LOCUS       NM_152524               4478 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens shugoshin 2 (SGO2), transcript variant 1, mRNA.
ACCESSION   NM_152524
VERSION     NM_152524.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4478)
  AUTHORS   Lv,T., He,D., Zhang,X., Guo,X., Li,Z., Zhang,A., Fan,B. and Wang,Z.
  TITLE     SGOL2 promotes prostate cancer progression by inhibiting RAB1A
            ubiquitination
  JOURNAL   Aging (Albany NY) 14 (24), 10050-10066 (2022)
   PUBMED   36566018
  REMARK    GeneRIF: SGOL2 promotes prostate cancer progression by inhibiting
            RAB1A ubiquitination.
REFERENCE   2  (bases 1 to 4478)
  AUTHORS   Kao,Y., Tsai,W.C., Chen,S.H., Hsu,S.Y., Huang,L.C., Chang,C.J.,
            Huang,S.M. and Hueng,D.Y.
  TITLE     Shugosin 2 is a biomarker for pathological grading and survival
            prediction in patients with gliomas
  JOURNAL   Sci Rep 11 (1), 18541 (2021)
   PUBMED   34535705
  REMARK    GeneRIF: Shugosin 2 is a biomarker for pathological grading and
            survival prediction in patients with gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4478)
  AUTHORS   Deng,M., Li,S., Mei,J., Lin,W., Zou,J., Wei,W. and Guo,R.
  TITLE     High SGO2 Expression Predicts Poor Overall Survival: A Potential
            Therapeutic Target for Hepatocellular Carcinoma
  JOURNAL   Genes (Basel) 12 (6), 876 (2021)
   PUBMED   34200261
  REMARK    GeneRIF: High SGO2 Expression Predicts Poor Overall Survival: A
            Potential Therapeutic Target for Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4478)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4478)
  AUTHORS   Hellmuth,S., Gomez-H,L., Pendas,A.M. and Stemmann,O.
  TITLE     Securin-independent regulation of separase by checkpoint-induced
            shugoshin-MAD2
  JOURNAL   Nature 580 (7804), 536-541 (2020)
   PUBMED   32322060
  REMARK    GeneRIF: results identify an unexpected function of SGO2 in
            mitotically dividing cells and a mechanism of separase regulation
            that is independent of securin but still supervised by the spindle
            assembly checkpoint
REFERENCE   6  (bases 1 to 4478)
  AUTHORS   Tsukahara,T., Tanno,Y. and Watanabe,Y.
  TITLE     Phosphorylation of the CPC by Cdk1 promotes chromosome
            bi-orientation
  JOURNAL   Nature 467 (7316), 719-723 (2010)
   PUBMED   20739936
REFERENCE   7  (bases 1 to 4478)
  AUTHORS   Ross,C.J., Katzov-Eckert,H., Dube,M.P., Brooks,B., Rassekh,S.R.,
            Barhdadi,A., Feroz-Zada,Y., Visscher,H., Brown,A.M., Rieder,M.J.,
            Rogers,P.C., Phillips,M.S., Carleton,B.C. and Hayden,M.R.
  CONSRTM   CPNDS Consortium
  TITLE     Genetic variants in TPMT and COMT are associated with hearing loss
            in children receiving cisplatin chemotherapy
  JOURNAL   Nat Genet 41 (12), 1345-1349 (2009)
   PUBMED   19898482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Nat Genet. 2013 May;45(5):578]
REFERENCE   8  (bases 1 to 4478)
  AUTHORS   Lee,J., Kitajima,T.S., Tanno,Y., Yoshida,K., Morita,T., Miyano,T.,
            Miyake,M. and Watanabe,Y.
  TITLE     Unified mode of centromeric protection by shugoshin in mammalian
            oocytes and somatic cells
  JOURNAL   Nat Cell Biol 10 (1), 42-52 (2008)
   PUBMED   18084284
REFERENCE   9  (bases 1 to 4478)
  AUTHORS   Huang,H., Feng,J., Famulski,J., Rattner,J.B., Liu,S.T., Kao,G.D.,
            Muschel,R., Chan,G.K. and Yen,T.J.
  TITLE     Tripin/hSgo2 recruits MCAK to the inner centromere to correct
            defective kinetochore attachments
  JOURNAL   J Cell Biol 177 (3), 413-424 (2007)
   PUBMED   17485487
REFERENCE   10 (bases 1 to 4478)
  AUTHORS   Kitajima,T.S., Sakuno,T., Ishiguro,K., Iemura,S., Natsume,T.,
            Kawashima,S.A. and Watanabe,Y.
  TITLE     Shugoshin collaborates with protein phosphatase 2A to protect
            cohesin
  JOURNAL   Nature 441 (7089), 46-52 (2006)
   PUBMED   16541025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012459.7, BC092412.1, DB369428.1 and AC080164.6.
