LOCUS       NM_003021               2231 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens small glutamine rich tetratricopeptide repeat
            co-chaperone alpha (SGTA), mRNA.
ACCESSION   NM_003021
VERSION     NM_003021.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Hill,J. and Nyathi,Y.
  TITLE     USP5 enhances SGTA mediated protein quality control
  JOURNAL   PLoS One 17 (7), e0257786 (2022)
   PUBMED   35895711
  REMARK    GeneRIF: USP5 enhances SGTA mediated protein quality control.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Kubota,S., Doi,H., Koyano,S., Tanaka,K., Komiya,H., Katsumoto,A.,
            Ikeda,S., Hashiguchi,S., Nakamura,H., Fukai,R., Takahashi,K.,
            Kunii,M., Tada,M., Takeuchi,H. and Tanaka,F.
  TITLE     SGTA associates with intracellular aggregates in neurodegenerative
            diseases
  JOURNAL   Mol Brain 14 (1), 59 (2021)
   PUBMED   33757575
  REMARK    GeneRIF: SGTA associates with intracellular aggregates in
            neurodegenerative diseases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Leznicki,P. and High,S.
  TITLE     SGTA associates with nascent membrane protein precursors
  JOURNAL   EMBO Rep 21 (5), e48835 (2020)
   PUBMED   32216016
  REMARK    GeneRIF: SGTA associates with nascent membrane protein precursors.
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2231)
  AUTHORS   Kordes,E., Savelyeva,L., Schwab,M., Rommelaere,J., Jauniaux,J.C.
            and Cziepluch,C.
  TITLE     Isolation and characterization of human SGT and identification of
            homologues in Saccharomyces cerevisiae and Caenorhabditis elegans
  JOURNAL   Genomics 52 (1), 90-94 (1998)
   PUBMED   9740675
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Callahan,M.A., Handley,M.A., Lee,Y.H., Talbot,K.J., Harper,J.W. and
            Panganiban,A.T.
  TITLE     Functional interaction of human immunodeficiency virus type 1 Vpu
            and Gag with a novel member of the tetratricopeptide repeat protein
            family
  JOURNAL   J Virol 72 (6), 5189-5197 (1998)
   PUBMED   9573291
  REMARK    Erratum:[J Virol. 1998 Oct;72(10):8461.. PMID: 9766974]
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Cziepluch,C., Kordes,E., Poirey,R., Grewenig,A., Rommelaere,J. and
            Jauniaux,J.C.
  TITLE     Identification of a novel cellular TPR-containing protein, SGT,
            that interacts with the nonstructural protein NS1 of parvovirus H-1
  JOURNAL   J Virol 72 (5), 4149-4156 (1998)
   PUBMED   9557704
REFERENCE   9  (bases 1 to 2231)
  AUTHORS   Geraghty,R.J., Talbot,K.J., Callahan,M., Harper,W. and
            Panganiban,A.T.
  TITLE     Cell type-dependence for Vpu function
  JOURNAL   J Med Primatol 23 (2-3), 146-150 (1994)
   PUBMED   7966229
REFERENCE   10 (bases 1 to 2231)
  AUTHORS   Heavner,G.A., Audhya,T. and Goldstein,G.
  TITLE     Peptide analogs of thymopentin distinguish distinct thymopoietin
            receptor specificities on two human T cell lines
  JOURNAL   Regul Pept 27 (2), 257-262 (1990)
   PUBMED   2158125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050156.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003021.3.
