LOCUS       NM_015705               2986 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens small G protein signaling modulator 3 (SGSM3),
            transcript variant 1, mRNA.
ACCESSION   NM_015705
VERSION     NM_015705.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Birnbaum,R., Ezer,S., Lotan,N.S., Eilat,A., Sternlicht,K.,
            Benyamini,L., Reish,O., Falik-Zaccai,T., Ben-Gad,G., Rod,R.,
            Segel,R., Kim,K., Burton,B., Keegan,C.E., Wagner,M.,
            Henderson,L.B., Mor,N., Barel,O., Hirsch,Y., Meiner,V., Elpeleg,O.,
            Harel,T. and Mor-Shakad,H.
  TITLE     Intellectual disability syndrome associated with a homozygous
            founder variant in SGSM3 in Ashkenazi Jews
  JOURNAL   J Med Genet 61 (3), 289-293 (2024)
   PUBMED   37833060
  REMARK    GeneRIF: Intellectual disability syndrome associated with a
            homozygous founder variant in SGSM3 in Ashkenazi Jews.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Hashemi,M., Bahari,G., Bizhani,F., Danesh,H., Sarhadi,S.,
            Ziaee,S.A.M., Basiri,A., Narouie,B., Taheri,M. and Ghavami,S.
  TITLE     Evaluation of 4-bp insertion/deletion polymorphism within the 3'UTR
            of SGSM3 in bladder cancer using mismatch PCR-RFLP method: A
            preliminary report
  JOURNAL   J Cell Biochem 119 (8), 6566-6574 (2018)
   PUBMED   29693742
  REMARK    GeneRIF: findings support an association between 4-bp ins/del
            polymorphism in the 3'UTR of SGSM3 and the risk of bladder cancer
            in an Iranian population.
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Yang,H., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification of three novel proteins (SGSM1, 2, 3) which modulate
            small G protein (RAP and RAB)-mediated signaling pathway
  JOURNAL   Genomics 90 (2), 249-260 (2007)
   PUBMED   17509819
  REMARK    GeneRIF: Identification of novel protein SGSM3 which modulates
            small G protein (RAP and RAB)-mediated signaling pathway.
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Haas,A.K., Fuchs,E., Kopajtich,R. and Barr,F.A.
  TITLE     A GTPase-activating protein controls Rab5 function in endocytic
            trafficking
  JOURNAL   Nat Cell Biol 7 (9), 887-893 (2005)
   PUBMED   16086013
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Lee,I.K., Kim,K.S., Kim,H., Lee,J.Y., Ryu,C.H., Chun,H.J.,
            Lee,K.U., Lim,Y., Kim,Y.H., Huh,P.W., Lee,K.H., Han,S.I., Jun,T.Y.
            and Rha,H.K.
  TITLE     MAP, a protein interacting with a tumor suppressor, merlin, through
            the run domain
  JOURNAL   Biochem Biophys Res Commun 325 (3), 774-783 (2004)
   PUBMED   15541357
  REMARK    GeneRIF: MAP decreased the AP-1-dependent promoter activity
            additively with merlin in NIH3T3 cells.Results suggest that MAP may
            play a cooperative role in the merlin-mediated growth suppression
            of cells.
