LOCUS       NM_001160046            4029 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens shugoshin 2 (SGO2), transcript variant 3, mRNA.
ACCESSION   NM_001160046
VERSION     NM_001160046.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4029)
  AUTHORS   Lv,T., He,D., Zhang,X., Guo,X., Li,Z., Zhang,A., Fan,B. and Wang,Z.
  TITLE     SGOL2 promotes prostate cancer progression by inhibiting RAB1A
            ubiquitination
  JOURNAL   Aging (Albany NY) 14 (24), 10050-10066 (2022)
   PUBMED   36566018
  REMARK    GeneRIF: SGOL2 promotes prostate cancer progression by inhibiting
            RAB1A ubiquitination.
REFERENCE   2  (bases 1 to 4029)
  AUTHORS   Kao,Y., Tsai,W.C., Chen,S.H., Hsu,S.Y., Huang,L.C., Chang,C.J.,
            Huang,S.M. and Hueng,D.Y.
  TITLE     Shugosin 2 is a biomarker for pathological grading and survival
            prediction in patients with gliomas
  JOURNAL   Sci Rep 11 (1), 18541 (2021)
   PUBMED   34535705
  REMARK    GeneRIF: Shugosin 2 is a biomarker for pathological grading and
            survival prediction in patients with gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4029)
  AUTHORS   Deng,M., Li,S., Mei,J., Lin,W., Zou,J., Wei,W. and Guo,R.
  TITLE     High SGO2 Expression Predicts Poor Overall Survival: A Potential
            Therapeutic Target for Hepatocellular Carcinoma
  JOURNAL   Genes (Basel) 12 (6), 876 (2021)
   PUBMED   34200261
  REMARK    GeneRIF: High SGO2 Expression Predicts Poor Overall Survival: A
            Potential Therapeutic Target for Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4029)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4029)
  AUTHORS   Hellmuth,S., Gomez-H,L., Pendas,A.M. and Stemmann,O.
  TITLE     Securin-independent regulation of separase by checkpoint-induced
            shugoshin-MAD2
  JOURNAL   Nature 580 (7804), 536-541 (2020)
   PUBMED   32322060
  REMARK    GeneRIF: results identify an unexpected function of SGO2 in
            mitotically dividing cells and a mechanism of separase regulation
            that is independent of securin but still supervised by the spindle
            assembly checkpoint
REFERENCE   6  (bases 1 to 4029)
  AUTHORS   Tsukahara,T., Tanno,Y. and Watanabe,Y.
  TITLE     Phosphorylation of the CPC by Cdk1 promotes chromosome
            bi-orientation
  JOURNAL   Nature 467 (7316), 719-723 (2010)
   PUBMED   20739936
REFERENCE   7  (bases 1 to 4029)
  AUTHORS   Ross,C.J., Katzov-Eckert,H., Dube,M.P., Brooks,B., Rassekh,S.R.,
            Barhdadi,A., Feroz-Zada,Y., Visscher,H., Brown,A.M., Rieder,M.J.,
            Rogers,P.C., Phillips,M.S., Carleton,B.C. and Hayden,M.R.
  CONSRTM   CPNDS Consortium
  TITLE     Genetic variants in TPMT and COMT are associated with hearing loss
            in children receiving cisplatin chemotherapy
  JOURNAL   Nat Genet 41 (12), 1345-1349 (2009)
   PUBMED   19898482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Nat Genet. 2013 May;45(5):578]
REFERENCE   8  (bases 1 to 4029)
  AUTHORS   Lee,J., Kitajima,T.S., Tanno,Y., Yoshida,K., Morita,T., Miyano,T.,
            Miyake,M. and Watanabe,Y.
  TITLE     Unified mode of centromeric protection by shugoshin in mammalian
            oocytes and somatic cells
  JOURNAL   Nat Cell Biol 10 (1), 42-52 (2008)
   PUBMED   18084284
REFERENCE   9  (bases 1 to 4029)
  AUTHORS   Huang,H., Feng,J., Famulski,J., Rattner,J.B., Liu,S.T., Kao,G.D.,
            Muschel,R., Chan,G.K. and Yen,T.J.
  TITLE     Tripin/hSgo2 recruits MCAK to the inner centromere to correct
            defective kinetochore attachments
  JOURNAL   J Cell Biol 177 (3), 413-424 (2007)
   PUBMED   17485487
REFERENCE   10 (bases 1 to 4029)
  AUTHORS   Kitajima,T.S., Sakuno,T., Ishiguro,K., Iemura,S., Natsume,T.,
            Kawashima,S.A. and Watanabe,Y.
