LOCUS       NM_030971               3095 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens sideroflexin 3 (SFXN3), transcript variant 1, mRNA.
ACCESSION   NM_030971
VERSION     NM_030971.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Mi,D., Yanatori,I., Zheng,H., Kong,Y., Hirayama,T. and Toyokuni,S.
  TITLE     Association of poly(rC)-binding protein-2 with sideroflexin-3
            through TOM20 as an iron entry pathway to mitochondria
  JOURNAL   Free Radic Res 58 (4), 261-275 (2024)
   PUBMED   38599240
  REMARK    GeneRIF: Association of poly(rC)-binding protein-2 with
            sideroflexin-3 through TOM20 as an iron entry pathway to
            mitochondria.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Dong,Y., Jin,F., Wang,J., Li,Q., Huang,Z., Xia,L. and Yang,M.
  TITLE     SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to
            the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia
            Patients
  JOURNAL   Curr Gene Ther 23 (5), 410-418 (2023)
   PUBMED   37491851
  REMARK    GeneRIF: SFXN3 is Associated with Poor Clinical Outcomes and
            Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid
            Leukemia Patients.
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Chen,K., Gong,S., Fang,X., Li,Q., Ye,M., Li,J., Huang,S., Zhao,Y.,
            Liu,N., Li,Y. and Ma,J.
  TITLE     Non-coding RNA-mediated high expression of SFXN3 as a prognostic
            biomarker associated with paclitaxel resistance and
            immunosuppressive microenvironment in head and neck cancer
  JOURNAL   Front Immunol 13, 920136 (2022)
   PUBMED   36159813
  REMARK    GeneRIF: Non-coding RNA-mediated high expression of SFXN3 as a
            prognostic biomarker associated with paclitaxel resistance and
            immunosuppressive microenvironment in head and neck cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Kory,N., Wyant,G.A., Prakash,G., Uit de Bos,J., Bottanelli,F.,
            Pacold,M.E., Chan,S.H., Lewis,C.A., Wang,T., Keys,H.R., Guo,Y.E.
            and Sabatini,D.M.
  TITLE     SFXN1 is a mitochondrial serine transporter required for one-carbon
            metabolism
  JOURNAL   Science 362 (6416) (2018)
   PUBMED   30442778
REFERENCE   9  (bases 1 to 3095)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   10 (bases 1 to 3095)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133215.17.
            
            On Jun 30, 2021 this sequence version replaced NM_030971.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.3868.1,
                                           SRR11853560.4052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000393459.6/
                                                ENSP00000377103.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AL133215.17        114058-114358
            302-470             AL133215.17        115138-115306
            471-634             AL133215.17        117516-117679
            635-805             AL133215.17        118321-118491
            806-904             AL133215.17        118827-118925
            905-980             AL133215.17        119310-119385
            981-1066            AL133215.17        119547-119632
            1067-1194           AL133215.17        119900-120027
            1195-1244           AL133215.17        120206-120255
            1245-1294           AL133215.17        121467-121516
            1295-1342           AL133215.17        121999-122046
            1343-3095           AL133215.17        122313-124065
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..3095
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /note="sideroflexin 3"
                     /db_xref="GeneID:81855"
                     /db_xref="HGNC:HGNC:16087"
                     /db_xref="MIM:615571"
     exon            1..301
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..470
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..634
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..1439
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sideroflexin-3 isoform 1"
                     /protein_id="NP_112233.3"
                     /db_xref="CCDS:CCDS7508.3"
                     /db_xref="GeneID:81855"
                     /db_xref="HGNC:HGNC:16087"
                     /db_xref="MIM:615571"
                     /translation="MGELPLDINIQEPRWDQSTFLGRARHFFTVTDPRNLLLSGAQLE
                     ASRNIVQNYRAGVVTPGITEDQLWRAKYVYDSAFHPDTGEKVVLIGRMSAQVPMNMTI
                     TGCMLTFYRKTPTVVFWQWVNQSFNAIVNYSNRSGDTPITVRQLGTAYVSATTGAVAT
                     ALGLKSLTKHLPPLVGRFVPFAAVAAANCINIPLMRQRELQVGIPVADEAGQRLGYSV
                     TAAKQGIFQVVISRICMAIPAMAIPPLIMDTLEKKDFLKRRPWLGAPLQVGLVGFCLV
