LOCUS       NM_001033578            4106 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens serum/glucocorticoid regulated kinase family member 3
            (SGK3), transcript variant 3, mRNA.
ACCESSION   NM_001033578
VERSION     NM_001033578.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4106)
  AUTHORS   Xu,N., Li,L.S., Li,H., Zhang,L.H., Zhang,N., Wang,P.J., Cheng,Y.X.,
            Xiang,J.Y., Linghu,E.Q. and Chai,N.L.
  TITLE     SGK3 overexpression correlates with a poor prognosis in
            endoscopically resected superficial esophageal squamous cell
            neoplasia: A long-term study
  JOURNAL   World J Gastroenterol 29 (23), 3658-3667 (2023)
   PUBMED   37398883
  REMARK    GeneRIF: SGK3 overexpression correlates with a poor prognosis in
            endoscopically resected superficial esophageal squamous cell
            neoplasia: A long-term study.
REFERENCE   2  (bases 1 to 4106)
  AUTHORS   Cui,Y., Liu,R., Hong,Y., Wang,Y., Zhu,Y., Wen,T., Lu,J., Mao,S.,
            Wang,X., Pan,J. and Luo,Y.
  TITLE     MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in
            Vascular Endothelial Cells
  JOURNAL   Invest Ophthalmol Vis Sci 63 (11), 19 (2022)
   PUBMED   36269185
  REMARK    GeneRIF: MicroRNA-92a-3p Regulates Retinal Angiogenesis by
            Targeting SGK3 in Vascular Endothelial Cells.
REFERENCE   3  (bases 1 to 4106)
  AUTHORS   Xu,L., Xiong,F., Bai,Y., Xiao,J., Zhang,Y., Chen,J. and Li,Q.
  TITLE     Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell
            progression in polycystic ovary syndrome
  JOURNAL   Reprod Biol Endocrinol 19 (1), 167 (2021)
   PUBMED   34740363
  REMARK    GeneRIF: Circ_0043532 regulates miR-182/SGK3 axis to promote
            granulosa cell progression in polycystic ovary syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4106)
  AUTHORS   Nalairndran,G., Hassan Abdul Razack,A., Mai,C.W., Fei-Lei Chung,F.,
            Chan,K.K., Hii,L.W., Lim,W.M., Chung,I. and Leong,C.O.
  TITLE     Phosphoinositide-dependent Kinase-1 (PDPK1) regulates
            serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer
            cell survival
  JOURNAL   J Cell Mol Med 24 (20), 12188-12198 (2020)
   PUBMED   32926495
  REMARK    GeneRIF: Phosphoinositide-dependent Kinase-1 (PDPK1) regulates
            serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer
            cell survival.
            Erratum:[J Cell Mol Med. 2020 Dec;24(23):14122-14124. doi:
            10.1111/jcmm.16112.. PMID: 33615700]
REFERENCE   5  (bases 1 to 4106)
  AUTHORS   Zheng,H., Wu,L., Wang,X. and Chen,Q.
  TITLE     Risk of Nasopharyngeal Carcinoma Associated with Single Nucleotide
            Polymorphisms in the MicroRNA Binding Site of SGK3
  JOURNAL   Genet Test Mol Biomarkers 24 (8), 508-519 (2020)
   PUBMED   32644852
  REMARK    GeneRIF: Risk of Nasopharyngeal Carcinoma Associated with Single
            Nucleotide Polymorphisms in the MicroRNA Binding Site of SGK3.
REFERENCE   6  (bases 1 to 4106)
  AUTHORS   Lang,F. and Cohen,P.
  TITLE     Regulation and physiological roles of serum- and
            glucocorticoid-induced protein kinase isoforms
  JOURNAL   Sci STKE 2001 (108), re17 (2001)
   PUBMED   11707620
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4106)
  AUTHORS   Xu,J., Liu,D., Gill,G. and Songyang,Z.
  TITLE     Regulation of cytokine-independent survival kinase (CISK) by the
            Phox homology domain and phosphoinositides
  JOURNAL   J Cell Biol 154 (4), 699-705 (2001)
   PUBMED   11514587
REFERENCE   8  (bases 1 to 4106)
  AUTHORS   Fang,X., Yu,S.X., Lu,Y., Bast,R.C. Jr., Woodgett,J.R. and
            Mills,G.B.
  TITLE     Phosphorylation and inactivation of glycogen synthase kinase 3 by
            protein kinase A
  JOURNAL   Proc Natl Acad Sci U S A 97 (22), 11960-11965 (2000)
   PUBMED   11035810
REFERENCE   9  (bases 1 to 4106)
  AUTHORS   Dai,F., Yu,L., He,H., Zhao,Y., Yang,J., Zhang,X. and Zhao,S.