  TITLE     Shugoshin collaborates with protein phosphatase 2A to protect
            cohesin
  JOURNAL   Nature 441 (7089), 46-52 (2006)
   PUBMED   16541025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012459.7, AK095291.1 and AC080164.6.
            
            Transcript Variant: This variant (3) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (3)
            has a distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC012459.7         42964-42978         c
            16-2056             AK095291.1         1-2041
            2057-2655           AC080164.6         5171-5769
            2656-4029           AK095291.1         2642-4015
FEATURES             Location/Qualifiers
     source          1..4029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..4029
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="shugoshin 2"
                     /db_xref="GeneID:151246"
                     /db_xref="HGNC:HGNC:30812"
                     /db_xref="MIM:612425"
     exon            1..111
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            112..246
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3899
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /note="isoform 3 is encoded by transcript variant 3;
                     shugoshin-like 2"
                     /codon_start=1
                     /product="shugoshin 2 isoform 3"
                     /protein_id="NP_001153518.1"
                     /db_xref="GeneID:151246"
                     /db_xref="HGNC:HGNC:30812"
                     /db_xref="MIM:612425"
                     /translation="MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKIL
                     NNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNN
                     LNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVP
                     LTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYG
                     LDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKR
                     GSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSS
                     ESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNE
                     HGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
                     IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQ
                     SSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTN
                     EFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIIS
                     GMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCD
                     YRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVK
                     SHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPAC
                     QNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENL
                     QVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKT
                     EIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKES
                     CDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEA
                     DSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDP
                     SPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPN
                     IQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKVNRR
                     TQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLRE"
     exon            247..422
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            423..500
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            501..586
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            587..816
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            817..3744
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3895
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4029
                     /gene="SGO2"
                     /gene_synonym="SGOL2; TRIPIN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggctgat ggggcaaccg ccaacggctg tggcgtttaa acccaagccg cagccgctgc
       61 tgctcgccga gctcccggag ctgggtgggg gtgccccacg ctgaaagaga gtgatggagt
      121 gcccagtgat ggaaactggc tcacttttta cctcaggaat taagagacat ttgaaagaca
      181 aaagaatttc aaagactact aagttgaatg tttctcttgc ttcaaaaata aaaacaaaaa
      241 tactaaataa ttcttctatt ttcaaaatat ctttaaagca caacaacagg gcattagctc
      301 aggctcttag tagagaaaaa gagaattctc gaagaattac aactgaaaag atgctattgc
      361 aaaaagaagt agagaaactg aattttgaga acacatttct tcgcctaaag ctaaataact
      421 tgaataagaa gcttatagac atagaagctc tcatgaacaa taacttgata actgcaattg
