LOCUS       NM_016276               2413 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2),
            transcript variant 2, mRNA.
ACCESSION   NM_016276
VERSION     NM_016276.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Cheng,L., He,Q., Liu,B., Chen,L., Lv,F., Li,X., Li,Y., Liu,C.,
            Song,Y. and Xing,Y.
  TITLE     SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis
            via upregulating GPX4
  JOURNAL   Cell Death Dis 14 (1), 74 (2023)
   PUBMED   36720852
  REMARK    GeneRIF: SGK2 promotes prostate cancer metastasis by inhibiting
            ferroptosis via upregulating GPX4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Ranzuglia,V., Lorenzon,I., Pellarin,I., Sonego,M., Dall'Acqua,A.,
            D'Andrea,S., Lovisa,S., Segatto,I., Coan,M., Polesel,J.,
            Serraino,D., Sabatelli,P., Spessotto,P., Belletti,B.,
            Baldassarre,G. and Schiappacassi,M.
  TITLE     Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel
            autophagy regulator and modulates platinum drugs response in cancer
            cells
  JOURNAL   Oncogene 39 (40), 6370-6386 (2020)
   PUBMED   32848212
  REMARK    GeneRIF: Serum- and glucocorticoid- inducible kinase 2, SGK2, is a
            novel autophagy regulator and modulates platinum drugs response in
            cancer cells.
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Liu,Y., Liu,J., Kong,X., Li,H., Shao,J. and Jiang,Z.
  TITLE     SGK2 is overexpressed in colon cancer and promotes
            epithelial-mesenchymal transition in colon cancer cells
  JOURNAL   Eur J Surg Oncol 46 (10 Pt A), 1912-1917 (2020)
   PUBMED   32565024
  REMARK    GeneRIF: SGK2 is overexpressed in colon cancer and promotes
            epithelial-mesenchymal transition in colon cancer cells.
REFERENCE   5  (bases 1 to 2413)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 2413)
  AUTHORS   Friedrich,B., Feng,Y., Cohen,P., Risler,T., Vandewalle,A.,
            Broer,S., Wang,J., Pearce,D. and Lang,F.
  TITLE     The serine/threonine kinases SGK2 and SGK3 are potent stimulators
            of the epithelial Na+ channel alpha,beta,gamma-ENaC
  JOURNAL   Pflugers Arch 445 (6), 693-696 (2003)
   PUBMED   12632189
REFERENCE   7  (bases 1 to 2413)
  AUTHORS   Gamper,N., Fillon,S., Feng,Y., Friedrich,B., Lang,P.A., Henke,G.,
            Huber,S.M., Kobayashi,T., Cohen,P. and Lang,F.
  TITLE     K+ channel activation by all three isoforms of serum- and
            glucocorticoid-dependent protein kinase SGK
  JOURNAL   Pflugers Arch 445 (1), 60-66 (2002)
   PUBMED   12397388
  REMARK    GeneRIF: Powerful stimulating effect of all three isoforms of SGK
            on K(+) channels. Those effects may participate in regulation of
            epithelial transport, cell proliferation, and neuromuscular
            excitability.
REFERENCE   8  (bases 1 to 2413)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 2413)
  AUTHORS   Lang,F. and Cohen,P.
  TITLE     Regulation and physiological roles of serum- and
            glucocorticoid-induced protein kinase isoforms
  JOURNAL   Sci STKE 2001 (108), re17 (2001)
   PUBMED   11707620
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2413)
  AUTHORS   Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
  TITLE     Characterization of the structure and regulation of two novel
            isoforms of serum- and glucocorticoid-induced protein kinase
  JOURNAL   Biochem J 344 Pt 1 (Pt 1), 189-197 (1999)
   PUBMED   10548550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98752.16, AF186470.1,
            CD627734.1 and BC065511.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 22, 2021 this sequence version replaced NM_016276.4.
            
            Summary: This gene encodes a serine/threonine protein kinase.
