LOCUS       NM_001143676            3245 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1),
            transcript variant 2, mRNA.
ACCESSION   NM_001143676
VERSION     NM_001143676.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3245)
  AUTHORS   Hanin,A., Comi,M., Sumida,T.S. and Hafler,D.A.
  TITLE     Cholesterol promotes IFNG mRNA expression in CD4+ effector/memory
            cells by SGK1 activation
  JOURNAL   Life Sci Alliance 7 (12), e202402890 (2024)
   PUBMED   39366761
  REMARK    GeneRIF: Cholesterol promotes IFNG mRNA expression in CD4[+]
            effector/memory cells by SGK1 activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3245)
  AUTHORS   Oda,S., Yokoyama,A., Kishii,R. and Nagasawa,M.
  TITLE     Serum/glucocorticoid-regulated kinase 1 contributes to the
            proliferation of varicella-zoster virus and induction of cyclin B1
            expression
  JOURNAL   Arch Virol 169 (5), 116 (2024)
   PUBMED   38722402
  REMARK    GeneRIF: Serum/glucocorticoid-regulated kinase 1 contributes to the
            proliferation of varicella-zoster virus and induction of cyclin B1
            expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3245)
  AUTHORS   Lu,C., Zheng,F., Pan,L., Han,Q., Wu,J. and Zhang,W.
  TITLE     Suppression of circular RNA serum and glucocorticoid-induced kinase
            1 elevates antioxidant molecules and angiogenesis in trophoblast
            cells to attenuate preeclampsia via microRNA-508-3p to target and
            restrain PUM homolog 1
  JOURNAL   J Obstet Gynaecol Res 50 (3), 322-333 (2024)
   PUBMED   38081797
  REMARK    GeneRIF: Suppression of circular RNA serum and
            glucocorticoid-induced kinase 1 elevates antioxidant molecules and
            angiogenesis in trophoblast cells to attenuate preeclampsia via
            microRNA-508-3p to target and restrain PUM homolog 1.
REFERENCE   4  (bases 1 to 3245)
  AUTHORS   Wu,J., Gong,L., Li,Y., Liu,T., Sun,R., Jia,K., Liu,R., Dong,F.,
            Gu,X. and Li,X.
  TITLE     SGK1 aggravates idiopathic pulmonary fibrosis by triggering
            H3k27ac-mediated macrophage reprogramming and disturbing immune
            homeostasis
  JOURNAL   Int J Biol Sci 20 (3), 968-986 (2024)
   PUBMED   38250161
  REMARK    GeneRIF: SGK1 aggravates idiopathic pulmonary fibrosis by
            triggering H3k27ac-mediated macrophage reprogramming and disturbing
            immune homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3245)
  AUTHORS   Chen,D., Li,K., Pan,L., Chen,M., Zhang,X., Chen,H., Xu,J. and
            Cai,F.
  TITLE     MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation
            in Sepsis-Associated Acute Kidney Injury
  JOURNAL   Kidney Blood Press Res 49 (1), 657-666 (2024)
   PUBMED   39025049
  REMARK    GeneRIF: MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and
            Inflammation in Sepsis-Associated Acute Kidney Injury.
REFERENCE   6  (bases 1 to 3245)
  AUTHORS   Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
  TITLE     Characterization of the structure and regulation of two novel
            isoforms of serum- and glucocorticoid-induced protein kinase
  JOURNAL   Biochem J 344 Pt 1 (Pt 1), 189-197 (1999)
   PUBMED   10548550
REFERENCE   7  (bases 1 to 3245)
  AUTHORS   Park,J., Leong,M.L., Buse,P., Maiyar,A.C., Firestone,G.L. and
            Hemmings,B.A.
  TITLE     Serum and glucocorticoid-inducible kinase (SGK) is a target of the
            PI 3-kinase-stimulated signaling pathway
  JOURNAL   EMBO J 18 (11), 3024-3033 (1999)
   PUBMED   10357815
REFERENCE   8  (bases 1 to 3245)
  AUTHORS   Kobayashi,T. and Cohen,P.
  TITLE     Activation of serum- and glucocorticoid-regulated protein kinase by
            agonists that activate phosphatidylinositide 3-kinase is mediated
            by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
  JOURNAL   Biochem J 339 (Pt 2) (Pt 2), 319-328 (1999)
   PUBMED   10191262
REFERENCE   9  (bases 1 to 3245)
  AUTHORS   Waldegger,S., Erdel,M., Nagl,U.O., Barth,P., Raber,G., Steuer,S.,
            Utermann,G., Paulmichl,M. and Lang,F.
  TITLE     Genomic organization and chromosomal localization of the human SGK
            protein kinase gene
  JOURNAL   Genomics 51 (2), 299-302 (1998)
   PUBMED   9722955
REFERENCE   10 (bases 1 to 3245)
  AUTHORS   Waldegger,S., Barth,P., Raber,G. and Lang,F.
