LOCUS       NM_014853               4878 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens small G protein signaling modulator 2 (SGSM2),
            transcript variant 1, mRNA.
ACCESSION   NM_014853 XM_029438
VERSION     NM_014853.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4878)
  AUTHORS   Su,X., Chen,D., Zhu,L., Jia,H., Cai,J., Li,P., Han,B., Wang,D.,
            Li,H., Fan,J., Gu,M., Zhou,Y., Guan,H. and Wei,W.
  TITLE     SGSM2 inhibits thyroid cancer progression by activating RAP1 and
            enhancing competitive RAS inhibition
  JOURNAL   Cell Death Dis 13 (3), 218 (2022)
   PUBMED   35264562
  REMARK    GeneRIF: SGSM2 inhibits thyroid cancer progression by activating
            RAP1 and enhancing competitive RAS inhibition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4878)
  AUTHORS   Geng,R., Li,Z., Yu,S., Yuan,C., Hong,W., Wang,Z., Wang,Q., Yi,Z.
            and Fang,Y.
  TITLE     Weighted gene co-expression network analysis identifies specific
            modules and hub genes related to subsyndromal symptomatic
            depression
  JOURNAL   World J Biol Psychiatry 21 (2), 102-110 (2020)
   PUBMED   30489189
  REMARK    GeneRIF: Weighted gene co-expression network analysis identifies
            specific modules and hub genes related to subsyndromal symptomatic
            depression.
REFERENCE   3  (bases 1 to 4878)
  AUTHORS   Lin,J.H., Lee,W.J., Wu,H.C., Wu,C.H., Chen,L.C., Huang,C.C.,
            Chang,H.L., Cheng,T.C., Chang,H.W., Ho,C.T., Tu,S.H. and Ho,Y.S.
  TITLE     Small G protein signalling modulator 2 (SGSM2) is involved in
            oestrogen receptor-positive breast cancer metastasis through
            enhancement of migratory cell adhesion via interaction with
            E-cadherin
  JOURNAL   Cell Adh Migr 13 (1), 120-137 (2019)
   PUBMED   30744493
  REMARK    GeneRIF: Increased expression of SGSM2 is associated with estrogen
            receptor-positive breast cancer metastasis.
REFERENCE   4  (bases 1 to 4878)
  AUTHORS   Marubashi,S., Shimada,H., Fukuda,M. and Ohbayashi,N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
  REMARK    GeneRIF: Data suggest RUTBC1/SGSM2 in melanocytes functions as
            physiological GTPase-activating protein for Rab32/Rab38 in
            regulation of transport of melanogenic enzymes (tyrosinase,
            tyrosinase-related protein 1, dopachrome isomerase) into
            melanosomes.
REFERENCE   5  (bases 1 to 4878)
  AUTHORS   Strawbridge,R.J., Dupuis,J., Prokopenko,I., Barker,A., Ahlqvist,E.,
            Rybin,D., Petrie,J.R., Travers,M.E., Bouatia-Naji,N., Dimas,A.S.,
            Nica,A., Wheeler,E., Chen,H., Voight,B.F., Taneera,J., Kanoni,S.,
            Peden,J.F., Turrini,F., Gustafsson,S., Zabena,C., Almgren,P.,
            Barker,D.J., Barnes,D., Dennison,E.M., Eriksson,J.G., Eriksson,P.,
            Eury,E., Folkersen,L., Fox,C.S., Frayling,T.M., Goel,A., Gu,H.F.,
            Horikoshi,M., Isomaa,B., Jackson,A.U., Jameson,K.A., Kajantie,E.,
            Kerr-Conte,J., Kuulasmaa,T., Kuusisto,J., Loos,R.J., Luan,J.,
            Makrilakis,K., Manning,A.K., Martinez-Larrad,M.T., Narisu,N.,
            Nastase Mannila,M., Ohrvik,J., Osmond,C., Pascoe,L., Payne,F.,
            Sayer,A.A., Sennblad,B., Silveira,A., Stancakova,A., Stirrups,K.,
            Swift,A.J., Syvanen,A.C., Tuomi,T., van 't Hooft,F.M., Walker,M.,
            Weedon,M.N., Xie,W., Zethelius,B., Ongen,H., Malarstig,A.,
            Hopewell,J.C., Saleheen,D., Chambers,J., Parish,S., Danesh,J.,
            Kooner,J., Ostenson,C.G., Lind,L., Cooper,C.C., Serrano-Rios,M.,
            Ferrannini,E., Forsen,T.J., Clarke,R., Franzosi,M.G., Seedorf,U.,
            Watkins,H., Froguel,P., Johnson,P., Deloukas,P., Collins,F.S.,
            Laakso,M., Dermitzakis,E.T., Boehnke,M., McCarthy,M.I.,
            Wareham,N.J., Groop,L., Pattou,F., Gloyn,A.L., Dedoussis,G.V.,
            Lyssenko,V., Meigs,J.B., Barroso,I., Watanabe,R.M., Ingelsson,E.,
            Langenberg,C., Hamsten,A. and Florez,J.C.
