LOCUS       NM_001199264            1801 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens serum/glucocorticoid regulated kinase 2 (SGK2),
            transcript variant 3, mRNA.
ACCESSION   NM_001199264
VERSION     NM_001199264.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1801)
  AUTHORS   Cheng,L., He,Q., Liu,B., Chen,L., Lv,F., Li,X., Li,Y., Liu,C.,
            Song,Y. and Xing,Y.
  TITLE     SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis
            via upregulating GPX4
  JOURNAL   Cell Death Dis 14 (1), 74 (2023)
   PUBMED   36720852
  REMARK    GeneRIF: SGK2 promotes prostate cancer metastasis by inhibiting
            ferroptosis via upregulating GPX4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1801)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1801)
  AUTHORS   Ranzuglia,V., Lorenzon,I., Pellarin,I., Sonego,M., Dall'Acqua,A.,
            D'Andrea,S., Lovisa,S., Segatto,I., Coan,M., Polesel,J.,
            Serraino,D., Sabatelli,P., Spessotto,P., Belletti,B.,
            Baldassarre,G. and Schiappacassi,M.
  TITLE     Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel
            autophagy regulator and modulates platinum drugs response in cancer
            cells
  JOURNAL   Oncogene 39 (40), 6370-6386 (2020)
   PUBMED   32848212
  REMARK    GeneRIF: Serum- and glucocorticoid- inducible kinase 2, SGK2, is a
            novel autophagy regulator and modulates platinum drugs response in
            cancer cells.
REFERENCE   4  (bases 1 to 1801)
  AUTHORS   Liu,Y., Liu,J., Kong,X., Li,H., Shao,J. and Jiang,Z.
  TITLE     SGK2 is overexpressed in colon cancer and promotes
            epithelial-mesenchymal transition in colon cancer cells
  JOURNAL   Eur J Surg Oncol 46 (10 Pt A), 1912-1917 (2020)
   PUBMED   32565024
  REMARK    GeneRIF: SGK2 is overexpressed in colon cancer and promotes
            epithelial-mesenchymal transition in colon cancer cells.
REFERENCE   5  (bases 1 to 1801)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 1801)
  AUTHORS   Friedrich,B., Feng,Y., Cohen,P., Risler,T., Vandewalle,A.,
            Broer,S., Wang,J., Pearce,D. and Lang,F.
  TITLE     The serine/threonine kinases SGK2 and SGK3 are potent stimulators
            of the epithelial Na+ channel alpha,beta,gamma-ENaC
  JOURNAL   Pflugers Arch 445 (6), 693-696 (2003)
   PUBMED   12632189
REFERENCE   7  (bases 1 to 1801)
  AUTHORS   Gamper,N., Fillon,S., Feng,Y., Friedrich,B., Lang,P.A., Henke,G.,
            Huber,S.M., Kobayashi,T., Cohen,P. and Lang,F.
  TITLE     K+ channel activation by all three isoforms of serum- and
            glucocorticoid-dependent protein kinase SGK
  JOURNAL   Pflugers Arch 445 (1), 60-66 (2002)
   PUBMED   12397388
  REMARK    GeneRIF: Powerful stimulating effect of all three isoforms of SGK
            on K(+) channels. Those effects may participate in regulation of
            epithelial transport, cell proliferation, and neuromuscular
            excitability.
REFERENCE   8  (bases 1 to 1801)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 1801)
  AUTHORS   Lang,F. and Cohen,P.
  TITLE     Regulation and physiological roles of serum- and
            glucocorticoid-induced protein kinase isoforms
  JOURNAL   Sci STKE 2001 (108), re17 (2001)
   PUBMED   11707620
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1801)
  AUTHORS   Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
  TITLE     Characterization of the structure and regulation of two novel
            isoforms of serum- and glucocorticoid-induced protein kinase
  JOURNAL   Biochem J 344 Pt 1 (Pt 1), 189-197 (1999)
   PUBMED   10548550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065511.1 and DA244897.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_001199264.1.
            
            Summary: This gene encodes a serine/threonine protein kinase.
