125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713334.1, BC012044.1 and AC008560.6.
            
            On Nov 23, 2018 this sequence version replaced NM_019072.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.40478.1,
                                           SRR3476690.422441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381007.9/ ENSP00000370395.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AL713334.1         6-404
            400-1302            BC012044.1         382-1284
            1303-5448           AC008560.6         13014-17159
FEATURES             Location/Qualifiers
     source          1..5448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..5448
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /note="small glutamine rich tetratricopeptide repeat
                     co-chaperone beta"
                     /db_xref="GeneID:54557"
                     /db_xref="HGNC:HGNC:23567"
                     /db_xref="MIM:620526"
     exon            1..193
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            194..315
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1130
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /note="small glutamine rich protein with tetratricopeptide
                     repeats 2; beta-SGT; small glutamine rich
                     tetratricopeptide repeat containing beta; small
                     glutamine-rich tetratricopeptide repeat (TPR)-containing,
                     beta"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein beta"
                     /protein_id="NP_061945.1"
                     /db_xref="CCDS:CCDS3988.1"
                     /db_xref="GeneID:54557"
                     /db_xref="HGNC:HGNC:23567"
                     /db_xref="MIM:620526"
                     /translation="MSSIKHLVYAVIRFLREQSQMDTYTSDEQESLEVAIQCLETVFK
                     ISPEDTHLAVSQPLTEMFTSSFCKNDVLPLSNSVPEDVGKADQLKDEGNNHMKEENYA
                     AAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMG
                     LALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDMASL
                     INNPAFISMAASLMQNPQVQQLMSGMMTNAIGGPAAGVGGLTDLSSLIQAGQQFAQQI
                     QQQNPELIEQLRNHIRSRSFSSSAEEHS"
     exon            316..419
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..489
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..589
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..694
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..833
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..896
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..934
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1018
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..5448
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5425..5430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /note="hexamer: AATAAT"
     polyA_site      5448
                     /gene="SGTB"
                     /gene_synonym="SGT2"
                     /note="major polyA site"
ORIGIN      
        1 agaccctgcc gcctgagaga gagcacagcc tggtgggttc tggggtctac ggcctagggg
       61 ccggggaagt ttgcgccgcc gcgaccagtg ctgcgatccc gagccgggct ccagccccga
      121 ggaccagggg tcgggcgggc ctgcctacgg aaccccgcgg gccagcagca gtcgtctcgc
      181 gtcctcctgc ttggaaaagt gtttaagctt ctaaaatgtc atctatcaag cacctggttt