  TITLE     Cloning and mapping of a novel human serum/glucocorticoid regulated
            kinase-like gene, SGKL, to chromosome 8q12.3-q13.1
  JOURNAL   Genomics 62 (1), 95-97 (1999)
   PUBMED   10585774
REFERENCE   10 (bases 1 to 4106)
  AUTHORS   Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
  TITLE     Characterization of the structure and regulation of two novel
            isoforms of serum- and glucocorticoid-induced protein kinase
  JOURNAL   Biochem J 344 Pt 1 (Pt 1), 189-197 (1999)
   PUBMED   10548550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291428.1, CR933673.1,
            BQ777590.1, BU177012.1, CK822899.1 and AI127772.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001033578.2.
            
            Summary: This gene is a member of the Ser/Thr protein kinase family
            and encodes a phosphoprotein with a PX (phox homology) domain. The
            protein phosphorylates several target proteins and has a role in
            neutral amino acid transport and activation of potassium and
            chloride channels. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.18644.1,
                                           SRR1803612.161950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521198.7/ ENSP00000430463.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AK291428.1         364-578
            216-216             CR933673.1         236-236
            217-989             AK291428.1         580-1352
            990-1139            CR933673.1         1010-1159
            1140-1715           AK291428.1         1503-2078
            1716-2550           CR933673.1         1736-2570
            2551-2788           BQ777590.1         111-348             c
            2789-3227           BU177012.1         1-439
            3228-3645           CK822899.1         1-418
            3646-4106           AI127772.1         15-475              c
FEATURES             Location/Qualifiers
     source          1..4106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..4106
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /note="serum/glucocorticoid regulated kinase family member
                     3"
                     /db_xref="GeneID:23678"
                     /db_xref="HGNC:HGNC:10812"
                     /db_xref="MIM:607591"
     exon            1..53
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            54..270
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1665
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     cytokine-independent survival kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk3 isoform 1"
                     /protein_id="NP_001028750.1"
                     /db_xref="GeneID:23678"
                     /db_xref="HGNC:HGNC:10812"
                     /db_xref="MIM:607591"
                     /translation="MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSE
                     WFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLV
                     RYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPT
                     DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNV
                     KHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGY
                     LHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIR
                     KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSIL
                     EELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFD
                     TAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL"
     exon            271..354
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            355..427
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            428..503
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            504..591
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            592..641
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            642..699
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            700..783
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            784..915
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1028
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1065
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1152
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1248
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1404
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1494
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..4106
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3929..3934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /note="hexamer: AATAAA"
     polyA_site      3951
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /note="major polyA site"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /note="hexamer: AATAAA"
     polyA_site      4106
                     /gene="SGK3"
                     /gene_synonym="CISK; SGK2; SGKL"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgtt cggctccgcg cccgccgcgc cgggagcagc accgcggggc caggttgcat
       61 gatggaattt gaacattact tcaagaggtt ttgtattttg gattagttaa ttgggtttgt