      481 aaatgagcag tctttctgag ttccatcaga gttcctttct actgtcagct agcaagaaga
      541 aacgaattag taaacagtgc aagttgatgc gtcttccatt tgcaagggtt ccattaactt
      601 caaatgatga tgaagatgaa gataaagaga aaatgcagtg tgacaacaat attaaatcaa
      661 agacattacc tgatattccc tcttcaggat caacaacaca acctttatca actcaggata
      721 attcggaagt gttatttctt aaagaaaata atcaaaatgt atatggttta gatgattcag
      781 aacatatttc ttctatagtt gatgtacctc ccagagaaag ccattcccac tcagaccaaa
      841 gttctaagac ttctctaatg agtgagatga gaaacgccca gtctattggc cgcagatggg
      901 agaaaccatc tcctagtaat gtgactgaaa ggaagaagcg tgggtcatct tgggaatcaa
      961 ataatctttc tgcagacact ccctgtgcaa cagttttaga taaacaacac atttcaagtc
     1021 cagaattaaa ttgcaataat gagataaatg gtcatactaa tgaaacaaat actgaaatgc
     1081 aaagaaataa acaggatctt cctggcttat cttctgagtc tgccagagaa cctaatgcag
     1141 agtgcatgaa tcaaattgag gataatgatg actttcaatt gcagaaaact gtgtatgatg
     1201 ctgacatgga tttaactgct agtgaagtca gcaaaattgt cacagtctca acaggcatta
     1261 aaaagaaaag taataaaaaa acaaatgaac atggaatgaa aactttcaga aaagtgaaag
     1321 attccagctc tgaaaaaaag agagaaagat caaagagaca gtttaaaaat agttcagatg
     1381 tcgatattgg ggaaaagatt gaaaacagga cagaaagatc tgatgtcctg gatggcaaaa
     1441 ggggtgcaga agatcccggt tttattttca ataatgaaca gctggctcag atgaatgaac
     1501 agctggctca ggtgaatgaa ctaaagaaaa tgacccttca aactggcttt gaacaaggtg
     1561 acagagaaaa tgtactgtgt aataaaaagg agaaaagaat aacaaatgag caagaggaaa
     1621 catactcttt atcccaaagt tcaggtaaat ttcaccagga gagtaaattt gataagggtc
     1681 agaattccct aacttgtaat aaaagtaaag cttctagaca gacatttgtg attcacaaat
     1741 tagaaaaaga taacttactc ccaaaccaaa aggataaagt aaccatttat gaaaacctag
     1801 acgtcacaaa tgaatttcac acagccaatc tttccaccaa agataatgga aatttatgtg
     1861 attatgggac ccacaatata ttggatttga aaaagtatgt cactgatatt caaccctcag
     1921 agcaaaatga atcaaacatt aataagctta gaaagaaagt aaaccggaag acagaaataa
     1981 tttctggaat gaaccacatg tatgaggata atgataaaga tgtggtgcat ggcctaaaaa
     2041 aaggtaattt ttttttcaaa acccaagagg ataaagaacc tatctctgaa aacatagaag
     2101 tttccaaaga gcttcaaatc ccagctcttt ctactagaga taatgaaaat caatgtgact
     2161 ataggaccca gaatgtgttg ggtttgcaaa agcagatcac caatatgtac cccgttcagc
     2221 aaaatgaatc aaaagttaat aagaagctta ggcagaaagt aaatcggaag acagaaataa
     2281 tttctgaagt gaatcattta gataatgaca aaagtataga atacacagtt aaaagtcact
     2341 cactcttttt aacgcaaaaa gataaggaaa tcatccctgg aaacctagaa gacccaagtg
     2401 agtttgaaac acctgctctt tctaccaaag atagtggaaa cctgtatgat tctgagattc
     2461 aaaatgtttt gggggtgaaa catggccatg atatgcaacc tgcttgtcaa aatgattcaa
     2521 aaataggtaa gaagcctaga ctaaatgtat gtcaaaagtc agaaataatt cctgaaacca
     2581 accaaatata tgagaatgat aacaaaggtg tacatgacct agaaaaagat aacttcttct
     2641 ctctaacccc aaaggataaa gaaacaattt ctgaaaatct acaagtcaca aatgaatttc
     2701 aaacagttga tcttctcatc aaagataatg gaaatttatg tgattatgac acccagaata
     2761 tattggagtt gaaaaagtat gttactgata ggaaatctgc tgagcaaaat gaatcaaaaa
     2821 taaataagct caggaataaa gtgaattgga agacagaaat aatttctgaa atgaaccaga
     2881 tatatgagga taatgataaa gatgcacatg tccaagaaag ctatacaaaa gatcttgatt
     2941 ttaaagtaaa taaatctaaa caaaaacttg aatgccaaga cattatcaat aaacactata
     3001 tggaagtcaa cagtaatgaa aaggaaagtt gtgatcaaat tttagattcc tacaaagtag
     3061 ttaaaaaacg taagaaagaa tcatcatgca aggcaaagaa cattttgaca aaagctaaga
     3121 acaaacttgc ttcacagtta acagaatctt cacagacatc tatctcctta gaatctgatt
     3181 taaaacatat tactagtgaa gcagattctg atccaggaaa cccagttgaa ctatgtaaga
     3241 ctcagaagca aagcactacc actttgaata aaaaagatct cccttttgtg gaagaaataa
     3301 aagaaggaga gtgtcaggtt aaaaaggtaa ataaaatgac atctaagtca aagaaaagga
     3361 agacctccat agatccttct ccagagagcc atgaagtaat ggaaagaata cttgacagcg
     3421 ttcagggaaa gtctactgta tctgaacaag ctgataagga aaacaatttg gagaatgaga
     3481 aaatggtcaa aaataagcca gacttttaca caaaggcatt tagatctttg tctgagatac
     3541 attcacctaa catacaagat tcttcctttg acagtgttcg tgaaggttta gtacctttga
     3601 gcgtttcttc tggtaaaaat gtgataataa aagaaaattt tgccttggag tgctccccag
     3661 cctttcaagt aagtgatgat gagcatgaga agatgaacaa gatgaaattt aaagtcaacc
     3721 ggagaaccca aaaatcagga ataggtgata gaccattaca ggacttgtca aataccagtt
     3781 ttgtttcaaa taacactgct gaatctgaaa ataagtcaga agatctatct tcagaacgga
     3841 caagcagaag aagaaggtgt actcctttct attttaaaga gccaagcctc agagaataac
     3901 agtgttttat ggacaggcac agtggctcac acctgtaatc ccaatacttt gggtggctga
     3961 ggtgagagga tcacttgagc ccaagagtcg gagaccagcc tgggcaacac agggagacgc
     4021 tcactctac
//
