LOCUS       NM_178858               6770 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sideroflexin 2 (SFXN2), transcript variant 1, mRNA.
ACCESSION   NM_178858
VERSION     NM_178858.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6770)
  AUTHORS   Chen,Y., Qian,J., Ding,P., Wang,W., Li,X., Tang,X., Tang,C.,
            Yang,Y. and Gu,C.
  TITLE     Elevated SFXN2 limits mitochondrial autophagy and increases
            iron-mediated energy production to promote multiple myeloma cell
            proliferation
  JOURNAL   Cell Death Dis 13 (9), 822 (2022)
   PUBMED   36163342
  REMARK    GeneRIF: Elevated SFXN2 limits mitochondrial autophagy and
            increases iron-mediated energy production to promote multiple
            myeloma cell proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6770)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 6770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6770)
  AUTHORS   Mon,E.E., Wei,F.Y., Ahmad,R.N.R., Yamamoto,T., Moroishi,T. and
            Tomizawa,K.
  TITLE     Regulation of mitochondrial iron homeostasis by sideroflexin 2
  JOURNAL   J Physiol Sci 69 (2), 359-373 (2019)
   PUBMED   30570704
  REMARK    GeneRIF: SFXN2 functions in mitochondrial iron metabolism by
            regulating heme biosynthesis.
REFERENCE   5  (bases 1 to 6770)
  AUTHORS   Kory,N., Wyant,G.A., Prakash,G., Uit de Bos,J., Bottanelli,F.,
            Pacold,M.E., Chan,S.H., Lewis,C.A., Wang,T., Keys,H.R., Guo,Y.E.
            and Sabatini,D.M.
  TITLE     SFXN1 is a mitochondrial serine transporter required for one-carbon
            metabolism
  JOURNAL   Science 362 (6416) (2018)
   PUBMED   30442778
REFERENCE   6  (bases 1 to 6770)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6770)
  AUTHORS   Simon-Sanchez,J., Schulte,C., Bras,J.M., Sharma,M., Gibbs,J.R.,
            Berg,D., Paisan-Ruiz,C., Lichtner,P., Scholz,S.W., Hernandez,D.G.,
            Kruger,R., Federoff,M., Klein,C., Goate,A., Perlmutter,J.,
            Bonin,M., Nalls,M.A., Illig,T., Gieger,C., Houlden,H., Steffens,M.,
            Okun,M.S., Racette,B.A., Cookson,M.R., Foote,K.D., Fernandez,H.H.,
            Traynor,B.J., Schreiber,S., Arepalli,S., Zonozi,R., Gwinn,K., van
            der Brug,M., Lopez,G., Chanock,S.J., Schatzkin,A., Park,Y.,
            Hollenbeck,A., Gao,J., Huang,X., Wood,N.W., Lorenz,D., Deuschl,G.,
            Chen,H., Riess,O., Hardy,J.A., Singleton,A.B. and Gasser,T.
  TITLE     Genome-wide association study reveals genetic risk underlying
            Parkinson's disease
  JOURNAL   Nat Genet 41 (12), 1308-1312 (2009)
   PUBMED   19915575
REFERENCE   8  (bases 1 to 6770)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   9  (bases 1 to 6770)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6770)
  AUTHORS   Ye,X., Xu,J., Cheng,C., Yin,G., Zeng,L., Ji,C., Gu,S., Xie,Y. and
            Mao,Y.
  TITLE     Isolation and characterization of a novel human putative
            anemia-related gene homologous to mouse sideroflexin
  JOURNAL   Biochem Genet 41 (3-4), 119-125 (2003)
   PUBMED   12670026
  REMARK    GeneRIF: molecular cloning of SFXN2
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022091.2, BX350016.2, BX090573.1 and AL391121.29.
