LOCUS       NM_000337               9383 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sarcoglycan delta (SGCD), transcript variant 1, mRNA.
ACCESSION   NM_000337
VERSION     NM_000337.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9383)
  AUTHORS   Li,J., Yang,S., Pu,Z., Dai,J., Jiang,T., Du,F., Jiang,Z., Cheng,Y.,
            Dai,G., Wang,J., Qi,J., Cao,L., Cheng,X., Ren,C., Li,X. and Qin,Y.
  TITLE     Whole-exome sequencing identifies SGCD and ACVRL1 mutations
            associated with total anomalous pulmonary venous return (TAPVR) in
            Chinese population
  JOURNAL   Oncotarget 8 (17), 27812-27819 (2017)
   PUBMED   28412737
  REMARK    GeneRIF: Study identified 2 non-synonymous missense mutations:
            c.C652T, p.R218W in ACVRL1, c.C717G, p.D239E in SGCD in Chinese
            population with total anomalous pulmonary venous return.
REFERENCE   2  (bases 1 to 9383)
  AUTHORS   Campbell,M.D., Witcher,M., Gopal,A. and Michele,D.E.
  TITLE     Dilated cardiomyopathy mutations in delta-sarcoglycan exert a
            dominant-negative effect on cardiac myocyte mechanical stability
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (9), H1140-H1150 (2016)
   PUBMED   26968544
  REMARK    GeneRIF: Dilated cardiomyopathy mutations in delta-sarcoglycan can
            exert a dominant negative effect on dystrophin-glycoprotein complex
            function leading to myocardial mechanical instability that may
            underlie the pathogenesis of delta-sarcoglycan-associated DCM.
REFERENCE   3  (bases 1 to 9383)
  AUTHORS   Chen,J., Jin,Y., Wang,H., Wei,S., Chen,D., Ying,L., Zhou,Q., Li,G.,
            Li,J., Gao,J., Kato,N., Hu,W., Li,Y. and Wang,Y.
  TITLE     A Haplotype of Two Novel Polymorphisms in delta-Sarcoglycan Gene
            Increases Risk of Dilated Cardiomyopathy in Mongoloid Population
  JOURNAL   PLoS One 10 (12), e0145602 (2015)
   PUBMED   26720722
  REMARK    GeneRIF: haplotype -_G composed of c.-100~-110 and A848G confers
            higher susceptibility to dilated cardiomyopathy in the Mongoloid
            population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9383)
  AUTHORS   Ye,R., Yang,W., Yuan,Y. and Deng,X.
  TITLE     The CC genotype of the delta-sarcoglycan gene polymorphism
            rs13170573 is associated with obstructive sleep apnea in the
            Chinese population
  JOURNAL   PLoS One 9 (12), e114160 (2014)
   PUBMED   25474115
  REMARK    GeneRIF: CC genotype of the delta-sarcoglycan gene polymorphism
            rs13170573 is associated with obstructive sleep apnea in the
            Chinese population
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9383)
  AUTHORS   Jung,D., Duclos,F., Apostol,B., Straub,V., Lee,J.C., Allamand,V.,
            Venzke,D.P., Sunada,Y., Moomaw,C.R., Leveille,C.J., Slaughter,C.A.,
            Crawford,T.O., McPherson,J.D. and Campbell,K.P.
  TITLE     Characterization of delta-sarcoglycan, a novel component of the
            oligomeric sarcoglycan complex involved in limb-girdle muscular
            dystrophy
  JOURNAL   J Biol Chem 271 (50), 32321-32329 (1996)
   PUBMED   8943294
REFERENCE   6  (bases 1 to 9383)
  AUTHORS   Nigro,V., de Sa Moreira,E., Piluso,G., Vainzof,M., Belsito,A.,
            Politano,L., Puca,A.A., Passos-Bueno,M.R. and Zatz,M.
  TITLE     Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is
            caused by a mutation in the delta-sarcoglycan gene
  JOURNAL   Nat Genet 14 (2), 195-198 (1996)
   PUBMED   8841194
REFERENCE   7  (bases 1 to 9383)
  AUTHORS   Nigro,V., Piluso,G., Belsito,A., Politano,L., Puca,A.A.,
            Papparella,S., Rossi,E., Viglietto,G., Esposito,M.G.,
            Abbondanza,C., Medici,N., Molinari,A.M., Nigro,G. and Puca,G.A.
