LOCUS       NM_001199251            3070 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens shugoshin 1 (SGO1), transcript variant 1, mRNA.
ACCESSION   NM_001199251
VERSION     NM_001199251.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3070)
  AUTHORS   Yang,Z., Jiang,Y., Wang,L., Yu,B., Cai,H., Fan,J. and Zhang,M.
  TITLE     Prognosis and biological function of SGOL1 in clear cell renal cell
            carcinoma: a multiomics analysis
  JOURNAL   BMC Med Genomics 17 (1), 60 (2024)
   PUBMED   38383432
  REMARK    GeneRIF: Prognosis and biological function of SGOL1 in clear cell
            renal cell carcinoma: a multiomics analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3070)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3070)
  AUTHORS   Ueki,Y., Hadders,M.A., Weisser,M.B., Nasa,I., Sotelo-Parrilla,P.,
            Cressey,L.E., Gupta,T., Hertz,E.P.T., Kruse,T., Montoya,G.,
            Jeyaprakash,A.A., Kettenbach,A., Lens,S.M.A. and Nilsson,J.
  TITLE     A highly conserved pocket on PP2A-B56 is required for hSgo1 binding
            and cohesion protection during mitosis
  JOURNAL   EMBO Rep 22 (7), e52295 (2021)
   PUBMED   33973335
  REMARK    GeneRIF: A highly conserved pocket on PP2A-B56 is required for
            hSgo1 binding and cohesion protection during mitosis.
REFERENCE   4  (bases 1 to 3070)
  AUTHORS   Chetaille,P., Preuss,C., Burkhard,S., Cote,J.M., Houde,C.,
            Castilloux,J., Piche,J., Gosset,N., Leclerc,S., Wunnemann,F.,
            Thibeault,M., Gagnon,C., Galli,A., Tuck,E., Hickson,G.R., El
            Amine,N., Boufaied,I., Lemyre,E., de Santa Barbara,P., Faure,S.,
            Jonzon,A., Cameron,M., Dietz,H.C., Gallo-McFarlane,E., Benson,D.W.,
            Moreau,C., Labuda,D., Zhan,S.H., Shen,Y., Jomphe,M., Jones,S.J.,
            Bakkers,J. and Andelfinger,G.
  CONSRTM   FORGE Canada Consortium
  TITLE     Mutations in SGOL1 cause a novel cohesinopathy affecting heart and
            gut rhythm
  JOURNAL   Nat Genet 46 (11), 1245-1249 (2014)
   PUBMED   25282101
  REMARK    GeneRIF: Mutations in SGOL1 cause a novel cohesinopathy affecting
            heart and gut rhythm.
REFERENCE   5  (bases 1 to 3070)
  AUTHORS   Wang,X., Yang,Y., Duan,Q., Jiang,N., Huang,Y., Darzynkiewicz,Z. and
            Dai,W.
  TITLE     sSgo1, a major splice variant of Sgo1, functions in centriole
            cohesion where it is regulated by Plk1
  JOURNAL   Dev Cell 14 (3), 331-341 (2008)
   PUBMED   18331714
  REMARK    GeneRIF: Centriole splitting induced by Sgo1 depletion or
            expression of a dominant negative mutant is suppressed by ectopic
            expression of sSgo1 or by Plk1 knockdown.
REFERENCE   6  (bases 1 to 3070)
  AUTHORS   Kitajima,T.S., Sakuno,T., Ishiguro,K., Iemura,S., Natsume,T.,
            Kawashima,S.A. and Watanabe,Y.
  TITLE     Shugoshin collaborates with protein phosphatase 2A to protect
            cohesin
  JOURNAL   Nature 441 (7089), 46-52 (2006)
   PUBMED   16541025
  REMARK    GeneRIF: a specific subtype of serine/threonine protein phosphatase
            2A (PP2A) associates with human shugoshin
REFERENCE   7  (bases 1 to 3070)
  AUTHORS   Wang,X., Yang,Y. and Dai,W.
  TITLE     Differential subcellular localizations of two human Sgo1 isoforms:
            implications in regulation of sister chromatid cohesion and
            microtubule dynamics
  JOURNAL   Cell Cycle 5 (6), 635-640 (2006)
   PUBMED   16582621
REFERENCE   8  (bases 1 to 3070)
  AUTHORS   McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K.
  TITLE     Shugoshin prevents dissociation of cohesin from centromeres during
            mitosis in vertebrate cells
  JOURNAL   PLoS Biol 3 (3), e86 (2005)
   PUBMED   15737064
  REMARK    GeneRIF: A shugoshin-like protein associates with centromeres
            during prophase and disappears at the onset of anaphase
REFERENCE   9  (bases 1 to 3070)
  AUTHORS   Tang,Z., Sun,Y., Harley,S.E., Zou,H. and Yu,H.