            
            Summary: This gene encodes a protein which is capable of
            interacting with the major nonstructural protein of parvovirus H-1
            and 70-kDa heat shock cognate protein; however, its function is not
            known. Since this transcript is expressed ubiquitously in various
            tissues, this protein may serve a housekeeping function. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1084371.1, AL050156.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221566.7/ ENSP00000221566.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2231              AL050156.1         46-2276
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2231
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /note="small glutamine rich tetratricopeptide repeat
                     co-chaperone alpha"
                     /db_xref="GeneID:6449"
                     /db_xref="HGNC:HGNC:10819"
                     /db_xref="MIM:603419"
     exon            1..41
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            42..164
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1006
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /note="protein containing three tetratricopeptide repeats;
                     small glutamine rich tetratricopeptide repeat containing
                     alpha; UBP; viral protein U-binding protein; alpha-SGT;
                     vpu-binding protein; small glutamine-rich
                     tetratricopeptide repeat (TPR)-containing, alpha"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein alpha"
                     /protein_id="NP_003012.1"
                     /db_xref="CCDS:CCDS12094.1"
                     /db_xref="GeneID:6449"
                     /db_xref="HGNC:HGNC:10819"
                     /db_xref="MIM:603419"
                     /translation="MDNKKRLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFG
                     VTVEDSDLALPQTLPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQM
                     KVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSK
                     AYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLREAPSPTGGVGS
                     FDIAGLLNNPGFMSMASNLMNNPQIQQLMSGMISGGNNPLGTPGTSPSQNDLASLIQA
                     GQQFAQQMQQQNPELIEQLRSQIRSRTPSASNDDQQE"
     exon            165..271
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            272..356
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            357..456
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            457..561
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            562..700
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            701..763
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            764..801
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            802..891
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1012
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..2231
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /note="hexamer: AATAAA"
     polyA_site      2231
                     /gene="SGTA"
                     /gene_synonym="alphaSGT; hSGT; SGT; SGT1; Vpu"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcaacc gtcggtgggt cggggatcgg tcgcctgaga ggtatcacct cttctgggct
       61 caagatggac aacaagaagc gcctggccta cgccatcatc cagttcctgc atgaccagct
      121 ccggcacggg ggcctctcgt ccgatgctca ggagagcttg gaagtcgcca tccagtgcct
      181 ggagactgcg tttggggtga cggtagaaga cagtgacctt gcgctccctc agactctgcc
      241 ggagatattt gaagcggctg ccacgggcaa ggagatgccg caggacctga ggagccccgc
      301 gcgaaccccg ccttccgagg aggactcagc agaggcagag cgcctcaaaa ccgaaggaaa
      361 cgagcagatg aaagtggaaa actttgaagc tgccgtgcat ttctacggaa aagccatcga
      421 gctcaaccca gccaacgccg tctatttctg caacagagcc gcagcctaca gcaaactcgg
      481 caactacgca ggcgcggtgc aggactgtga gcgggccatc tgcattgacc cggcctacag
      541 caaggcctac ggcaggatgg gcctggcgct ctccagcctc aacaagcacg tggaggccgt
      601 ggcttactac aagaaggctc tggagctgga ccccgacaac gagacataca agtccaacct
      661 caagatagcg gagctgaagc tgcgggaggc ccccagcccc acgggaggcg tgggcagctt
      721 cgacatcgcc ggcctgctga acaaccctgg cttcatgagc atggcttcga acctaatgaa
      781 caatccccag attcagcagc tcatgtccgg catgatttcg ggtggcaaca accccttggg
      841 aactcccggc accagcccct cgcagaacga cctggccagc ctcatccagg cgggccagca
      901 gtttgcccag cagatgcagc agcagaaccc agagttgata gagcagctca ggagccagat
      961 ccggagtcgg acgcccagcg ccagcaacga cgaccagcag gagtgacgct gcctgctccc
     1021 ggtgtgaccg cgtccttccc tggccgaccc gaaggaagcc ttctggttgt ctgccacttc
     1081 ctcctgttgg actgcctgag agaggggaag agagagacct cggacctgca tgtcaagatg
     1141 gattttcccc ttttatctct gccctcctcc actccctttt tgtaactccc ttacagcccc
     1201 cagacccttc ttgaaacgag agccagcaag ctgagcacag accagcagcg acctcccttc
     1261 cagcccccag aaagctcggt cacttgagtg ttttctagaa tcctggggtg ctcccgggcc
     1321 gctctcagag aagtggcagg tttcacgttc agccgtgtgg cggatcgtgt ggcttccaaa
     1381 gccttttaca gcccccgccc cccatcccgt ggtctgtctg caggaactct cccgtctgtg
     1441 agaagcctct ttccgagtcg acctcccggc caccccggcc ctgtgcctgc tcggaagagc
     1501 tcactgccag ctgcggcctg ggcaccgcgg gccatgtgtg tttgcatgag gaactcttta
     1561 gtggcagaca cctaagagac ggctgcggtc accccacgcc tccgcggctc aggagccgtc
     1621 ctgggtgcat aggaccagtt tctgtgactt ttctccagtt gggcatgttg acagacatgt
     1681 ttcccctcct cccaccctca ttttctggtc ctcgcgactg agagccaggg gcgacatcat
     1741 gaccttctgt cccggccgcc ttagccccgg gcacagggaa ggcagctggg ccgtttctgt
     1801 ctgtgtccca tcctgctgtc cttctgtcct ggatgtttca tgggcccggg gccccccagg
     1861 gaagcttacc cctcctgtgc tgggtggagg ccacgggaca cctcaggtgc cacccacctt
     1921 ggccctaaaa cagccaccag gaaagcagcc ggagagccgg acagcaggca gcctgtctgg
     1981 gttcctgagg cctgggggtg gcagacgagc ccacggcgcc gtggtcccag cagcagggtt
     2041 gtcagtcgga gcatcctggg gctccctggc tcctggccgt ctgtgaggta ggcgcagtac
     2101 cgtgtatcgt aggtagcagt aggaacgggg gccgccgcgg ccctgcagcc gctcatggcg
     2161 gtgaggtgtg tgccaagccc acccggggtg cagggcgtga cgtgtgggga ataaataggc
     2221 gttgtgacct c
//
