LOCUS       NM_001322982            4065 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens sideroflexin 1 (SFXN1), transcript variant 6, mRNA.
ACCESSION   NM_001322982
VERSION     NM_001322982.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Andriani,L., Ling,Y.X., Yang,S.Y., Zhao,Q., Ma,X.Y., Huang,M.Y.,
            Zhang,Y.L., Zhang,F.L., Li,D.Q. and Shao,Z.M.
  TITLE     Sideroflexin-1 promotes progression and sensitivity to lapatinib in
            triple-negative breast cancer by inhibiting TOLLIP-mediated
            autophagic degradation of CIP2A
  JOURNAL   Cancer Lett 597, 217008 (2024)
   PUBMED   38849012
  REMARK    GeneRIF: Sideroflexin-1 promotes progression and sensitivity to
            lapatinib in triple-negative breast cancer by inhibiting
            TOLLIP-mediated autophagic degradation of CIP2A.
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Li,Y., Yang,W., Liu,C., Zhou,S., Liu,X., Zhang,T., Wu,L., Li,X.,
            Zhang,J. and Chang,E.
  TITLE     SFXN1-mediated immune cell infiltration and tumorigenesis in lung
            adenocarcinoma: A potential therapeutic target
  JOURNAL   Int Immunopharmacol 132, 111918 (2024)
   PUBMED   38537539
  REMARK    GeneRIF: SFXN1-mediated immune cell infiltration and tumorigenesis
            in lung adenocarcinoma: A potential therapeutic target.
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Liu,W., Du,Q., Mei,T., Wang,J., Huang,D. and Qin,T.
  TITLE     Comprehensive analysis the prognostic and immune characteristics of
            mitochondrial transport-related gene SFXN1 in lung adenocarcinoma
  JOURNAL   BMC Cancer 24 (1), 94 (2024)
   PUBMED   38233752
  REMARK    GeneRIF: Comprehensive analysis the prognostic and immune
            characteristics of mitochondrial transport-related gene SFXN1 in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Yagi,K., Shimada,S., Akiyama,Y., Hatano,M., Asano,D., Ishikawa,Y.,
            Ueda,H., Watanabe,S., Akahoshi,K., Ono,H., Tanabe,M. and Tanaka,S.
  TITLE     Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in
            non-viral hepatocellular carcinoma
  JOURNAL   Sci Rep 13 (1), 9449 (2023)
   PUBMED   37296228
  REMARK    GeneRIF: Loss of SFXN1 mitigates lipotoxicity and predicts poor
            outcome in non-viral hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Chen,L., Kang,Y., Jiang,Y., You,J., Huang,C., Xu,X. and Chen,F.
  TITLE     Overexpression of SFXN1 indicates poor prognosis and promotes tumor
            progression in lung adenocarcinoma
  JOURNAL   Pathol Res Pract 237, 154031 (2022)
   PUBMED   35878532
  REMARK    GeneRIF: Overexpression of SFXN1 indicates poor prognosis and
            promotes tumor progression in lung adenocarcinoma.
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Giudetti,A.M., Sabetta,S., di Summa,R., Leo,M., Damiano,F.,
            Siculella,L. and Gnoni,G.V.
  TITLE     Differential effects of coconut oil- and fish oil-enriched diets on
            tricarboxylate carrier in rat liver mitochondria
  JOURNAL   J Lipid Res 44 (11), 2135-2141 (2003)
   PUBMED   14634051
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Miyake,S., Yamashita,T., Taniguchi,M., Tamatani,M., Sato,K. and
            Tohyama,M.
  TITLE     Identification and characterization of a novel mitochondrial
            tricarboxylate carrier
  JOURNAL   Biochem Biophys Res Commun 295 (2), 463-468 (2002)
   PUBMED   12150972
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Zara,V., Giudetti,A.M., Siculella,L., Palmieri,F. and Gnoni,G.V.
  TITLE     Covariance of tricarboxylate carrier activity and lipogenesis in
            liver of polyunsaturated fatty acid (n-6) fed rats
  JOURNAL   Eur J Biochem 268 (22), 5734-5739 (2001)
   PUBMED   11722557
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Fleming,M.D., Campagna,D.R., Haslett,J.N., Trenor,C.C. 3rd and
            Andrews,N.C.
  TITLE     A mutation in a mitochondrial transmembrane protein is responsible
            for the pleiotropic hematological and skeletal phenotype of
            flexed-tail (f/f) mice
  JOURNAL   Genes Dev 15 (6), 652-657 (2001)
   PUBMED   11274051
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Kaplan,R.S. and Mayor,J.A.
  TITLE     Structure, function and regulation of the tricarboxylate transport
            protein from rat liver mitochondria
  JOURNAL   J Bioenerg Biomembr 25 (5), 503-514 (1993)
   PUBMED   8132490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091393.3.
