LOCUS       NM_001098497            6701 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens small G protein signaling modulator 1 (SGSM1),
            transcript variant 3, mRNA.
ACCESSION   NM_001098497
VERSION     NM_001098497.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6701)
  AUTHORS   Li,J., Wang,J., Ding,Y., Zhao,J. and Wang,W.
  TITLE     Prognostic biomarker SGSM1 and its correlation with immune
            infiltration in gliomas
  JOURNAL   BMC Cancer 22 (1), 466 (2022)
   PUBMED   35484511
  REMARK    GeneRIF: Prognostic biomarker SGSM1 and its correlation with immune
            infiltration in gliomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6701)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6701)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6701)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6701)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6701)
  AUTHORS   Nottingham,R.M., Pusapati,G.V., Ganley,I.G., Barr,F.A.,
            Lambright,D.G. and Pfeffer,S.R.
  TITLE     RUTBC2 protein, a Rab9A effector and GTPase-activating protein for
            Rab36
  JOURNAL   J Biol Chem 287 (27), 22740-22748 (2012)
   PUBMED   22637480
  REMARK    GeneRIF: These data show that RUTBC2 can act as a Rab36 GAP in
            cells and suggest that RUTBC2 links Rab9A function to Rab36
            function in the endosomal system.
REFERENCE   7  (bases 1 to 6701)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 6701)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6701)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   10 (bases 1 to 6701)
  AUTHORS   Yang,H., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification of three novel proteins (SGSM1, 2, 3) which modulate
            small G protein (RAP and RAB)-mediated signaling pathway
  JOURNAL   Genomics 90 (2), 249-260 (2007)
   PUBMED   17509819
  REMARK    GeneRIF: Identification of novel protein SGSM1 which modulate small
            G protein (RAP and RAB)-mediated signaling pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000359.1, AW028652.1, AB275761.1, BM930881.1 and AL050312.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001098497.2.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon, and includes an alternate in-frame exon, compared to variant
            1, resulting in a shorter protein (isoform 3), compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB275761.1, SRR1803611.109626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400358.9/ ENSP00000383211.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AP000359.1         3788-3797           c
            11-34               AW028652.1         53-76
            35-5926             AB275761.1         25-5916
            5927-5969           BM930881.1         274-316
            5970-6701           AL050312.8         1810-2541
FEATURES             Location/Qualifiers
     source          1..6701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..6701
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /note="small G protein signaling modulator 1"
                     /db_xref="GeneID:129049"
                     /db_xref="HGNC:HGNC:29410"
                     /db_xref="MIM:611417"
     exon            1..134
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3397
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /note="isoform 3 is encoded by transcript variant 3; RUN
                     and TBC1 domain containing 2; small G protein signaling
                     modulator 1 protein; RUN and TBC1 domain-containing
                     protein 2"
                     /codon_start=1
                     /product="small G protein signaling modulator 1 isoform 3"
                     /protein_id="NP_001091967.1"
                     /db_xref="CCDS:CCDS46675.1"
                     /db_xref="GeneID:129049"
                     /db_xref="HGNC:HGNC:29410"
                     /db_xref="MIM:611417"
