LOCUS       NM_022754               4066 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens sideroflexin 1 (SFXN1), transcript variant 1, mRNA.
ACCESSION   NM_022754
VERSION     NM_022754.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4066)
  AUTHORS   Andriani,L., Ling,Y.X., Yang,S.Y., Zhao,Q., Ma,X.Y., Huang,M.Y.,
            Zhang,Y.L., Zhang,F.L., Li,D.Q. and Shao,Z.M.
  TITLE     Sideroflexin-1 promotes progression and sensitivity to lapatinib in
            triple-negative breast cancer by inhibiting TOLLIP-mediated
            autophagic degradation of CIP2A
  JOURNAL   Cancer Lett 597, 217008 (2024)
   PUBMED   38849012
  REMARK    GeneRIF: Sideroflexin-1 promotes progression and sensitivity to
            lapatinib in triple-negative breast cancer by inhibiting
            TOLLIP-mediated autophagic degradation of CIP2A.
REFERENCE   2  (bases 1 to 4066)
  AUTHORS   Li,Y., Yang,W., Liu,C., Zhou,S., Liu,X., Zhang,T., Wu,L., Li,X.,
            Zhang,J. and Chang,E.
  TITLE     SFXN1-mediated immune cell infiltration and tumorigenesis in lung
            adenocarcinoma: A potential therapeutic target
  JOURNAL   Int Immunopharmacol 132, 111918 (2024)
   PUBMED   38537539
  REMARK    GeneRIF: SFXN1-mediated immune cell infiltration and tumorigenesis
            in lung adenocarcinoma: A potential therapeutic target.
REFERENCE   3  (bases 1 to 4066)
  AUTHORS   Liu,W., Du,Q., Mei,T., Wang,J., Huang,D. and Qin,T.
  TITLE     Comprehensive analysis the prognostic and immune characteristics of
            mitochondrial transport-related gene SFXN1 in lung adenocarcinoma
  JOURNAL   BMC Cancer 24 (1), 94 (2024)
   PUBMED   38233752
  REMARK    GeneRIF: Comprehensive analysis the prognostic and immune
            characteristics of mitochondrial transport-related gene SFXN1 in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4066)
  AUTHORS   Yagi,K., Shimada,S., Akiyama,Y., Hatano,M., Asano,D., Ishikawa,Y.,
            Ueda,H., Watanabe,S., Akahoshi,K., Ono,H., Tanabe,M. and Tanaka,S.
  TITLE     Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in
            non-viral hepatocellular carcinoma
  JOURNAL   Sci Rep 13 (1), 9449 (2023)
   PUBMED   37296228
  REMARK    GeneRIF: Loss of SFXN1 mitigates lipotoxicity and predicts poor
            outcome in non-viral hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4066)
  AUTHORS   Chen,L., Kang,Y., Jiang,Y., You,J., Huang,C., Xu,X. and Chen,F.
  TITLE     Overexpression of SFXN1 indicates poor prognosis and promotes tumor
            progression in lung adenocarcinoma
  JOURNAL   Pathol Res Pract 237, 154031 (2022)
   PUBMED   35878532
  REMARK    GeneRIF: Overexpression of SFXN1 indicates poor prognosis and
            promotes tumor progression in lung adenocarcinoma.
REFERENCE   6  (bases 1 to 4066)
  AUTHORS   Giudetti,A.M., Sabetta,S., di Summa,R., Leo,M., Damiano,F.,
            Siculella,L. and Gnoni,G.V.
  TITLE     Differential effects of coconut oil- and fish oil-enriched diets on
            tricarboxylate carrier in rat liver mitochondria
  JOURNAL   J Lipid Res 44 (11), 2135-2141 (2003)
   PUBMED   14634051
REFERENCE   7  (bases 1 to 4066)
  AUTHORS   Miyake,S., Yamashita,T., Taniguchi,M., Tamatani,M., Sato,K. and
            Tohyama,M.
  TITLE     Identification and characterization of a novel mitochondrial
            tricarboxylate carrier
  JOURNAL   Biochem Biophys Res Commun 295 (2), 463-468 (2002)
   PUBMED   12150972
REFERENCE   8  (bases 1 to 4066)
  AUTHORS   Zara,V., Giudetti,A.M., Siculella,L., Palmieri,F. and Gnoni,G.V.
  TITLE     Covariance of tricarboxylate carrier activity and lipogenesis in
            liver of polyunsaturated fatty acid (n-6) fed rats
  JOURNAL   Eur J Biochem 268 (22), 5734-5739 (2001)
   PUBMED   11722557
REFERENCE   9  (bases 1 to 4066)
  AUTHORS   Fleming,M.D., Campagna,D.R., Haslett,J.N., Trenor,C.C. 3rd and
            Andrews,N.C.
