LOCUS       NM_152386               4983 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens sphingosine-1-phosphate phosphatase 2 (SGPP2),
            transcript variant 1, mRNA.
ACCESSION   NM_152386 XM_938742
VERSION     NM_152386.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4983)
  AUTHORS   Taguchi,Y., Allende,M.L., Mizukami,H., Cook,E.K., Gavrilova,O.,
            Tuymetova,G., Clarke,B.A., Chen,W., Olivera,A. and Proia,R.L.
  TITLE     Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet
            beta-Cell Endoplasmic Reticulum Stress and Proliferation
  JOURNAL   J Biol Chem 291 (23), 12029-12038 (2016)
   PUBMED   27059959
REFERENCE   2  (bases 1 to 4983)
  AUTHORS   Reardon,B.J., Hansen,J.G., Crystal,R.G., Houston,D.K.,
            Kritchevsky,S.B., Harris,T., Lohman,K., Liu,Y., O'Connor,G.T.,
            Wilk,J.B., Mezey,J., Gao,C. and Cassano,P.A.
  TITLE     Vitamin D-responsive SGPP2 variants associated with lung cell
            expression and lung function
  JOURNAL   BMC Med Genet 14, 122 (2013)
   PUBMED   24274704
  REMARK    GeneRIF: SGPP2, a sphingosine-1-phosphate phosphatase, is a novel
            vitamin D-responsive gene associated with lung function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4983)
  AUTHORS   Santulli,P., Marcellin,L., Noel,J.C., Borghese,B., Fayt,I.,
            Vaiman,D., Chapron,C. and Mehats,C.
  TITLE     Sphingosine pathway deregulation in endometriotic tissues
  JOURNAL   Fertil Steril 97 (4), 904-911 (2012)
   PUBMED   22277765
REFERENCE   4  (bases 1 to 4983)
  AUTHORS   Mechtcheriakova,D., Wlachos,A., Sobanov,J., Kopp,T., Reuschel,R.,
            Bornancin,F., Cai,R., Zemann,B., Urtz,N., Stingl,G., Zlabinger,G.,
            Woisetschlager,M., Baumruker,T. and Billich,A.
  TITLE     Sphingosine 1-phosphate phosphatase 2 is induced during
            inflammatory responses
  JOURNAL   Cell Signal 19 (4), 748-760 (2007)
   PUBMED   17113265
  REMARK    GeneRIF: This study provides detailed insights into the regulation
            of SPP2 gene expression and suggests that SPP2 might be a novel
            player in pro-inflammatory signalling.
REFERENCE   5  (bases 1 to 4983)
  AUTHORS   Ogawa,C., Kihara,A., Gokoh,M. and Igarashi,Y.
  TITLE     Identification and characterization of a novel human
            sphingosine-1-phosphate phosphohydrolase, hSPP2
  JOURNAL   J Biol Chem 278 (2), 1268-1272 (2003)
   PUBMED   12411432
  REMARK    GeneRIF: characterization of SPP2, another member of the SPP family
            that may play a role in attenuating intracellular S1P signaling.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314322.1, AF542512.1,
            AC097461.3 and BU676534.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152386.3.
            
            Summary: The protein encoded by this gene is a transmembrane
            protein that degrades the bioactive signaling molecule sphingosine
            1-phosphate. The encoded protein is induced during inflammatory
            responses and has been shown to be downregulated by the microRNA-31
            tumor suppressor. Alternative splice variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.96913.1,
                                           SRR1660805.197603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321276.8/ ENSP00000315137.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1004              AK314322.1         37-1040
            1005-1260           AF542512.1         945-1200
            1261-4980           AC097461.3         110702-114421
            4981-4983           BU676534.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..4983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..4983
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /note="sphingosine-1-phosphate phosphatase 2"
                     /db_xref="GeneID:130367"
                     /db_xref="HGNC:HGNC:19953"
                     /db_xref="MIM:612827"
     exon            1..279
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1260
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /note="isoform a is encoded by transcript variant 1;
