LOCUS       NM_170693               1871 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2),
            transcript variant 1, mRNA.
ACCESSION   NM_170693
VERSION     NM_170693.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Cheng,L., He,Q., Liu,B., Chen,L., Lv,F., Li,X., Li,Y., Liu,C.,
            Song,Y. and Xing,Y.
  TITLE     SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis
            via upregulating GPX4
  JOURNAL   Cell Death Dis 14 (1), 74 (2023)
   PUBMED   36720852
  REMARK    GeneRIF: SGK2 promotes prostate cancer metastasis by inhibiting
            ferroptosis via upregulating GPX4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Ranzuglia,V., Lorenzon,I., Pellarin,I., Sonego,M., Dall'Acqua,A.,
            D'Andrea,S., Lovisa,S., Segatto,I., Coan,M., Polesel,J.,
            Serraino,D., Sabatelli,P., Spessotto,P., Belletti,B.,
            Baldassarre,G. and Schiappacassi,M.
  TITLE     Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel
            autophagy regulator and modulates platinum drugs response in cancer
            cells
  JOURNAL   Oncogene 39 (40), 6370-6386 (2020)
   PUBMED   32848212
  REMARK    GeneRIF: Serum- and glucocorticoid- inducible kinase 2, SGK2, is a
            novel autophagy regulator and modulates platinum drugs response in
            cancer cells.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Liu,Y., Liu,J., Kong,X., Li,H., Shao,J. and Jiang,Z.
  TITLE     SGK2 is overexpressed in colon cancer and promotes
            epithelial-mesenchymal transition in colon cancer cells
  JOURNAL   Eur J Surg Oncol 46 (10 Pt A), 1912-1917 (2020)
   PUBMED   32565024
  REMARK    GeneRIF: SGK2 is overexpressed in colon cancer and promotes
            epithelial-mesenchymal transition in colon cancer cells.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Friedrich,B., Feng,Y., Cohen,P., Risler,T., Vandewalle,A.,
            Broer,S., Wang,J., Pearce,D. and Lang,F.
  TITLE     The serine/threonine kinases SGK2 and SGK3 are potent stimulators
            of the epithelial Na+ channel alpha,beta,gamma-ENaC
  JOURNAL   Pflugers Arch 445 (6), 693-696 (2003)
   PUBMED   12632189
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Gamper,N., Fillon,S., Feng,Y., Friedrich,B., Lang,P.A., Henke,G.,
            Huber,S.M., Kobayashi,T., Cohen,P. and Lang,F.
  TITLE     K+ channel activation by all three isoforms of serum- and
            glucocorticoid-dependent protein kinase SGK
  JOURNAL   Pflugers Arch 445 (1), 60-66 (2002)
   PUBMED   12397388
  REMARK    GeneRIF: Powerful stimulating effect of all three isoforms of SGK
            on K(+) channels. Those effects may participate in regulation of
            epithelial transport, cell proliferation, and neuromuscular
            excitability.
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Lang,F. and Cohen,P.
  TITLE     Regulation and physiological roles of serum- and
            glucocorticoid-induced protein kinase isoforms
  JOURNAL   Sci STKE 2001 (108), re17 (2001)
   PUBMED   11707620
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
  TITLE     Characterization of the structure and regulation of two novel
            isoforms of serum- and glucocorticoid-induced protein kinase
  JOURNAL   Biochem J 344 Pt 1 (Pt 1), 189-197 (1999)
   PUBMED   10548550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB183229.1, AF169034.2 and
            BC065511.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_170693.2.
            
            Summary: This gene encodes a serine/threonine protein kinase.