  CONSRTM   DIAGRAM Consortium; GIANT Consortium; MuTHER Consortium; CARDIoGRAM
            Consortium; C4D Consortium
  TITLE     Genome-wide association identifies nine common variants associated
            with fasting proinsulin levels and provides new insights into the
            pathophysiology of type 2 diabetes
  JOURNAL   Diabetes 60 (10), 2624-2634 (2011)
   PUBMED   21873549
REFERENCE   6  (bases 1 to 4878)
  AUTHORS   Nottingham,R.M., Ganley,I.G., Barr,F.A., Lambright,D.G. and
            Pfeffer,S.R.
  TITLE     RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by
            Rab32 and Rab33B proteins
  JOURNAL   J Biol Chem 286 (38), 33213-33222 (2011)
   PUBMED   21808068
  REMARK    GeneRIF: RUTBC1 is a Tre2/Bub2/Cdc16 domain-containing protein that
            binds to Rab9A-GTP both in vitro and in cultured cells, but is not
            a GTPase-activating protein for Rab9A.
REFERENCE   7  (bases 1 to 4878)
  AUTHORS   Vasan,R.S., Glazer,N.L., Felix,J.F., Lieb,W., Wild,P.S.,
            Felix,S.B., Watzinger,N., Larson,M.G., Smith,N.L., Dehghan,A.,
            Grosshennig,A., Schillert,A., Teumer,A., Schmidt,R., Kathiresan,S.,
            Lumley,T., Aulchenko,Y.S., Konig,I.R., Zeller,T., Homuth,G.,
            Struchalin,M., Aragam,J., Bis,J.C., Rivadeneira,F., Erdmann,J.,
            Schnabel,R.B., Dorr,M., Zweiker,R., Lind,L., Rodeheffer,R.J.,
            Greiser,K.H., Levy,D., Haritunians,T., Deckers,J.W., Stritzke,J.,
            Lackner,K.J., Volker,U., Ingelsson,E., Kullo,I., Haerting,J.,
            O'Donnell,C.J., Heckbert,S.R., Stricker,B.H., Ziegler,A.,
            Reffelmann,T., Redfield,M.M., Werdan,K., Mitchell,G.F., Rice,K.,
            Arnett,D.K., Hofman,A., Gottdiener,J.S., Uitterlinden,A.G.,
            Meitinger,T., Blettner,M., Friedrich,N., Wang,T.J., Psaty,B.M., van
            Duijn,C.M., Wichmann,H.E., Munzel,T.F., Kroemer,H.K.,
            Benjamin,E.J., Rotter,J.I., Witteman,J.C., Schunkert,H.,
            Schmidt,H., Volzke,H. and Blankenberg,S.
  TITLE     Genetic variants associated with cardiac structure and function: a
            meta-analysis and replication of genome-wide association data
  JOURNAL   JAMA 302 (2), 168-178 (2009)
   PUBMED   19584346
REFERENCE   8  (bases 1 to 4878)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   9  (bases 1 to 4878)
  AUTHORS   Yang,H., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification of three novel proteins (SGSM1, 2, 3) which modulate
            small G protein (RAP and RAB)-mediated signaling pathway
  JOURNAL   Genomics 90 (2), 249-260 (2007)
   PUBMED   17509819
  REMARK    GeneRIF: Identification of novel protein SGSM2 which modulate small
            G protein (RAP and RAB)-mediated signaling pathway
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450226.1, BC039204.1 and
            AB007857.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014853.2.