  TITLE     Cloning and characterization of a putative human serine/threonine
            protein kinase transcriptionally modified during anisotonic and
            isotonic alterations of cell volume
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4440-4445 (1997)
   PUBMED   9114008
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z84486.1, AL355881.15 and
            AL135839.15.
            
            On Nov 19, 2020 this sequence version replaced NM_001143676.2.
            
            Summary: This gene encodes a serine/threonine protein kinase that
            plays an important role in cellular stress response. This kinase
            activates certain potassium, sodium, and chloride channels,
            suggesting an involvement in the regulation of processes such as
            cell survival, neuronal excitability, and renal sodium excretion.
            High levels of expression of this gene may contribute to conditions
            such as hypertension and diabetic nephropathy. Several
            alternatively spliced transcript variants encoding different
            isoforms have been noted for this gene. [provided by RefSeq, Jan
            2009].
            
            Transcript Variant: This variant (2) contains additional in-frame
            exons at the 5' end compared to transcript variant 1, resulting in
            an isoform (2) with a longer and an unique N-terminus compared to
            isoform 1. Isoform 2 is reported to have an increased protein
            half-life, and is preferentially targeted to the plasma membrane.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2954948.1, AK055077.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367858.10/ ENSP00000356832.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-721               Z84486.1           71894-72614
            722-937             AL355881.15        1145-1360           c
            938-1013            AL135839.15        60141-60216         c
            1014-1089           AL135839.15        27296-27371         c
            1090-1165           AL135839.15        26790-26865         c
            1166-1270           AL135839.15        26247-26351         c
            1271-1354           AL135839.15        26059-26142         c
            1355-1486           AL135839.15        25808-25939         c
            1487-1599           AL135839.15        25447-25559         c
            1600-1723           AL135839.15        24978-25101         c
            1724-1819           AL135839.15        24422-24517         c
            1820-1975           AL135839.15        23808-23963         c
            1976-2065           AL135839.15        23611-23700         c
            2066-3245           AL135839.15        22041-23220         c
FEATURES             Location/Qualifiers
     source          1..3245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..3245
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /note="serum/glucocorticoid regulated kinase 1"
                     /db_xref="GeneID:6446"
                     /db_xref="HGNC:HGNC:10810"
                     /db_xref="MIM:602958"
     exon            1..721
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..2233
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine protein kinase SGK;
                     serine/threonine-protein kinase Sgk1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk1 isoform 2"
                     /protein_id="NP_001137148.1"
                     /db_xref="CCDS:CCDS47476.1"
                     /db_xref="GeneID:6446"
                     /db_xref="HGNC:HGNC:10810"
                     /db_xref="MIM:602958"
                     /translation="MVNKDMNGFPVKKCSAFQFFKKRVRRWIKSPMVSVDKHQSPSLK
                     YTGSSMVHIPPGEPDFESSLCQTCLGEHAFQRGVLPQENESCSWETQSGCEVREPCNH
                     ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQE
                     PELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF
                     YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYING
                     GELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLT
                     DFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF
                     YSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF
                     SLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKE
                     AAEAFLGFSYAPPTDSFL"
     exon            722..937
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1013
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1089
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1165
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1270
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1354