                     /translation="MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIIS
                     FCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESAR
                     NQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEAL
                     LMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTK
                     RPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPG
                     YLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDS
                     GGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPK
                     LRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVPQDLMDVSVSNLPSLWQPS
                     PRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFYGWLAYCRHLST
                     VRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPE
                     IRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQRERESHAAA
                     LAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEV
                     EQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLD
                     AQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSI
                     TGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSA
                     NEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYI
                     WQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMR
                     SLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSS
                     AHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQT
                     LIENK"
     exon            135..178
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            179..254
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..417
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..570
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..638
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..784
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..916
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1041
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1109
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1273
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1406
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1545
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1610
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1756
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1885
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2068
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2137
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2725
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2850
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2933
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3043
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3140
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3308
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..6701
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5942..5947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /note="hexamer: AATATA"
     regulatory      5948..5953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /note="hexamer: TATAAA"
     polyA_site      5961
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
     polyA_site      5969
                     /gene="SGSM1"
                     /gene_synonym="RUTBC2"
                     /note="major polyA site"
ORIGIN      
        1 actcagcgct cggccccgcc ccgccgcggc tgcagcagca gcgccgcggc cggaggagct
       61 accgccgcca ccgccgccac cgcctcctgg gactcggaac gcagcgctcg gagccatggc
      121 ctcggccccc gcggaggcgg agacccgaca gaggctgcta cgcaccgtca agaaggaggt
      181 gaagcagatc atggaggagg ctgtgacacg caagtttgtc cacgaagaca gcagccacat
      241 catctccttc tgtgcggctg tggaggcctg cgttctgcac gggcttcggc ggcgggcggc
      301 tggcttccta cgcagcaata agattgcagc cctctttatg aaagtgggca agaacttccc
      361 gccggctgag gatctgagcc gcaaggtgca agacctggag cagctgatcg agagcgcgag
