LOCUS       NM_030791               3336 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sphingosine-1-phosphate phosphatase 1 (SGPP1), mRNA.
ACCESSION   NM_030791
VERSION     NM_030791.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3336)
  AUTHORS   Zhang,B., Gao,S., Bao,Z., Pan,C., Tian,Q. and Tang,Q.
  TITLE     MicroRNA-656-3p inhibits colorectal cancer cell migration,
            invasion, and chemo-resistance by targeting sphingosine-1-phosphate
            phosphatase 1
  JOURNAL   Bioengineered 13 (2), 3810-3826 (2022)
   PUBMED   35081855
  REMARK    GeneRIF: MicroRNA-656-3p inhibits colorectal cancer cell migration,
            invasion, and chemo-resistance by targeting sphingosine-1-phosphate
            phosphatase 1.
REFERENCE   2  (bases 1 to 3336)
  AUTHORS   He,J., Zhao,H., Liu,X., Wang,D., Wang,Y., Ai,Y. and Yang,J.
  TITLE     Sevoflurane suppresses cell viability and invasion and promotes
            cell apoptosis in colon cancer by modulating exosome-mediated
            circ-HMGCS1 via the miR-34a-5p/SGPP1 axis
  JOURNAL   Oncol Rep 44 (6), 2429-2442 (2020)
   PUBMED   33125091
  REMARK    GeneRIF: Sevoflurane suppresses cell viability and invasion and
            promotes cell apoptosis in colon cancer by modulating
            exosomemediated circHMGCS1 via the miR34a5p/SGPP1 axis.
REFERENCE   3  (bases 1 to 3336)
  AUTHORS   Schwiebs,A., Thomas,D., Kleuser,B., Pfeilschifter,J.M. and
            Radeke,H.H.
  TITLE     Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity
            Contribute to Sphingolipid Rheostat Regulation of Inflammatory
            Dendritic Cells
  JOURNAL   Mediators Inflamm 2017, 5187368 (2017)
   PUBMED   29375197
  REMARK    GeneRIF: the sequential expression and localization of the
            endogenous S1P regulators SGPP-1 and SGPL-1 and highlight their
            contribution to the sphingolipid rheostat in inflammation.
REFERENCE   4  (bases 1 to 3336)
  AUTHORS   Gao,X.Y., Li,L., Wang,X.H., Wen,X.Z., Ji,K., Ye,L., Cai,J.,
            Jiang,W.G. and Ji,J.F.
  TITLE     Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer
            cells migration in gastric cancer: Clinical implications
  JOURNAL   Oncol Rep 34 (4), 1977-1987 (2015)
   PUBMED   26239167
  REMARK    GeneRIF: The two gastric cancer cells transfected with pEF-SGPP1
            exhibited a slower rate of growth with less adhesion. Thus, our
            findings provided evidence that SGPP1 may serve as a prognostic
            biomarker for patients with advanced gastric cancers.
            Erratum:[Oncol Rep. 2018 Apr;39(4):2051. doi:
            10.3892/or.2018.6269.. PMID: 29484410]
REFERENCE   5  (bases 1 to 3336)
  AUTHORS   Bao,Y., Chen,Z., Guo,Y., Feng,Y., Li,Z., Han,W., Wang,J., Zhao,W.,
            Jiao,Y., Li,K., Wang,Q., Wang,J., Zhang,H., Wang,L. and Yang,W.
  TITLE     Tumor suppressor microRNA-27a in colorectal carcinogenesis and
            progression by targeting SGPP1 and Smad2
  JOURNAL   PLoS One 9 (8), e105991 (2014)
   PUBMED   25166914
  REMARK    GeneRIF: Study has revealed miR-27a as a tumor suppressor and has
            identified SGPP1 and Smad2 as novel targets of miR-27a, linking to
            STAT3 for regulating cancer cell proliferation, apoptosis and
            migration in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3336)
  AUTHORS   Le Stunff,H., Mikami,A., Giussani,P., Hobson,J.P., Jolly,P.S.,
            Milstien,S. and Spiegel,S.
  TITLE     Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth
            factor-induced chemotaxis
  JOURNAL   J Biol Chem 279 (33), 34290-34297 (2004)
   PUBMED   15180992
  REMARK    GeneRIF: sphingosine-1-phosphate phosphatase 1 has a role in
            epidermal growth factor-induced chemotaxis
REFERENCE   7  (bases 1 to 3336)
  AUTHORS   Johnson,K.R., Johnson,K.Y., Becker,K.P., Bielawski,J., Mao,C. and
            Obeid,L.M.