                     sphingosine-1-phosphate phosphotase 2; sphingosine
                     1-phosphate phosphohydrolase 2; sphingosine-1-phosphatase
                     2"
                     /codon_start=1
                     /product="sphingosine-1-phosphate phosphatase 2 isoform a"
                     /protein_id="NP_689599.2"
                     /db_xref="CCDS:CCDS2453.1"
                     /db_xref="GeneID:130367"
                     /db_xref="HGNC:HGNC:19953"
                     /db_xref="MIM:612827"
                     /translation="MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAAR
                     VPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFY
                     ITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEY
                     GMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDV
                     LGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRAD
                     TTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVL
                     ILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPML
                     HRFLGLP"
     exon            280..438
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..618
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..708
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..4983
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1393..1398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /note="hexamer: GATAAA"
     polyA_site      1420
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /note="major polyA site"
     regulatory      4964..4969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /note="hexamer: ATTAAA"
     polyA_site      4983
                     /gene="SGPP2"
                     /gene_synonym="SPP2; SPPase2"
                     /note="major polyA site"
ORIGIN      
        1 gccagcggag ggcaccggcc cggcgtggca gcggcggcgg agcgcggccc cgggcacacc
       61 atggccgagc tgctgcggag cctgcaggat tcccagctcg tcgcccgctt ccagcgccgc
      121 tgcgggctct tccccgctcc ggatgaaggc ccccgggaga acggcgcgga ccccacggag
      181 cgcgcggcgc gggtccccgg ggtcgagcat ctccccgcag ccaacggcaa gggcggcgag
      241 gctccggcca acgggctgcg cagagccgcg gcgccggagg cttatgtaca gaagtacgtc
      301 gtgaagaatt atttctacta ttacctattc caattttcag ctgctttggg ccaagaagtg
      361 ttctacatca cgtttcttcc attcactcac tggaatattg acccttattt atccagaaga
      421 ttgatcatca tatgggtttt ggtgatgtat attggccaag tggccaagga tgtcttgaag
      481 tggccccgtc cctcctcccc tccagttgta aaactggaaa agagactgat cgctgaatat
      541 ggaatgccat ccacccacgc catggcggcc actgccattg ccttcaccct ccttatctct
      601 actatggaca gataccagta tccatttgtg ttgggactgg tgatggccgt ggtgttttcc
      661 accttggtgt gtctcagcag gctctacact gggatgcata cggtcctgga tgtgctgggt
      721 ggcgtcctga tcaccgcact cctcatcgtc ctcacctacc ctgcctggac cttcatcgac
      781 tgcctggact cggccagccc cctcttcccc gtgtgtgtca tagttgtgcc attcttcctg
      841 tgttacaatt accctgtttc tgattactac agcccaaccc gggcggacac caccaccatt
      901 ctggctgccg gggctggagt gaccatagga ttctggatca accatttctt ccagcttgta
      961 tccaagcccg ctgaatctct ccctgttatt cagaacatcc caccactcac cacctacatg
     1021 ttagttttgg gtctgaccaa atttgcagtg ggaattgtgt tgatcctctt ggttcgtcag
     1081 cttgtacaaa atctctcact gcaagtatta tactcatggt tcaaggtggt caccaggaac
     1141 aaggaggcca ggcggagact ggagattgaa gtgccttaca agtttgttac ctacacatct
     1201 gttggcatct gcgctacaac ctttgtgccg atgcttcaca ggtttctggg attaccctga
     1261 gtctcaaaca gttggaaact agcccactgg acatgaaagc caagacatag gaaagttatt
     1321 ggtaggcaaa tcttgacaac ttatttttct ttaacaacaa caaaaagtca tacggctgtc
     1381 ttgctactac cagataaatg atgctgctgt gtgaaaggaa gaactgtctc atagcggtca
     1441 ttggtcgtcc gtggtggttg gttgtgctac agttgaaccc aggctaaaga ccataatccg
     1501 gatctttaaa ggcacacacc gcgccccccc cccccccgcc cggcccctgc tcctctcgct
     1561 gttgcacggg ctttggatct agtcatgggc tggcaggaat tgtggcctgg cttaggaata
     1621 gctatgagcc ccactgggtt ctggagagcc agtagagatg gggtgatctg ggaggctgga
     1681 ggtagagcct ttcttttccg ttacaacctt gcctagcatg gagttatttc taaaatggga