      421 aaaccagatt caaggcctcc aggagaatgt gcggaagctg ccgaagctgc ccaacttgtc
      481 cccacttgcc atcaagcatc tgtggattcg cacagccttg tttgagaagg tcctggacaa
      541 aattgtgcat taccttgtgg aaaacagcag taaatactat gagaaggaag ctctcctgat
      601 ggaccctgtg gacggcccca tccttgcatc tttgttggtg gggccctgtg ccctagagta
      661 caccaagatg aagactgcag atcacttctg gaccgatccc tcggctgacg aacttgtcca
      721 gaggcaccgc atccacagct cccacgtgcg gcaggactcg cccaccaagc gtcctgccct
      781 ctgtatccag aagaggcatt ccagtggcag catggatgac cggccatccc tctctgcccg
      841 cgactacgtg gagtccctgc atcagaactc ccgtgccacc cttctctatg gcaaaaacaa
      901 cgttcttgtt cagccgaggg acgacatgga ggctgtgcca gggtacctgt ccctgcacca
      961 gacggctgac gtcatgacct tgaagtggac acccaaccag ctgatgaacg ggtctgtggg
     1021 ggacctggac tatgagaaga gcgtctactg ggactatgcc atgaccatcc gcttggagga
     1081 gattgtctac ctgcactgcc accagcaagt tgacagcggc gggacagtgg tattggtcag
     1141 ccaggacggg atccagaggc cgcccttccg cttccccaag ggcgggcacc tcctgcagtt
     1201 cctctcgtgc ctggagaatg ggctgctccc acatgggcag ttggacccgc cactgtggtc
     1261 ccagaggggt aagggcaaag tgtttcctaa actgcgcaag cgaagccctc agggttctgc
     1321 cgagtccaca tcttcagaca aagatgatga tgaggccacg gattatgtgt tcaggatcat
     1381 ctaccctggc atgcagtcgg aattcgtgcc ccaggatctg atggacgtct ctgtaagcaa
     1441 cctcccatcc ctgtggcagc ccagtccccg gaagtcctcc tgttcatcct gttcacagag
     1501 tggctcggct gatggtagct cgaccaatgg ctgcaaccat gagagggctc ccctgaaact
     1561 tctctgtgac aatatgaagt accagatcct ctccagagcc ttctatggat ggctggccta
     1621 ctgcagacac ctgtccaccg tgagaaccca cctatcagcc ctggtcaatc acatgatcgt
     1681 gtctccagac ttgccctgcg atgctggaca gggactgaca gccaggatct gggagcagta
     1741 ccttcacgac agcacaagtt acgaggagca ggagctgctg cgcctcatct actacggggg
     1801 catccagcct gagatccgca aggccgtgtg gcccttcctc ctgggccact accagttcgg
     1861 gatgacggaa acagaaagga aagaggtgga cgagcagatt catgcctgct atgcacagac
     1921 catggctgag tggctgggct gcgaggcgat cgtgcggcag agggagcggg agtcccatgc
     1981 ggccgccctg gccaaatgct catccggggc cagcttggac agccacctgc accggatgtt
     2041 gcacagggac tcaaccatca gcaatgagtc ctcccagagc tgcagttcgg gccgccagaa
     2101 catccgcctg cacagcgact ccagcagcag cacacaggtg tttgagtctg tggatgaggt
     2161 ggagcaggtg gaggctgaag gcagattgga ggagaaacag cccaagatcc ccaatgggaa
     2221 cctagtgaac ggcacttgtt ccccagactc gggtcatcct tcctcccata acttctcctc
     2281 gggcctctca gagcactcag agcccagtct gagcacagaa gacagtgtct tggacgccca
     2341 gcggaacacc cccacggtgc tgcgacctag ggatggcagc gtggatgaca ggcagagcag
     2401 cgaggccacc acatctcagg atgaggctcc ccgggaggag ctggccgtgc aggacagcct
     2461 ggagagtgac ctcctggcca acgagagcat ggacgagttc atgtccatca cgggcagcct
     2521 ggacatggcc ctgcctgaaa aggacgatgt tgtgatggag ggctggagga gcagcgagac
     2581 agagaaacat ggccaggcgg acagtgagga caacctctcg gaggagcctg agatggaaag
     2641 tctcttccct gccctggctt ctctggctgt gactacttct gccaacgagg tgtcccctgt
     2701 gtcttccagc ggcgtcacct actctccaga gctgctggat ctgtacacgg tgaacctgca
     2761 ccgcatcgag aaggatgtgc agaggtgcga ccgcaactac tggtacttca cgcccgccaa
     2821 cttggagaag ctgcgtaaca tcatgtgcag ctacatctgg cagcacattg agatcggcta
     2881 tgtccagggc atgtgtgatc ttctggctcc actgctggtc attctggatg atgaggccct
     2941 tgccttcagc tgcttcacgg agctcatgaa gaggatgaac cagaacttcc cccacggagg
     3001 cgccatggac acgcactttg caaacatgag atcgttgatc cagatcctgg actcagagct
     3061 gtttgagctg atgcatcaga acggggacta tactcacttc tacttctgct accgctggtt
     3121 cctgctggat ttcaagcgag aactcgtcta tgatgacgtc ttcttggtct gggagaccat
     3181 ctgggcagcc aaacacgtct cctctgcgca ctacgtcctg ttcattgcgc tggctctggt
     3241 ggaagtctac cgtgacatca ttttggagaa caacatggat ttcacagaca tcatcaaatt
     3301 ctttaatgaa atggctgagc gacacaacac caagcaagtc ctgaagctgg cgcgggacct
     3361 cgtgtacaag gtgcagactc tgattgagaa caagtgaggg gcacctcacc ccggcagcct
     3421 cagccaagct gcccctgccc cgctcctctg cttacttttc ctcctggctg gatgggcacc
     3481 ccgggagcgg ggtcctggtg tctgttcaca agcgtggagt tcagtgcgca aagaaactac