            
            On Nov 23, 2018 this sequence version replaced NM_178858.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.262422.1, BC022091.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369893.10/ ENSP00000358909.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1219              BC022091.2         96-1314
            1220-1621           BX350016.2         19-420              c
            1622-2053           BC022091.2         1716-2147
            2054-2468           BX090573.1         1-415
            2469-6770           AL391121.29        148541-152842
FEATURES             Location/Qualifiers
     source          1..6770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..6770
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /note="sideroflexin 2"
                     /db_xref="GeneID:118980"
                     /db_xref="HGNC:HGNC:16086"
                     /db_xref="MIM:615570"
     exon            1..46
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..232
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1040
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /codon_start=1
                     /product="sideroflexin-2"
                     /protein_id="NP_849189.1"
                     /db_xref="CCDS:CCDS7539.1"
                     /db_xref="GeneID:118980"
                     /db_xref="HGNC:HGNC:16086"
                     /db_xref="MIM:615570"
                     /translation="MEADLSGFNIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELD
                     WAKVMVEKSRMGVVPPGTQVEQLLYAKKLYDSAFHPDTGEKMNVIGRMSFQLPGGMII
                     TGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVAT
                     AVGMNMLTKKAPPLVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSR
                     RAAAIGITQVVISRITMSAPGMILLPVIMERLEKLHFMQKVKVLHAPLQVMLSGCFLI
                     FMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEPYVYFNKGL"
     exon            233..403
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..502
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..578
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..664
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..725
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..792
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..842
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..892
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..940
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..6770
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2430..2435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /note="hexamer: AATAAA"
     polyA_site      2450
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /note="major polyA site"
     regulatory      6748..6753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
                     /note="hexamer: ATTAAA"
     polyA_site      6770
                     /gene="SFXN2"
                     /gene_synonym="SLC56A2"
ORIGIN      
        1 agttttcaag gcgggctgta actggtggca tttgtcccgg gaccaggtcc acagttttat
       61 gtgtgagcaa gatggaggct gacctgtctg gctttaacat cgatgccccc cgttgggacc
      121 agcgcacctt cctggggaga gtgaagcact tcctaaacat cacggacccc cgcactgtct
      181 ttgtatctga gcgggagctg gactgggcca aggtgatggt ggagaagagc aggatggggg
      241 ttgtgccccc aggcacccaa gtggagcagc tgctgtatgc caagaagctg tatgactcgg
      301 ccttccaccc cgacactggg gagaagatga atgtcatcgg gcgcatgtct ttccagcttc
      361 ctggcggcat gatcatcacg ggcttcatgc tccagttcta caggacgatg ccggcggtga
      421 tcttctggca gtgggtgaac cagtccttca atgccttagt caactacacc aacaggaatg
      481 cggcttcccc cacatcagtc aggcagatgg ccctttccta cttcacagcc acaaccactg
      541 ctgtggccac ggctgtgggc atgaacatgt tgacaaagaa agcgccgccc ttggtgggcc
      601 gctgggtgcc ctttgccgct gtggctgcgg ctaactgtgt caatatcccc atgatgcgac
