LOCUS       NM_147156               3717 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sphingomyelin synthase 1 (SGMS1), mRNA.
ACCESSION   NM_147156
VERSION     NM_147156.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3717)
  AUTHORS   Suzuki,R., Murakami,C., Dilimulati,K., Atsuta-Tsunoda,K., Kawai,T.
            and Sakane,F.
  TITLE     Human sphingomyelin synthase 1 generates diacylglycerol in the
            presence and absence of ceramide via multiple enzymatic activities
  JOURNAL   FEBS Lett 597 (21), 2672-2686 (2023)
   PUBMED   37715942
  REMARK    GeneRIF: Human sphingomyelin synthase 1 generates diacylglycerol in
            the presence and absence of ceramide via multiple enzymatic
            activities.
REFERENCE   2  (bases 1 to 3717)
  AUTHORS   Furuta,M., Murakami,C., Numagami,Y., Suzuki,R. and Sakane,F.
  TITLE     Diacylglycerol kinase zeta interacts with sphingomyelin synthase 1
            and sphingomyelin synthase-related protein via different regions
  JOURNAL   FEBS Open Bio 13 (7), 1333-1345 (2023)
   PUBMED   37166445
  REMARK    GeneRIF: Diacylglycerol kinase zeta interacts with sphingomyelin
            synthase 1 and sphingomyelin synthase-related protein via different
            regions.
REFERENCE   3  (bases 1 to 3717)
  AUTHORS   Lu,H., Zhou,L., Zuo,H., Le,W., Hu,J., Zhang,T., Li,M. and Yuan,Y.
  TITLE     Overriding sorafenib resistance via blocking lipid metabolism and
            Ras by sphingomyelin synthase 1 inhibition in hepatocellular
            carcinoma
  JOURNAL   Cancer Chemother Pharmacol 87 (2), 217-228 (2021)
   PUBMED   33226447
  REMARK    GeneRIF: Overriding sorafenib resistance via blocking lipid
            metabolism and Ras by sphingomyelin synthase 1 inhibition in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 3717)
  AUTHORS   Niekamp,P., Guzman,G., Leier,H.C., Rashidfarrokhi,A., Richina,V.,
            Pott,F., Barisch,C., Holthuis,J.C.M. and Tafesse,F.G.
  TITLE     Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling
            during Mycobacterium tuberculosis Host Cell Entry
  JOURNAL   mBio 12 (1), e03141-20 (2021)
   PUBMED   33500344
  REMARK    GeneRIF: Sphingomyelin Biosynthesis Is Essential for Phagocytic
            Signaling during Mycobacterium tuberculosis Host Cell Entry.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3717)
  AUTHORS   Daian,F., Esper,B.S., Ashrafi,N., Yu,G.Q., Luciano,G., Moorthi,S.
            and Luberto,C.
  TITLE     Regulation of human sphingomyelin synthase 1 translation through
            its 5'-untranslated region
  JOURNAL   FEBS Lett 594 (22), 3751-3764 (2020)
   PUBMED   33037626
  REMARK    GeneRIF: Regulation of human sphingomyelin synthase 1 translation
            through its 5'-untranslated region.
REFERENCE   6  (bases 1 to 3717)
  AUTHORS   Vladychenskaya,I.P., Dergunova,L.V., Dmitrieva,V.G. and
            Limborska,S.A.
  TITLE     Human gene MOB: structure specification and aspects of
            transcriptional activity
  JOURNAL   Gene 338 (2), 257-265 (2004)
   PUBMED   15315829
  REMARK    GeneRIF: MOB gene activity is believed to be controlled at least at
            the transcriptional and the posttranscriptional levels, strictly
            regulating the amount of the encoded protein product.
REFERENCE   7  (bases 1 to 3717)
  AUTHORS   Yamaoka,S., Miyaji,M., Kitano,T., Umehara,H. and Okazaki,T.
  TITLE     Expression cloning of a human cDNA restoring sphingomyelin
            synthesis and cell growth in sphingomyelin synthase-defective
            lymphoid cells
  JOURNAL   J Biol Chem 279 (18), 18688-18693 (2004)
   PUBMED   14976195
  REMARK    GeneRIF: SMS1 is responsible for SM synthase activity in mammalian
            cells and plays a critical role in cell growth of lymphoid cells.
REFERENCE   8  (bases 1 to 3717)
  AUTHORS   Huitema,K., van den Dikkenberg,J., Brouwers,J.F. and Holthuis,J.C.
  TITLE     Identification of a family of animal sphingomyelin synthases
  JOURNAL   EMBO J 23 (1), 33-44 (2004)
   PUBMED   14685263
REFERENCE   9  (bases 1 to 3717)
  AUTHORS   Vladychenskaya,I.P., Dergunova,L.V. and Limborska,S.A.