  TITLE     Human Bub1 protects centromeric sister-chromatid cohesion through
            Shugoshin during mitosis
  JOURNAL   Proc Natl Acad Sci U S A 101 (52), 18012-18017 (2004)
   PUBMED   15604152
  REMARK    GeneRIF: Bub1 protects centromeric cohesion through Shugoshin in
            mitosis
REFERENCE   10 (bases 1 to 3070)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK308095.1, AB190994.1,
            AF308299.1, BC032696.1, BX648516.1 and AC099057.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001199251.2.
            
            Summary: The protein encoded by this gene is a member of the
            shugoshin family of proteins. This protein is thought to protect
            centromeric cohesin from cleavage during mitotic prophase by
            preventing phosphorylation of a cohesin subunit. Reduced expression
            of this gene leads to the premature loss of centromeric cohesion,
            mis-segregation of sister chromatids, and mitotic arrest. Evidence
            suggests that this protein also protects a small subset of cohesin
            found along the length of the chromosome arms during mitotic
            prophase. An isoform lacking exon 6 has been shown to play a role
            in the cohesion of centrioles (PMID: 16582621 and PMID:18331714).
            Mutations in this gene have been associated with Chronic Atrial and
            Intestinal Dysrhythmia (CAID) syndrome, characterized by the
            co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal
            Pseudo-obstruction (CIPO) within the first four decades of life
            (PMID:25282101). Fibroblast cells from CAID patients exhibited both
            increased cell proliferation and higher rates of senescence.
            Pseudogenes of this gene have been found on chromosomes 1 and 7.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and A1 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB190994.1, SRR9304714.96190.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267758, SAMN03267770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412997.6/ ENSP00000410458.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AK308095.1         16-274
            260-1856            AB190994.1         24-1620
            1857-2060           AF308299.1         845-1048
            2061-2501           BC032696.1         901-1341
            2502-3068           BX648516.1         1696-2262
            3069-3070           AC099057.3         146567-146568       c
FEATURES             Location/Qualifiers
     source          1..3070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..3070
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="shugoshin 1"
                     /db_xref="GeneID:151648"
                     /db_xref="HGNC:HGNC:25088"
                     /db_xref="MIM:609168"
     exon            1..259
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..408
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1850
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     shugoshin 1AB protein; shugoshin 1CD protein; shugoshin
                     1EF protein; shugoshin 1GH protein; shugoshin 1KL protein;
                     serologically defined breast cancer antigen NY-BR-85"
                     /codon_start=1
                     /product="shugoshin 1 isoform 1"
                     /protein_id="NP_001186180.1"
                     /db_xref="CCDS:CCDS46773.1"
                     /db_xref="GeneID:151648"
                     /db_xref="HGNC:HGNC:25088"
                     /db_xref="MIM:609168"
                     /translation="MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPC
                     QIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGK
                     LTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQ
                     IPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQFDSLDDFETSHLAG
                     KSFEFERVGFLDPLVNMHIPENVQHNACQWSKDQVNLSPKLIQPGTFTKTKEDILESK
                     SEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKKMHKSVSSNDA
                     YNFNLEEGVHLTPFRQKVSNDSNREENNESEVSLCESSGSGDDSDDLYLPTCKYIQNP
                     TSNSDRPVTRPLAKRALKYTDEKETEGSKPTKTPTTTPPETQQSPHLSLKDITNVSLY
                     PVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSP
                     IFKQKKDLRRSKKSMKQIQ"
     exon            409..605
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..682
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..741
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1548
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1738