            
            Summary: The protein encoded by this gene is a GTPase activator
            with activity towards RAB32 and RAB33B, which are regulators of
            membrane trafficking. The encoded protein inactivates RAB32 and can
            bind RAB9A-GTP, a protein required for RAB32 activation. [provided
            by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039204.1, AB275762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268989.8/ ENSP00000268989.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL450226.1         1697-1707           c
            12-13               BC039204.1         1-2
            14-1476             AB007857.3         1-1463
            1477-2344           BC039204.1         1466-2333
            2345-3449           AB007857.3         2197-3301
            3450-3718           BC039204.1         3439-3707
            3719-4857           AB007857.3         3571-4709
            4858-4878           BC039204.1         4846-4866
FEATURES             Location/Qualifiers
     source          1..4878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4878
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /note="small G protein signaling modulator 2"
                     /db_xref="GeneID:9905"
                     /db_xref="HGNC:HGNC:29026"
                     /db_xref="MIM:611418"
     exon            1..245
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..3344
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /EC_number="5.1.1.18"
                     /note="isoform 1 is encoded by transcript variant 1; RUN
                     and TBC1 domain containing 1; small G protein signaling
                     modulator 2 protein"
                     /codon_start=1
                     /product="small G protein signaling modulator 2 isoform 1"
                     /protein_id="NP_055668.2"
                     /db_xref="CCDS:CCDS32526.1"
                     /db_xref="GeneID:9905"
                     /db_xref="HGNC:HGNC:29026"
                     /db_xref="MIM:611418"
                     /translation="MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALC
                     GAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPS
                     GVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEA
                     LLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPA
                     KRPALGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAV
                     PGYLSLHQSAESLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQK
                     SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP
                     KLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEE
                     EEDKLHAMLSMICSRNLTAPNPMKDAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCS
                     SSSSPHATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALV
                     HHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFL
                     LGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSS
                     IDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQ
                     HSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLR
                     EPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYF
                     TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQ
                     NFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYED
                     VFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDA
                     QEILRIARDLVHKVQMLIENK"
     exon            246..321
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..484
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..646
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..714