            
            On May 31, 2019 this sequence version replaced NM_001322982.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.135141.1,
                                           SRR1660807.154284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC091393.3         77385-77492         c
            109-281             AC091393.3         63785-63957         c
            282-423             AC091393.3         46850-46991         c
            424-522             AC091393.3         45845-45943         c
            523-598             AC091393.3         44526-44601         c
            599-684             AC091393.3         43856-43941         c
            685-812             AC091393.3         42462-42589         c
            813-862             AC091393.3         39389-39438         c
            863-912             AC091393.3         34084-34133         c
            913-960             AC091393.3         33630-33677         c
            961-4065            AC091393.3         26310-29414         c
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4065
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="sideroflexin 1"
                     /db_xref="GeneID:94081"
                     /db_xref="HGNC:HGNC:16085"
                     /db_xref="MIM:615569"
     exon            1..108
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            109..281
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1057
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="isoform 2 is encoded by transcript variant 6;
                     tricarboxylate carrier protein"
                     /codon_start=1
                     /product="sideroflexin-1 isoform 2"
                     /protein_id="NP_001309911.1"
                     /db_xref="GeneID:94081"
                     /db_xref="HGNC:HGNC:16085"
                     /db_xref="MIM:615569"
                     /translation="MITENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITG
                     CMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATAL
                     GLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANA
                     AKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFA
                     TPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL"
     exon            282..423
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            424..522
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            523..598
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            599..684
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            685..812
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            813..862
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            863..912
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            913..960
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     exon            961..4065
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="hexamer: AAGAAA"
     polyA_site      2935
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
     regulatory      4043..4048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="hexamer: AATAAA"
     polyA_site      4065
                     /gene="SFXN1"
                     /gene_synonym="SLC56A1; TCC"
                     /note="major polyA site"
ORIGIN      
        1 gggagaagcg tttccggtgg cggcggaggc tgcactgagc gggacctgcg agcagcgcgg
       61 gcggcagccc gggggaagcg gtgagtcgcg ggcggcaggc ccagccagtc cgggaccatg
      121 tctggagaac taccaccaaa cattaacatc aaggaacctc gatgggatca aagcactttc
      181 attggacgag ccaatcattt cttcactgta actgacccca ggaacattct gttaaccaac
      241 gaacaactcg agagtgcgag aaaaatagta catgattaca gaaaatgaat tgtggagagc
      301 aaagtacatc tatgattcag cttttcatcc tgacactggt gagaagatga ttttgatagg
      361 aagaatgtca gcccaggttc ccatgaacat gaccatcaca ggttgtatga tgacgtttta
      421 caggactacg ccggctgtgc tgttctggca gtggattaac cagtccttca atgccgtcgt
      481 caattacacc aacagaagtg gagacgcacc cctcactgtc aatgagttgg gaacagctta
      541 cgtttctgca acaactggtg ccgtagcaac agctctagga ctcaatgcat tgaccaagca
      601 tgtctcacca ctgataggac gttttgttcc ctttgctgcc gtagctgctg ctaattgcat
      661 taatattcca ttaatgaggc aaagggaact caaagttggc attcccgtca cggatgagaa