            
            On Nov 23, 2018 this sequence version replaced NM_152524.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647433.1, BC092412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357799.9/ ENSP00000350447.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC012459.7         42902-42913         c
            13-73               BC092412.1         3-63
            74-74               AC012459.7         36119-36119         c
            75-4046             BC092412.1         65-4036
            4047-4477           DB369428.1         1-431               c
            4478-4478           AC080164.6         16977-16977
FEATURES             Location/Qualifiers
     source          1..4478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..4478
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="shugoshin 2"
                     /db_xref="GeneID:151246"
                     /db_xref="HGNC:HGNC:30812"
                     /db_xref="MIM:612425"
     exon            1..46
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            47..181
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3846
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     shugoshin-like 2"
                     /codon_start=1
                     /product="shugoshin 2 isoform 1"
                     /protein_id="NP_689737.4"
                     /db_xref="CCDS:CCDS42796.1"
                     /db_xref="GeneID:151246"
                     /db_xref="HGNC:HGNC:30812"
                     /db_xref="MIM:612425"
                     /translation="MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKIL
                     NNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNN
                     LNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVP
                     LTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYG
                     LDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKR
                     GSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSS
                     ESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNE
                     HGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
                     IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQ
                     SSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTN
                     EFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIIS
                     GMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCD
                     YRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVK
                     SHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPAC
                     QNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENL
                     QVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKT
                     EIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKES
                     CDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEA
                     DSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDP
                     SPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPN
                     IQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKVNRR
                     TQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLRDK
                     MRR"
     exon            182..357
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            358..435
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            436..521
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            522..751
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            752..3679
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3830
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4478
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4144..4149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="hexamer: AATAAA"
     regulatory      4157..4162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="hexamer: AATAAA"
     polyA_site      4164
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="major polyA site"
     polyA_site      4186
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
     regulatory      4457..4462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="hexamer: AATAAA"
     polyA_site      4478
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
ORIGIN      
        1 gccgagctcc cggagctggg tgggggtgcc ccacgctgaa agagagtgat ggagtgccca
       61 gtgatggaaa ctggctcact ttttacctca ggaattaaga gacatttgaa agacaaaaga
      121 atttcaaaga ctactaagtt gaatgtttct cttgcttcaa aaataaaaac aaaaatacta
      181 aataattctt ctattttcaa aatatcttta aagcacaaca acagggcatt agctcaggct
      241 cttagtagag aaaaagagaa ttctcgaaga attacaactg aaaagatgct attgcaaaaa
      301 gaagtagaga aactgaattt tgagaacaca tttcttcgcc taaagctaaa taacttgaat
      361 aagaagctta tagacataga agctctcatg aacaataact tgataactgc aattgaaatg
      421 agcagtcttt ctgagttcca tcagagttcc tttctactgt cagctagcaa gaagaaacga
      481 attagtaaac agtgcaagtt gatgcgtctt ccatttgcaa gggttccatt aacttcaaat