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..860
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..995
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1120
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1188
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1349
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1476
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1611
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1765
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1830
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1976
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2105
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2288
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2672
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2797
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2880
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2990
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3087
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3255
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..4878
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4858..4863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /note="hexamer: AATAAA"
     polyA_site      4878
                     /gene="SGSM2"
                     /gene_synonym="RUTBC1"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggggct cggaagatgg ctgcggagcc gagcaccggg cagtggctgc ggcggcggcg
       61 gcggcggcgg gccgggagcg cggcgggcgg gggctccgcc ttgcgcgtgg ggcgctgagc
      121 cgagaggcgc ggaggcggcg agggcgcggg ggctctgagg accgctcggc gccgcctcct
      181 gccacaccat gggcagcgca gaggacgcag tcaaagagaa actgctgtgg aacgtgaaga
      241 aggaggtgaa gcaaatcatg gaggaggctg tcaccaggaa gtttgtgcat gaagacagca
      301 gccacatcat tgctttatgt ggtgcagtgg aggcttgcct cttgcatcag ctgagacgcc
      361 gtgccgctgg cttcctgcgc agtgacaaga tggcagccct gttcaccaag gtggggaaga
      421 cgtgcccagt ggcgggggag atttgccaca aggtacagga gctgcagcaa caagcagagg
      481 gcaggaaacc ctcaggggtc agccaggagg ccctgcggag acagggctca gccagcggga
      541 aggccccggc cctcagccct caggccttga aacacgtatg ggtacgcacg gcgctcatcg
      601 agaaagttct ggacaaggtc gtgcaatacc tggcggaaaa ctgcagcaag tactacgaga
      661 aggaggcact gctggcagac cctgtgttcg gcccgatcct ggcctctctt ctagtgggac
      721 cctgtgcctt ggaatacact aagctcaaga cagccgatca ctactggact gacccctctg
      781 ctgatgagct ggtccagcgg caccgcatcc ggggtccacc tactcgccag gactcccctg
      841 caaagcgccc agccctgggg atccggaaac ggcactcaag cggcagcgcg tcggaggaca
      901 ggctggctgc ctgtgcccgc gagtgtgtgg agtccctgca ccagaactca cggacgcggc
      961 tgctctatgg caagaaccac gtgctggtgc agccgaagga ggatatggag gcggtccctg
     1021 gctacctctc cctgcaccag tctgcagaga gcctgactct gaagtggacc cccaaccagc
     1081 tcatgaatgg gactctgggg gactccgagc tggaaaagag cgtttactgg gactatgccc
     1141 tcgtggtgcc cttcagccag gtcgtgtgca tccactgcca ccagcaaaag agcggtggca
     1201 cgcttgtgct ggtgagccag gatggcatcc agaggccgcc gctgcatttc ccacagggag
     1261 gacacctgct gtcctttctg tcctgtctgg agaatgggct gctgcctcgg ggacagctag
     1321 agcccccgct gtggacccag caagggaagg ggaaagtgtt ccccaagcta cggaaacgaa
     1381 gcagcattcg ctccgtggat atggaggaga tgggcacggg gcgggccacc gactatgtgt
     1441 tccggatcat ctaccccggc cacaggcacg agcacatcac tattaactac caccacctag
     1501 cggccagccg cgcggcctcg gtggacgatg atgaggaaga ggaggataaa ctgcacgcga
     1561 tgctctcaat gatctgctcg cggaacctca cagctcccaa tccgatgaaa gacgctggtg
     1621 acatgatcga gatgcagggc tttgggccca gcctgccagc ctggcacctg gagcccctgt
     1681 gcagtcaggg ctcctcctgc ctctcctgct cctccagcag ctccccacat gcaaccccca
     1741 gccactgtag ctgcatcccc gaccggttgc cgctcaggct actgtgtgag agtatgaaga
     1801 ggcagatcgt gtcccgggcc ttctacggct ggctggcaca ctgccgccac ctgtccacgg
     1861 tgcggaccca cctgtcggcg ctggtgcacc atagcgttat cccacctgac cggcccccgg