      721 tgggaaccgc ttgggggagt cggcgaacgc tgcgaaacaa gccatcacgc aagttgtcgt
      781 gtccaggatt ctcatggcag cccctggcat ggccatccct ccattcatta tgaacacttt
      841 ggaaaagaaa gcctttttga agaggttccc atggatgagt gcacccattc aagttgggtt
      901 agttggcttc tgtttggtgt ttgctacacc cctgtgttgt gccctgtttc ctcagaaaag
      961 ttccatgtct gtgacaagct tggaggccga gttgcaagct aagatccaag agagccatcc
     1021 tgaattgcga cgcgtgtact tcaataaggg attgtaaagc agggaggaaa cctctgcagc
     1081 tcattctgcc actgcaaagc tggtgtagcc atgctggtga gaaaaatcct gttcaacctg
     1141 ggttctccca gttacggaaa ccttttaaag atccacatta gccttttaga ataaagctgc
     1201 tactttaaca gagcacctgg cgtgggccaa gtgcctgata ctcccttaca ctgaatcatg
     1261 ttatgattta tagaaatacc tttcctgtag cttttatagt cattgttttt caaagacgat
     1321 ataccagccc tcacccaggt tttaaaaaag cactggtagg catagaatag gtgctcagta
     1381 tatggtcagt aaatgttcta ttgattatca atcagtgaaa aaagaaatct gtttaaaata
     1441 ctgaattttc atctcactcc cattgcaaat caaggagatc tcagcagtga actgggaaaa
     1501 tacaaaagct ctgggctaat ctataaaaac ttaccctgaa atattaaggg cagtttgctt
     1561 ctagtttggg gattgcgcta gcccaatgaa ggtgatgaag cttttggatt tggagggtaa
     1621 aagctccttc acaccccttc caaaagtcag tcacagacca ctgcaacatg ccttccctgc
     1681 tggatcatta tatacattca gattgtgagt ggattgcctt ggttgacttt taatttattg
     1741 ttttttgttc ttataaagat gataatctta ccttgcagtt attgacttta tattcaatta
     1801 tttacatcaa ataatgaaat aactgaaatg tacaaatgtc aaattttgga agtatattca
     1861 ataccaatgc tgtatgagtg ggctgaatcc agttcattgt tttttttttg gtaagaagtg
     1921 agactacagt tccagctacc tacatgtctt ttcttgtcat ccttatagat ctctttggct
     1981 ttcagaaaga tacagtgata atgtgtgtat gaatcagtca caatgaattt tacttgaata
     2041 ttgtatgttg cattccactt catttgaaaa taatgaaacc atgtaccact gtttacatca
     2101 tctgtagtga tttcatagat aatatattta atatgacaga ttatgtttca actctgtaga
     2161 tgtttaacgt catagacagt tggccctctg tatccgtgag ctctatatct gtgaattcaa
     2221 ccaagtttgg atggaaaatt tttttttttt tttttttttt gagacggagt ctcgctctgt
     2281 cacccaggct ggagtgcagt ggcgtagtct cggctcactg caagctccgc ctcccgggtt
     2341 cacgccgttc tcctgcctca gcctctctga gaagctggga ctacaggcgc ccgccaccac
     2401 gcccggctaa tttttttgta tttttagtag agacggggtt tcactgtggt ctcgatctcc
     2461 tgacctcgtg atccgcccgc cttggcctcc caaggtgctg ggattacaag cgtgagccac
     2521 cgcacccggc ctgaaaatat tttctaaaaa gataaaaaat atacataacg atgaaaaata
     2581 atacaaattt aaaaaccaat acagtataac aactatttac atagtgctta cattgtatta
     2641 ggtgttataa gcaatctaga gatgatttag caagtataca ggaggatgtg cctaggttat
     2701 atgcaaatac tgtgccattt tatatcagga acttgagcat ctgcagatat tggtatcgga
     2761 gggcggtcct ggaaccaagc atccacggat actgaggggt gacatttcat gaagtgtaga
     2821 tcattgtatt cagagattgt aaatgaaaaa aatatagaaa ctatttagtt ttggtagatt
     2881 ttttttctga caatgtgacc agactgaatt tcctcataaa gaaaaaatgg cgtgccttgt
     2941 gtctgtgttt ctcttttctc tgaaaggatt aatagatctg aagctttggg ccactcagag
     3001 ccttccttga tgctgccaga gtcttcttat ttagattttc tgtcttaaac cattggaagc
     3061 aaaacggttt tcccatgaca ttctggcctt ggacagattc tgttgtcctc gacgcgtctc
     3121 tttataaagt ggtaaaagcc tgaaattcag ggcagctctc catgaggtgc tgaagggctc
     3181 ttttcataag aagctaaggc actgctgcct gccccaggtg tcccgctcct ctcagagtcc
     3241 tccccctacc aggtagtgtg tagctccatt tcagaatgtt aacctccagt gaagagctaa
     3301 tgactggtta gaagattgac aaactaacca aaattttaca cactccggtt atgtgtgtga
     3361 aaggttataa aaggaatggc cgggtgcggt ggctcacccc tgtaatccca gcactttggg
     3421 aggccgaggc gggtggatca cctgaggtca ggagtttgag accagcctgg ccaacatgga
     3481 gaaaccccgc ctctactaaa aatacaaaaa attagccagg catggaggca catgcctata
     3541 atcccagcta ctcgggaggc tgaggtagga gaatcgcttg aatccgggag ctggaggttg
     3601 cagtgagcca agatcgcacc attgcactcc agcctgggca acaagagcga aactccatct
     3661 caaaaaaaaa aaaaagagat tataaaaggg atgatgaaca tggagctgca tctttttaaa
     3721 cgttgttttt tgatgcttca gactcttaat gcttttatat aaagctatca actgtatgtt
     3781 gatcacagtt tataagaaag aacaaatcaa gattggcaat ccttgccgat cttttagaaa
     3841 taccttttct ggagaaaaaa aaatccacat gaagtgcaat aagcttataa agctaagtag
     3901 ttattaatat ttctattaac atgatacaaa ggatgatgat tgtaagtgtt tactgactgg
     3961 cagcttttat ttcagtatta gcacagcgtc ttgccagtgt tggaggccat gtattatttc
     4021 agttcaactg gatgaaatgt taaataaact cagaatgaaa ataaa
//