            Although this gene product is similar to serum- and
            glucocorticoid-induced protein kinase (SGK), this gene is not
            induced by serum or glucocorticoids. This gene is induced in
            response to signals that activate phosphatidylinositol 3-kinase,
            which is also true for SGK. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) encodes the longest
            transcript. Variants 1, 2 and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186470.1, BT020098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               Z98752.16          43195-43493
            300-646             AF186470.1         1-347
            647-712             CD627734.1         30-95               c
            713-2153            AF186470.1         414-1854
            2154-2413           BC065511.1         1560-1819
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2413
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="serum/glucocorticoid regulated kinase 2"
                     /db_xref="GeneID:10110"
                     /db_xref="HGNC:HGNC:13900"
                     /db_xref="MIM:607589"
     exon            1..734
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             699..1802
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /EC_number="2.7.11.1"
                     /note="SGK2, serine/threonine kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk2"
                     /protein_id="NP_057360.3"
                     /db_xref="CCDS:CCDS13321.1"
                     /db_xref="GeneID:10110"
                     /db_xref="HGNC:HGNC:13900"
                     /db_xref="MIM:607589"
                     /translation="MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKG
                     NYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYS
                     FQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL
                     KPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWW
                     CLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQR
                     LGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKS
                     IGCTPDTVASSSGASSAFLGFSYAPEDDDILDC"
     exon            735..784
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..842
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..926
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1058
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1171
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1208
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1295
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1391
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1547
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1637
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..2413
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="hexamer: AACAAG"
     polyA_site      2413
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="major polyA site"
ORIGIN      
        1 atagatcagc tggtcacacc ttctgttgtt tggccccgaa tagatattgg ccagtcttgg
       61 gtctctctgt ggccccagcc caaggcttcc agggcagctg cctttcctga ggcattgggc
      121 agaattcctt gtggcaagga gatcgtagca cagagcccag ctgggactgc gcacagtaat
      181 tcagggttgc cattgttcct ctatgggagt ccggagagcc cagcctgtgc ttcacaaggc
      241 tatgtggccc taggaaggtc cttttttagg ccacaggcct tccatctgtg aaatggggga
      301 tgggttcaga ctttatgccc tgaaaagatc cttccagccc tggccatctt ggacttctgg
      361 agctaccctg gctcacaggg gtcttgttgc cctgggtgtc cccagttctt gaaaagaatc
      421 agcctgggag gggccacacc ctgaccatcc ccctttatcc cttctgagat gtttgttagg
      481 aagtctgggt ccaggggata tcatttcttg ttccatccat gcaggggttg cttacctcgg
      541 gtaggaaacc ctcaggcggt ggcaggtgca caggtagggg aggatggaga gggcagtggt
      601 gcctgaagcc ctggatgggc ggagctgacc ccccaacacc aactctctca tgcctgctcc
      661 tccctgtccc cccagagctg cctgatcatt gctacagaat gaactctagc ccagctggga
      721 ccccaagtcc acagccctcc agggccaatg ggaacatcaa cctggggcct tcagccaacc
      781 caaatgccca gcccacggac ttcgacttcc tcaaagtcat cggcaaaggg aactacggga
      841 aggtcctact ggccaagcgc aagtctgatg gggcgttcta tgcagtgaag gtactacaga
      901 aaaagtccat cttaaagaag aaagagcaga gccacatcat ggcagagcgc agtgtgcttc
      961 tgaagaacgt gcggcacccc ttcctcgtgg gcctgcgcta ctccttccag acacctgaga
     1021 agctctactt cgtgctcgac tatgtcaacg ggggagagct cttcttccac ctgcagcggg
     1081 agcgccggtt cctggagccc cgggccaggt tctacgctgc tgaggtggcc agcgccattg
     1141 gctacctgca ctccctcaac atcatttaca gggatctgaa accagagaac attctcttgg
     1201 actgccaggg acacgtggtg ctgacggatt ttggcctctg caaggaaggt gtagagcctg
     1261 aagacaccac atccacattc tgtggtaccc ctgagtactt ggcacctgaa gtgcttcgga
     1321 aagagcctta tgatcgagca gtggactggt ggtgcttggg ggcagtcctc tacgagatgc
     1381 tccatggcct gccgcccttc tacagccaag atgtatccca gatgtatgag aacattctgc
     1441 accagccgct acagatcccc ggaggccgga cagtggccgc ctgtgacctc ctgcaaagcc
     1501 ttctccacaa ggaccagagg cagcggctgg gctccaaagc agactttctt gagattaaga
     1561 accatgtatt cttcagcccc ataaactggg atgacctgta ccacaagagg ctaactccac
     1621 ccttcaaccc aaatgtgaca ggacctgctg acttgaagca ttttgaccca gagttcaccc
     1681 aggaagctgt gtccaagtcc attggctgta cccctgacac tgtggccagc agctctgggg
     1741 cctcaagtgc attcctggga ttttcttatg cgccagagga tgatgacatc ttggattgct
     1801 agaagagaag gacctgtgaa actactgagg ccagctggta ttagtaagga attaccttca
     1861 gctgctagga agagcgactc aaactaacaa tggcttcaac gagaagcagg tttatttttt
     1921 ccagcacata aaagaaaaat aatgtttcgg agtccaggac tggcaggaca ggtcatcaga
     1981 tactcagagg ctgtatctct gccctgccaa ccttgacaaa tggcttccaa tgttaggttt
     2041 gctacaagat ggttactgga gctctagctg cctattttgt gtttagggaa gggaaaatgg
     2101 aggaaagggg agaagagcaa agggcgcttt taaagagctt tcccaaaagc tccacccaat
     2161 gacttctgct tccatctcac taaccaccca cccctacctg gaatggaggc tgggagatgt
     2221 ggcttatttg ctgggtacgt gactatccct aataacaaag gggttctgac actaagacat
     2281 taggggagaa tgttgggtag gcagccagca ctcttttacc agagggcctc ctggtgtttg
     2341 gattttgatc tcaatgtgta aaatgacaga gatgtaacaa gctcataggg tatcaatatc
     2401 tcttattgtt cta
//