  TITLE     A mutation in a mitochondrial transmembrane protein is responsible
            for the pleiotropic hematological and skeletal phenotype of
            flexed-tail (f/f) mice
  JOURNAL   Genes Dev 15 (6), 652-657 (2001)
   PUBMED   11274051
REFERENCE   10 (bases 1 to 4066)
  AUTHORS   Kaplan,R.S. and Mayor,J.A.
  TITLE     Structure, function and regulation of the tricarboxylate transport
            protein from rat liver mitochondria
  JOURNAL   J Bioenerg Biomembr 25 (5), 503-514 (1993)
   PUBMED   8132490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP199230.1, BC063241.1, BU689165.1, AK022938.1, AC091393.3 and
            CN480623.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022754.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063241.1, BX648188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321442.10/ ENSP00000316905.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP199230.1         63-82
            21-2261             BC063241.1         1-2241
            2262-2417           BU689165.1         45-200              c
            2418-2942           AK022938.1         2118-2642
            2943-3653           AC091393.3         26723-27433         c
            3654-4066           CN480623.1         11-423              c
FEATURES             Location/Qualifiers
     source          1..4066
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4066
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="sideroflexin 1"
                     /db_xref="GeneID:94081"
                     /db_xref="HGNC:HGNC:16085"
                     /db_xref="MIM:615569"
     exon            1..80
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            81..253
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1058
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tricarboxylate carrier protein"
                     /codon_start=1
                     /product="sideroflexin-1 isoform 1"
                     /protein_id="NP_073591.2"
                     /db_xref="CCDS:CCDS4394.1"
                     /db_xref="GeneID:94081"
                     /db_xref="HGNC:HGNC:16085"
                     /db_xref="MIM:615569"
                     /translation="MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQL
                     ESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMT
                     ITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVA
                     TALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGES
                     ANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCL
                     VFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL"
     exon            254..424
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            425..523
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            524..599
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            600..685
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            686..813
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            814..863
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            864..913
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            914..961
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            962..4066
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="hexamer: AAGAAA"
     polyA_site      2936
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="hexamer: AATAAA"
     polyA_site      4066
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="major polyA site"
ORIGIN      
        1 gggagaagcg tttccggtgg cggcggaggc tgcactgagc gggacctgcg agcagcgcgg
       61 gcggcagccc gggggaagcg tccgggacca tgtctggaga actaccacca aacattaaca
      121 tcaaggaacc tcgatgggat caaagcactt tcattggacg agccaatcat ttcttcactg
      181 taactgaccc caggaacatt ctgttaacca acgaacaact cgagagtgcg agaaaaatag
      241 tacatgatta caggcaagga attgttcctc ctggtcttac agaaaatgaa ttgtggagag
      301 caaagtacat ctatgattca gcttttcatc ctgacactgg tgagaagatg attttgatag
      361 gaagaatgtc agcccaggtt cccatgaaca tgaccatcac aggttgtatg atgacgtttt
      421 acaggactac gccggctgtg ctgttctggc agtggattaa ccagtccttc aatgccgtcg
      481 tcaattacac caacagaagt ggagacgcac ccctcactgt caatgagttg ggaacagctt
      541 acgtttctgc aacaactggt gccgtagcaa cagctctagg actcaatgca ttgaccaagc