      661 agcaggagct cataaaggga atctgcgtga aggacaggaa tgaaaatgag attggtcatt
      721 cccggagagc tgcggccata ggcatcaccc aagtagttat ttctcggatc accatgtcag
      781 ctcctgggat gatcttgctg ccagtcatca tggaaaggct tgagaaattg cacttcatgc
      841 agaaagtcaa ggtcctgcac gccccattgc aggtcatgct gagcgggtgc ttcctcatct
      901 tcatggtgcc agtggcgtgt gggcttttcc cacagaaatg tgaattgcca gtttcctatc
      961 tggaaccgaa gctccaagac actatcaagg ccaagtatgg agaacttgag ccttatgtct
     1021 acttcaataa gggtctctaa atgccccact tcagcaagga ccagtctatt cccatattca
     1081 ccagctcctc cttagctacg tgcacacttg tgtcctcctt cccctttgcc aacaaggcct
     1141 gaaggccagg gtagattggg gggtgggaca atgaatgcct catacttaca ccctggtact
     1201 ggttgattgg acctcagggg aaaaaagtga aaaagggtag caaaggccaa tgtcttctag
     1261 ctgcttcctc aacccctgtc ccctggagac cagaagctga ggccctctca gggaggagac
     1321 atccaagcaa atcatttgga aaagttagga aacctttagg attctggttc cagccagggt
     1381 tgaggaaaag accttggatc aaaaggaagc ttctatacct ctttcttctt cgcttcctcc
     1441 tctcccaagc aatggaaact tttacccatg taattctagc tgaactcagg aaaaagaagg
     1501 gggaaaggac tctgtcccct tggggctcat cacccttcca catcctcctc ctcgttgccc
     1561 cctggtcagg cagcttcttt tttttttttt tcaagatgga gtcttgctct gtcgcccagg
     1621 ctggaatgca gtggcgcgat ctcggctcac tgcaaactct gcctcctgga ttcaagcgat
     1681 tctcctgcct cagcctctca agtagctggg attacagggc acctgccacc acgcctggct
     1741 aatttttgta ttttagtgga gacggggttt caccatgctg gccagactgg tctcgaactc
     1801 ctgacctcag gtgatccgcc cgcctcagcc tctgaaattg ctgggattac aggcatgagc
     1861 caccacaccc agcccggaca gcttctttgg gagtgctgct aaccttgaaa ttatcagaca
     1921 cttaggagtt attagtgcta aaaaggggac cgtgcaaggc agcagagtta catggttctt
     1981 caaatcatgt ctgaacctat tcttggaatc ttctctataa taagggaagt tctcttaccc
     2041 cactgccaca tacctctgtt ttaaaagata agtccactaa ctgtgagtaa aaatgatata
     2101 tataggcatt aaccacacac tttaatgggt ataatttcct ggctgcctcc cttcctcagc
     2161 ccattaggtt aaacaccaaa gaaagactgg tgtgtactga ataggaaagg gaagttttat
     2221 ttggaacctt ctaagaggaa atcaaccagg accaaagagc cttaaaggac acacagcaat
     2281 gcacagccac ttcccttccc cagcttggct gccctaggtg atttctcaag ctccttgggg
     2341 gactgttgtt tctcatctgg aatcaatgtg tgtatgagtt ttgtctggta ggattgctga
     2401 ctctgtccaa cagatatcac tgtgaattga ataaatttgt tgaaagagca cacaggcaca
     2461 catacacaca aactgtaaac taagttaatg aagcctgaat ggaaagcagg atctggcctt
     2521 actttggcct tggcatgtca gaaggtatca caactactat ataaggggaa cttgtctgat
     2581 gcctggaggc tgttgtttat ttccctcatt aaaggggaaa tccacctgtc tccacaggaa
     2641 gctccagatc tcccagaatg ggagctgtgt tgccctagag caagagttgg caagctatgg
     2701 ctcaaggggc caaatccacc tgccacctgt ttttgtgcaa ttggaagcta agaatgtttt
     2761 tacattttta aagagttgta aaagggaaca acaggaatga cagagaccct acctatgtgg
     2821 catacaaagc ctaaaatatt tactgtctga tccttgacac aaaaagtttc ccctgccctg
     2881 gagcagtggt tcttaagcac atgcatcaac cgggcgcagt ggctcatgcc tgtaatcccc
     2941 acactttggg aggccgaggc aggtggatca cctgaggtca ggagttcgag accagcctga
     3001 tcaacatggt gaaacccgat ctctactaaa aatacaaaaa atttgctggg tgtggtggca
     3061 tacacctgta atcccagcta ctcggggggc tgagactgga gaatcacttg aacctgggag
     3121 gtggaggttg tggtgagcca agattgcgcc actgcactcc aacctgggcg actccgtctc
     3181 aaaaaaaaaa aagaaaacac atcagaatta gctggcaggc ttgttaaagc acagattgca
     3241 ggatccattg ccagattctg tcactctggg ctggagcctg agaacgtgca tttctagtca
     3301 ttgcccggtg atgctgattc tgttggtctt ggcaccatac gtggaggagc actgctctaa
     3361 ggggaaaggg cctcctcccc gaggccaagg aattcactgc aacttgattt ttctccccgt
     3421 ttaaaaaagt taaaatataa ctcacatacc ataaacttag tccttttaaa gtgtacaatt
     3481 cagtggtttt taatgtagtc acaaagttgt acaagcatca ccactaattc cagaattatt
     3541 ttgagacagg atctcactct gttaccctgg ttggagtgca gtagtgcaat cactgctcat
     3601 tgcagcctca acctcctgag ctcaagtaat cctcctgcct cagcctctgg ggtagctggg
     3661 accacaggct aatttgattt ttttgatgag gtctcactat gttgccccag gctggtctcg