  TITLE     Identification of a novel sarcoglycan gene at 5q33 encoding a
            sarcolemmal 35 kDa glycoprotein
  JOURNAL   Hum Mol Genet 5 (8), 1179-1186 (1996)
   PUBMED   8842738
REFERENCE   8  (bases 1 to 9383)
  AUTHORS   Passos-Bueno,M.R., Moreira,E.S., Vainzof,M., Marie,S.K. and Zatz,M.
  TITLE     Linkage analysis in autosomal recessive limb-girdle muscular
            dystrophy (AR LGMD) maps a sixth form to 5q33-34 (LGMD2F) and
            indicates that there is at least one more subtype of AR LGMD
  JOURNAL   Hum Mol Genet 5 (6), 815-820 (1996)
   PUBMED   8776597
REFERENCE   9  (bases 1 to 9383)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301582
REFERENCE   10 (bases 1 to 9383)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ434817.1, BC020740.1,
            BX537948.1, AC025434.6 and BQ446019.1.
            
            On Jun 5, 2020 this sequence version replaced NM_000337.5.
            
            Summary: The protein encoded by this gene is one of the four known
            components of the sarcoglycan complex, which is a subcomplex of the
            dystrophin-glycoprotein complex (DGC). DGC forms a link between the
            F-actin cytoskeleton and the extracellular matrix. This protein is
            expressed most abundantly in skeletal and cardiac muscle. Mutations
            in this gene have been associated with autosomal recessive
            limb-girdle muscular dystrophy and dilated cardiomyopathy.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been observed for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1, also known as SGCD1), encodes
            the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020740.1, SRR1803615.106454.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337851.9/ ENSP00000338343.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               BQ434817.1         408-777
            371-1195            BC020740.1         371-1195
            1196-1424           BX537948.1         1568-1796
            1425-9099           AC025434.6         36104-43778         c
            9100-9383           BQ446019.1         16-299              c
FEATURES             Location/Qualifiers
     source          1..9383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2-q33.3"
     gene            1..9383
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="sarcoglycan delta"
                     /db_xref="GeneID:6444"
                     /db_xref="HGNC:HGNC:10807"
                     /db_xref="MIM:601411"
     exon            1..69
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            70..115
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..985
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     placental delta sarcoglycan; dystrophin associated
                     glycoprotein, delta sarcoglycan; sarcoglycan, delta (35kDa
                     dystrophin-associated glycoprotein); delta-SG; 35 kDa
                     dystrophin-associated glycoprotein"
                     /codon_start=1
                     /product="delta-sarcoglycan isoform 1"
                     /protein_id="NP_000328.2"
                     /db_xref="CCDS:CCDS47325.1"
                     /db_xref="GeneID:6444"
                     /db_xref="HGNC:HGNC:10807"
                     /db_xref="MIM:601411"