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP283990.1, BC008078.2, HY229847.1 and AW512418.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015705.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.242202.1,
                                           SRR1660803.89127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248929.14/ ENSP00000248929.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BP283990.1         33-74
            43-2801             BC008078.2         1-2759
            2802-2978           HY229847.1         1-177               c
            2979-2986           AW512418.1         16-23               c
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2986
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /note="small G protein signaling modulator 3"
                     /db_xref="GeneID:27352"
                     /db_xref="HGNC:HGNC:25228"
                     /db_xref="MIM:610440"
     exon            1..95
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            96..213
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2456
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /note="isoform 1 is encoded by transcript variant 1; RUN
                     and SH3 containing 3; RUN and TBC1 domain containing 3;
                     merlin binding protein; merlin-associated protein; small G
                     protein signaling modulator 3 protein; RUN and TBC1
                     domain-containing protein 3; rab-GTPase-activating
                     protein-like protein"
                     /codon_start=1
                     /product="small G protein signaling modulator 3 isoform 1"
                     /protein_id="NP_056520.2"
                     /db_xref="CCDS:CCDS14002.1"
                     /db_xref="GeneID:27352"
                     /db_xref="HGNC:HGNC:25228"
                     /db_xref="MIM:610440"
                     /translation="MSGSHTPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDE
                     FGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP
                     RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIE
                     KDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE
                     DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLI
                     TLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIF
                     NTLSDIPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQLLGAGTLTN
                     LSQVVRRRTQRRKSTITALLFGEDDLEALKAKNIKQTELVADLREAILRVARHFQCTD
                     PKNCSVELTPDYSMESHQRDHENYVACSRSHRRRAKALLDFERHDDDELGFRKNDIIT
                     IVSQKDEHCWVGELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVTEGVTDLVRGTLCP
                     ALKALFEHGLKKPSLLGGACHPWLFIEEAAGREVERDFASVYSRLVLCKTFRLDEDGK
                     VLTPEELLYRAVQSVNVTHDAVHAQMDVKLRSLICVGLNEQVLHLWLEVLCSSLPTVE
                     KWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELPAKREAQQPLKEGVRDMLVKH
                     HLFSWDVDG"
     exon            214..296
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..363
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..572
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..680
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..824
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1020
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1166
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1391
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1446
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1574
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1730
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1785
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1835
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1988
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2059
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2108
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2194
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2317
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2378
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2986
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2780..2785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /note="hexamer: AATAAA"