            Although this gene product is similar to serum- and
            glucocorticoid-induced protein kinase (SGK), this gene is not
            induced by serum or glucocorticoids. This gene is induced in
            response to signals that activate phosphatidylinositol 3-kinase,
            which is also true for SGK. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) contains an alternate in-frame
            exon in the 5' coding region, compared to variant 2. Variants 1, 2
            and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.131813.1,
                                           SRR5189664.60084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373100.7/ ENSP00000362192.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                DB183229.1         37-105
            70-1611             AF169034.2         1-1542
            1612-1871           BC065511.1         1560-1819
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1871
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="serum/glucocorticoid regulated kinase 2"
                     /db_xref="GeneID:10110"
                     /db_xref="HGNC:HGNC:13900"
                     /db_xref="MIM:607589"
     exon            1..133
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..192
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1260
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /EC_number="2.7.11.1"
                     /note="SGK2, serine/threonine kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk2"
                     /protein_id="NP_733794.1"
                     /db_xref="CCDS:CCDS13321.1"
                     /db_xref="GeneID:10110"
                     /db_xref="HGNC:HGNC:13900"
                     /db_xref="MIM:607589"
                     /translation="MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKG
                     NYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYS
                     FQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL
                     KPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWW
                     CLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQR
                     LGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKS
                     IGCTPDTVASSSGASSAFLGFSYAPEDDDILDC"
     exon            193..242
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..300
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..384
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..516
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..629
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..666
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..753
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..849
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1005
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1095
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1871
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="hexamer: AACAAG"
     polyA_site      1871
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="major polyA site"
ORIGIN      
        1 attcctgact gggaaggttg cttgacaagt caggattgtg cctccagtca gaaggaccat
       61 gaagagagag aagagggcag agccgtgcat ggggctgctc cccaggacct gagcaggaac
      121 ctggagtttt cagagctgcc tgatcattgc tacagaatga actctagccc agctgggacc
      181 ccaagtccac agccctccag ggccaatggg aacatcaacc tggggccttc agccaaccca
      241 aatgcccagc ccacggactt cgacttcctc aaagtcatcg gcaaagggaa ctacgggaag
      301 gtcctactgg ccaagcgcaa gtctgatggg gcgttctatg cagtgaaggt actacagaaa
      361 aagtccatct taaagaagaa agagcagagc cacatcatgg cagagcgcag tgtgcttctg
      421 aagaacgtgc ggcacccctt cctcgtgggc ctgcgctact ccttccagac acctgagaag
      481 ctctacttcg tgctcgacta tgtcaacggg ggagagctct tcttccacct gcagcgggag
      541 cgccggttcc tggagccccg ggccaggttc tacgctgctg aggtggccag cgccattggc
      601 tacctgcact ccctcaacat catttacagg gatctgaaac cagagaacat tctcttggac
      661 tgccagggac acgtggtgct gacggatttt ggcctctgca aggaaggtgt agagcctgaa
      721 gacaccacat ccacattctg tggtacccct gagtacttgg cacctgaagt gcttcggaaa
      781 gagccttatg atcgagcagt ggactggtgg tgcttggggg cagtcctcta cgagatgctc
      841 catggcctgc cgcccttcta cagccaagat gtatcccaga tgtatgagaa cattctgcac
      901 cagccgctac agatccccgg aggccggaca gtggccgcct gtgacctcct gcaaagcctt
      961 ctccacaagg accagaggca gcggctgggc tccaaagcag actttcttga gattaagaac
     1021 catgtattct tcagccccat aaactgggat gacctgtacc acaagaggct aactccaccc
     1081 ttcaacccaa atgtgacagg acctgctgac ttgaagcatt ttgacccaga gttcacccag
     1141 gaagctgtgt ccaagtccat tggctgtacc cctgacactg tggccagcag ctctggggcc
     1201 tcaagtgcat tcctgggatt ttcttatgcg ccagaggatg atgacatctt ggattgctag
     1261 aagagaagga cctgtgaaac tactgaggcc agctggtatt agtaaggaat taccttcagc
     1321 tgctaggaag agcgactcaa actaacaatg gcttcaacga gaagcaggtt tattttttcc
     1381 agcacataaa agaaaaataa tgtttcggag tccaggactg gcaggacagg tcatcagata
     1441 ctcagaggct gtatctctgc cctgccaacc ttgacaaatg gcttccaatg ttaggtttgc
     1501 tacaagatgg ttactggagc tctagctgcc tattttgtgt ttagggaagg gaaaatggag
     1561 gaaaggggag aagagcaaag ggcgctttta aagagctttc ccaaaagctc cacccaatga
     1621 cttctgcttc catctcacta accacccacc cctacctgga atggaggctg ggagatgtgg
     1681 cttatttgct gggtacgtga ctatccctaa taacaaaggg gttctgacac taagacatta
     1741 ggggagaatg ttgggtaggc agccagcact cttttaccag agggcctcct ggtgtttgga
     1801 ttttgatctc aatgtgtaaa atgacagaga tgtaacaagc tcatagggta tcaatatctc
     1861 ttattgttct a
//