                     /translation="MMPQEQYTHHRSTMPGSVGPQVYKVGIYGWRKRCLYFFVLLLMI
                     LILVNLAMTIWILKVMNFTIDGMGNLRITEKGLKLEGDSEFLQPLYAKEIQSRPGNAL
                     YFKSARNVTVNILNDQTKVLTQLITGPKAVEAYGKKFEVKTVSGKLLFSADNNEVVVG
                     AERLRVLGAEGTVFPKSIETPNVRADPFKELRLESPTRSLVMEAPKGVEINAEAGNME
                     ATCRTELRLESKDGEIKLDAAKIRLPRLPHGSYTPTGTRQKVFEICVCANGRLFLSQA
                     GAGSTCQINTSVCL"
     exon            116..304
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            305..406
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            407..494
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            495..614
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            615..687
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            688..811
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     exon            812..9383
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1176..1181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="hexamer: AATATA"
     polyA_site      1194
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="major polyA site"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="hexamer: ATTAAA"
     polyA_site      3754
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
     regulatory      9361..9366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="hexamer: AATAAT"
     polyA_site      9383
                     /gene="SGCD"
                     /gene_synonym="35DAG; CMD1L; DAGD; LGMDR6; SG-delta;
                     SGCDP; SGD"
                     /note="major polyA site"
ORIGIN      
        1 agagctgctc agcacgccct gggatcgcgg gcggttttca tcggccggtt tgtgaaacgg
       61 acaagagaga gacattactg ccgggagtgt tgagtgaagg gaccaggtgg agatgatgcc
      121 tcaggagcag tacactcacc accggagcac catgcctggc tctgtggggc cacaggtata
      181 caaggtgggg atttatggct ggcggaaacg atgcctgtat ttctttgtcc tgctcctcat
      241 gattttaata ctggtgaact tggccatgac catctggatt ctcaaagtca tgaacttcac
      301 aattgatgga atgggaaacc tgaggatcac agaaaaaggt ctaaagctag aaggagactc
      361 tgaattctta caacctctct acgccaaaga aatccagtcc cgaccaggta atgccctgta
      421 cttcaagtct gccagaaatg ttacagtgaa cattctcaat gaccagacta aagtgctaac
      481 tcagcttata acaggtccaa aagccgtaga agcttatggt aaaaaatttg aggtaaaaac
      541 tgtttctgga aaattgctct tctctgcaga caataatgaa gtggtagtag gagctgaaag
      601 attacgagtt ttaggagcgg agggcacagt gttccctaaa tctatagaaa cacctaatgt
      661 cagggcagac cccttcaaag aactaaggtt ggagtcccca acccggtctc tagtgatgga
      721 ggccccaaaa ggagtggaaa tcaatgcaga agctggcaat atggaagcca cctgcaggac
      781 agagctgaga ctggaatcca aagatggaga gattaagtta gatgctgcga aaatcaggct
      841 acctagactg cctcatggat cctacacgcc tacaggaacg aggcagaagg tcttcgagat
      901 ctgcgtctgc gccaatggga gattattcct gtctcaggca ggagctgggt ccacttgtca
      961 gataaacaca agtgtctgcc tctgaaagac tatccatagt ggacattgtt ggcagcataa
     1021 aggccttttt tggctttaga cactggctgc cagctatttt tactagaaca cagaaagcct
     1081 atcaaagacc ttgtgtgtat gtgtacgtgt gtgtgcgtgc ttgagtgtgt tcgcgtgtgt
     1141 gggtggatat aaatatatat aaatatatat aaataaatat atatatcctc tgtataaaat
     1201 gaggtttcag tacaaaagga accatgggtg accctgcgat atccactgtc attttccatc
     1261 ccatccccac cacctgagtg acagaaatct aaacacacat ccgtcccaac attccccaga
     1321 ccattcagaa tcacacagcg tattaaacac tgacagaatc ttcatctaga tattcgagta