     polyA_site      2808
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /note="major polyA site"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
                     /note="hexamer: AATAAG"
     polyA_site      2986
                     /gene="SGSM3"
                     /gene_synonym="CIP85; MAP; RabGAP-5; RABGAP5; rabGAPLP;
                     RUSC3; RUTBC3"
ORIGIN      
        1 acgcgtgcgc ttaggcgccg ctgagcgctg actgggtgcg agtggggaag ctgctaaccc
       61 gacccggatt ggcgctgagg tggcccgtgg ggcagggcag atgattctgg accagatgaa
      121 gcctgaggag ccttccagct ctaagatagc aggataggag acttctaaga ttggagctgc
      181 agaagacttg ccagcccacc agcacaatgt caggaagcca tacacctgcc tgtggccctt
      241 tctcagccct gactccgagc atatggcccc aggagatctt ggccaagtac acgcagaagg
      301 aagagtcagc agagcaacca gagttctact acgatgagtt tggtttccgt gtgtacaagg
      361 aagaaggtga tgagcctggc tccagtctgc tggcgaactc ccctctgatg gaggatgctc
      421 cacagaggct gcggtggcag gcccacctgg agttcaccca taaccacgat gtgggggatc
      481 tcacctggga caagattgcc gtctccctac cccgctctga gaagctccgc tccctggtgc
      541 tggccggcat cccacatggc atgaggccac agctgtggat gcggctctct ggggccctgc
      601 agaagaagag gaactctgag ctgtcctacc gcgagattgt gaagaacagc tccaacgatg
      661 agaccatcgc tgccaagcag atcgagaagg acctgctccg caccatgccc agcaacgcct
      721 gcttcgccag catgggtagc atcggggtgc cccgcctgcg cagggtgctc cgggccctgg
      781 cctggctcta cccagagatc ggctactgcc agggcaccgg catggtggcc gcctgcctcc
      841 tgctgttcct ggaggaggag gacgccttct ggatgatgtc tgccatcatc gaggacctgc
      901 tccccgcctc ctacttcagc accaccctgc tgggtgtcca gactgaccag cgggtcctgc
      961 gccacctcat tgtccagtac ctgcctcgcc tggacaagct gctccaggag catgacattg
     1021 agctgtccct gatcacactg cactggttcc tcacggcctt cgccagcgtg gtggacatca
     1081 agctgctcct gcgcatctgg gacctgtttt tctacgaggg ctcccgggtg ctgttccagc
     1141 tcacgctggg catgctgcac ctcaaggagg aagagctgat ccagtcagag aactcggcct
     1201 ccatcttcaa cacgctatcg gatatcccgt cgcagatgga ggacgcggag ctgcttctgg
     1261 gggtggccat gcggctggcc ggctccctca ccgatgtggc cgtggagact cagcgccgca
     1321 agcacctggc ctatctcatt gcagaccagg gccagctcct gggggccggc accctcacca
     1381 acctctctca ggttgttcgc cgcaggaccc agcggaggaa gtccaccatc actgctctgc
     1441 tcttcgggga ggatgacctg gaggcactca aggccaagaa catcaagcag acggaactgg
     1501 tggctgacct ccgggaagcc atcctgcgcg tggcacgcca cttccagtgc acagacccca
     1561 aaaactgcag cgtggagctg actccagact atagcatgga gagccaccag cgggaccacg
     1621 agaactacgt ggcgtgctca cgcagccacc ggcgccgagc caaggccctg ctggactttg
     1681 agcggcacga cgacgacgag ctgggcttcc gcaagaacga catcatcaca atcgtgtctc
     1741 agaaggacga gcactgctgg gtgggggagc tcaacggcct gcgaggctgg tttccagcca
     1801 agttcgtgga agtcctggat gagcgcagca aagagtactc catcgcgggg gatgactcgg
     1861 tgacggaggg ggtcacagac ctcgtgcgag ggaccctctg cccggccctt aaggccctgt
     1921 tcgaacatgg actgaagaag ccatccctgc ttgggggcgc ctgccacccc tggctgttta
     1981 tcgaggaggc tgcaggccgg gaggtcgaga gagactttgc ctccgtgtat tcccgtctgg
     2041 tgctctgtaa gaccttcagg ttggatgaag atggcaaagt cctgaccccg gaggagctgc
     2101 tctaccgggc tgtgcagtct gtgaacgtga cccacgatgc agtgcatgca caaatggatg
     2161 tgaagctccg ctcactgatc tgcgtggggc tcaatgagca ggtgctgcac ctgtggctgg
     2221 aggtgctctg ctccagcctg cccaccgtgg agaagtggta ccagccctgg tccttcctgc
     2281 gcagcccggg ctgggtccag atcaagtgtg agctccgagt cctctgctgc tttgccttca
     2341 gcctctccca ggactgggag ctccctgcga agagagaggc gcagcagccc ctgaaggagg
     2401 gcgtccggga catgctggtg aagcaccacc tcttcagctg ggatgtggac gggtgacccc
     2461 ctcctcccca gcccaacctc gggcctgcgt ctgaggtggc ccaggacccc aagctgcaga
     2521 gcccagggaa gagcagctcc agagccctgg ccggggccgc gggatatcaa tatcaggctg
     2581 ccccactcca cgttccccag cacatcccag gtggtgggag cagagggtac cctgccccac
     2641 cagggtcctt agggatgctc taggccaaac cacagtttgt accaaaaacc ttgtgaggag
     2701 gtgggggagc catgtctgtg ctcaggaaga gggaagggga tgggggtggc tagtaggctc
     2761 ctggcctctt tggtttataa ataaactgtg tctgtctttg agaaagcacc tacctgtctt
     2821 ctgtgcagct agggctgcag agctgtattc aggtccaagg ttctgccctt ccttgagtgg
     2881 tctagaaggc actgcgtggc ccctcagatg ctgggacaca acagacccgg gacccagctg
     2941 tgctacccac cccttccatg gactgaataa gatggactaa caggcc
//