     1741 actttggtct aggagaaggg gtggcaccat atgaaacggc attccttgga cagggtgact
     1801 tccttatcgt ttatttggtg attttttgtt ttgttttgtt tgagacagga tcttgctctg
     1861 tttcccaggc tgtattacag tggcacaatc tcagctcact gcaaactctg cctcccgggc
     1921 tcaagcaatc ctcctgcctg agccaactga gtagctggga ctgtaagcat agaccaccat
     1981 gtgcccagct aatttttgta gagacagggt ttctccatgt tgcccaggta cgtctgaaac
     2041 tcctgggctt aagtgatcca cccacctcag cctcccaaag tgctgggatt ataggcatga
     2101 gccactgtgc ccggcctcct ccttgttatg atcaaattag actgtgcctg gttgggtggt
     2161 aagatcactc tgaaagaaag ctcactgtga agagatgaaa ggtggaggca gagctgtgag
     2221 gtcatgggga aaagcctgct ttccttataa gtcctgctgt tcatgttgga ataaggatct
     2281 gctcttcctt gtttccatgc attttgcagg attccaggta ccattaccac actcttctga
     2341 cccatgaaac caactggctg ctcacacatc accaaacagg ttgggggtta gccttcagca
     2401 caggtggata catctgggat tcactgagat tcctgccctc tcctgcttcc tagtggtttg
     2461 ggacaggccc tctgcccatc gtcagcagtt ttttgctttc atacaaacct ggaaggcact
     2521 ggcatctgcc taggaaagtg gatctgtgaa gaacagatga actcaatcct ttctggagtc
     2581 tgacaaagaa gggataggct tccttgacat tgcctgtcct gacaaggcct ccctgacatt
     2641 actcctccaa tttcacagtt accttctgta aatctatttt ctcatctact gaatagaatc
     2701 aggcgccctt tttgtcttcc cacctcttat ctcttggcaa ttttaagggg aattaatgca
     2761 agaacaactt tagtgtctct tgggaaaaca agccaaccaa atacaaaacc cattaagcct
     2821 actagggtga gtcctcttaa catgggaagg cgatgattat gcaaacaccg gagttccctc
     2881 ctcttcagtt cctaagaata aagaacaggt atcaagaact ttctttaaag ttagtgtaac
     2941 tatagttaac aaagtatcca ttgaagttta gtgcctgtag gactgagcca gtgctttatc
     3001 aacccaacac atcatcacca tgtgcatact ctagaaaaaa aaatagcttc cttaaaagtt
     3061 acagaggctc ttaacgtgtt aaaaccgaaa aatcacattt ttcttgattt caaatatgtt
     3121 ctacggcctt actgttggga tgatatttag tatgtaactt agcattccaa tttctcaaga
     3181 atttttaggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggccgaggt
     3241 gggcggacca cgaggtcagg agatcgagac catcctggct aacacggtac cccgtctcta
     3301 ctgaaaatac aaaaaaatta gccggacgtg gtggagggcg cctgtagtcc cagctactca
     3361 ggaggctgag gcaggagaat ggcgtgaacc cggtgagcgg agcttgcagt gagccgagat
     3421 tgcgccactg cactccagcc tgggcgacag agcgagactc tctcaaaaaa aaaaaaaaag
     3481 aatttttagc aaaacatcct gtttttactt aaaattcttc tcatatttat tatagttaga
     3541 aggcaaagat caagatgacc tgccgtttga ctgcttttac atcaaactct gcccagtatt
     3601 tgcagcacaa ctcaggggaa gggccttagc ttacaggtac tcccagcctt catctgcccc
     3661 tgcagagcag tggctgtcag ccggatgcgg cacttttctg tattttcatc cacacagctg
     3721 cccagccaga gttcgcaaca ctggatattt acaccaaata attgtggttg acttgtctga
     3781 agccagctga caaaaggatc agcttttccc acttgtattt tttaaaaaga gggattgtga
     3841 tcattgtcac agagtgggtg ctggcctctc atatatatga tatatatata tcattttata
     3901 tatatatata tatcatatac ataattttta ctgctgtctc tagttttaag tcccaacaat
     3961 aggaaggccg atcagctata ttgatatatt taaggctgta cttaactaat ttgggctgag
     4021 gatgaatata tcagccacag cacattaaag aatgagccaa ggatttgtca tggttggtca
     4081 ctttttaaag tatttgatta ctgcaactgg agaatgaaaa gtgtatattg gtgacgccaa
     4141 cctcagtttc tgagcactcc tgctctgtgg tgagaatcag acaaaaattc atcggggtga
     4201 aaaaggcatt acctgattca cacccttgtc ttgctagccc tcttccattc atttctcaca
     4261 cagcactttg ctctgttaaa tcctctctct gtctcagacc attgcttgcc ccttcaaagg
     4321 gtatggttca ggctcctttc aagacatttg gagtttctct ctggggaaag agagccccct
     4381 actggtttgg cttcagtcta ggtccaccat ccctctcgat ctggcatctt ggagattaat
     4441 ttaaaaggca agctcaccac aatgtaagcc tatggtctgg ccaaccttgc ttttgggaac
     4501 tgtgacacca aagcccccag gactatctgc ctctccagga gccagataga atgacatgcc
     4561 tttttcctaa ttgtccacat tccaccccca acccactgcc actgtgggcc aagccatcca
     4621 tcttgcaatc ttcatctaaa acagctctca tttcatgcca gttttgctca aacctgcacc
     4681 gtcacaagat attcagaaga tgaaaacgta gaagacaccc ctgaattaaa aacacttaca
     4741 tagcagtggc tggaattact ccaaaacgtg cccagtgatc gcactgtaac atgggatttt
     4801 ctcacccaaa taggcaactc atgcttcctg agtgtaatca aagcatgtgg tgttttgggg
     4861 ccatatgcac caggtttcta ttttagaaac cttcagctgt cttgcttatg tactgtatgt
     4921 aaatttattc tttttaaaaa tcacttttat ttgattttga cttattaaat gctttaaaag
     4981 cca
//