     1921 gggcctccgc gggcctcacc aaggacgtgt ggagcaagta tcagaaggac aaaaagaact
     1981 acaaagagct ggagctgctg cggcaagttt actacggagg catagagcac gagatccgca
     2041 aggacgtctg gccctttctg cttggccact acaagttcgg catgagcaag aaggagatgg
     2101 agcaggtgga cgcagtggtg gcagcaaggt accagcaggt gttggcagag tggaaggcct
     2161 gcgaggtggt ggtgaggcag cgggagcggg aggcccaccc agccacacgc accaagttct
     2221 cctcaggcag cagcatcgac agccacgtgc agcgcctcat ccaccgagac tccaccatca
     2281 gcaacgatgt gtttatctca gtggatgatc tggaaccccc ggagccccag gaccctgaag
     2341 attccagacc aaaacctgag caggaagcag gacccgggac tccgggcacc gccgtggtgg
     2401 agcagcagca ttccgtggag ttcgactctc cagactcagg actgccctcc tctcgcaatt
     2461 actccgtggc ctcgggcatc cagtcaagcc tagatgaggg gcagagcgtg ggcttcgaag
     2521 aggaggacgg cggtggggag gaaggctcca gtgggcccgg ccctgcagct cacactttga
     2581 gggagcccca ggatcccagc caggagaagc ctcaggccgg agaactggag gccggagagg
     2641 agcttgcggc tgtgtgtgcg gctgcctaca ctatagaatt actggacact gtggccttaa
     2701 acctgcaccg catagacaag gatgtgcaga ggtgtgaccg caactactgg tacttcacgc
     2761 cccccaacct cgagaggctc agagacgtca tgtgcagcta cgtgtgggag cacctggacg
     2821 tgggctatgt gcagggcatg tgcgatctgc tggcgcctct cctggtcacc ctcgacaatg
     2881 atcagctggc ctacagctgc ttcagccacc tcatgaagag gatgagccag aacttcccca
     2941 acgggggtgc catggacacc cactttgcca acatgcgctc cctcatccag atcctggact
     3001 cagagctgtt tgagctgatg catcagaatg gagactacac ccacttctac ttctgttatc
     3061 gctggttcct gctggatttt aagagagaac tgctgtatga ggatgtgttt gctgtgtggg
     3121 aggtgatctg ggcagccagg cacatctcat cggagcactt tgtcctgttc atcgccctcg
     3181 ccctggtgga ggcctaccga gagatcatcc gtgacaacaa catggacttc actgacatca
     3241 tcaagttttt caatgaacgt gctgagcatc acgatgccca ggagatcctg cggattgccc
     3301 gggacctcgt ccacaaggtg cagatgctca tagagaacaa gtgagctggg gccaggaggc
     3361 agcagccgtg cagagcctgg gctccggcag ggagaggtgc aggggagtca ccgcccagac
     3421 ctccccagcc accaaccgac cccacctctg ttcctaacaa agcggttgtg agcctggatc
     3481 cgactcccgg cagtgctgac cctgcagggc aagtcagggg ccaggatgcc ctcggatcag
     3541 ggccgggatg ggaggggtca gcctcaggga gcagctgcct tgggggacac acctactctg
     3601 ctcccctctc acacatctgg gagtagcccc actgccacct gcagccgcag cctggactgc
     3661 tgcccacgag tgaacctggg gccccacagg attaacaggg gctatagcgg cctgggccct
     3721 actcagctgg ggtggcagag ggcgagaggc tctgtgctgt gtcccttctg agggtccctt
     3781 tgcagtccca gtatattgtg cgtgcaccag ccccagctgg agcaaccaaa actgcttctg
     3841 gtttaggcac acgtcacggg tgcgggagac ccgggcacgg gagacccggg ccgccttcag
     3901 gccgctcccc cgagattctg gggcagtcgg aagatgtggg ccctgggtgg gagcagccca
     3961 cttcagcagc actgccactg cctttggcca cctgaggtga cccccaggcc tccccggcct
     4021 tgtacagtgt acctctgtgt atctgtacag cctcgctcct gccaccccac ccttgcgttc
     4081 tgcattaggt acttccctga aaaccacgtg taagaagtga tgcttttgcc agtggatgat
     4141 ctggaatgcg accggagcac ttgctctgag gaatcccagg gtgactctgt cggggaagaa
     4201 tccggtcaca gcctcccctc agagacaggc ctcagttcga gggcagccca ttatctgtcg
     4261 cagacatctg ccatgtccct gagactgcgg gaggcagggg atgcatgggt gtccccatct
     4321 gtccctggtg agaagcaagg ctagctctgc cttccacatg cttctcagga tgccaagagg
     4381 cctaggaacc cagaaacccc cttggaggag ctgtgtatgc gggggtgcca ggaagggcat
     4441 agctcctgcc cccaggccta ggcatgctgc ttgctcggcc atccccactt cctcctctac
     4501 cccaacacat gcaggctagg ccttgccctg gaacatggag gccctgcccg gggctggggc
     4561 ctagtccagc agccaccaaa gtctggcaga ctttctgcat ttgagaaaca tgacaaaggg
     4621 ccccgcagcc cttctgcacc cagcacagcc tgcccagccc agccctgccc ccgggcactg
     4681 cacagcctgt ctgggggcca gaccacccca ttgtccatcc ttgttgtccg tgagtccttg
     4741 gcctccacca agcacgtgtg gccattgtgt gcctgcctta gtgactccgt ggttttgtga
     4801 ggagcagagt gtgtatgatt tttgcctcag aaactatact cttctgtgta acagaccaat
     4861 aaacaacatt tgtcaaca
//