  TITLE     In vitro and in silico analysis of the predicted human MOB gene
            encoding a phylogenetically conserved transmembrane protein
  JOURNAL   Biomol Eng 18 (6), 263-268 (2002)
   PUBMED   11841947
  REMARK    GeneRIF: The 1.6 kb Hmob33 clone obtained from the medulla
            oblongata cDNA library and mapped to the human chromosome 10 was
            examined to find the coding region(MOB)
REFERENCE   10 (bases 1 to 3717)
  AUTHORS   Albi,E. and Magni,M.V.
  TITLE     Sphingomyelin synthase in rat liver nuclear membrane and chromatin
  JOURNAL   FEBS Lett 460 (2), 369-372 (1999)
   PUBMED   10544266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM764008.1, AY332650.1,
            BC042899.1 and BM141853.1.
            
            On Nov 22, 2018 this sequence version replaced NM_147156.3.
            
            Summary: The protein encoded by this gene is predicted to be a
            five-pass transmembrane protein. This gene may be predominately
            expressed in brain. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.122998.1, BN000143.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361781.7/ ENSP00000354829.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BM764008.1         22-169
            149-1674            AY332650.1         45-1570
            1675-3186           BC042899.1         957-2468
            3187-3717           BM141853.1         5-535               c
FEATURES             Location/Qualifiers
     source          1..3717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..3717
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /note="sphingomyelin synthase 1"
                     /db_xref="GeneID:259230"
                     /db_xref="HGNC:HGNC:29799"
                     /db_xref="MIM:611573"
     exon            1..250
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            251..345
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            346..436
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            437..479
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            480..621
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            622..702
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1556
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     CDS             934..2175
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /EC_number="2.7.8.27"
                     /note="transmembrane protein 23; medulla oblongata-derived
                     protein; protein Mob"
                     /codon_start=1
                     /product="phosphatidylcholine:ceramide
                     cholinephosphotransferase 1"
                     /protein_id="NP_671512.1"
                     /db_xref="CCDS:CCDS7240.1"
                     /db_xref="GeneID:259230"
                     /db_xref="HGNC:HGNC:29799"
                     /db_xref="MIM:611573"
                     /translation="MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDF
                     KKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKI
                     KPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERV
                     PPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCI
                     VGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNM
                     CGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVV
                     VAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWP
                     FPWPVVHLSRQVKYSRLVNDT"
     exon            1557..1674
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1828
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1995
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..3717
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3576..3581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
     regulatory      3693..3698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /note="hexamer: AATAAA"
     polyA_site      3717
                     /gene="SGMS1"
                     /gene_synonym="hmob33; MOB; MOB1; SMS1; TMEM23"
                     /note="major polyA site"
ORIGIN      
        1 agcccgggag gctcgcggtg gcaagtcgaa agcgttcgca ccagcggggc agcggctgcg
       61 ggcggcaggc ggcgggcagg tcgggagtga gaaggaccgg cctgggctga ctgctctccc
      121 ctcgcgccta gggagccggt cggagagcgc gattggggtg cggagccccg acgctgccct
      181 gccccggatt tcattccgcg gcgggggctc cgcgagcgga attccggcgg ctgccgtgac