     1381 gcagcatatc ttctctttta gtgtcattac gagggagtga tggcgggaat ctcagtcgca
     1441 ctcaagctct gagacctttg tatcaaaaat aggcatttga tttcctgttt tagctttagt
     1501 aaggctggct aacttccccc tcttcaagct aggaactggc aatgctgtag aagtcagccg
     1561 taggaattca aaatggctgg cctaccttgg ctaccagaca tattggggtt tttgtagttg
     1621 aatgaatgag gaggatgaat ttcagcaaat tttgaactgc tcacccaact tctgctatct
     1681 tgctccctcc aaactcacag attctcctac agtcaaatta ggagctgtaa atcagcacaa
     1741 aataagataa cagctgttcc tcagtgagct ggaagctact taatggcctg atgggcaatg
     1801 aacaaacggg tgatatgtct ctgtttaagg gaaaaatggc ttaaaagctg ttctgttctc
     1861 acttctgact ttaaccaaaa gatttcaacc cacaatgatc aggtcaatca aaatccctaa
     1921 gagcagaact cctaccccaa aagaagcctg gaagtctaat taagagtagc ataaggaacc
     1981 taattatgtt taccatgttt cttgggattg gtgggaaatg tcaaaacatg ccctttattt
     2041 ttaaaggcat tcacaaactc tctgactttg ttcttcttat atattttttc agtgccggga
     2101 tattcatatt cctaaagcca ctattgtgtt ttctctaaga agcactacat gccaccagaa
     2161 ttgtgcactg aaagataata caaactgagt gtctttatga gaatcactgt gtcccctgag
     2221 gcccagcagt acctgcttcc ctgtatgtgg aagcagcacc tcattcccgc catcagctac
     2281 ctctcatcac cccaccttca tcatcatgct ccagggtcac cctggccagc tcttgtgctg
     2341 ggacagggga ttacaccatc tctgttcaaa gagggggaaa tgtgcctatg ccttaagtca
     2401 atgcactcag caaggagaag cacatcttat ttatcttgtt acctatagtt tactttgggt
     2461 gattggaggg gaatgactta gttatgactg gacatcttaa aagctgatag acaagccaaa
     2521 tggctggcag atgatgtgga tttcaaagag cccagaatga actcatcact ggcttagaca
     2581 gtcctggatg ccatttggaa agtagtggcc ctgcaagcct aaatgaagta gtatttgtag
     2641 gcctgggtgg catttggatt tttcttttcc ctcaacaagg ttttactttt tcttacttta
     2701 caagcaaggg aagttttgtg ataggagaga aataaaagat ttgatatttt ttgagatgac
     2761 actcaagcat caggctgaga tttgcacaca tgggatgtaa aagcaagctg tgtgttgctt
     2821 agtcacttac ttagaagtag atggtggggg acagcggcgt gggtcctagc ctggccagtg
     2881 atgctgctgg cgtccagacc ccagactcac tccaagcact cttgttcaat atctcatgca
     2941 gaagagttgg gctggtcact cttaggggtg agaccccgtg attggttggt ttgtagcact
     3001 aaggtctaaa aaggaaaacc ataaaagaca tcagattacg ctggatcagt ataattaata
     3061 ttccataggg ccatgttgcc agaatctgta tgtatcaata cagggttttt ccaagccagg
     3121 aaacgccctc cttggctact aggagcacct atcccatatc attcagataa acaatgatag
     3181 ctacaaagtc atttgtggct agataggtta agacaggtga ttttttaaag tagactgtct
     3241 ttgcattttg ccatctgaag ttcattaatc tttagatgac aaaaaagcaa aaagttccca
     3301 gaacgttttt gcttagattt tgttctaatc accacgtgaa ggaatgagat tagcaccaca
     3361 agtttcatgc caataaaaga gactggtgtg atcccacatg caaaatttaa tcctaagggt
     3421 agtgagatca caaacagaat aaaaataaga gcaatcaacc atataaatca agtacctatt
     3481 gggaacagac ataacattca atttttcatt tatgctaagt gaccacagta tacaaagtaa
     3541 taagcaggaa atttgatatg ggttaaatta tgcattttgt tcagattttg gaaattggta
     3601 tgcattataa gtttctcaat gtacatcttt ttatcccaac accctcaaac tagaatattt
     3661 gtcagtggtc aagagaaaaa attttacctg aattcttggg ggccggcggg gagcttttac
     3721 attaaaaatc tactaacgcc tactttttaa aaaatgagat tctttctaat ctttatatat
     3781 gacattttct agacaatcgc acctttgggt atattaaaca gctggtatca taacaaagaa
     3841 tccaaatgaa ccttcaatat actagaagtt ctagtaggtt aatattgttc agaagatttt
     3901 tacaaattaa aaactgattt ccaaatatgt tcaacattta cttctatttg atatctgctc
     3961 aagaagtcat agaagtcttg ggaaactatt cgagtatcac agaggttttc aaaagccctt
     4021 atggtgacat ctacctaggt aaaagcctga catgtggctt tataattgtt atgttaccca