     3541 cctgactttt acttctgggc agatggggtg gagggagtac cccttcaatt cagccttaca
     3601 ttttcctgtt tgaccaaaga ttgcccaagt ctggcgttcc tcccttgcag gaggtggagg
     3661 ttgttggtgg aggaggagcc atctttgttt gctggtgccc ggaatggtct cctcttcttc
     3721 tttccctatc cctccaaact gtcttgtaag atgagacctg gggaggaaac ttctttttgg
     3781 aaattggtgt agaagaggtg tgtggggcta cctctatgct cctctgcaag gggcctttgg
     3841 cgatgttctg gacatggctg aagattgact tagagattga ccctccacct cgacattact
     3901 gacatttggg gccaggtgat tctttttgag gggactgtcc cctgcattgt aggatgctga
     3961 gcagcatccc gggcctcacc agatgccagt agtgccatcc cccaaccata cccctggttg
     4021 tgacagcccc caaaaatgtc tctagacatt gcgaaatgtt ccctgcaggg caaaattgcc
     4081 cccatttgag aaccactggc ttggagaagg gactacaaat gtacttcctc ccccattctt
     4141 ttgacgctaa gccaccctgg tcctgacgcc tcccctcact tagaaaaggc atacaggagg
     4201 ccgggcatgg tggctcacac ctgtaatccc agcactttgg gaggctaagg tgggcggatc
     4261 acaaggtcag gagttttgag accagcctgg ccaacatggt gaaaccccat ctctactaaa
     4321 aatacaaaaa ttagctgggt gtggtggcgg gtgcctgtaa tcccagctac ttgggaggct
     4381 gaggcaggag aatcacttga acctgggagg tggaggttgc agtgagttga gatcacgcca
     4441 ctgcactcca gcccgggcga cagttcaaga ctccatctca aaaaaaaaaa gaaaaggcac
     4501 acaagagtcc ctcacacatc tctcttggag tctgggattc catctgttgt attttctcct
     4561 tttttctcct ctgtctgatg ccagaagata cttgttttct tcttttcaag aaaagtatct
     4621 ccccacatag gcggtggacc caaaaagtgt aggcatgaga cggtcagagc tctttggggt
     4681 cctgctcaga gtcccccagg cagggcagag tctgtatcct gctgccatct tgcaagggaa
     4741 aaccgcctct ccttccaagt attgggtctt ggaaaggtgt gtgtttggtg aaagccactt
     4801 aatggtggtg gggtgcagct tttctctaag tgcagttact cactcaggac aaaggaggaa
     4861 aaggaaggca gaggtcagcc agggtagagg gtgatgtctg ttttccttgg gaaacatctg
     4921 ctgatgaact gggtccaggg ccgtgctagg tctgggaaca atcctctcca ggtcttcaca
     4981 cagagtatca ccaatccaca aacagacccg aagtgaacta gtttactctg cctacctgtc
     5041 ctttcaatag agcagtcttt cccgctcttc tgttctgaga atgcacccgg aatgggggaa
     5101 acccagcaag cagcagagag aaaggctctt cccgggagac ctgccgcctc tagggtggtc
     5161 agagaatagc agctgggatt ttggagaggg agaggatagg taaagcagcg tattgaagca
     5221 tttgcggagg ggtgtattag tcctcccacc ctgagcacac caggacgggg atgcatcctt
     5281 gccttgtgtg cttgtaaagg cttctttccc ttggtatagc aacttcaact gcacctgaac
     5341 ctccaacctc tgcccagcct ctggtgcagg gtggatagag gtctagccag cccttacttc
     5401 ctgaagagag ctctgtggga aactcgaggc tacagtagct tcccggctcc cagctcctac
     5461 cctaccccca ccaaagcaga aacgggagac ggcaacgttc tggctgccat tagacttacg
     5521 tctccctccc ctacgtcccc tagcttccca agacaggaag aaatgtgcaa aaggcccctc
     5581 cggagaaaac tattttgccg ttcagctgtt ctttacagag gatgttattt tagtgagacc
     5641 caggtcctag accttctgat tcctatttat ttttttaaca gactagtctc aaagtacagc
     5701 acaaaatctc ttctctgcct tctcttgtga tgttccagag agcatctgtg gttgtgattt
     5761 ggaataagtc atatttattt ggtttactgt gcctattcag atctctgtat gttgtgtgtg
     5821 tttctgtgtc ctggaattgg atgcgtggga ctcgttctgt ccgcggagtg cactcttttt
     5881 ttcagtgtgg cccacatatc ttgtaaatgt ttgctgaaga gttgtgtcta tatatagaga
     5941 aaatatatat aaacagagaa atatgtgaat ctgttttttt ttgtcttttt ttttttaatt
     6001 tgaaagaaaa aaatgcttgc ttctgaggac tgtgtcctcc cactcacacc ccagtgaccc
     6061 tatatggggt cagatttttg taatagctgc ctggcctttt cccagaaaag gtgaatcact
     6121 tctgacttct tgtattagct ggctcttacc acaagtaatg ctgcattaca aatgacccaa
     6181 aaagtagtgg tttaaaacag ccatgtattt acctcataat tctgtgggtc agcatcccag
     6241 gctaggttca gctaggaggt tcttctgttc tcagacttct tcatgtgtct gtggtcagct
     6301 gatgtccaga taggcaactc tgcttctgat ggttgtctgg ctgttgacta gggcagtggg
     6361 ggaaactgga ttccgtatct tgcatcctcc agcaggctag cttaggcttg tttacatggc
     6421 tatgatagca gatcccagaa ggtaagcaga aacacacact gtctcttggt ctcagcttct
     6481 ctggcataaa gtcatttctg ccacattctg ttggtcagag taagtcacat gactcagccc
     6541 agcttcatag ggtagggaaa tagactgtac ttcctgatga gaatctttgg aaagtgacac
     6601 tgaaaaggag catgggccag gcacagtggc ttacccctgt aatcccagca ctttgggagg
     6661 ccaaagcagg aggatcactt gaggccaaga gttcaagatc a
//