            Although this gene product is similar to serum- and
            glucocorticoid-induced protein kinase (SGK), this gene is not
            induced by serum or glucocorticoids. This gene is induced in
            response to signals that activate phosphatidylinositol 3-kinase,
            which is also true for SGK. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (3) contains an alternate in-frame
            exon in the 5' coding region, compared to variant 2. Variants 1, 2
            and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065511.1, AK289596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BC065511.1         19-54
            37-596              DA244897.1         14-573
            597-1801            BC065511.1         615-1819
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1801
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="serum/glucocorticoid regulated kinase 2"
                     /db_xref="GeneID:10110"
                     /db_xref="HGNC:HGNC:13900"
                     /db_xref="MIM:607589"
     exon            1..63
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..122
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1190
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /EC_number="2.7.11.1"
                     /note="SGK2, serine/threonine kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk2"
                     /protein_id="NP_001186193.1"
                     /db_xref="CCDS:CCDS13321.1"
                     /db_xref="GeneID:10110"
                     /db_xref="HGNC:HGNC:13900"
                     /db_xref="MIM:607589"
                     /translation="MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKG
                     NYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYS
                     FQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL
                     KPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWW
                     CLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQR
                     LGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKS
                     IGCTPDTVASSSGASSAFLGFSYAPEDDDILDC"
     exon            123..172
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..230
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..314
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..446
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            447..559
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..596
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..683
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..779
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..935
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1025
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1801
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1764..1769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="hexamer: AACAAG"
     polyA_site      1801
                     /gene="SGK2"
                     /gene_synonym="dJ138B7.2; H-SGK2"
                     /note="major polyA site"
ORIGIN      
        1 gtccactgcc tgtcttcggt tccaactgct ggttctccta gaggcctctc ctcagactcg
       61 cagagctgcc tgatcattgc tacagaatga actctagccc agctgggacc ccaagtccac
      121 agccctccag ggccaatggg aacatcaacc tggggccttc agccaaccca aatgcccagc
      181 ccacggactt cgacttcctc aaagtcatcg gcaaagggaa ctacgggaag gtcctactgg
      241 ccaagcgcaa gtctgatggg gcgttctatg cagtgaaggt actacagaaa aagtccatct
      301 taaagaagaa agagcagagc cacatcatgg cagagcgcag tgtgcttctg aagaacgtgc
      361 ggcacccctt cctcgtgggc ctgcgctact ccttccagac acctgagaag ctctacttcg
      421 tgctcgacta tgtcaacggg ggagagctct tcttccacct gcagcgggag cgccggttcc
      481 tggagccccg ggccaggttc tacgctgctg aggtggccag cgccattggc tacctgcact
      541 ccctcaacat catttacagg gatctgaaac cagagaacat tctcttggac tgccagggac
      601 acgtggtgct gacggatttt ggcctctgca aggaaggtgt agagcctgaa gacaccacat
      661 ccacattctg tggtacccct gagtacttgg cacctgaagt gcttcggaaa gagccttatg
      721 atcgagcagt ggactggtgg tgcttggggg cagtcctcta cgagatgctc catggcctgc
      781 cgcccttcta cagccaagat gtatcccaga tgtatgagaa cattctgcac cagccgctac
      841 agatccccgg aggccggaca gtggccgcct gtgacctcct gcaaagcctt ctccacaagg
      901 accagaggca gcggctgggc tccaaagcag actttcttga gattaagaac catgtattct
      961 tcagccccat aaactgggat gacctgtacc acaagaggct aactccaccc ttcaacccaa
     1021 atgtgacagg acctgctgac ttgaagcatt ttgacccaga gttcacccag gaagctgtgt
     1081 ccaagtccat tggctgtacc cctgacactg tggccagcag ctctggggcc tcaagtgcat
     1141 tcctgggatt ttcttatgcg ccagaggatg atgacatctt ggattgctag aagagaagga
     1201 cctgtgaaac tactgaggcc agctggtatt agtaaggaat taccttcagc tgctaggaag
     1261 agcgactcaa actaacaatg gcttcaacga gaagcaggtt tattttttcc agcacataaa
     1321 agaaaaataa tgtttcggag tccaggactg gcaggacagg tcatcagata ctcagaggct
     1381 gtatctctgc cctgccaacc ttgacaaatg gcttccaatg ttaggtttgc tacaagatgg
     1441 ttactggagc tctagctgcc tattttgtgt ttagggaagg gaaaatggag gaaaggggag
     1501 aagagcaaag ggcgctttta aagagctttc ccaaaagctc cacccaatga cttctgcttc
     1561 catctcacta accacccacc cctacctgga atggaggctg ggagatgtgg cttatttgct
     1621 gggtacgtga ctatccctaa taacaaaggg gttctgacac taagacatta ggggagaatg
     1681 ttgggtaggc agccagcact cttttaccag agggcctcct ggtgtttgga ttttgatctc
     1741 aatgtgtaaa atgacagaga tgtaacaagc tcatagggta tcaatatctc ttattgttct
     1801 a
//