      601 atgtctcacc actgatagga cgttttgttc cctttgctgc cgtagctgct gctaattgca
      661 ttaatattcc attaatgagg caaagggaac tcaaagttgg cattcccgtc acggatgaga
      721 atgggaaccg cttgggggag tcggcgaacg ctgcgaaaca agccatcacg caagttgtcg
      781 tgtccaggat tctcatggca gcccctggca tggccatccc tccattcatt atgaacactt
      841 tggaaaagaa agcctttttg aagaggttcc catggatgag tgcacccatt caagttgggt
      901 tagttggctt ctgtttggtg tttgctacac ccctgtgttg tgccctgttt cctcagaaaa
      961 gttccatgtc tgtgacaagc ttggaggccg agttgcaagc taagatccaa gagagccatc
     1021 ctgaattgcg acgcgtgtac ttcaataagg gattgtaaag cagggaggaa acctctgcag
     1081 ctcattctgc cactgcaaag ctggtgtagc catgctggtg agaaaaatcc tgttcaacct
     1141 gggttctccc agttacggaa accttttaaa gatccacatt agccttttag aataaagctg
     1201 ctactttaac agagcacctg gcgtgggcca agtgcctgat actcccttac actgaatcat
     1261 gttatgattt atagaaatac ctttcctgta gcttttatag tcattgtttt tcaaagacga
     1321 tataccagcc ctcacccagg ttttaaaaaa gcactggtag gcatagaata ggtgctcagt
     1381 atatggtcag taaatgttct attgattatc aatcagtgaa aaaagaaatc tgtttaaaat
     1441 actgaatttt catctcactc ccattgcaaa tcaaggagat ctcagcagtg aactgggaaa
     1501 atacaaaagc tctgggctaa tctataaaaa cttaccctga aatattaagg gcagtttgct
     1561 tctagtttgg ggattgcgct agcccaatga aggtgatgaa gcttttggat ttggagggta
     1621 aaagctcctt cacacccctt ccaaaagtca gtcacagacc actgcaacat gccttccctg
     1681 ctggatcatt atatacattc agattgtgag tggattgcct tggttgactt ttaatttatt
     1741 gttttttgtt cttataaaga tgataatctt accttgcagt tattgacttt atattcaatt
     1801 atttacatca aataatgaaa taactgaaat gtacaaatgt caaattttgg aagtatattc
     1861 aataccaatg ctgtatgagt gggctgaatc cagttcattg tttttttttt ggtaagaagt
     1921 gagactacag ttccagctac ctacatgtct tttcttgtca tccttataga tctctttggc
     1981 tttcagaaag atacagtgat aatgtgtgta tgaatcagtc acaatgaatt ttacttgaat
     2041 attgtatgtt gcattccact tcatttgaaa ataatgaaac catgtaccac tgtttacatc
     2101 atctgtagtg atttcataga taatatattt aatatgacag attatgtttc aactctgtag
     2161 atgtttaacg tcatagacag ttggccctct gtatccgtga gctctatatc tgtgaattca
     2221 accaagtttg gatggaaaat tttttttttt tttttttttt tgagacggag tctcgctctg
     2281 tcacccaggc tggagtgcag tggcgtagtc tcggctcact gcaagctccg cctcccgggt
     2341 tcacgccgtt ctcctgcctc agcctctctg agaagctggg actacaggcg cccgccacca
     2401 cgcccggcta atttttttgt atttttagta gagacggggt ttcactgtgg tctcgatctc
     2461 ctgacctcgt gatccgcccg ccttggcctc ccaaggtgct gggattacaa gcgtgagcca
     2521 ccgcacccgg cctgaaaata ttttctaaaa agataaaaaa tatacataac gatgaaaaat
     2581 aatacaaatt taaaaaccaa tacagtataa caactattta catagtgctt acattgtatt
     2641 aggtgttata agcaatctag agatgattta gcaagtatac aggaggatgt gcctaggtta
     2701 tatgcaaata ctgtgccatt ttatatcagg aacttgagca tctgcagata ttggtatcgg
     2761 agggcggtcc tggaaccaag catccacgga tactgagggg tgacatttca tgaagtgtag
     2821 atcattgtat tcagagattg taaatgaaaa aaatatagaa actatttagt tttggtagat
     2881 tttttttctg acaatgtgac cagactgaat ttcctcataa agaaaaaatg gcgtgccttg
     2941 tgtctgtgtt tctcttttct ctgaaaggat taatagatct gaagctttgg gccactcaga
     3001 gccttccttg atgctgccag agtcttctta tttagatttt ctgtcttaaa ccattggaag
     3061 caaaacggtt ttcccatgac attctggcct tggacagatt ctgttgtcct cgacgcgtct
     3121 ctttataaag tggtaaaagc ctgaaattca gggcagctct ccatgaggtg ctgaagggct
     3181 cttttcataa gaagctaagg cactgctgcc tgccccaggt gtcccgctcc tctcagagtc
     3241 ctccccctac caggtagtgt gtagctccat ttcagaatgt taacctccag tgaagagcta
     3301 atgactggtt agaagattga caaactaacc aaaattttac acactccggt tatgtgtgtg
     3361 aaaggttata aaaggaatgg ccgggtgcgg tggctcaccc ctgtaatccc agcactttgg
     3421 gaggccgagg cgggtggatc acctgaggtc aggagtttga gaccagcctg gccaacatgg
     3481 agaaaccccg cctctactaa aaatacaaaa aattagccag gcatggaggc acatgcctat
     3541 aatcccagct actcgggagg ctgaggtagg agaatcgctt gaatccggga gctggaggtt
     3601 gcagtgagcc aagatcgcac cattgcactc cagcctgggc aacaagagcg aaactccatc
     3661 tcaaaaaaaa aaaaaagaga ttataaaagg gatgatgaac atggagctgc atctttttaa
     3721 acgttgtttt ttgatgcttc agactcttaa tgcttttata taaagctatc aactgtatgt
     3781 tgatcacagt ttataagaaa gaacaaatca agattggcaa tccttgccga tcttttagaa
     3841 ataccttttc tggagaaaaa aaaatccaca tgaagtgcaa taagcttata aagctaagta
     3901 gttattaata tttctattaa catgatacaa aggatgatga ttgtaagtgt ttactgactg
     3961 gcagctttta tttcagtatt agcacagcgt cttgccagtg ttggaggcca tgtattattt
     4021 cagttcaact ggatgaaatg ttaaataaac tcagaatgaa aataaa
//
