LOCUS       NM_138414               1159 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SAGA complex associated factor 29 (SGF29), mRNA.
ACCESSION   NM_138414 XM_941168
VERSION     NM_138414.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Barbosa,K., Deshpande,A., Perales,M., Xiang,P., Murad,R.,
            Pramod,A.B., Minkina,A., Robertson,N., Schischlik,F., Lei,X.,
            Sun,Y., Brown,A., Amend,D., Jeremias,I., Doench,J.G.,
            Humphries,R.K., Ruppin,E., Shendure,J., Mali,P., Adams,P.D. and
            Deshpande,A.J.
  TITLE     Transcriptional control of leukemogenesis by the chromatin reader
            SGF29
  JOURNAL   Blood 143 (8), 697-712 (2024)
   PUBMED   38048593
  REMARK    GeneRIF: Transcriptional control of leukemogenesis by the chromatin
            reader SGF29.
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Arras,S.D.M., Ormerod,K.L., Erpf,P.E., Espinosa,M.I.,
            Carpenter,A.C., Blundell,R.D., Stowasser,S.R., Schulz,B.L.,
            Tanurdzic,M. and Fraser,J.A.
  TITLE     Convergent microevolution of Cryptococcus neoformans hypervirulence
            in the laboratory and the clinic
  JOURNAL   Sci Rep 7 (1), 17918 (2017)
   PUBMED   29263343
  REMARK    GeneRIF: Loss of function SGF29 mutation is associated with
            Cryptococcus neoformans hypervirulence.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Kurabe,N., Katagiri,K., Komiya,Y., Ito,R., Sugiyama,A., Kawasaki,Y.
            and Tashiro,F.
  TITLE     Deregulated expression of a novel component of TFTC/STAGA histone
            acetyltransferase complexes, rat SGF29, in hepatocellular
            carcinoma: possible implication for the oncogenic potential of
            c-Myc
  JOURNAL   Oncogene 26 (38), 5626-5634 (2007)
   PUBMED   17334388
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020765.8, AA132818.1, BC011981.1 and AA132314.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138414.2.
            
            Summary: CCDC101 is a subunit of 2 histone acetyltransferase
            complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex
            and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A;
            MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex.
            Both of these complexes contain either GCN5 or PCAF, which are
            paralogous acetyltransferases (Wang et al., 2008 [PubMed
            18838386]).[supplied by OMIM, Apr 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.22172.1,
                                           SRR5189667.236079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317058.8/ ENSP00000316114.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC020765.8         92387-92394
            9-37                AA132818.1         1-29
            38-1157             BC011981.1         21-1140
            1158-1159           AA132314.1         10-11               c
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1159
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /note="SAGA complex associated factor 29"
                     /db_xref="GeneID:112869"
                     /db_xref="HGNC:HGNC:25156"
                     /db_xref="MIM:613374"
     exon            1..178
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            179..268
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1075
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /note="SAGA-associated factor 29 homolog; coiled-coil
                     domain-containing protein 101; coiled-coil domain
                     containing 101"
                     /codon_start=1
                     /product="SAGA-associated factor 29"
                     /protein_id="NP_612423.1"
                     /db_xref="CCDS:CCDS10635.1"
                     /db_xref="GeneID:112869"
                     /db_xref="HGNC:HGNC:25156"
                     /db_xref="MIM:613374"
                     /translation="MALVSADSRIAELLTELHQLIKQTQEERSRSEHNLVNIQKTHER
                     MQTENKISPYYRTKLRGLYTTAKADAEAECNILRKALDKIAEIKSLLEERRIAAKIAG
                     LYNDSEPPRKTMRRGVLMTLLQQSAMTLPLWIGKPGDKPPPLCGAIPASGDYVARPGD
                     KVAARVKAVDGDEQWILAEVVSYSHATNKYEVDDIDEEGKERHTLSRRRVIPLPQWKA
                     NPETDPEALFQKEQLVLALYPQTTCFYRALIHAPPQRPQDDYSVLFEDTSYADGYSPP
                     LNVAQRYVVACKEPKKK"
     exon            269..344
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            345..417
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            418..482
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            483..612
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            613..759
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            760..795
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            796..958
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1159
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /note="hexamer: ATTAAA"
     polyA_site      1159
                     /gene="SGF29"
                     /gene_synonym="CCDC101; STAF36; TDRD29"
                     /note="major polyA site"
ORIGIN      
        1 cctccgcgcg cgactacgct cataaaagga aaaaaaagcg tgtgcggttc tcgacgtgcc
       61 gccaatcttc gaacgcaggt ctgtgatcat ccgcagactc cgaaaaaggg ttcgaggaac
      121 gcgcctgctc ccctcgtcgc agtttccagc ccgacgagct tgttttgtcc cggactcggt
      181 gcccctgtag acaatggccc tcgtgtctgc cgattcccgc attgcagaac ttctcacaga
      241 gctccatcag ctgatcaaac aaacccagga agagcgttcg cggagcgaac acaacttagt
      301 gaacatccag aagacccatg agcggatgca gacagagaac aagatttctc cctattaccg
      361 gacaaagctg cgtggcctct acacaaccgc caaggccgat gcagaggctg agtgcaacat
      421 ccttcggaaa gctctggaca agatcgcgga aatcaagtct ctgttggaag agaggcggat
      481 tgcggccaag attgccggtc tctacaatga ctcggagcca ccccggaaga ccatgcgcag
      541 aggggtgctg atgaccctgc tgcagcagtc ggccatgacc ctgcccctgt ggatcgggaa
      601 gcctggtgac aagcccccac ccctctgtgg ggccatccct gcctcaggag actacgtggc
      661 cagacctgga gacaaggtgg ctgcccgggt gaaggccgtg gatggggacg agcagtggat
      721 cctggccgag gtggtcagtt acagccatgc caccaacaag tatgaggtag atgacatcga
      781 tgaagaaggc aaagagagac acaccctgag ccggcgccgt gtcatcccgc tgccccagtg
      841 gaaggccaac ccggagacgg accctgaggc cttgttccag aaggagcagc tcgtgctggc
      901 cctgtatccc cagactacct gcttctaccg cgccctgatc catgcgcccc cacagcggcc
      961 ccaggatgac tactcggtcc tgtttgaaga cacctcctat gcagatggct attcccctcc
     1021 cctcaatgtg gctcagagat acgtggtggc ttgtaaggaa cccaagaaaa agtgatgccg
     1081 cctggcagac tcgccatccc ccaacgacac agggcaggac agcagaggac gtgctgggat
     1141 taaacacatt ccccctcta
//