      241 atgcagttat tcgtttctta cgggaacaaa gtcagatgga cacttacacc tcggatgaac
      301 aagaaagttt ggaagttgca attcagtgct tggagacagt ttttaagatc agcccagaag
      361 atacacacct agcagtttca cagcctttga cagaaatgtt taccagttcc ttctgtaaga
      421 atgacgttct gcccctttca aactcagtgc ctgaagatgt gggaaaagct gaccaattaa
      481 aagatgaagg caataaccac atgaaagaag aaaattatgc tgctgcagtg gattgttaca
      541 cacaggcaat agaattggat cccaataatg cagtttacta ttgcaacagg gctgctgctc
      601 agagcaaatt aggtcactac acagatgcga taaaggattg tgaaaaagca atagcaattg
      661 attcaaagta cagcaaggcc tatgggagaa tggggctggc cctcactgcc ttgaataaat
      721 ttgaagaagc agttacaagt tatcaaaagg cattagatct tgaccctgaa aatgattcct
      781 ataagtcaaa tctgaaaata gcagaacaga agttaagaga ggtatccagt cctacaggaa
      841 ctggactgag ctttgacatg gctagcttga taaataatcc agccttcatt agtatggcgg
      901 caagtttaat gcagaaccct caagttcaac agctaatgtc aggaatgatg acaaatgcca
      961 ttgggggacc tgctgctgga gttgggggcc taactgacct gtcaagcctc atccaagcgg
     1021 gacagcagtt tgctcagcag atacagcaac aaaatcctga acttatagag caactgagaa
     1081 atcacatccg gagcagatca ttcagcagca gcgctgaaga gcattcctga tttaaccagg
     1141 ggctcaagcc caagatacaa atggtttatg gctatgaatg aagtatttgt tgtagatagt
     1201 accccctccc tccttcaaaa aaccaaacac catatctgat gtgtgaaaat aatggaggaa
     1261 aacctcttgt gtatattctt aaagaataaa tctgtttaga caataggttt atcacaaaca
     1321 aactcaaaac ataacatgac tccttttgaa atgatcacta gccatgttac gtgccaatat
     1381 agcactggga taaggttcca ttttcaaact tctatcatat ttgtatatta gacttaatag
     1441 caaagcatat ttattgaact ctagtagggc tatttgttgg taagctcttt agctccaatt
     1501 tcccttaagc aaagtttttt gagaagggaa atgacccaaa ggaaaggttt cctatgctgg
     1561 ttgagaagaa gtgtacttgc cactgagcag tatgtcagga aagaaggaat attatctagg
     1621 tttagctttg ataagtgcta ttagtaatga atatataaca tgggaaccaa tgttatcttt
     1681 aatgttgctt gttctggtga acagagaatc ttaagagctg ttagaaagta gcacttgatg
     1741 caagggatgt tttgaaaaga aaaaattggt aatgcgaatg tatagaaagt aaaggtagga
     1801 tgctcaggtt ttctgcatag ttcttaacta atcttgtctg cagtttggta ttgataatat
     1861 tagcatggcc acttatgcta aatacacaat aagatacatt tagaaatcct taatgtactg
     1921 gttaggtcag tggtacaact gtttgactta attatcacaa tttccccaat ggtaacctta
     1981 ccttggaaac tatcaaatat aaatatactt taactaagcc agtgacctgg tcctaagtta
     2041 aggattttct aaatggtatt taattgtgtg cccataaaca ctgatttttt ttaaaaagaa
     2101 aacttagtaa ttatttgatg gataacaaaa agcatctatc actaacattg cttgttcatg
     2161 taatcttctg tgataatttg gcttggcatg ccagtcttat aattaacata atttaaattt
     2221 gatgcaattt aaatataaca ggagacttaa aatattttat tataaattag atgccatatt
     2281 agttagtgga gaaaaggggc attaggtatt aattgcatgg gtctaactac attgatgatg
     2341 agagtttaat tccaactaga gtatattttt tgtttattaa taatgaaatt ggtgctgaca
     2401 tgtaatgact tcacaagttt tacgagggaa aactgaaaaa ggaagtaata taaattttgt
     2461 ggggtttttt tgagatggag tcttactctt ttgccaggct agagtggtgt tgcaatgtca
     2521 gctcactgca acctccacct cctggattca agtgattctc gagccttaag ctcccaagta
     2581 gctgggatta cgggcgccca ccaccacgcc cagctaattt tttttttttt tttcttgaga
     2641 tggagtctct ctctgtcgcc aggctggagt gcagtggcgc aatcgcggct cactgcaacc
     2701 tctgcctccc gggttcaagt gattctcctg cctcagcctc ctgagtagct gggattacag
     2761 gcacgtgtca ccatgcccag ctaatttttg tatttttagt agagacgggg tttcaccatg