     3721 aactcatggc ctcaagtgat cctcctccct cagccttcca aagtgttgga attacacaca
     3781 tgagccactg catctggtct cagaacattt ttcttagccc caaaagaaac cccataccca
     3841 ttggcagtca ctccacattc tccctacctg ccagcgcctc acaattcact tcctgtcttt
     3901 agagatttgc gtattctgaa catttcatgt aagtggagta atgcagtatg tggccctctg
     3961 tgtctggttt ctttccttag gataatgttt tcaaggttca tccatgttgt agcatatgca
     4021 atttgatttt agctggtgtc tgaacagaaa agtctgtctt tgagctagct tctttaggac
     4081 aggagacctg gctttatttc caaaagcaaa taggaaaagg gaaacattac cagagccagt
     4141 agagcttgga aacaactcct gactgatgtt ctttcagaac atacaatgtt tccccttcct
     4201 tctcagctcc tcaagcctct tggatttcct gttctcttat agacaactgc tcttttggaa
     4261 atgtctggaa ggtatgtggt ggctataatg ttcagggaca ttctaaaaag tggtcactca
     4321 aactgcatct cagtctcatt ttgtaacatc tctcttcttt gagttggctg ctgtgggatg
     4381 ttgaataaga ggcagttaag gttactaaaa ggccttggtg tgggaagtgc taatccagac
     4441 tgtcctatcc aatagctcag cttgagcttt caggtaaaag gagaaaggga agttggggca
     4501 aaatcccctg tgtttgccaa actgaattgg ggtttcttat ttattgagag aaagagggta
     4561 tcactttctt gcccaggctg gagtgcaatg gtatgatcat gactcattgc ttcctcagcc
     4621 tcctggactc aagtgatcct cctgccttag cctcccgagt agcttctttt tcctgagttc
     4681 ggctagaata gcatgggtaa aaggttccat tgctcgggag aggaggagga agggaagaag
     4741 aagaggtata gaagcttcct tttgatccaa ggtcttttcc tcaatcctgg ctagaaccag
     4801 aatcctaaag gtttcctgac tacaggtaca tgccaccatg cccagctaat ttttaaattt
     4861 tttgtagaca gagggcctca ctatgtttcc caggttggtc ttgaacccct gacctcaagc
     4921 aatcctcatg ccttggcctc ccaaagtgtt gggattacag gcgtgagcca ctacatccca
     4981 cctggggttt cttagtgatg atgaaaccta gcctttatgt ggaagactta caactttttg
     5041 aggccaggaa ttagagacct tgtgccatga aaataatttg gtccttccct agtactcaat
     5101 ttttacttct cctctaagga gcttgacttg tggaatggat aaatttctaa gaaacgagag
     5161 attggcaaaa atacgtgtca ctttttatag tacttggaaa agcaggatca agataaaggc
     5221 agaactatgg actttcttaa gctgagggaa gactgactta actcttacct gtttcccatt
     5281 tttccaacac ttaagccaag aacaacttcc tctgggctca gatgtgggct agactgggcc
     5341 aggctgtaaa acactttgac aggtttttga gaggaaattg actgctaaag tcaactgtgt
     5401 tatttgccat gggtcttcct ttgtccattt attttaccaa cttttttttt tctttttttt
     5461 ttgagacaga gtctcactct gtcacctagg gtggagtgca gtggcacagt cttggctcac
     5521 tgcaacctct gcctcccagg ttcaagcgat tcttctgctt tagcctcctg agtagctggg
     5581 actacaggca tgcaccacca cgcctggcta attttttgta tttttagtag agattgggtt
     5641 tcacaatgtt ggccaggctc gaactcctga ccatgtgatc cgcccacctc ggcctcccaa
     5701 agtgctggga ttacaggcag gagccaccgc acctggcctt tttttttttt tgagacaggg
     5761 tctcactctg ttgcccaggc tggagtacag tggcacaatc aaggctcatt gcagcttcaa
     5821 tctccctagc tctggtgatt gtcccacctc agcctcccaa gtagctggga ctacaagtgt
     5881 gcaccaccat gcttggctaa tttggctaat ttagtttttt tatttttgta gagacagggt
     5941 tctctccatg ttgcccaggc tggtttcaaa ctcctgagct caagggatct acctgcctca
     6001 gcctcccaaa gggctaggat tataagcatg agccaccaca cctggctatt ttaccaacat
     6061 tgatcaagct ctggttgagc cttgtacagg atattatagg ctttaaaaga agaagaagaa
     6121 agacctggta tgctgtacaa aaaactgcaa accaggcacg cagatataag tgttacaaga
     6181 atccagaaga agcagcaagg agatggggct aggagtttgt aagcagggaa ctgtatctgt
     6241 aatatgtaaa tgaagttact gggcatctct tcaatggtca gtgtgagtgg aatgtgtggg
     6301 aaaatgtagt ggtgagaggt gagataaaga gaagtagaca gggacgaagt cacagagagg
     6361 accgtgttgg gaagtttgga ctctctattc tgtaggtaga tgaagtattt aaaagaagag
     6421 gccatgatat agtaatattt ggtttaatgt ggtatggttg tagtgtgtgg cggaaatttg
     6481 agaggaagaa ttgtcaactt gcagggcagc agggaagcca tttgtattta gctagaagaa
     6541 catggattga agcaatggat gatggatttc agagcaattt gtgaagtaga accagaattt
     6601 tgtccgtcga acttggggtg acgaagcact atgcctcaga taaaggtact atcttctagg
     6661 gaattcaaac ggacctaagc tgctatttgg gcagttgaga ccaagagagg catcctggta
     6721 atagtgctgt gcttcaagac aaaagacatt aaaatatttt tacattgcaa
//