      541 gatgatgaag atgaagataa agagaaaatg cagtgtgaca acaatattaa atcaaagaca
      601 ttacctgata ttccctcttc aggatcaaca acacaacctt tatcaactca ggataattcg
      661 gaagtgttat ttcttaaaga aaataatcaa aatgtatatg gtttagatga ttcagaacat
      721 atttcttcta tagttgatgt acctcccaga gaaagccatt cccactcaga ccaaagttct
      781 aagacttctc taatgagtga gatgagaaac gcccagtcta ttggccgcag atgggagaaa
      841 ccatctccta gtaatgtgac tgaaaggaag aagcgtgggt catcttggga atcaaataat
      901 ctttctgcag acactccctg tgcaacagtt ttagataaac aacacatttc aagtccagaa
      961 ttaaattgca ataatgagat aaatggtcat actaatgaaa caaatactga aatgcaaaga
     1021 aataaacagg atcttcctgg cttatcttct gagtctgcca gagaacctaa tgcagagtgc
     1081 atgaatcaaa ttgaggataa tgatgacttt caattgcaga aaactgtgta tgatgctgac
     1141 atggatttaa ctgctagtga agtcagcaaa attgtcacag tctcaacagg cattaaaaag
     1201 aaaagtaata aaaaaacaaa tgaacatgga atgaaaactt tcagaaaagt gaaagattcc
     1261 agctctgaaa aaaagagaga aagatcaaag agacagttta aaaatagttc agatgtcgat
     1321 attggggaaa agattgaaaa caggacagaa agatctgatg tcctggatgg caaaaggggt
     1381 gcagaagatc ccggttttat tttcaataat gaacagctgg ctcagatgaa tgaacagctg
     1441 gctcaggtga atgaactaaa gaaaatgacc cttcaaactg gctttgaaca aggtgacaga
     1501 gaaaatgtac tgtgtaataa aaaggagaaa agaataacaa atgagcaaga ggaaacatac
     1561 tctttatccc aaagttcagg taaatttcac caggagagta aatttgataa gggtcagaat
     1621 tccctaactt gtaataaaag taaagcttct agacagacat ttgtgattca caaattagaa
     1681 aaagataact tactcccaaa ccaaaaggat aaagtaacca tttatgaaaa cctagacgtc
     1741 acaaatgaat ttcacacagc caatctttcc accaaagata atggaaattt atgtgattat
     1801 gggacccaca atatattgga tttgaaaaag tatgtcactg atattcaacc ctcagagcaa
     1861 aatgaatcaa acattaataa gcttagaaag aaagtaaacc ggaagacaga aataatttct
     1921 ggaatgaacc acatgtatga ggataatgat aaagatgtgg tgcatggcct aaaaaaaggt
     1981 aatttttttt tcaaaaccca agaggataaa gaacctatct ctgaaaacat agaagtttcc
     2041 aaagagcttc aaatcccagc tctttctact agagataatg aaaatcaatg tgactatagg
     2101 acccagaatg tgttgggttt gcaaaagcag atcaccaata tgtaccccgt tcagcaaaat
     2161 gaatcaaaag ttaataagaa gcttaggcag aaagtaaatc ggaagacaga aataatttct
     2221 gaagtgaatc atttagataa tgacaaaagt atagaataca cagttaaaag tcactcactc
     2281 tttttaacgc aaaaagataa ggaaatcatc cctggaaacc tagaagaccc aagtgagttt
     2341 gaaacacctg ctctttctac caaagatagt ggaaacctgt atgattctga gattcaaaat
     2401 gttttggggg tgaaacatgg ccatgatatg caacctgctt gtcaaaatga ttcaaaaata
     2461 ggtaagaagc ctagactaaa tgtatgtcaa aagtcagaaa taattcctga aaccaaccaa
     2521 atatatgaga atgataacaa aggtgtacat gacctagaaa aagataactt cttctctcta
     2581 accccaaagg ataaagaaac aatttctgaa aatctacaag tcacaaatga atttcaaaca
     2641 gttgatcttc tcatcaaaga taatggaaat ttatgtgatt atgacaccca gaatatattg
     2701 gagttgaaaa agtatgttac tgataggaaa tctgctgagc aaaatgaatc aaaaataaat
     2761 aagctcagga ataaagtgaa ttggaagaca gaaataattt ctgaaatgaa ccagatatat
     2821 gaggataatg ataaagatgc acatgtccaa gaaagctata caaaagatct tgattttaaa
     2881 gtaaataaat ctaaacaaaa acttgaatgc caagacatta tcaataaaca ctatatggaa
     2941 gtcaacagta atgaaaagga aagttgtgat caaattttag attcctacaa agtagttaaa
     3001 aaacgtaaga aagaatcatc atgcaaggca aagaacattt tgacaaaagc taagaacaaa
     3061 cttgcttcac agttaacaga atcttcacag acatctatct ccttagaatc tgatttaaaa
     3121 catattacta gtgaagcaga ttctgatcca ggaaacccag ttgaactatg taagactcag
     3181 aagcaaagca ctaccacttt gaataaaaaa gatctccctt ttgtggaaga aataaaagaa
     3241 ggagagtgtc aggttaaaaa ggtaaataaa atgacatcta agtcaaagaa aaggaagacc
     3301 tccatagatc cttctccaga gagccatgaa gtaatggaaa gaatacttga cagcgttcag
     3361 ggaaagtcta ctgtatctga acaagctgat aaggaaaaca atttggagaa tgagaaaatg
     3421 gtcaaaaata agccagactt ttacacaaag gcatttagat ctttgtctga gatacattca
     3481 cctaacatac aagattcttc ctttgacagt gttcgtgaag gtttagtacc tttgagcgtt
     3541 tcttctggta aaaatgtgat aataaaagaa aattttgcct tggagtgctc cccagccttt
     3601 caagtaagtg atgatgagca tgagaagatg aacaagatga aatttaaagt caaccggaga
     3661 acccaaaaat caggaatagg tgatagacca ttacaggact tgtcaaatac cagttttgtt
     3721 tcaaataaca ctgctgaatc tgaaaataag tcagaagatc tatcttcaga acggacaagc
     3781 agaagaagaa ggtgtactcc tttctatttt aaagagccaa gcctcagaga caagatgaga
     3841 agatgaagtg aatttatgga ttctggtttt tctgaatttt caaagcataa ggaatcaaaa
     3901 cagaaatata gtatcaagaa gatgaaatgc ttaatgaaaa ggtttttttt ttgtttcttt
     3961 ggcctttcat ggagtgttga tttgtccatt cttaatgttt attaataggt atatgtgcat
     4021 aaaatagcta ttttgtaaca ttaaactttt tgagtcattt tggtcatcat ataacttacc
     4081 ttcctgttta tttaagcttc tttttaccta gtagccttta accaaacaat aaccttttaa
     4141 ccaaataaaa tgtgttaata aatacctttg cattggttat cttgtatact aggctgtctt
     4201 gttttgctgt ctgtttttaa cccattcaat atatgtggac atccaaaagg gtttaaaagc
     4261 cacctcctgc cctggcccgt tttctctccc ttcattcttc tgttttcaga aatacatgtt
     4321 gaatgtcagc ttctgtatta tttctattat atgtaatctg atgacttaga ggaggagatt
     4381 aacctttcag gctcttttga atttggtttt tataatttgg ttttaaagat cacttactct
     4441 tccagtaata agtagtaata aatcctgttc atatctga
//