     2821 tttgccagga ttgtctcaat ctcttgacct cgtgatccgc ctgccttggc ctcccaaatg
     2881 ctgggattac aggcgtgagc caccgtgcct ggccgctaat ttttgttttt aatggagaga
     2941 gttccaccgt atcggccagg ctggtctcga actcctgacc tcaagtgatc tgcccatctt
     3001 ggcccctcaa agtgctggga ttagaggtgt gagccactgt gcctggccag gaagtaatat
     3061 acaattaaat gagtaataat gcagatgatt aggccttata gaacccttat caaaagacta
     3121 attggccggg cgctgtggct catgcctgta atcccagcac tttgggaggc caaggcaggg
     3181 gggatcacct gaggtcagga gtttgagacc agcctggcca acatggtgaa acccacctct
     3241 actgaaaata caaaaattag cctggcttgg tggcgggcac ccgtagtccc agctacttgg
     3301 gaggctgaag catgagaatt gctcgaacct gagaggcaga ggttgcagtg agccaagatt
     3361 gcgccactgc actccagcct gggtgacaga gcaagactcc atttcaaaaa aaaaaaaaaa
     3421 aagaaaaaga gactaagaga ctaattattt tgtatcttga agtttaaaat ccaacttttc
     3481 tctttctcct ttgtgacatt agaacagtag ttctataact tcattgtaag aatcacctgg
     3541 ataattcatt aaagatgcag attcagggcc acgtgttcaa ttctgataca gtaggtcctg
     3601 taataaggcc taggaatggc catttttaaa cagtacacta ggtggttttg atacagatcc
     3661 aaggactcta atttagagga acactaggtt agaggtttct cagacctgca aacacctaag
     3721 cacctgggcc aaacaaagct acaacgaaga tctgtatgaa gatatatagt tctgcagaat
     3781 ttaaaaagag cacaatttaa gtcttcggcc ctcagaagtt aaattcatat tccatctaag
     3841 ccaactttga ttttcattaa gttagaatga actcctagta ttccagtatt acacagaacg
     3901 aagtactact actaacacat agaagtcatt actgtgatat aaaaagcaaa atagatcctt
     3961 aattaaaaat tagtcactca tattcagtgt tgaataagaa gttaaagttt ctagcataac
     4021 tatcttgagt gcattaaaaa tgcttttaga gcaataagat aagcttctag ctgactgcct
     4081 agaaaaacag aagatacaaa ttcagtgtca gaaatgaaag ggaatacact acagacacta
     4141 tagttattaa aaggctaact agaaaacacc atgaccaact caaggattgt atatttaaca
     4201 acttagatga aacagattcc ctataggata caaactagaa agctcactgt agaaacagat
     4261 aacctaaaca gaaccatatt tattaaggaa attgagtttg tggttaagtt aaaaaccttc
     4321 cagtaaagaa aactacaggc ccagataact tccgtgatga attttaccaa acacttaagg
     4381 gagaaataat atcaattcta aacaatctct tccaggaaac agaagaggag gaaatacttc
     4441 ccaactcatt ttatttgacc agtattaccc agacaaagat actataagaa aaaaaacttt
     4501 aaaacaatgt cttcatgtgc taacatctgt agttaaatta gccattcttt ttacatgaaa
     4561 taatgggaat tggtatattt cttccatttc atttttctat ttctttgcta atataccacc
     4621 tgtaacaaat tcaatctaga tgctatctgt ccacttgcct acatttccat tctattcaag
     4681 ccatttttgc tcttcaagta ccttgatcac tttggaatca tagcattgca agctatttca
     4741 aaaaaagttg cgtggttgga ttgtgctagc tacttttaaa tttataaaaa atgccccata
     4801 tattttcttg cttgtctggg aaatatagtt gctatctaac tagaaaaata agagggcatt
     4861 attaaagtaa ctctttaagc atcgtactaa atgtttgact tccattaacc atatttcttg
     4921 tagtagctgt agctattatg atactgtgta aaacagaaca ggttctatat atgcaaatga
     4981 cattttcatt taatgtacca aattgtgtat ctaactttta taatataggt taaacagatc
     5041 ctttctaaga tggcattatt taatctttac ttaaaactat gaaaaatatg tgtaagttat
     5101 tgtttataaa cagaagagac tataattaaa atatagagca gattccaagt gaccatcatt
     5161 ttacttttta gatttaaaac agaatgaaac agaagattta gtcataagaa gatgcttgaa
     5221 aaacaatcca agtatccaat gcagtggcta taaaatatta tttcatcatt taatcttaat
     5281 cattttgaaa caaagacaga cttcaatttt acactgcttg cactttattt tgtacagaca
     5341 tttcattaat tattactcaa ttttgaggtg caaaccttct gaatatagct ttcattttgg
     5401 accaaacaat ttgttatggc aataaataat gatgcattga aaaaccaa
//