                     FATPLCCALFPQKSSIHISNLEPELRAQIHEQNPSVEVVYYNKGL"
     exon            635..805
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            806..904
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..980
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1066
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1194
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1244
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1294
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1342
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..3095
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3075..3080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="SFXN3"
                     /gene_synonym="BA108L7.2; SFX3; SLC56A3"
                     /note="major polyA site"
ORIGIN      
        1 attccggcac ctcccttagg cgccagggac agccgagcgt tacctggtcc cgggcagcgg
       61 agttctttac ccaccccagt tctggttctg acgccctagc tcattccgca aatttagggc
      121 ttgggtctgg cttgttcccc tccggctcga accacctctt ctctgagccg agccagctac
      181 cggggctcct ggaattgcca cccctccctg ggcacccttg aggcctccgt ggagggacgt
      241 cacggggcag agcgggacgt gagcctgagt ttgctgcagg cgtgctctgt gtggtggctg
      301 ggttctgcca atccccgtgc ccaccgggtg ggcgcggccg ggaagctcct gcccctccct
      361 gctggtcggc gtcacgcgtg acgtcccgcg tgatggctgg gagggcccgg cggcgacagc
      421 ggaggcagag aggaaggcgg ttctgagagc ttcagagagc gatggaaagc aaaatgggtg
      481 aattgccttt agacatcaac atccaggaac ctcgctggga ccaaagtact ttcctgggca
      541 gagcccggca ctttttcact gttactgatc ctcgaaatct gctgctgtcc ggggcacagc
      601 tggaagcttc tcggaacatc gtgcagaact acagggccgg cgtggtgacc ccagggatca
      661 ccgaggacca gctgtggagg gccaagtatg tgtatgactc cgccttccat ccggacacag
      721 gggagaaggt ggtcctgatt ggccgcatgt cagcccaggt gcccatgaac atgaccatca
      781 ctggctgcat gctcacattc tacaggaaga ccccaaccgt ggtgttctgg cagtgggtga
      841 atcagtcctt caatgccatt gttaactact ccaaccgcag tggtgacact cccatcactg
      901 tgaggcagct ggggacagcc tatgtgagtg ccaccactgg agctgtggcc acggccctgg
      961 gactcaaatc cctcaccaag cacctgcccc ccttggtcgg cagatttgtg ccctttgcag
     1021 cagtggcagc tgccaactgc atcaacatcc ccctgatgag gcagagagag ctgcaggtgg
     1081 gcatcccggt ggctgatgag gcaggtcaga ggcttggcta ctcggtgact gcagccaagc
     1141 agggaatctt ccaggtggtg atttcaagaa tctgcatggc gattcctgcc atggccatcc
     1201 caccactgat catggacact ctggagaaga aagacttcct gaagcgccgc ccctggctgg
     1261 gggcacccct gcaggtggga ctggtgggct tctgcctggt atttgcaacc cccctgtgct
     1321 gtgccctatt cccccagaag agctccatac acataagcaa cctggaacca gagctgagag
     1381 ctcagatcca tgagcaaaac cccagcgttg aagtggtcta ctacaacaag gggctttgag
     1441 gagggtcagc ctctgtcccc tccctcactt ccttgggctg ctgctttagt ggagtcatgt
     1501 cacccctacc acttggctat ctgcctagca ctgggcaggg gccttggtgg gcagatggca
     1561 attgagggta gcaacctatt agggtggggg agggacctcc ataaggcttt tcctcccttc
     1621 tctggtttca aagatcagag cacataaccc ctcctgtgct tgagtgtcca tgcatataca
     1681 tacatgatac acatgtgtat gtgtacattg ggtcctgaaa gctagaagca ggcatgctag
     1741 cctagtatgt tctgacatct ggcttccctt ctcagcctca tgtccacctg cctgccagcc
     1801 aggctacagg tgtgacttcc ttctctaaac tgttacacca gccaagttat ttttgatggc
     1861 acctcatccc ttctagaaat aggaggagcc ccaggatctc aggacagaga cttatagaca
     1921 ctagtaggac aaagcgggct gaatccttca ggtttctgat acctagctcc ccaagctgac
     1981 tgggctggca gaggagaaca tgttgagaca agggaggcag gggacttatg catccctcag
     2041 tgccatccct tgtatcctgg aatagctcca tttcccctcc tcctctctac cagacaaagg
     2101 agtgcctgtg tcctgtactg ccctcgctgt ctcccccacc accctacttg acagcgtggg
     2161 catcttcagg cacagccttg ggagttcctg gtgtgctctg acatcatgac ctcaaatcta
     2221 aatcctccaa tcccaactcc ctttcccaaa caaaaagcca cagaggcaga gcaagcattc
     2281 ccctttaaga gcttccactg caccccctcc caagggacac agcggtagga atggtgctta
     2341 aactccacag gtatcagaga gggtgtaact aggacatcct caagggcagc taggccccga
     2401 atgtacaatg ttaagacagg gaattttgtg ttccattgac tttttttttt ttttttaatg
     2461 gagtttcact attttgccca ggctggagtg cgatggtgcg atcttggctc actgcaacct
     2521 ctgcctcctg ggttcaagtg attctcttgc ctcagtctcc cgagtagtgg aaattacagg
     2581 tgtgtgctac cacatcttgc tagttttgta tttttagcag agatgggggt ttcaccatgt
     2641 tggccaggct agtctcgaac tcctgacctc aggtgatcca cctgccttgg cctcccaaag
     2701 cactgggatt acaagcatga gccactgtgc ccagcctgtt ccactgacat ttcttagaca
     2761 ttcagcaaaa cccccacctt aacctctttt ctttcttgag ggttggtcct gtccccacct
     2821 ccaccctccc accccctgga agaggaaggg cccgggcatc agtggctagt ccaaataaaa
     2881 tatgggcttg gggatggaat gggtggtggt aagttcacag agtgtagtta gatcccaact
     2941 cccatgacct ctggcttcag tggtgggtgg ggcagggcag atgaaagggc ttcagtggga
     3001 acctctgaga gcattttcct gttcccccta tcaaccgccc ccagtgataa catctgtgaa
     3061 gccagccatt actcaataaa ctgcaaactt gtcta
//