  TITLE     Role of human sphingosine-1-phosphate phosphatase 1 in the
            regulation of intra- and extracellular sphingosine-1-phosphate
            levels and cell viability
  JOURNAL   J Biol Chem 278 (36), 34541-34547 (2003)
   PUBMED   12815058
  REMARK    GeneRIF: sphingosine-1-phosphate phosphatase 1 plays roles in the
            regulation of intra- and extracellular sphingosine-1-phosphate
            levels and cell viability
REFERENCE   8  (bases 1 to 3336)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   9  (bases 1 to 3336)
  AUTHORS   Ogawa,C., Kihara,A., Gokoh,M. and Igarashi,Y.
  TITLE     Identification and characterization of a novel human
            sphingosine-1-phosphate phosphohydrolase, hSPP2
  JOURNAL   J Biol Chem 278 (2), 1268-1272 (2003)
   PUBMED   12411432
REFERENCE   10 (bases 1 to 3336)
  AUTHORS   Mandala,S.M., Thornton,R., Galve-Roperh,I., Poulton,S.,
            Peterson,C., Olivera,A., Bergstrom,J., Kurtz,M.B. and Spiegel,S.
  TITLE     Molecular cloning and characterization of a lipid phosphohydrolase
            that degrades sphingosine-1- phosphate and induces cell death
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7859-7864 (2000)
   PUBMED   10859351
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY008514.1, BC063839.1 and AJ293294.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030791.3.
            
            Summary: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid
            metabolite that regulates diverse biologic processes. SGPP1
            catalyzes the degradation of S1P via salvage and recycling of
            sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed
            10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by
            OMIM, Jun 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070060.1, SRR1660809.241567.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247225.7/ ENSP00000247225.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                HY008514.1         31-57
            28-1755             BC063839.1         1-1728
            1756-1756           AJ293294.1         1667-1667
            1757-3336           BC063839.1         1730-3309
FEATURES             Location/Qualifiers
     source          1..3336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2"
     gene            1..3336
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /note="sphingosine-1-phosphate phosphatase 1"
                     /db_xref="GeneID:81537"
                     /db_xref="HGNC:HGNC:17720"
                     /db_xref="MIM:612826"
     exon            1..805
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1447
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /note="spp1; hSPP1; hSPPase1; sphingosine-1-phosphate
                     phosphohydrolase 1; sphingosine-1-phosphatase 1"
                     /codon_start=1
                     /product="sphingosine-1-phosphate phosphatase 1"
                     /protein_id="NP_110418.1"
                     /db_xref="CCDS:CCDS9760.1"
                     /db_xref="GeneID:81537"
                     /db_xref="HGNC:HGNC:17720"
                     /db_xref="MIM:612826"
                     /translation="MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEK
                     AEAPLAGDPRLRGRQPGAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASP
                     RRAGALRRNSLTGEEGQLARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVG
                     RRLVVIWVLVMYLGQCTKDIIRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPIS
                     MVLLTYGRWQYPLIYGLILIPCWCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYP
                     FVDLIDNFNQTHKYAPFIIIGLHLALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSH
                     VTYNMGLVLDPSLDTLPLAGPPITVTLFGKAILRILIGMVFVLIIRDVMKKITIPLAC
                     KIFNIPCDDIRKARQHMEVELPYRYITYGMVGFSITFFVPYIFFFIGIS"
     exon            806..895
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..3336
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3312..3317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /note="hexamer: AATAAA"
     polyA_site      3336
                     /gene="SGPP1"
                     /gene_synonym="SPP-1; SPPase1"