      121 cctctgctga ctgtttcttc ggatgcattt tttggtgtgc tcttgaggga ttaaatgcaa
      181 agagatcaca ccatggacta caaggaaagc tgcccaagtg taagcattcc cagctccgat
      241 gaacacagag agaaaaagaa gaggtttact gtttataaag ttctggtttc agtgggaaga
      301 agtgaatggt ttgtcttcag gagatatgca gagtttgata aactttataa cactttaaaa
      361 aaacagtttc ctgctatggc cctgaagatt cctgccaaga gaatatttgg tgataatttt
      421 gatccagatt ttattaaaca aagacgagca ggactaaacg aattcattca gaacctagtt
      481 aggtatccag aactttataa ccatccagat gtcagagcat tccttcaaat ggacagtcca
      541 aaacaccagt cagatccatc tgaagatgag gatgaaagaa gttctcagaa gctacactct
      601 acctcacaga acatcaacct gggaccgtct ggaaatcctc atgccaaacc aactgacttt
      661 gatttcttaa aagttattgg aaaaggcagc tttggcaagg ttcttcttgc aaaacggaaa
      721 ctggatggaa aattttatgc tgtcaaagtg ttacagaaaa aaatagttct caacagaaaa
      781 gagcaaaaac atattatggc tgaacgtaat gtgctcttga aaaatgtgaa acatccgttt
      841 ttggttggat tgcattattc cttccaaaca actgaaaagc tttattttgt tctggatttt
      901 gttaatggag gggagctttt tttccactta caaagagaac ggtcctttcc tgagcacaga
      961 gctaggtttt acgctgctga aattgctagt gcattgggtt acttacattc catcaaaata
     1021 gtatacagag acttgaaacc agaaaatatt cttttggatt cagtaggaca tgttgtctta
     1081 acagattttg ggctttgtaa agaaggaatt gctatttctg acaccactac cacattttgt
     1141 gggacaccag agtatcttgc acctgaagta attagaaaac agccctatga caatactgta
     1201 gattggtggt gccttggggc tgttctgtat gaaatgctgt atggattgcc tcctttttat
     1261 tgccgagatg ttgctgaaat gtatgacaat atccttcaca aacccctaag tttgaggcca
     1321 ggagtgagtc ttacagcctg gtccattctg gaagaactcc tagaaaaaga caggcaaaat
     1381 cgacttggtg ccaaggaaga ctttcttgaa attcagaatc atcctttttt tgaatcactc
     1441 agctgggctg accttgtaca aaagaagatt ccaccaccat ttaatcctaa tgtggctgga
     1501 ccagatgata tcagaaactt tgacacagca tttacagaag aaacagttcc atattctgtg
     1561 tgtgtatctt ctgactattc tatagtgaat gccagtgtat tggaggcaga tgatgcattc
     1621 gttggtttct cttatgcacc tccttcagaa gacttatttt tgtgagcagt ttgccattca
     1681 gaaaccattg agcaaaataa gtctatagat gggactgaaa cttctatttg tgtgaatata
     1741 ttcaaatatg tataactagt gcctcatttt tatatgtaat gatgaaaact atgaaaaaat
     1801 gtattttctt ctatgtgcaa gaaaaatagg gcatttcaaa gagctgtttt gattaaaatt
     1861 tatattcttg tttaataagc ttatttttaa acaatttaaa agctattatt cttagcatta
     1921 acctattttt aaagaaacct tttttgctat tgactgtttt ttccctctaa gtttacacta
     1981 acatctaccc aagatagact gttttttaac agtcaatttc agttcagcta acatatatta
     2041 atacctttgt aactctttgc tatggctttt gttatcacac caaaactatg caattggtac
     2101 atggttgttt aagaagaaac cgtatttttc catgataaat cactgtttga aatatttggt
     2161 tcatggtatg atcgaaatgt aaaagcataa ttaacacatt ggctgctagt taacaattgg
     2221 aataacttta ttctgcagat catttaagaa gtaacaggcc gggcgcggtg gctcacgcct
     2281 gtaatcccag cactttggga ggctgaggcg ggcagatcac ctgaggtcag gagttggaga
     2341 ccagcctgac caacatggac aaaccccgtc tctactaaaa atacaaaatt ggcagggtgt
     2401 ggtggcacat gcctataatc ccagctactt gggaggctaa ggcaggagaa tcgcttgaac
     2461 ccgggaggcg gaggttgcag tgagccgaga tcgcaccatt gcactcctgc ctgggcaaca
     2521 agagtgaaac tccatctcca aaaaaaaaaa gaaaaagtaa caaaaggaaa ttatttgttt
     2581 ttgaaatacc agttcaactt tgtggattat ttttcctctg aaggaaaaga aaaggcttaa
     2641 tggttaggat ttttaagtat tcccaaagat ctgaagggta ataaaatgta ctggattttt
     2701 taaggtggta ccaaaaatga atgtctgtca tatatttata ttacaaatac attatattta
     2761 tgttctattc atcttttgaa tgtttagtat gctattaagt cattctgaat ctttgtattt
     2821 gcttttgcaa ataggtattt caaagctctt ttcctaactg gttaagtaaa ataaaaaatt
     2881 gagctttcta gaatatttgc ctaattggga attaaaaagt aaaataatag gccaggcatg
     2941 gtggctcatg cctataagca ccctgggagg ccgaggcagg cagattattt gagctcagga
     3001 gtttgagacc atcctgggca acatggcgaa accctatctc tacaaaaaat acaaaaatta
     3061 gccagacatg gtggcacatg cctttagtcc cagctactct ggaggctgaa gttggaggat
     3121 ggcttgagcc cacgagatgg aagttgcagt gaactgaaat tgtgccactg cacttttcag
     3181 cctgggtgcc acagcgagac cctagttaag agaaaaaaaa agtaaaaaca aattgtgggt
     3241 caaagtaaat gtatacagtt ttattacaat gtaacaaaag ttgaaaatca ggcagatgtg
     3301 tattcagtat ccaattcaat atatcttaga aaaagcacag gaaacagacc ttaaaattgt
     3361 aacctaccaa ctaacttaca tgcttataaa agtaaaggag aataactggc cgggcacggt
     3421 ggctcatgcc tataaaattc cagcactttg ggaggccaag gcaggaggat cacttgagcc
     3481 tatgagttca agaccagcct aggcaatgta gtgacacctc atttctattt attttaaaaa
     3541 aaagagagag taactacaga agaactttaa aaaataaaaa ataagcttac cttggattct
     3601 tggcttagag tagaggtttt ttttaagtta tggaggaaac atttttgtaa aagtttaatg
     3661 acccacttta gatgctccaa gaacaagcat cccttccatg tatgtcttga gaaagaaatc
     3721 acagaagcat ttctcaccaa tactctttgg cttaaaatgt tcagcagaat tgggcagtgg
     3781 gggtgacttt tcttatatta ataatattta catccaatac actgaatctt cctttagagg
     3841 taagacttta atatctatac tgtaaatatt tggtttattt ggcactactg taagttttgt
     3901 ttttcacaaa gctcttatta tgaagcaaaa taaaaattct agtttcttgt atgatttttt
     3961 gtactcattc attcctgtta agctgccaaa aattaaagtg caatattgta tatttttaag
     4021 aacaaattta aaatagaatt ttgatgtttc tcagatcaca agaaatacaa atctatatag
     4081 tataataaaa tcagcaaaaa gatcaa
//