      241 tccagtgcaa cgtgacgaca gcatgtacga tccctgaatg ggcccgtggg catatttagt
      301 cattcatttt tgatcaggag aaagaagaca gccatcattt gaaaggtaaa gcttcagcga
      361 ctgaaggagt gtggactttt tgaatttcaa gaacagtaaa gttggaacac agcagagggt
      421 gtgtaataaa atacagattg gaaagaagac tgatgaagaa aaataacagc atgattcagg
      481 cacaccattg agttctttgg gatgcccgaa agtgtctggt tgggaaacat gaaatagaag
      541 acgagaacct gcctcagcaa gcgtacctga gaatactttt aaaggaacct gttgataaat
      601 gcaaaacagt ggctgttgca ggtgatggaa ctgtactgga acaatgggag aagctggtag
      661 cttataggaa gccaagatga ccagaatgtt tttaaataat ccaaggaaga atcctgctca
      721 aaaatgaggt gaattaatac ttgggcgctc aggaaccctg gacagctaca tgaggtgttt
      781 aaaaactgcc ctgaccatct tgccaaacaa gtctctgctc atgaggcccc acaggatgaa
      841 cgagccgagg caggacagtg tcctgccctg tcggaacagt gactgctgac ctgccaagag
      901 agagctgggg actgcctgct gtctgccagt acaatgaagg aagtggttta ttggtcaccc
      961 aagaaggtgg cagactggct gctggagaat gctatgccag aatactgtga gcctctggag
     1021 catttcacag gccaggactt gatcaaccta acccaagagg atttcaaaaa accccccttg
     1081 tgccgagtct cctctgacaa tgggcagcgg ctcctggaca tgatagaaac cctgaaaatg
     1141 gagcaccatt tggaagcaca caagaacggc catgccaatg ggcacctcaa cattggcgta
     1201 gacatcccca cccccgacgg cagcttcagc atcaagatta aacccaacgg gatgccaaat
     1261 gggtatagga aagagatgat aaagatcccc atgccagaac tggagcgctc tcagtacccc
     1321 atggagtggg gcaagacttt tctggccttt ctttatgcac tttcctgttt cgttctcacc
     1381 acagtgatga tctcggtcgt ccacgaacga gtacctccta aggaggtgca gcctccacta
     1441 ccggacacat tttttgacca ttttaaccgg gtgcagtggg ccttttctat ttgtgaaatt
     1501 aatggcatga tccttgtagg actctggtta attcagtggc tgctcttaaa atacaagtct
     1561 attattagca gaagattttt ctgcatagtt ggcacgctgt acctgtatcg gtgtattaca
     1621 atgtatgtaa ctacactccc agtacctggt atgcatttca actgttctcc gaagcttttc
     1681 ggagactggg aagcccaact gcgaagaata atgaagctca ttgctggagg tggcttgtct
     1741 atcactggct ctcacaacat gtgtggggac tatctgtaca gcggccacac ggtcatgcta
     1801 acacttacct acttatttat caaagagtat tcccctcggc gactctggtg gtatcactgg
     1861 atttgctggc ttctcagcgt agttggaatc ttctgtattc tcttagcgca tgaccactac
     1921 actgtggacg tggtggtggc atattacatc accacgagac tcttctggtg gtatcacact
     1981 atggccaatc agcaagtgct aaaggaagct tcccagatga acctcctggc cagggtgtgg
     2041 tggtacaggc catttcagta ctttgaaaag aatgtccaag gaattgtacc tcgatcttac
     2101 cattggcctt tcccctggcc agtagtccac ctcagtaggc aagttaaata cagccggctg
     2161 gtgaatgaca cataacagct gtacaaagtg gggaaaagac aaattgtccg aagtgctaag
     2221 aactccatga gagaagatgc cataaaataa acacctccct aatcctatta tctttcaatg
     2281 gttaccttga cttaacctat tgagttacct ggtcagcact gtgatctttt tttctctcca
     2341 aaggacctgc gttggacaac aataaagaaa aatttaacct atcatgcact gtacacattt
     2401 cctgttcata agtttgggat ttacataacc cgcaaccacc atgttccttt gtatatgatg
     2461 cagcagcata aatgtaagct tttatatcat aagttctggt ctttccagtc acatctggaa
     2521 ataaagcgta ttattttctt gggaaaacat acttttcata tctcttgccc caaagattgg
     2581 gctgtaagcc attttctagc aaatgtctct atgaaggttt ctaagtacct gaatggggtt
     2641 tgattctgaa atctttctac ctgttgcacc gatattcaaa taaaaatgat agacacagaa
     2701 aggtttggta actttgggtt ttgtaaaatc agcaaaggca gtgtttcaaa aagtgcaaaa
     2761 aaaaagattc tgttataaag tgattttcta agtatttcct aactttattt ttcaaaatga
     2821 tgttatgaac accaaattta aagattttta acatgtcaga gagaagagag ttaaaattta
     2881 aaaatgcatc ttgggagaga aatttgtcta tgtttctagt gcctttcttg tcttgattgt
     2941 atggtcagta ggcaatctta aatgttttta tttaaaataa agtattcctt gaaaatataa
     3001 atatatgtat acactactaa attttgcatt tatagctaaa ttgaatcaga agactgctta
     3061 tggttttaaa attgcaatga cttaaataat gaggttgtta attagagtca gagcctgttc
     3121 acatattgtg atcaggtagc aatgacatgt accacttaaa ttattttatc gtcgatttgg
     3181 tagttcaatt ttaactactc aatgaaaaca gccatgaata tcttttctta aagagagttt
     3241 tgaaaatgat cacttaccta aaacttgaaa gctatgaatt agttatccat actctcatga
     3301 caattttgtt ggtgaacaac aaaaaagaga tctatttctt taaaagatat ttgtgcagaa
     3361 actgcatgta actctaagtt ttactcctaa catacatatg tttggggaag tattctattc
     3421 tatacttgcc aatgtggaga acaaaatagt tttttaagaa tgaagaagta tatatatcca
     3481 ttctgtattt tacgtgcagc agaattatct tccgtaggat ttttttgtgt attcacaagg
     3541 tgatatttgt attgtaaaac aataatggtg aaggaaataa aaaggctttt aaaattttgt
     3601 ttgttttaaa tctttgtaaa gttattattc cagagagtat actggtatct tacagcttac
     3661 ctagatcata aattaatcaa aatgcacttt ttaataaaaa ctgatactta aaataaa
//
