LOCUS       NM_144579               4016 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens sideroflexin 5 (SFXN5), transcript variant 2, mRNA.
ACCESSION   NM_144579
VERSION     NM_144579.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4016)
  AUTHORS   Kory,N., Wyant,G.A., Prakash,G., Uit de Bos,J., Bottanelli,F.,
            Pacold,M.E., Chan,S.H., Lewis,C.A., Wang,T., Keys,H.R., Guo,Y.E.
            and Sabatini,D.M.
  TITLE     SFXN1 is a mitochondrial serine transporter required for one-carbon
            metabolism
  JOURNAL   Science 362 (6416) (2018)
   PUBMED   30442778
REFERENCE   5  (bases 1 to 4016)
  AUTHORS   Miyake,S., Yamashita,T., Taniguchi,M., Tamatani,M., Sato,K. and
            Tohyama,M.
  TITLE     Identification and characterization of a novel mitochondrial
            tricarboxylate carrier
  JOURNAL   Biochem Biophys Res Commun 295 (2), 463-468 (2002)
   PUBMED   12150972
REFERENCE   6  (bases 1 to 4016)
  AUTHORS   Lockhart,P.J., Holtom,B., Lincoln,S., Hussey,J., Zimprich,A.,
            Gasser,T., Wszolek,Z.K., Hardy,J. and Farrer,M.J.
  TITLE     The human sideroflexin 5 (SFXN5) gene: sequence, expression
            analysis and exclusion as a candidate for PARK3
  JOURNAL   Gene 285 (1-2), 229-237 (2002)
   PUBMED   12039050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012366.10.
            
            On Jul 23, 2019 this sequence version replaced NM_144579.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY044437.1, SRR1660809.261565.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000272433.7/
                                                  ENSP00000272433.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC012366.10        181646-181754       c
            110-178             AC012366.10        168570-168638       c
            179-256             AC012366.10        150896-150973       c
            257-283             AC012366.10        133230-133256       c
            284-338             AC012366.10        132564-132618       c
            339-364             AC012366.10        130281-130306       c
            365-418             AC012366.10        111567-111620       c
            419-475             AC012366.10        110473-110529       c
            476-541             AC012366.10        108991-109056       c
            542-632             AC012366.10        98300-98390         c
            633-748             AC012366.10        81612-81727         c
            749-834             AC012366.10        78490-78575         c
            835-952             AC012366.10        71173-71290         c
            953-4016            AC012366.10        52078-55141         c
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..4016
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /note="sideroflexin 5"
                     /db_xref="GeneID:94097"
                     /db_xref="HGNC:HGNC:16073"
                     /db_xref="MIM:615572"
     exon            1..109
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1030
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sideroflexin-5 isoform 2"
                     /protein_id="NP_653180.1"
                     /db_xref="CCDS:CCDS1922.1"
                     /db_xref="GeneID:94097"
                     /db_xref="HGNC:HGNC:16073"
                     /db_xref="MIM:615572"
                     /translation="MADTATTASAAAASAASASSDAPPFQLGKPRFQQTSFYGRFRHF
                     LDIIDPRTLFVTERRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEK
                     IFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPA
                     SKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLIQRFVPFPAVASANICNVVL
                     MRYGELEEGIDVLDSDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEK
                     TALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTV
                     VYNKGL"
     exon            110..178
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            179..256
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            257..283
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            284..338
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            339..364
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            365..418
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..475
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            476..541
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            542..632
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            633..748
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            749..834
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            835..952
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     exon            953..4016
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /note="hexamer: AATAAA"
     polyA_site      4016
                     /gene="SFXN5"
                     /gene_synonym="BBG-TCC; SLC56A5"
                     /note="major polyA site"
ORIGIN      