                     /note="major polyA site"
ORIGIN      
        1 gtcacccggc agactccgga gggtagagcg ctgtgccggt tccgctgccg ctggccagga
       61 gcgcggggac agttcggggc tgcgccggag gccggcccgc cttcccgggg gttccgttat
      121 catgtcgctg aggcagcgcc tggcccagct ggttggccgt ctgcaggacc cgcagaaagt
      181 ggcccgtttc cagcggctgt gcggggtgga agcgccgccg cgccgctcag cagaccggag
      241 ggaggatgag aaagcggagg cgcctctcgc cggagaccct cgactgcgag ggcggcagcc
      301 aggggcgcct ggaggccccc agcctcccgg gagcgaccgc aatcagtgcc cggccaagcc
      361 ggacggcggc ggcgccccca acggcgtgcg gaacgggctg gcggccgagc tgggcccggc
      421 ctcgccgcgg cgcgcgggcg ctctgcgccg caactcgctg acgggcgagg agggccagct
      481 ggcccgcgtg agcaactggc cgctctactg cctgttctgc ttcggcacgg agctgggcaa
      541 cgaactcttc tacatcctgt tcttcccctt ctggatctgg aacctggacc ctctggtggg
      601 ccggaggctc gtggtcatct gggtgctggt catgtacctg ggccagtgca ccaaggacat
      661 catccgctgg ccgaggcccg cctcgccgcc cgtggtcaag ttggaggtct tctacaactc
      721 tgagtacagc atgccctcca cccatgccat gtccggcacc gccatcccca tttctatggt
      781 cctcctcacc tatggccgct ggcagtaccc tcttatatat ggactgattc ttattccctg
      841 ctggtgttct ctagtttgcc taagtagaat ttacatggga atgcactcta ttctggatat
      901 tattgctgga ttcctatata ccattttaat cttagctgtc ttctatccat ttgtggacct
      961 gattgacaac ttcaaccaaa ctcacaaata tgctccattc atcatcatcg ggcttcattt
     1021 agctttgggg atcttttctt tcactcttga cacctggagc acatcccgag gagacacagc
     1081 cgagatacta ggaagtggtg ctggaattgc atgtggatct catgttactt ataacatggg
     1141 tctagtatta gatccttctc tagatacatt acctttagct gggcccccca ttactgtgac
     1201 tctgtttgga aaagccatat tgcggatcct catagggatg gtatttgtac taataatcag
     1261 agatgtaatg aaaaagatca ccattccttt agcctgcaaa atcttcaata taccgtgtga
     1321 tgatattcga aaagcaagac agcacatgga agttgaactt ccttatcggt atattaccta
     1381 tggaatggtt ggtttctcca tcacattttt tgttccttac atatttttct ttattggtat
     1441 ctcttgatgg agaagtattg tttatgataa gaaaggaggg tatcagttac tgatacccaa
     1501 aaatatattc caggtaaagc caggtcagaa ttaggctttt gcaggaattt aacttaaata
     1561 attatttaag taaattcata agagtcagtg cattttatca ttgcacatcc agatactgtt
     1621 ttaggtgagc tgagctattt cgttactgag aaaatgataa gtatccattt agaatgttca
     1681 tgtaatgttt ggagagtttt gtattatgga ttcaacttat atataatata tataaggtac
     1741 ataatatgca attatatatc tgatatatat tatatataaa ataatatacc taagtgtttt
     1801 tttaaactat gggagtgtat tataaaatca ataataatat gcaaacagtt gtgcctgtgt
     1861 atttgaacta catacaggta tgttgttatt aacagatata tttaacattt atttactatg
     1921 ggagccattt cctaattgaa ttgcgtaatt actagaccag aatgcatatg ctactataca
     1981 ttgatttact gcctgttttt acactgccat tacctttcat gttatccatg atgttgaaca
     2041 tgggaggcat ttttaatgga ccaaattttt agaaaaatta gtttttggat ttttttttaa
     2101 gttctgtata ctgttttgaa tgaactttat ttgcagctat tctggatgtc agtttaataa
     2161 ttcaggtact gaattttatt gcttgctaat tgtgcctttc cgttgctaaa ttaagaaatg
     2221 ctatgtgtac tgtgatgtaa aaataagaca ttaactttat cttaagttac atataatcaa
     2281 gcaaatattt taaaaaatgt atgtcagggt gacaggcata aaagtaaatt acccttaact
     2341 ctttagcctt tatttagaaa gaaatgtgga atgggctaaa ctttctcacc aatttattag
     2401 aaagctaaat ggataaatac ttcccttttt gtagatattt ttctgtgcat tgtaagttat
     2461 aggagcagga catatttttt gtacattgtc ttgattgttt atactgcagg taggtatttc
     2521 cagtgaatgg aaacgttgaa atttatagat gggacaatgc acatacttca tatgtaaaca
     2581 aagcattttt ctaaataatt tggaaaggat tggatttagc accgttaact tttaataccc
     2641 atttattggc tatttaaggt aaattataaa acctaaaatt agtatcagta ttttagatcc
     2701 tattattttt tcaactttct attattttca cagtggaaaa tttgcgtata gtattaaact
     2761 attctttttt ctgtctacct ttatattttg aagtgtggtt gtacttacgt taatagtaag
     2821 tgtatttgta gaaagttttt cataaagaag agattaactt tccatataaa taaataccag
     2881 gtatgaaatt actgatttta gtgcaatatc tgtatgatta tccagaacta tcacttcaga
     2941 tgtttctatt ttgggcacca taactatttg agctcatatt tttataattc tgattgagaa
     3001 tttaggggca tggtaatttt taccaaaact gaagctggta attttaagta aagcaactaa
     3061 atttaccctt tacttattag ttaaaaggaa accaaggcat gtaggaaaat attggtacgt
     3121 tggaaaatgt gaaaagagct ttactttcaa aatgtatgtt taatgaattg aattttaggg
     3181 accgtttccc ataatttggg cctatgctat cctgttgatt tttatgtcta gcttaaaagg
     3241 tatttgaaaa tgttccattt gtgttttatt attttctgtc ctatgacagt tctatgctaa
     3301 atgtatttta aaataaaagc caaattgaag attaaa
//