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..3070
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="hexamer: AATAAA"
     polyA_site      2066
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="major polyA site"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="major polyA site"
     regulatory      2647..2652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="hexamer: AATAAA"
     polyA_site      2675
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="major polyA site"
     regulatory      3051..3056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="hexamer: AATAAA"
     polyA_site      3070
                     /gene="SGO1"
                     /gene_synonym="CAID; NY-BR-85; SGO; SGOL1"
                     /note="major polyA site"
ORIGIN      
        1 gaatgtggcg gcggtagttc caggcgacgg cggacggtgg tacggtcctg gagggcccag
       61 tgcgcggggc tagccgtggc tggagagctt cgaagagcct tgaaatgtga ggaggaggaa
      121 gatagctgtt gcagaagtag tggccaaggt atcgttctgg acgcgcctgc ggcaggaggg
      181 tcgccgcgtc cacttccgcc agccccacct ccccccggcc ttcctggagt ccctgaaaga
      241 ggaagaagta ggttttaagg caaaagatgg ccaaggaaag atgcctgaaa aagtcctttc
      301 aagatagtct tgaagacata aagaagcgaa tgaaagagaa aaggaataaa aacttggcag
      361 agattggcaa acgcaggtct tttatagctg caccatgcca aataatcacc aacacttcta
      421 cactgctgaa aaattaccaa gacaacaaca aaatgttagt tttagctttg gaaaatgaaa
      481 aatccaaagt gaaagaagcc caagatatca tcctacagct gagaaaagaa tgttactatc
      541 tcacatgtca gctatatgca ttgaaaggaa aacttacatc acaacaaaca gtagaacctg
      601 ctcagaacca ggaaatatgt tcctctggaa tggaccccaa tagtgatgac agctccagaa
      661 atttatttgt gaaggattta ccgcaaattc ctcttgaaga aactgaactt ccaggacaag
      721 gagaatcatt tcaaatagaa gatcagatac ctactattcc tcaagacaca ctgggagttg
      781 attttgattc aggtgaagct aagtctactg ataatgtctt acctagaact gtatctgttc
      841 gtagcagttt aaagaaacat tgtaacagta tatgtcagtt tgatagcttg gatgattttg
      901 aaaccagtca tttggcaggg aagtcttttg aattcgaaag agttggattt ttagacccac
      961 tagtaaacat gcacatacct gaaaatgtac aacacaatgc ttgtcaatgg agcaaggacc
     1021 aagttaactt atcaccaaag ctgattcagc caggaacgtt tactaaaaca aaagaagaca
     1081 ttttagaatc taaatctgaa caaactaaaa gtaagcaaag agatacacaa gaaagaaaaa
     1141 gagaagagaa aagaaaagct aacaggagaa aatcaaaacg tatgtcaaaa tataaagaga
     1201 ataaaagcga aaataaaaaa actgttcccc aaaaaaaaat gcacaaatct gtcagttcca
     1261 atgatgctta caattttaat ttggaagagg gtgttcatct tactcctttc cgacaaaaag
     1321 tgagcaatga ctctaataga gaagaaaaca acgagtctga agtgagcctc tgtgaatcaa
     1381 gtggttcagg agatgattcc gatgacctct atttgcccac ttgcaagtac attcagaatc
     1441 ccacgagcaa ttcagataga ccagtcacca ggcctctagc taaaagagca ctgaaataca
     1501 cagatgaaaa agagacggag ggttctaagc caacaaaaac tcctaccact acaccacctg
     1561 aaactcagca gtcacctcat cttagcctga aggatatcac caatgtctcc ttgtatcctg
     1621 ttgtgaaaat cagaagactt tctctttctc caaaaaagaa taaagcaagc ccagcagtgg
     1681 ctctgcctaa acgtaggtgc acagccagcg tgaactataa ggagcccacc ctcgcttcga
     1741 aactgagaag aggggaccct tttacagatt tgtgtttttt gaattctcct attttcaagc
     1801 agaaaaagga tttgagacgt tctaaaaaaa gtatgaaaca aatacaatga aggttttgtt
     1861 ggatattgtt taaattcaat ctacacctct ttctgttgct tcaggagagg atctgtaaga
     1921 gtacacaaac agagtgagcc attgccatag aatattctct tgacaggacc ctagctcata
     1981 aacatttctt cagaactata cttcaaatgg gatgctttgt attaaaactt taataaattt
     2041 aatttatttt ttcttttgaa tataaataac tgagcttaag cattatcatc atatcgattt
     2101 cttatgctgc ctaaacctct taattttagt cgaaatatat cttttttttt ttttggaggc
     2161 ggaatttcat tcttgttgcc caggctggag tgcaatggca cgatctcagc ttaccgcaac
     2221 ctccgcctcc caggttcaag cgattctcct gcctcagact cccgagtagc tgggactaca
     2281 ggcatgtgcc actacgcccg gctaattttg tatttttagt agagacaggg tttctccatg
     2341 ttggtcaggt tgctctcaaa ctcccaacct caggtgatct gcccacctcg gcctcccaaa
     2401 gtgctgggat tactgagcca ctgtgcccag cccaaaatgt atcttataca aacattgtag
     2461 aaatgaataa tgattactca aataagatct tttaattata agcttctggc atctctattt
     2521 ttcccttaag taggggatac taaagtgaat gattttctaa gaggatcttt tgaaactctt
     2581 tagtacaata tttgagtaaa ataaattatt gtggatcttt tgaaactctg tgtagtattc
     2641 gagtaaaata aatatttgac atttacagta gggtacaccc taagttgttt atgaattcct
     2701 tataccactg ttatatttaa tttttcagat aaaatatgta tgggaaaatg actagagaaa
     2761 ttgattcttt tttaggctca gggacaagat aagtgactaa ttgtgaaccc caagctctaa
     2821 ttgtatgttc agagtgatgt ctccataaaa ttacaaatgt catgtacttt cagggtagct
     2881 ccttatttag tcagaaatct cagagattaa atgtgtgaat atttagggtt tttgcatatt
     2941 tttgaccaac caatgaaagc gaattagttc agtttagaaa gtttgatgtc tatacttgta
     3001 tatacctctt taaattttag aactttgtag gttattcatt tttaaagagc aataaagttt
     3061 gtataagata
//