        1 agtggccatg gcggatacag cgactacagc atcggcggcg gcggctagtg ccgctagcgc
       61 ctcgagcgat gcacctcctt tccaactggg caaaccccgc ttccagcaga cgtccttcta
      121 tggccgcttc aggcacttct tggatatcat cgaccctcgc acactctttg tcactgagag
      181 acgtctcaga gaggctgtgc agctgctgga ggactataag catgggaccc tgcgcccggg
      241 ggtcaccaat gaacagctct ggagtgcaca gaaaatcaag caggctattc tacatccgga
      301 caccaatgag aagatcttca tgccatttag aatgtcaggt tatattcctt ttgggacgcc
      361 aattgtagtc ggtcttctct tgcccaacca gacactggca tccactgtct tctggcagtg
      421 gctgaaccag agccacaatg cctgtgtcaa ctatgcaaac cgcaatgcga ccaagccttc
      481 acctgcatcc aagttcatcc agggatacct gggagctgtc atcagcgccg tctccattgc
      541 tgtgggcctt aatgtcctgg ttcagaaagc caacaagttc accccagcca cccgccttct
      601 catccagagg tttgtgccgt tccctgctgt agccagtgcc aatatctgca atgtggtcct
      661 gatgcggtac ggggagctgg aggaagggat tgatgtcctg gacagcgatg gcaacctcgt
      721 gggctcctcc aagatcgcag cccgacacgc cctgctggag acggcgctga cgcgagtggt
      781 cctgcccatg cccatcctgg tgctaccccc gatcgtcatg tccatgctgg agaagacggc
      841 tctcctgcag gcacgccccc ggctgctcct ccctgtgcaa agcctcgtgt gcctggcagc
      901 cttcggcctg gccctgccgc tggccatcag cctcttcccg caaatgtcag agattgaaac
      961 atcccaatta gagccggaga tagcccaggc cacgagcagc cggacagtgg tgtacaacaa
     1021 ggggttgtga gtgtggtcag cggcctgggg acggagcact gtgcagccgg ggagctgagg
     1081 ggcagggccg tagactcacg gctgcacctg cagggagcag cacgccaacc ccagcagtcc
     1141 tgggccccct gggagagtgc tcaacctaca gtggagggag actgacccat tcacatttta
     1201 acataggcaa gaggagttct aacacatttc gtacaaaaaa ataatcaagt gcatttctgg
     1261 gccttatgtg gggttgtcaa aactccactc agcacaatta tgtgtgaagc tgaaaaattg
     1321 tagagtgccc atggggtaga agtagaatcc ttttatactt tggttccttt tttattttta
     1381 ttttttatca gaatcaaatc tgagccttag tttcagctga ccagaagtgg caggaggaca
     1441 ggtggaggcg agccagatta ggcctggagt tgggctggtt tggtggccag gctggtaaat
     1501 ttaggatatt acaatggcca gcccagatgg ctccctgggc tggcatgggg aggggagaga
     1561 aggtggtctg caccccacag gatgaactag ccatgactag ggtcctcagg cagtggccca
     1621 gggaatcagg gagcactgga ggcctctgca agattctgtg ggcagctggc tctgaatgta
     1681 gccagcccac atccattcca gagctgcaga accagtccct ctgagtgaag tccagtgacc
     1741 ctggagctag ggtccccctt cgtggagctc taactgattc agggcccctg aagtgacccc
     1801 agctccaggc aggaaacccc gagaaggaat ggtgcttggc aggaaccatg gacctgcact
     1861 tggcctcttc gggaagatcc tccttccagg ccccaggctg gatgctgggt tctggggctg
     1921 agagtggggc tagactgggc tggctgcctt ctgcggagct tctccagcca ccaaggctgc
     1981 ctgccccatc ccatcccttt ctaagcagga aggtctcatg cctgagaatg cctaggccag
     2041 ctccttagac acctatcaga gaagcagcat caacctagga gcagtgggcc ctggctctgt
     2101 cactaaatgg cagtgagatg tcagacaaat tcattccctt ctctcagcct ccactccctg
     2161 tctgaaacca gaagactgga tcaaggggtt cccactggct cctccagcaa gacctcgtct
     2221 ttgcttgtcc tgctcagatg ctggtcatcc tgggcatgtc cccagtgtgg actctggact
     2281 gggaaggggg caggcccctt tggacctgca gttggcctca gcagaaggcc ttgccttgtg
     2341 tatgtgactc catatcccgg gagcagttga cctttgccaa acactttaca gttctggagg
     2401 aggaggtaac atagatgcct gggcctgatg gtggggccat acccatgtgt cgcctctcac
     2461 tctggcagcc tcagaggccc cttgctgctg gctcccatct ccctcccatt tgcagaccag
     2521 gaaggaagag caagctgtac aaagggaagc agagcctggg gtgggtgtga gcagggtgac
     2581 ccctcatctg aaaggcccaa accaggggga agcaccagcc tcagtgcagc cccctcctga
     2641 ccccacctag aatggaagcc tccacctgca gccccaggcc tccctccccc ggggtctcca
     2701 cctcagggga gacttaggcc agaggtgaac attcatgtgt aggaagaggc cgctgcaggg
     2761 tggcatctta gggtagggga agtgtgctga ggtgggcctt ccatgggcat ggccgttgcc
     2821 tctctgccag ccgctggtgc ccaccagctg gctctgcagc acattgccct gaggggcctg
     2881 ccactctcct gaggagcagc ccacctgctg cccgtgagga gggggagaag ggttagacaa
     2941 gcctggagga caaaacagcg ggagtgtggg ggtgccatgg tgttggaggg gcaggccttt
     3001 ttgagccaat cccaccataa tgtgaatatg ccagtgactg ctgcgctgtg ctggtctcta
     3061 ggcctgaact aggtgctggc atgtctgggt cgtcttttga aaagctcact tcaagctcac
     3121 cctgctccta cctatcataa ggtcttattc ttgtgcactt tatcttggga ccaaaactgc
     3181 ctacccaccc cttcccgccc tccccctgcc agaggcctgg tgccctggcc cagcctgtgg
     3241 cctcagcatc tcataactca tttgctttgt ctcccggatg atttccgtca tgctcccaaa
     3301 tgcagcttca ggtgagccaa ggggtctgct cctgtggcgg tgcagtggca aaggatccag
     3361 atagcctagg gtgagggtga cagagggaca gtgggctatg ccactaggcc ctggtctggc
     3421 tttggaaaga cctgtgaggg gaaaccttca cccagcaccc atgccccact ctgctgaggc
     3481 cagaggaagg gaggcctgag gggcagattg gttcatgcct ggggtggagg ctaagcctgg
     3541 acacagtcag ggcggggctg gccagctgtg cgagaacaca agccacgcct gcgatggtgc
     3601 tgcacccctg gtgtccctgc ctggccctcc tctggtcact tcaaacatgc cctcaggctt
     3661 ggggatgccc ttcttccatt cccagacagc agtgtgaggg tgcagggacc aagatgtcaa
     3721 gctggccgtg gagtcgagct ggccgacgga cccctttcac ctggttatga gccgacttct
     3781 ttggtgttct ggcctctggc ctgggaaaag ggcaggagcc tagaggagga aaaaggctgg
     3841 tggacagacc cagggtggtc ttcaagcctg gcccagtgag agtgaggccc ccgcacgcaa
     3901 gcctcagcca ctcccagggg cctttgcagc gtctttttaa cctcagaaaa tttctcaatc
     3961 tatgtgattt gtgtaatact aatgagcttt gggcaataaa tacgggattt aaagca
//