     4081 agggataaac ttgaactggc tttgaacatc ctttaggtca ttttctcttt ggataatttt
     4141 catcgcatat ccagcaacta tagaccaaag tttgcttaag gtttgaccct agagcagagg
     4201 tgggcaaact atgacctgga aaccaaatct gacttaccac cttttcctgt agttaaagtt
     4261 ttattgtcac atagccacat acattcattt acatgttttc tgattttaca ctacagcagc
     4321 aggatggagt agttgtgtca gagactatgt atcccacaaa gcatagatta cttactattt
     4381 agtcctttac aggcaaagtt tcctcacccc tgacctagag gtttttgtgg tatgcattgg
     4441 atatagcagg aaagaaagca catttccaaa cagcagggag taagcttaca tttctgtgta
     4501 ggtttgggaa tatagttact tggcaaagtc tttcaggaag gaagcccttc cttatgttac
     4561 atgtggaaag cctgccttcc aagacatgtg gaagtaattg atccacctgc cagagaaaca
     4621 caggctcaga ggatgcctgg gaacagggag gatgggatta gtggaagctt aatggaaaag
     4681 gaaagttatg atcctccaag acccttaatt gatagaccat accaggttct gcaggtcagc
     4741 atcattgtgt aatgagagtg aagtagggga ccctgtggtt caaccttaga atctgtttcc
     4801 tgtaggctct ttctgctgtc tatattcatt aaagttttcc acttcaccct cccatagtct
     4861 agagggatgc ccattccatg gtcctccaga gaatagtttt gacttaacat gtctgtttag
     4921 cccacatcac gtcagttatc aacaccgcca ctgtgcttac tgttcctaca gccacaccag
     4981 gcttgaagag ttagtgagac caacaaataa ttggaagtat tggaaaaagc aaaatacatg
     5041 gggacaaaaa aaatacagtg aaattctttt tatcaaactg atgctgtgag aaaccagatg
     5101 aatgccagtt tggctttatt tctaagaatc tgggtcttca ttctctggtg tagaaggaat
     5161 gcaaaaaact ataacaacaa caacaaaaac atattttgaa aagacatatt ctgacatctc
     5221 tgcttgtgtg tggtaaggca ggttcctatc agacatttat ccctttggtc aagatccctt
     5281 ttgctcatcc agggtttcat actcaatatc gcttaaaaaa aaaaaagtat cagctaggga
     5341 tgactctgga agtatgagta tcatggtggg gaggaaggaa ttttttttaa atgtaaatga
     5401 cccccattta ccagacccta atcaaagtca cttaagggaa tccctcagcc ttttatttgg
     5461 aaacagttga aataaactgg cagcagctag atcagagtat cttgctttat tttataaagg
     5521 ccaaaggtag tatgaagttt ggaccaaaaa ggtaaataga tccattccag cacctgatac
     5581 tgatttttca aggctctatg aaaggtcaaa aatttcatta aacaagacca gttctccctc
     5641 ttccccctgt cccaagaaat cttaggcatg aaaaggataa ggaaacagct cctggaatga
     5701 tacatttgca tagtgcccta gtagcaggtt gggaaaaagt tataatataa gaaacaacct
     5761 tcgaaaacag gccttttatc tcaaagataa aatgtctttc ttgtggtctt tcatcactat
     5821 ctccgtggtg gaaggttccc ctagttccaa catatttcca ttaaaatagt caaagccacg
     5881 gcattgggat gtcagatgcc tctctttctt tgtggtaatc ggaatttaaa attatacagt
     5941 tgcctctgaa tttctcatgc acaaagccaa accactgata agagataaag cagtctgaag
     6001 cctgctgctt cagccagcac agcacaccac acacgctcgc actttcaaaa gcaatgtgat
     6061 ttctatggtt cttaaaagct ttcttcataa gggagtccct gaaatttctc aaggcaggtt
     6121 tgaatggcaa agggaaaata attacttgtg ggaggtcctc cttttgagta ttgttagagc
     6181 atacatgtaa aagaaaataa cctttttggg gcaactcatg ctcacacatg ctgttttctt
     6241 tggttctccc cctaccttcc ttttgtagat attgacagaa taggaggaaa tgagcatcct
     6301 tatttgagaa agagcaagaa tgtcatgagc ccttgatgca atagtaagtg tgatgtcatc
     6361 atacagtgtt aatgatgcta tcaaatccat caataaacag tctcaaacct tccaacaaca
     6421 gtgctcactg ctgctcctca acttcagccc agcaagcagt aatatcatca cccattttga
     6481 gatatgcagg tggaatagaa caaagaaaca gccactgtaa tcgagaagca tgtttactgt
     6541 ctaaatccac ctgttgcagt aggaagccag agtggggttc caaatgcctc attaagtatg
     6601 tggacagcct cactagtaag tgagtgaatt tggcttcatc actgaacatt agctaaggtc
     6661 agcttaataa cacaaatatg aggccgactt ctttgcgaga agagaaaaga aaacatctgc