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1486
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1599
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1723
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1819
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1975
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2065
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..3245
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /note="hexamer: AATAAA"
     polyA_site      3245
                     /gene="SGK1"
                     /gene_synonym="SGK"
                     /note="major polyA site"
ORIGIN      
        1 aactgctctt cagtgtgccc tgagccggct gtgccttctc tccatccgct gctcagatat
       61 tcatgaaccg ttgcttcttc cagcctcgcc ttctcgctcc ctctgccttt ctggcgctgt
      121 tctccctccc tccctctggc ttctgctctt tcttactcct tctctcagct gcttaactac
      181 agctcccact ggaacttgca caatcaaaaa caactctcct ctctcaagcc gcctccagga
      241 gcgcatcacc tggagaagag cgactcgctc cccgcgccgg ccgcggaaga gcagccaggt
      301 agctgggggc ggggaggcgt acccttctcc cgctcggtaa gagccacagc atctccccgg
      361 agattggccg tatcccaccg tccggccccc agggtcctgc agcggtgatg catatgtttc
      421 ggagcaatga tggaaggaga aaagccgctg tcggtggcaa ctgaaagtgg ggagaggttg
      481 ctgcagtagc tggtgctgca gaatgcgcga gtgaagaact gagccccgct agattctcca
      541 tcccgctcag tcttcattaa ctgtctgcag gaggtaaacc ggggaaacag atatgcacta
      601 accaggcggg tgccaacctg gatctataac tgtgaattcc ccacggtgga aaatggtaaa
      661 caaagacatg aatggattcc cagtcaagaa atgctcagcc ttccaatttt ttaagaagcg
      721 ggtacgaagg tggatcaaga gcccaatggt cagtgtggac aagcatcaga gtcccagcct
      781 gaagtacacc ggctcctcca tggtgcacat ccctccaggg gagccagact tcgagtcttc
      841 cttgtgtcaa acatgcctgg gtgaacatgc tttccaaaga ggggttctcc ctcaggagaa
      901 cgagtcatgt tcatgggaaa ctcaatctgg gtgtgaagtg agagagccat gtaatcatgc
      961 caacatcctg accaagcccg atccaagaac cttctggact aatgatgatc cagctttcat
     1021 gaagcagagg aggatgggtc tgaacgactt tattcagaag attgccaata actcctatgc
     1081 atgcaaacac cctgaagttc agtccatctt gaagatctcc caacctcagg agcctgagct
     1141 tatgaatgcc aacccttctc ctccaccaag tccttctcag caaatcaacc ttggcccgtc
     1201 gtccaatcct catgctaaac catctgactt tcacttcttg aaagtgatcg gaaagggcag
     1261 ttttggaaag gttcttctag caagacacaa ggcagaagaa gtgttctatg cagtcaaagt
     1321 tttacagaag aaagcaatcc tgaaaaagaa agaggagaag catattatgt cggagcggaa
     1381 tgttctgttg aagaatgtga agcacccttt cctggtgggc cttcacttct ctttccagac
     1441 tgctgacaaa ttgtactttg tcctagacta cattaatggt ggagagttgt tctaccatct
     1501 ccagagggaa cgctgcttcc tggaaccacg ggctcgtttc tatgctgctg aaatagccag
     1561 tgccttgggc tacctgcatt cactgaacat cgtttataga gacttaaaac cagagaatat
     1621 tttgctagat tcacagggac acattgtcct tactgacttc ggactctgca aggagaacat
     1681 tgaacacaac agcacaacat ccaccttctg tggcacgccg gagtatctcg cacctgaggt
     1741 gcttcataag cagccttatg acaggactgt ggactggtgg tgcctgggag ctgtcttgta
     1801 tgagatgctg tatggcctgc cgccttttta tagccgaaac acagctgaaa tgtacgacaa
     1861 cattctgaac aagcctctcc agctgaaacc aaatattaca aattccgcaa gacacctcct
     1921 ggagggcctc ctgcagaagg acaggacaaa gcggctcggg gccaaggatg acttcatgga
     1981 gattaagagt catgtcttct tctccttaat taactgggat gatctcatta ataagaagat
     2041 tactccccct tttaacccaa atgtgagtgg gcccaacgac ctacggcact ttgaccccga
     2101 gtttaccgaa gagcctgtcc ccaactccat tggcaagtcc cctgacagcg tcctcgtcac
     2161 agccagcgtc aaggaagctg ccgaggcttt cctaggcttt tcctatgcgc ctcccacgga
     2221 ctctttcctc tgaaccctgt tagggcttgg ttttaaagga ttttatgtgt gtttccgaat
     2281 gttttagtta gccttttggt ggagccgcca gctgacagga catcttacaa gagaatttgc
     2341 acatctctgg aagcttagca atcttattgc acactgttcg ctggaagctt tttgaagagc
     2401 acattctcct cagtgagctc atgaggtttt catttttatt cttccttcca acgtggtgct
     2461 atctctgaaa cgagcgttag agtgccgcct tagacggagg caggagtttc gttagaaagc
     2521 ggacgctgtt ctaaaaaagg tctcctgcag atctgtctgg gctgtgatga cgaatattat
     2581 gaaatgtgcc ttttctgaag agattgtgtt agctccaaag cttttcctat cgcagtgttt
     2641 cagttcttta ttttcccttg tggatatgct gtgtgaaccg tcgtgtgagt gtggtatgcc
     2701 tgatcacaga tggattttgt tataagcatc aatgtgacac ttgcaggaca ctacaacgtg
     2761 ggacattgtt tgtttcttcc atatttggaa gataaattta tgtgtagact tttttgtaag
     2821 atacggttaa taactaaaat ttattgaaat ggtcttgcaa tgactcgtat tcagatgctt
     2881 aaagaaagca ttgctgctac aaatatttct atttttagaa agggttttta tggaccaatg
     2941 ccccagttgt cagtcagagc cgttggtgtt tttcattgtt taaaatgtca cctgtaaaat
     3001 gggcattatt tatgtttttt tttttgcatt cctgataatt gtatgtattg tataaagaac
     3061 gtctgtacat tgggttataa cactagtata tttaaactta caggcttatt tgtaatgtaa
     3121 accaccattt taatgtactg taattaacat ggttataata cgtacaatcc ttccctcatc
     3181 ccatcacaca actttttttg tgtgtgataa actgattttg gtttgcaata aaaccttgaa
     3241 aaata
//