     6721 ttgatttaaa atccacccca catgcctaga gttgtctaat agtccctcac tttccaatgg
     6781 cttcacatcc tacttctaca tttggggttt tttggtgaaa tcagagatag ctcaggattt
     6841 cataaaacga gaaactccaa actggtctat taggttccat gggaacactt gtagccaaag
     6901 gattgtctga gggcaggaag acgacacttg tcaacaagga agacagtgtt tctttagttc
     6961 ccatattcat ctaattcatg gggttctaac attttggggg gccatagatt cttttgacaa
     7021 tctgagccaa tctatgaaac ttctccccaa aaagaaccac cccacaaaat cttgcaaaac
     7081 gtaagagatt ttcctggatc tgaagctacc cgaagacatg ggaagagttg tattctatta
     7141 ttcaatttta agaatattta ttaatattca ctgagctatt gctagccact gtgctaaaca
     7201 ttttacatac attctcctat ttcatcctca aaacaatcct ttgagttggg ttttaatata
     7261 gttccaatat tcggatgtga aaactgaggc ttatagtggc taagaaactt gcccaaagcc
     7321 actacctaga aaatggcaga gctggaatgt aggtttaact cctgaccact atgctataaa
     7381 gtcaccacat gtcaaactaa ttttcaagtt gttgggacat gtcccctact aggttttaaa
     7441 ctagatcttc cttggtagat gaagctatag aacttctatt ttccctgctt tctgtagtct
     7501 ctcacagtga cagcatctat actaaagtat agatacctaa ggggaaaata tagaaagcct
     7561 gcctgaataa tagaatctag aacaacaaca aaaatattaa ttttttctgt gtatgcttag
     7621 gtcaagctta aaaaaaaaaa aaaaagaccg gaaaatacct gggttgttag cctcacattt
     7681 aggaaaaaat tgtaatactc agttatctgt gtgtgtggct aaacaagtca gcatttctgc
     7741 acacatacat ctctttcctt tatacttccc ttcaaaagac aaatatctta cttttgatct
     7801 ttgacactat ttggtcagta ttcttcttta cctttacttg tggcaaaact caaggaagcg
     7861 atcaaataga gggaagctca tttctatcat tgtctctgtt tccctataag aaagaactac
     7921 cagggactca ctgactgcat taggcataca atgtcagagc tgagctgacc actctggtcc
     7981 tgtaatgtct ttggcctcac accttggcag ccatcattaa tgggccatac ccttccccag
     8041 gtgcagaatt ctcctcccca gagcactcag gccgttacta ccaatttatc tgagttggaa
     8101 ataagactca tttgccagtt cttattttta aagtggcacc ctttaacttt gaacctgtgt
     8161 attttacact ggcatcctag attcagcaat gaggtttggt ggtgtttcaa ctaggaaggg
     8221 agaaaatgag tgcatctgaa gttccttaca gcttggtttc tttggaatgc tttcatcttc
     8281 taagcaaagg gatcagggtt tgatctgtaa gagttaaaaa gacaaagtca ttttgaagaa
     8341 ttaactcagc cagggatcat gcaaaaagat tagaaaccat aatgcccttg ttaaagccct
     8401 gctgtcaacc tgccttcacc cagagcttag agggccacag cagcaaagag gttggggtcc
     8461 atccctctct gatgtgcttt ttccacaaca catatctggt cctctggcag gattgtggat
     8521 agagctcctc accataccca aaagactcag ccccagtgcc agtgctttcc tggttcaaca
     8581 acccaccaca aaaccttagt aaaaggatga gccaaaaatg aaaaagactc gactctacag
     8641 taagtcagtc agggatttcc tttttaatgg tttaagacat ccaaatggca agccaggaat
     8701 agataccatt aaagggtctc ataggactaa ccttaccaga gccagaaatc tagctctctg
     8761 gaagagatgc aagattctag aaaagtaaag ggaagtgtcg gcacatctaa atttagtgaa
     8821 cacaaaatta atttttatct agtctgtgac ggagggaata aagtttttca tgtatcaacc
     8881 acctccccca gtcaggtttc tccctttttg agattatgaa gaagctgaga catacttctt
     8941 aaggaggtcg tgttttagaa ggaaaaggca gaggctatcc atcattatgc tggctagatg
     9001 cgcttctgaa gaagccggat tctgatgttc ttaaccaaaa tggtgaggtc atggaagtcc
     9061 catttgcttg gagattttga aaaaaaaaaa aaaaaaaaac ccattcccat aaagtaattg
     9121 agttcagcct ttggattatt tttggtttgg tttttctctg gttttgggtg tgatgtaaga
     9181 agagcttttt agttttgttt tgaataacat caatccttgc acactctatg caaaaatttt
     9241 gtaagcattt caataatgct atgaattaca aggaactatt ttaactttat tacactttct
     9301 gtataaaaaa tttgtattta atattatttc gaccacagtc ttgtaaaata tattaataaa
     9361 aataatgatt ggtaagaagg aaa
//
